| MeSH term | MeSH ID | Detail |
|---|---|---|
| Stomach Ulcer | D013276 | 75 associated lipids |
| Bacterial Infections | D001424 | 21 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Pleurisy | D010998 | 20 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
Carvacrol
Carvacrol is a lipid of Prenol Lipids (PR) class. Carvacrol is associated with abnormalities such as Consumption-archaic term for TB, Disintegration (morphologic abnormality), Infection, Corn of toe and Candidiasis of vagina. The involved functions are known as Stereochemistry, Anabolism, Oxidation, Process and Binding (Molecular Function). Carvacrol often locates in Skin, Nerve Tissue, Membrane, Endothelium and Plasma membrane. The associated genes with Carvacrol are P4HTM gene, TRPV3 gene, TRPV1 gene, TRPV2 gene and TRPV4 gene. The related lipids are Fatty Acids, Lipopolysaccharides, Octanols, Micelles and butyrate.
Cross Reference
Introduction
To understand associated biological information of Carvacrol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Carvacrol?
Carvacrol is suspected in Candidiasis of vagina, Infection, Infestation, Acquired partial lipodystrophy, Urticaria, Periodontitis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Carvacrol
PubChem Associated disorders and diseases
What pathways are associated with Carvacrol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Carvacrol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Carvacrol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Carvacrol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Carvacrol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Carvacrol?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Carvacrol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang P et al. | The Neuroprotective Effects of Carvacrol on Ethanol-Induced Hippocampal Neurons Impairment via the Antioxidative and Antiapoptotic Pathways. | 2017 | Oxid Med Cell Longev | pmid:28191274 |
| Meents JE et al. | Sensitization of TRPA1 by Protein Kinase A. | 2017 | PLoS ONE | pmid:28076424 |
| Figueiredo MB et al. | Lethal and sublethal effects of essential oil of Lippia sidoides (Verbenaceae) and monoterpenes on Chagas' disease vector Rhodnius prolixus. | 2017 | Mem. Inst. Oswaldo Cruz | pmid:27878214 |
| Vasconcelos SECB et al. | Plectranthus amboinicus essential oil and carvacrol bioactive against planktonic and biofilm of oxacillin- and vancomycin-resistant Staphylococcus aureus. | 2017 | BMC Complement Altern Med | pmid:28915875 |
| Sivaranjani A et al. | Chemopreventive effect of carvacrol on 1,2-dimethylhydrazine induced experimental colon carcinogenesis. | 2016 Apr-Jun | J Cancer Res Ther | pmid:27461646 |
| Xavier FJ et al. | Synthesis and In Vitro Anti Leishmania amazonensis Biological Screening of Morita-Baylis-Hillman Adducts Prepared from Eugenol, Thymol and Carvacrol. | 2016 | Molecules | pmid:27834831 |
| Luo Y et al. | Carvacrol Alleviates Prostate Cancer Cell Proliferation, Migration, and Invasion through Regulation of PI3K/Akt and MAPK Signaling Pathways. | 2016 | Oxid Med Cell Longev | pmid:27803760 |
| Costa-Júnior LM et al. | Acaricidal efficacies of Lippia gracilis essential oil and its phytochemicals against organophosphate-resistant and susceptible strains of Rhipicephalus (Boophilus) microplus. | 2016 | Vet. Parasitol. | pmid:27692332 |
| Burt SA et al. | Cinnamaldehyde, Carvacrol and Organic Acids Affect Gene Expression of Selected Oxidative Stress and Inflammation Markers in IPEC-J2 Cells Exposed to Salmonella typhimurium. | 2016 | Phytother Res | pmid:27561686 |
| Khosravi AR and Erle DJ | Chitin-Induced Airway Epithelial Cell Innate Immune Responses Are Inhibited by Carvacrol/Thymol. | 2016 | PLoS ONE | pmid:27463381 |
| Meents JE et al. | Agonist-induced sensitisation of the irritant receptor ion channel TRPA1. | 2016 | J. Physiol. (Lond.) | pmid:27307078 |
| Deepak V et al. | Carvacrol Inhibits Osteoclastogenesis and Negatively Regulates the Survival of Mature Osteoclasts. | 2016 | Biol. Pharm. Bull. | pmid:27170515 |
| Ran C et al. | Thymol and Carvacrol Affect Hybrid Tilapia through the Combination of Direct Stimulation and an Intestinal Microbiota-Mediated Effect: Insights from a Germ-Free Zebrafish Model. | 2016 | J. Nutr. | pmid:27075912 |
| Andre WP et al. | Comparative efficacy and toxic effects of carvacryl acetate and carvacrol on sheep gastrointestinal nematodes and mice. | 2016 | Vet. Parasitol. | pmid:26872928 |
| El-Sayed el-SM et al. | Thymol and Carvacrol Prevent Doxorubicin-Induced Cardiotoxicity by Abrogation of Oxidative Stress, Inflammation, and Apoptosis in Rats. | 2016 | J. Biochem. Mol. Toxicol. | pmid:26387986 |
| Games E et al. | Structurally Related Monoterpenes p-Cymene, Carvacrol and Thymol Isolated from Essential Oil from Leaves of Lippia sidoides Cham. (Verbenaceae) Protect Mice against Elastase-Induced Emphysema. | 2016 | Molecules | pmid:27775634 |
| Nóbrega RO et al. | Investigation of the antifungal activity of carvacrol against strains of Cryptococcus neoformans. | 2016 | Pharm Biol | pmid:27225838 |
| Cui ZW et al. | Carvacrol protects neuroblastoma SH-SY5Y cells against Fe(2+)-induced apoptosis by suppressing activation of MAPK/JNK-NF-κB signaling pathway. | 2015 | Acta Pharmacol. Sin. | pmid:26592517 |
| Kim JH et al. | Augmenting the Activity of Monoterpenoid Phenols against Fungal Pathogens Using 2-Hydroxy-4-methoxybenzaldehyde that Target Cell Wall Integrity. | 2015 | Int J Mol Sci | pmid:26569223 |
| Guevara L et al. | Impact of Moderate Heat, Carvacrol, and Thymol Treatments on the Viability, Injury, and Stress Response of Listeria monocytogenes. | 2015 | Biomed Res Int | pmid:26539510 |
| Feketa VV and Marrelli SP | Systemic Administration of the TRPV3 Ion Channel Agonist Carvacrol Induces Hypothermia in Conscious Rodents. | 2015 | PLoS ONE | pmid:26528923 |
| Novato TP et al. | Evaluation of the combined effect of thymol, carvacrol and (E)-cinnamaldehyde on Amblyomma sculptum (Acari: Ixodidae) and Dermacentor nitens (Acari: Ixodidae) larvae. | 2015 | Vet. Parasitol. | pmid:26346899 |
| Ahmed HH et al. | Implications of Sex Hormone Receptor Gene Expression in the Predominance of Hepatocellular Carcinoma in Males: Role of Natural Products. | 2015 | Asian Pac. J. Cancer Prev. | pmid:26163620 |
| Patricelli D et al. | Plant defences against ants provide a pathway to social parasitism in butterflies. | 2015 | Proc. Biol. Sci. | pmid:26156773 |
| Peng G et al. | Plant-Derived Tick Repellents Activate the Honey Bee Ectoparasitic Mite TRPA1. | 2015 | Cell Rep | pmid:26146083 |
| Yuan G et al. | Physical Properties, Antioxidant and Antimicrobial Activity of Chitosan Films Containing Carvacrol and Pomegranate Peel Extract. | 2015 | Molecules | pmid:26083037 |
| Pirgozliev V et al. | Partitioning of dietary energy of chickens fed maize- or wheat-based diets with and without a commercial blend of phytogenic feed additives. | 2015 | J. Anim. Sci. | pmid:26020191 |
| Chaillot J et al. | The Monoterpene Carvacrol Generates Endoplasmic Reticulum Stress in the Pathogenic Fungus Candida albicans. | 2015 | Antimicrob. Agents Chemother. | pmid:26014932 |
| Chen WL et al. | Inhibition of TRPM7 by carvacrol suppresses glioblastoma cell proliferation, migration and invasion. | 2015 | Oncotarget | pmid:25965832 |
| Trailović SM et al. | Interaction of carvacrol with the Ascaris suum nicotinic acetylcholine receptors and gamma-aminobutyric acid receptors, potential mechanism of antinematodal action. | 2015 | Parasitol. Res. | pmid:25944741 |
| Boskabady MH and Gholami Mahtaj L | Lung inflammation changes and oxidative stress induced by cigarette smoke exposure in guinea pigs affected by Zataria multiflora and its constituent, carvacrol. | 2015 | BMC Complement Altern Med | pmid:25881210 |
| Cacciatore I et al. | Carvacrol codrugs: a new approach in the antimicrobial plan. | 2015 | PLoS ONE | pmid:25859852 |
| Mith H et al. | The impact of oregano (Origanum heracleoticum) essential oil and carvacrol on virulence gene transcription by Escherichia coli O157:H7. | 2015 | FEMS Microbiol. Lett. | pmid:25790499 |
| Yadav MK et al. | Eugenol: a phyto-compound effective against methicillin-resistant and methicillin-sensitive Staphylococcus aureus clinical strain biofilms. | 2015 | PLoS ONE | pmid:25781975 |
| Rasooly R et al. | Plant compounds enhance the assay sensitivity for detection of active Bacillus cereus toxin. | 2015 | Toxins (Basel) | pmid:25767986 |
| Shaaban HA and Edris AE | Factors affecting the phase behavior and antimicrobial activity of carvacrol microemulsions. | 2015 | J Oleo Sci | pmid:25766929 |
| Chen W et al. | TRPM7 inhibitor carvacrol protects brain from neonatal hypoxic-ischemic injury. | 2015 | Mol Brain | pmid:25761704 |
| Field D et al. | Efficacies of nisin A and nisin V semipurified preparations alone and in combination with plant essential oils for controlling Listeria monocytogenes. | 2015 | Appl. Environ. Microbiol. | pmid:25662980 |
| Sarrazin SL et al. | Antimicrobial and seasonal evaluation of the carvacrol-chemotype oil from Lippia origanoides kunth. | 2015 | Molecules | pmid:25625681 |
| Lansdell SJ et al. | Activation of human 5-hydroxytryptamine type 3 receptors via an allosteric transmembrane site. | 2015 | Mol. Pharmacol. | pmid:25338672 |
| Pires PW et al. | Unitary TRPV3 channel Ca2+ influx events elicit endothelium-dependent dilation of cerebral parenchymal arterioles. | 2015 | Am. J. Physiol. Heart Circ. Physiol. | pmid:26453324 |
| Espina L et al. | Individual Constituents from Essential Oils Inhibit Biofilm Mass Production by Multi-Drug Resistant Staphylococcus aureus. | 2015 | Molecules | pmid:26102069 |
| Andrade-Ochoa S et al. | Quantitative structure-activity relationship of molecules constituent of different essential oils with antimycobacterial activity against Mycobacterium tuberculosis and Mycobacterium bovis. | 2015 | BMC Complement Altern Med | pmid:26400221 |
| Yousefzadi M et al. | Toxicity of essential oil of Satureja khuzistanica: in vitro cytotoxicity and anti-microbial activity. | 2014 Jan-Mar | J Immunotoxicol | pmid:23662744 |
| Klein AH et al. | Eugenol and carvacrol excite first- and second-order trigeminal neurons and enhance their heat-evoked responses. | 2014 | Neuroscience | pmid:24759772 |
| Quintanilla-Licea R et al. | Antiprotozoal activity against Entamoeba histolytica of plants used in northeast Mexican traditional medicine. Bioactive compounds from Lippia graveolens and Ruta chalepensis. | 2014 | Molecules | pmid:25517343 |
| Aristatile B et al. | Carvacrol ameliorates the PPAR-A and cytochrome P450 expression on D-galactosamine induced hepatotoxicity rats. | 2014 | Afr J Tradit Complement Altern Med | pmid:25371573 |
| Nowotarska SW et al. | Effect of structure on the interactions between five natural antimicrobial compounds and phospholipids of bacterial cell membrane on model monolayers. | 2014 | Molecules | pmid:24914896 |
| SelimoÄŸlu Åžen H et al. | Carvacrol and pomegranate extract in treating methotrexate-induced lung oxidative injury in rats. | 2014 | Med. Sci. Monit. | pmid:25326861 |
| Cruz EM et al. | Water deficit and seasonality study on essential oil constituents of Lippia gracilis Schauer germplasm. | 2014 | ScientificWorldJournal | pmid:25302321 |
| Hernández-Hernández E et al. | Microencapsulation, chemical characterization, and antimicrobial activity of Mexican (Lippia graveolens H.B.K.) and European (Origanum vulgare L.) oregano essential oils. | 2014 | ScientificWorldJournal | pmid:25177730 |
| Boskabady MH et al. | Carum copticum L.: a herbal medicine with various pharmacological effects. | 2014 | Biomed Res Int | pmid:25089273 |
| Suo L et al. | Carvacrol alleviates ischemia reperfusion injury by regulating the PI3K-Akt pathway in rats. | 2014 | PLoS ONE | pmid:25083879 |
| Moazeni M et al. | In vivo study of the efficacy of the aromatic water of Zataria multiflora on hydatid cysts. | 2014 | Antimicrob. Agents Chemother. | pmid:25070113 |
| Gilling DH et al. | Antiviral efficacy and mechanisms of action of oregano essential oil and its primary component carvacrol against murine norovirus. | 2014 | J. Appl. Microbiol. | pmid:24779581 |
| Burt SA et al. | The natural antimicrobial carvacrol inhibits quorum sensing in Chromobacterium violaceum and reduces bacterial biofilm formation at sub-lethal concentrations. | 2014 | PLoS ONE | pmid:24691035 |
| Zeidán-Chuliá F et al. | Focussed microarray analysis of apoptosis in periodontitis and its potential pharmacological targeting by carvacrol. | 2014 | Arch. Oral Biol. | pmid:24631628 |
| Mooyottu S et al. | Carvacrol and trans-cinnamaldehyde reduce Clostridium difficile toxin production and cytotoxicity in vitro. | 2014 | Int J Mol Sci | pmid:24625665 |
| Bravo D et al. | A mixture of carvacrol, cinnamaldehyde, and capsicum oleoresin improves energy utilization and growth performance of broiler chickens fed maize-based diet. | 2014 | J. Anim. Sci. | pmid:24496847 |
| Sleha R et al. | In vitro antimicrobial activities of cinnamon bark oil, anethole, carvacrol, eugenol and guaiazulene against Mycoplasma hominis clinical isolates. | 2014 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub | pmid:23128812 |
| Li H et al. | Antibacterial activity and mechanism of action of Monarda punctata essential oil and its main components against common bacterial pathogens in respiratory tract. | 2014 | Int J Clin Exp Pathol | pmid:25550774 |
| Ezhumalai M et al. | Antihyperglycemic effect of carvacrol in combination with rosiglitazone in high-fat diet-induced type 2 diabetic C57BL/6J mice. | 2014 | Mol. Cell. Biochem. | pmid:24057121 |
| Kurek M et al. | Effect of relative humidity on carvacrol release and permeation properties of chitosan based films and coatings. | 2014 | Food Chem | pmid:24099536 |
| Khadivi-Khub A et al. | Population genetic structure and trait associations in forest savory using molecular, morphological and phytochemical markers. | 2014 | Gene | pmid:24878369 |
| Gallucci MN et al. | In vitro activity of natural phenolic compounds against fluconazole-resistant Candida species: a quantitative structure-activity relationship analysis. | 2014 | J. Appl. Microbiol. | pmid:24387763 |
| Bozkurt M et al. | Carvacrol prevents methotrexate-induced renal oxidative injury and renal damage in rats. | 2014 | Clin Invest Med | pmid:24502808 |
| Zhu L et al. | Apple, carrot, and hibiscus edible films containing the plant antimicrobials carvacrol and cinnamaldehyde inactivate Salmonella Newport on organic leafy greens in sealed plastic bags. | 2014 | J. Food Sci. | pmid:24460771 |
| Peretto G et al. | Optimization of antimicrobial and physical properties of alginate coatings containing carvacrol and methyl cinnamate for strawberry application. | 2014 | J. Agric. Food Chem. | pmid:24405047 |
| Klein AS et al. | Cholesterol sensitises the transient receptor potential channel TRPV3 to lower temperatures and activator concentrations. | 2014 | Cell Calcium | pmid:24406294 |
| Fadli M et al. | Natural extracts stimulate membrane-associated mechanisms of resistance in Gram-negative bacteria. | 2014 | Lett. Appl. Microbiol. | pmid:24447247 |
| Llana-Ruiz-Cabello M et al. | Cytotoxicity and morphological effects induced by carvacrol and thymol on the human cell line Caco-2. | 2014 | Food Chem. Toxicol. | pmid:24326232 |
| Banji OJ et al. | Combination of carvacrol with methotrexate suppresses Complete Freund's Adjuvant induced synovial inflammation with reduced hepatotoxicity in rats. | 2014 | Eur. J. Pharmacol. | pmid:24333217 |
| Neyret C et al. | Plant-derived compounds as natural antimicrobials to control paper mill biofilms. | 2014 | J. Ind. Microbiol. Biotechnol. | pmid:24170384 |
| Higueras L et al. | Antimicrobial packaging of chicken fillets based on the release of carvacrol from chitosan/cyclodextrin films. | 2014 | Int. J. Food Microbiol. | pmid:25087205 |
| Landry KS et al. | Effectiveness of a novel spontaneous carvacrol nanoemulsion against Salmonella enterica Enteritidis and Escherichia coli O157:H7 on contaminated mung bean and alfalfa seeds. | 2014 | Int. J. Food Microbiol. | pmid:25033425 |
| Kortman GA et al. | Iron-induced virulence of Salmonella enterica serovar typhimurium at the intestinal epithelial interface can be suppressed by carvacrol. | 2014 | Antimicrob. Agents Chemother. | pmid:24379194 |
| de Santana MT et al. | Synthesis and pharmacological evaluation of carvacrol propionate. | 2014 | Inflammation | pmid:24710701 |
| Bitu Vde C et al. | Chemical composition of the essential oil of Lippia gracilis Schauer leaves and its potential as modulator of bacterial resistance. | 2014 | Nat. Prod. Res. | pmid:24479735 |
| Zanini SF et al. | Effect of citral and carvacrol on the susceptibility of Listeria monocytogenes and Listeria innocua to antibiotics. | 2014 | Lett. Appl. Microbiol. | pmid:24443987 |
| Espina L et al. | Combination of pulsed electric fields, mild heat and essential oils as an alternative to the ultrapasteurization of liquid whole egg. | 2014 | Int. J. Food Microbiol. | pmid:25146463 |
| Chueca B et al. | Oxygenated monoterpenes citral and carvacrol cause oxidative damage in Escherichia coli without the involvement of tricarboxylic acid cycle and Fenton reaction. | 2014 | Int. J. Food Microbiol. | pmid:25146464 |
| Medeiros Barreto H et al. | Phytochemical prospection and modulation of antibiotic activity in vitro by Lippia origanoides H.B.K. in methicillin resistant Staphylococcus aureus. | 2014 | Biomed Res Int | pmid:24683545 |
| Altintas A et al. | Characterization of volatile constituents from Origanum onites and their antifungal and antibacterial activity. | 2013 Nov-Dec | J AOAC Int | pmid:24645494 |
| Sakagami H et al. | Biological interaction between Sasa senanensis Rehder leaf extract and toothpaste ingredients. | 2013 Mar-Apr | In Vivo | pmid:23422490 |
| Dagli Gul AS et al. | The effects of oral carvacrol treatment against H2O2 induced injury on isolated pancreas islet cells of rats. | 2013 Jul-Aug | Islets | pmid:23817295 |
| Peek HW et al. | In vivo screening of five phytochemicals/extracts and a fungal immunomodulatory protein against colibacillosis in broilers. | 2013 | Avian Pathol. | pmid:23627727 |
| Ndoti-Nembe A et al. | Effect of combination of essential oils and bacteriocins on the efficacy of gamma radiation against Salmonella Typhimurium and Listeria monocytogenes. | 2013 | Int. J. Radiat. Biol. | pmid:23631567 |
| Reilly JM et al. | Kv7/M-type potassium channels in rat skin keratinocytes. | 2013 | Pflugers Arch. | pmid:23592175 |
| Hanlidou E and Lazari D | Essential oils of Thymus leucospermus Hartvig, a Greek endemic rich in phenolic monoterpenes. | 2013 | Nat. Prod. Res. | pmid:23297716 |
| Kurek M et al. | Carvacrol affects interfacial, structural and transfer properties of chitosan coatings applied onto polyethylene. | 2013 | Carbohydr Polym | pmid:23769540 |
| Esteban MD et al. | Combined effect of nisin, carvacrol and a previous thermal treatment on the growth of Salmonella enteritidis and Salmonella senftenberg. | 2013 | Food Sci Technol Int | pmid:23729416 |
| Juneja VK et al. | Predictive thermal inactivation model for the combined effect of temperature, cinnamaldehyde and carvacrol on starvation-stressed multiple Salmonella serotypes in ground chicken. | 2013 | Int. J. Food Microbiol. | pmid:23756235 |
| Adapala RK et al. | TRPV4 channels mediate cardiac fibroblast differentiation by integrating mechanical and soluble signals. | 2013 | J. Mol. Cell. Cardiol. | pmid:23142541 |
| Higueras L et al. | Preparation and characterization of chitosan/HP-β-cyclodextrins composites with high sorption capacity for carvacrol. | 2013 | Carbohydr Polym | pmid:23911444 |
| MartÃnez-Fernández G et al. | In vitro-in vivo study on the effects of plant compounds on rumen fermentation, microbial abundances and methane emissions in goats. | 2013 | Animal | pmid:24237672 |
| Klein AH et al. | Eugenol and carvacrol induce temporally desensitizing patterns of oral irritation and enhance innocuous warmth and noxious heat sensation on the tongue. | 2013 | Pain | pmid:23791894 |
| Belaqziz R et al. | Essential oil composition and antibacterial activity of the different parts of Thymus maroccanus Ball: an endemic species in Morocco. | 2013 | Nat. Prod. Res. | pmid:23425125 |
| Mugnaini L et al. | A herbal antifungal formulation of Thymus serpillum, Origanum vulgare and Rosmarinus officinalis for treating ovine dermatophytosis due to Trichophyton mentagrophytes. | 2013 | Mycoses | pmid:23368893 |
| Kawasaki H et al. | Inhibition by menthol and its related chemicals of compound action potentials in frog sciatic nerves. | 2013 | Life Sci. | pmid:23352972 |
| Lejonklev J et al. | Transfer of terpenes from essential oils into cow milk. | 2013 | J. Dairy Sci. | pmid:23628249 |