| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Esophageal Neoplasms | D004938 | 20 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Brain Neoplasms | D001932 | 15 associated lipids |
(-)-Perillyl alcohol
(-)-perillyl alcohol is a lipid of Prenol Lipids (PR) class. The involved functions are known as Cell Cycle Progression, Cell Cycle, Cell Proliferation, Apoptosis and Isoprenylation. (-)-perillyl alcohol often locates in Cytoplasm, Membrane and Plasma membrane. The associated genes with (-)-Perillyl alcohol are JUN gene, Candidate Disease Gene, IL24 gene, BCL2L1 gene and CFB gene. The related experimental models are Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of (-)-Perillyl alcohol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (-)-Perillyl alcohol?
There are no associated biomedical information in the current reference collection.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (-)-Perillyl alcohol
PubChem Associated disorders and diseases
What pathways are associated with (-)-Perillyl alcohol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with (-)-Perillyl alcohol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (-)-Perillyl alcohol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with (-)-Perillyl alcohol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (-)-Perillyl alcohol?
There are no associated biomedical information in the current reference collection.
What genes are associated with (-)-Perillyl alcohol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (-)-Perillyl alcohol?
Transgenic Model
Transgenic Model are used in the study 'A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer.' (Stratton SP et al., 2010).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with (-)-Perillyl alcohol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hua HY et al. | High-performance liquid chromatographic and pharmacokinetic analyses of an intravenous submicron emulsion of perillyl alcohol in rats. | 2008 | J Pharm Biomed Anal | pmid:18849133 |
| Bailey HH et al. | Phase II trial of daily oral perillyl alcohol (NSC 641066) in treatment-refractory metastatic breast cancer. | 2008 | Cancer Chemother. Pharmacol. | pmid:17885756 |
| da Fonseca CO et al. | Preliminary results from a phase I/II study of perillyl alcohol intranasal administration in adults with recurrent malignant gliomas. | 2008 | Surg Neurol | pmid:18295834 |
| Bisson JF et al. | Anti-inflammatory senescence actives 5203-L molecule to promote healthy aging and prolongation of lifespan. | 2008 | Rejuvenation Res | pmid:18370605 |
| Stratton SP et al. | Phase 1 study of topical perillyl alcohol cream for chemoprevention of skin cancer. | 2008 | Nutr Cancer | pmid:18444166 |
| Bhatia SP et al. | Fragrance material review on p-mentha-1,8-dien-7-ol. | 2008 | Food Chem. Toxicol. | pmid:18640209 |
| Lebedeva IV et al. | Chemoprevention by perillyl alcohol coupled with viral gene therapy reduces pancreatic cancer pathogenesis. | 2008 | Mol. Cancer Ther. | pmid:18645014 |
| Lebedeva IV et al. | Mechanism of in vitro pancreatic cancer cell growth inhibition by melanoma differentiation-associated gene-7/interleukin-24 and perillyl alcohol. | 2008 | Cancer Res. | pmid:18768668 |
| Yamamoto Y et al. | Synthesis of phosphatidylated-monoterpene alcohols catalyzed by phospholipase D and their antiproliferative effects on human cancer cells. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18556205 |
| Yeruva L et al. | Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells. | 2007 | Cancer Lett. | pmid:17888568 |
| Peffley DM et al. | Perillyl alcohol and genistein differentially regulate PKB/Akt and 4E-BP1 phosphorylation as well as eIF4E/eIF4G interactions in human tumor cells. | 2007 | Arch. Biochem. Biophys. | pmid:17601486 |
| Wiseman DA et al. | Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21(Cip1) and p27(Kip1) in human pancreatic adenocarcinoma cells. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17138864 |
| Chan NL et al. | Polycyclic aromatic hydrocarbon-induced CYP1B1 activity is suppressed by perillyl alcohol in MCF-7 cells. | 2006 | Toxicol. Appl. Pharmacol. | pmid:16307765 |
| Chung BH et al. | Perillyl alcohol inhibits the expression and function of the androgen receptor in human prostate cancer cells. | 2006 | Cancer Lett. | pmid:16029925 |
| Clark SS | Perillyl alcohol induces c-Myc-dependent apoptosis in Bcr/Abl-transformed leukemia cells. | 2006 | Oncology | pmid:16439861 |
| da Fonseca CO et al. | Recent advances in the molecular genetics of malignant gliomas disclose targets for antitumor agent perillyl alcohol. | 2006 | Surg Neurol | pmid:16427438 |
| Fischer Jde S et al. | Effects of perillyl alcohol and heat shock treatment in gene expression of human lung adenocarcinoma cell line A549. | 2006 | J. Exp. Ther. Oncol. | pmid:17024970 |
| Da Fonseca CO et al. | Anaplastic oligodendroglioma responding favorably to intranasal delivery of perillyl alcohol: a case report and literature review. | 2006 | Surg Neurol | pmid:17145324 |
| Gómez-Contreras PC et al. | In vitro induction of apoptosis in U937 cells by perillyl alcohol with sensitization by pentoxifylline: increased BCL-2 and BAX protein expression. | 2006 | Chemotherapy | pmid:17008791 |
| Loutrari H et al. | Mastic oil from Pistacia lentiscus var. chia inhibits growth and survival of human K562 leukemia cells and attenuates angiogenesis. | 2006 | Nutr Cancer | pmid:16965245 |
| Gupta A et al. | An HPLC method for quantitation of perillyl alcohol in a topical pharmaceutical cream formulation. | 2005 | J Pharm Biomed Anal | pmid:15740902 |
| Fernandes J et al. | Perillyl alcohol induces apoptosis in human glioblastoma multiforme cells. | 2005 | Oncol. Rep. | pmid:15809762 |
| Courdavault V et al. | CaaX-prenyltransferases are essential for expression of genes involvedin the early stages of monoterpenoid biosynthetic pathway in Catharanthus roseus cells. | 2005 | Plant Mol. Biol. | pmid:15952070 |
| Bassi AM et al. | Protein and m-RNA expression of farnesyl-transferases, RhoA and RhoB in rat liver hepatocytes: action of perillyl alcohol and vitamin A in vivo. | 2005 | J. Biomed. Sci. | pmid:15959631 |
| Del Toro-Arreola S et al. | Effect of D-limonene on immune response in BALB/c mice with lymphoma. | 2005 | Int. Immunopharmacol. | pmid:15778119 |
| Berchtold CM et al. | Perillyl alcohol inhibits a calcium-dependent constitutive nuclear factor-kappaB pathway. | 2005 | Cancer Res. | pmid:16166337 |
| van Beilen JB et al. | Biocatalytic production of perillyl alcohol from limonene by using a novel Mycobacterium sp. cytochrome P450 alkane hydroxylase expressed in Pseudomonas putida. | 2005 | Appl. Environ. Microbiol. | pmid:15811996 |
| Samaila D et al. | Monoterpenes enhanced the sensitivity of head and neck cancer cells to radiation treatment in vitro. | 2004 Sep-Oct | Anticancer Res. | pmid:15517920 |
| Bailey HH et al. | A phase I trial of perillyl alcohol administered four times daily for 14 days out of 28 days. | 2004 | Cancer Chemother. Pharmacol. | pmid:15205914 |
| Loutrari H et al. | Perillyl alcohol is an angiogenesis inhibitor. | 2004 | J. Pharmacol. Exp. Ther. | pmid:15210838 |
| Gupta A and Myrdal PB | Development of a perillyl alcohol topical cream formulation. | 2004 | Int J Pharm | pmid:14706249 |
| Stearns V et al. | A pilot surrogate end point biomarker trial of perillyl alcohol in breast neoplasia. | 2004 | Clin. Cancer Res. | pmid:15569989 |
| Xu M et al. | Perillyl alcohol-mediated inhibition of lung cancer cell line proliferation: potential mechanisms for its chemotherapeutic effects. | 2004 | Toxicol. Appl. Pharmacol. | pmid:14998688 |
| Yuri T et al. | Perillyl alcohol inhibits human breast cancer cell growth in vitro and in vivo. | 2004 | Breast Cancer Res. Treat. | pmid:15026623 |
| Chen Y and Hu D | Effects of POH in combination with STI571 on the proliferation and apoptosis of K562 cells. | 2004 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:15165112 |
| Kennedy S et al. | Effect of antiproliferative agents on vascular function in normal and in vitro balloon-injured porcine coronary arteries. | 2003 | Eur. J. Pharmacol. | pmid:14637181 |
| Ahn KJ et al. | Cytotoxicity of perillyl alcohol against cancer cells is potentiated by hyperthermia. | 2003 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:14529788 |
| Clark SS et al. | Anti-leukemia effect of perillyl alcohol in Bcr/Abl-transformed cells indirectly inhibits signaling through Mek in a Ras- and Raf-independent fashion. | 2003 | Clin. Cancer Res. | pmid:14555523 |
| Liu G et al. | Phase II trial of perillyl alcohol (NSC 641066) administered daily in patients with metastatic androgen independent prostate cancer. | 2003 | Invest New Drugs | pmid:14578686 |
| Russell J and Ling CC | Studies with cytotoxic agents suggest that apoptosis is not a major determinant of clonogenic death in neuroblastoma cells. | 2003 | Eur. J. Cancer | pmid:14522384 |
| Holstein SA and Hohl RJ | Monoterpene regulation of Ras and Ras-related protein expression. | 2003 | J. Lipid Res. | pmid:12671036 |
| Rajesh D et al. | Perillyl alcohol as a radio-/chemosensitizer in malignant glioma. | 2003 | J. Biol. Chem. | pmid:12805388 |
| Liston BW et al. | Perillyl alcohol as a chemopreventive agent in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis. | 2003 | Cancer Res. | pmid:12750258 |
| Azzoli CG et al. | A phase I trial of perillyl alcohol in patients with advanced solid tumors. | 2003 | Cancer Chemother. Pharmacol. | pmid:12695855 |
| Morgan-Meadows S et al. | Phase I trial of perillyl alcohol administered four times daily continuously. | 2003 | Cancer Chemother. Pharmacol. | pmid:12904896 |
| Rajesh D and Howard SP | Perillyl alcohol mediated radiosensitization via augmentation of the Fas pathway in prostate cancer cells. | 2003 | Prostate | pmid:12886519 |
| Elegbede JA et al. | Perillyl alcohol and perillaldehyde induced cell cycle arrest and cell death in BroTo and A549 cells cultured in vitro. | 2003 | Life Sci. | pmid:14511768 |
| Burke YD et al. | Effects of the isoprenoids perillyl alcohol and farnesol on apoptosis biomarkers in pancreatic cancer chemoprevention. | 2002 Nov-Dec | Anticancer Res. | pmid:12530055 |
| Murren JR et al. | Phase I study of perillyl alcohol in patients with refractory malignancies. | 2002 Mar-Apr | Cancer Biol. Ther. | pmid:12170772 |
| Bardon S et al. | Monoterpenes inhibit proliferation of human colon cancer cells by modulating cell cycle-related protein expression. | 2002 | Cancer Lett. | pmid:12175534 |