| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Esophageal Neoplasms | D004938 | 20 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Brain Neoplasms | D001932 | 15 associated lipids |
(-)-Perillyl alcohol
(-)-perillyl alcohol is a lipid of Prenol Lipids (PR) class. The involved functions are known as Cell Cycle Progression, Cell Cycle, Cell Proliferation, Apoptosis and Isoprenylation. (-)-perillyl alcohol often locates in Cytoplasm, Membrane and Plasma membrane. The associated genes with (-)-Perillyl alcohol are JUN gene, Candidate Disease Gene, IL24 gene, BCL2L1 gene and CFB gene. The related experimental models are Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of (-)-Perillyl alcohol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (-)-Perillyl alcohol?
There are no associated biomedical information in the current reference collection.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (-)-Perillyl alcohol
PubChem Associated disorders and diseases
What pathways are associated with (-)-Perillyl alcohol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with (-)-Perillyl alcohol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (-)-Perillyl alcohol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with (-)-Perillyl alcohol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (-)-Perillyl alcohol?
There are no associated biomedical information in the current reference collection.
What genes are associated with (-)-Perillyl alcohol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (-)-Perillyl alcohol?
Transgenic Model
Transgenic Model are used in the study 'A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer.' (Stratton SP et al., 2010).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with (-)-Perillyl alcohol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Berchtold CM et al. | Perillyl alcohol inhibits a calcium-dependent constitutive nuclear factor-kappaB pathway. | 2005 | Cancer Res. | pmid:16166337 |
| Lebedeva IV et al. | Mechanism of in vitro pancreatic cancer cell growth inhibition by melanoma differentiation-associated gene-7/interleukin-24 and perillyl alcohol. | 2008 | Cancer Res. | pmid:18768668 |
| Barthelman M et al. | Inhibitory effects of perillyl alcohol on UVB-induced murine skin cancer and AP-1 transactivation. | 1998 | Cancer Res. | pmid:9485025 |
| Reddy BS et al. | Chemoprevention of colon carcinogenesis by dietary perillyl alcohol. | 1997 | Cancer Res. | pmid:9012468 |
| Mills JJ et al. | Induction of apoptosis in liver tumors by the monoterpene perillyl alcohol. | 1995 | Cancer Res. | pmid:7867007 |
| Ariazi EA et al. | Activation of the transforming growth factor beta signaling pathway and induction of cytostasis and apoptosis in mammary carcinomas treated with the anticancer agent perillyl alcohol. | 1999 | Cancer Res. | pmid:10213501 |
| Liston BW et al. | Perillyl alcohol as a chemopreventive agent in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis. | 2003 | Cancer Res. | pmid:12750258 |
| Stayrook KR et al. | Induction of the apoptosis-promoting protein Bak by perillyl alcohol in pancreatic ductal adenocarcinoma relative to untransformed ductal epithelial cells. | 1997 | Carcinogenesis | pmid:9276644 |
| Satomi Y et al. | Induction of AP-1 activity by perillyl alcohol in breast cancer cells. | 1999 | Carcinogenesis | pmid:10506111 |
| Shi W and Gould MN | Induction of cytostasis in mammary carcinoma cells treated with the anticancer agent perillyl alcohol. | 2002 | Carcinogenesis | pmid:11756234 |
| Löw-Baselli A et al. | Failure to demonstrate chemoprevention by the monoterpene perillyl alcohol during early rat hepatocarcinogenesis: a cautionary note. | 2000 | Carcinogenesis | pmid:11023545 |
| Wei X et al. | Perillyl alcohol inhibits TCR-mediated [Ca(2+)](i) signaling, alters cell shape and motility, and induces apoptosis in T lymphocytes. | 2000 | Cell. Immunol. | pmid:10805968 |
| Chaudhary SC et al. | Perillyl alcohol attenuates Ras-ERK signaling to inhibit murine skin inflammation and tumorigenesis. | 2009 | Chem. Biol. Interact. | pmid:19161993 |
| Miyazawa M et al. | Sex differences in the metabolism of (+)- and (-)-limonene enantiomers to carveol and perillyl alcohol derivatives by cytochrome p450 enzymes in rat liver microsomes. | 2002 | Chem. Res. Toxicol. | pmid:11800592 |
| Seifert A et al. | An efficient route to selective bio-oxidation catalysts: an iterative approach comprising modeling, diversification, and screening, based on CYP102A1. | 2011 | Chembiochem | pmid:21591046 |
| Gómez-Contreras PC et al. | In vitro induction of apoptosis in U937 cells by perillyl alcohol with sensitization by pentoxifylline: increased BCL-2 and BAX protein expression. | 2006 | Chemotherapy | pmid:17008791 |
| Clark SS et al. | Anti-leukemia effect of perillyl alcohol in Bcr/Abl-transformed cells indirectly inhibits signaling through Mek in a Ras- and Raf-independent fashion. | 2003 | Clin. Cancer Res. | pmid:14555523 |
| Stearns V et al. | A pilot surrogate end point biomarker trial of perillyl alcohol in breast neoplasia. | 2004 | Clin. Cancer Res. | pmid:15569989 |
| Ripple GH et al. | Phase I clinical trial of perillyl alcohol administered daily. | 1998 | Clin. Cancer Res. | pmid:9607573 |
| Hudes GR et al. | Phase I pharmacokinetic trial of perillyl alcohol (NSC 641066) in patients with refractory solid malignancies. | 2000 | Clin. Cancer Res. | pmid:10955786 |
| Ripple GH et al. | Phase I clinical and pharmacokinetic study of perillyl alcohol administered four times a day. | 2000 | Clin. Cancer Res. | pmid:10690515 |
| Sarkar S et al. | Chemoprevention gene therapy (CGT) of pancreatic cancer using perillyl alcohol and a novel chimeric serotype cancer terminator virus. | 2014 | Curr. Mol. Med. | pmid:24236457 |
| Prado R et al. | Nonmelanoma skin cancer chemoprevention. | 2011 | Dermatol Surg | pmid:21895847 |
| Phillips LR et al. | Pharmacokinetics of active drug metabolites after oral administration of perillyl alcohol, an investigational antineoplastic agent, to the dog. | 1995 | Drug Metab. Dispos. | pmid:7587953 |
| Miyazawa M et al. | Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes. | 2002 | Drug Metab. Dispos. | pmid:11950794 |
| Lefranc F et al. | 4-Bromo-2-(piperidin-1-yl)thiazol-5-yl-phenyl methanone (12b) inhibits Na+/K(+)-ATPase and Ras oncogene activity in cancer cells. | 2013 | Eur J Med Chem | pmid:23474907 |
| Russell J and Ling CC | Studies with cytotoxic agents suggest that apoptosis is not a major determinant of clonogenic death in neuroblastoma cells. | 2003 | Eur. J. Cancer | pmid:14522384 |
| Kennedy S et al. | Effect of antiproliferative agents on vascular function in normal and in vitro balloon-injured porcine coronary arteries. | 2003 | Eur. J. Pharmacol. | pmid:14637181 |
| Sundin T et al. | eIF4E-Overexpression imparts perillyl alcohol and rapamycin-mediated regulation of telomerase reverse transcriptase. | 2013 | Exp. Cell Res. | pmid:23747720 |
| Lantry LE et al. | Chemopreventive efficacy of promising farnesyltransferase inhibitors. | 2000 | Exp. Lung Res. | pmid:11195470 |
| Bicas JL et al. | Evaluation of the antioxidant and antiproliferative potential of bioflavors. | 2011 | Food Chem. Toxicol. | pmid:21540069 |
| Bhatia SP et al. | Fragrance material review on p-mentha-1,8-dien-7-ol. | 2008 | Food Chem. Toxicol. | pmid:18640209 |
| Opdyke DL | Monographs on fragrance raw materials. | 1981 | Food Cosmet Toxicol | pmid:7286874 |
| Silva MM et al. | Influence of GSTM1 and GSTT1 polymorphisms on the survival rate of patients with malignant glioma under perillyl alcohol-based therapy. | 2013 | Genet. Mol. Res. | pmid:23765968 |
| Bailey HH et al. | A phase II trial of daily perillyl alcohol in patients with advanced ovarian cancer: Eastern Cooperative Oncology Group Study E2E96. | 2002 | Gynecol. Oncol. | pmid:12051875 |
| Sultana S et al. | Perillyl alcohol as a protective modulator against rat hepatocarcinogenesis via amelioration of oxidative damage and cell proliferation. | 2013 | Hum Exp Toxicol | pmid:23536516 |
| Alison M | Promoting apoptosis. | 1995 | Hum Exp Toxicol | pmid:7576838 |
| Meadows SM et al. | Phase II trial of perillyl alcohol in patients with metastatic colorectal cancer. | 2002 | Int J Gastrointest Cancer | pmid:12794248 |
| Chen TC et al. | Perillyl Alcohol and Its Drug-Conjugated Derivatives as Potential Novel Methods of Treating Brain Metastases. | 2016 | Int J Mol Sci | pmid:27598140 |
| Andrade LN et al. | In Vivo Anti-Tumor Activity and Toxicological Evaluations of Perillaldehyde 8,9-Epoxide, a Derivative of Perillyl Alcohol. | 2016 | Int J Mol Sci | pmid:26742032 |
| Farazuddin M et al. | Anticancer efficacy of perillyl alcohol-bearing PLGA microparticles. | 2012 | Int J Nanomedicine | pmid:22275821 |
| Gupta A and Myrdal PB | Development of a perillyl alcohol topical cream formulation. | 2004 | Int J Pharm | pmid:14706249 |
| Del Toro-Arreola S et al. | Effect of D-limonene on immune response in BALB/c mice with lymphoma. | 2005 | Int. Immunopharmacol. | pmid:15778119 |
| Teruszkin Balassiano I et al. | Effects of perillyl alcohol in glial C6 cell line in vitro and anti-metastatic activity in chorioallantoic membrane model. | 2002 | Int. J. Mol. Med. | pmid:12430008 |
| Ahn KJ et al. | Cytotoxicity of perillyl alcohol against cancer cells is potentiated by hyperthermia. | 2003 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:14529788 |
| Liu G et al. | Phase II trial of perillyl alcohol (NSC 641066) administered daily in patients with metastatic androgen independent prostate cancer. | 2003 | Invest New Drugs | pmid:14578686 |
| Da Fonseca CO et al. | Correlation of tumor topography and peritumoral edema of recurrent malignant gliomas with therapeutic response to intranasal administration of perillyl alcohol. | 2009 | Invest New Drugs | pmid:19139816 |
| Tao L and Pereira MA | Quantification of carvone, cineole, perillaldehyde, perillyl alcohol and sobrerol by isocratic high-performance liquid chromatography. | 1998 | J Chromatogr A | pmid:9468652 |
| Hua HY et al. | High-performance liquid chromatographic and pharmacokinetic analyses of an intravenous submicron emulsion of perillyl alcohol in rats. | 2008 | J Pharm Biomed Anal | pmid:18849133 |
| Gupta A et al. | An HPLC method for quantitation of perillyl alcohol in a topical pharmaceutical cream formulation. | 2005 | J Pharm Biomed Anal | pmid:15740902 |