MeSH term | MeSH ID | Detail |
---|---|---|
Body Weight | D001835 | 333 associated lipids |
Endophthalmitis | D009877 | 12 associated lipids |
Uveitis, Posterior | D015866 | 5 associated lipids |
(+)-pulegone is a lipid of Prenol Lipids (PR) class. The involved functions are known as Excretory function, conjugation, Competitive inhibition, radiochemical and Synthesis. (+)-pulegone often locates in Microsomes. The associated genes with (+)-Pulegone are 4S-limonene synthase.
To understand associated biological information of (+)-Pulegone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (+)-Pulegone
MeSH term | MeSH ID | Detail |
---|---|---|
Body Weight | D001835 | 333 associated lipids |
Endophthalmitis | D009877 | 12 associated lipids |
Uveitis, Posterior | D015866 | 5 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
pmid:27074837 | ||||
pmid:22782882 | ||||
pmid:22782877 | ||||
pmid:22727859 | ||||
pmid:28893105 | ||||
pmid:18969310 | ||||
pmid:22953891 | ||||
pmid:14987832 | ||||
pmid:21075197 | ||||
pmid:11393529 | ||||
pmid:15900460 | ||||
pmid:22871061 | ||||
pmid:21421570 | ||||
pmid:21142949 | ||||
pmid:11864761 | ||||
pmid:20496356 | ||||
pmid:20049972 | ||||
pmid:19401912 | ||||
pmid:19285534 | ||||
pmid:18533667 | ||||
pmid:12974293 | ||||
pmid:17945329 | ||||
pmid:16602084 | ||||
pmid:17061837 | ||||
pmid:16529887 | ||||
pmid:15714462 | ||||
pmid:15556450 | ||||
pmid:14575506 | ||||
pmid:12919025 | ||||
pmid:12580592 | ||||
pmid:12490239 | ||||
pmid:12375890 | ||||
pmid:11529771 | ||||
pmid:11405711 | ||||
pmid:27815078 | ||||
pmid:27561660 | ||||
pmid:26969934 | ||||
pmid:26067677 | ||||
pmid:25534256 | ||||
pmid:25529699 | ||||
pmid:25499726 | ||||
pmid:25143303 | ||||
pmid:24912864 | ||||
pmid:24506214 | ||||
pmid:25445298 | ||||
pmid:20658666 | ||||
pmid:15231435 | ||||
pmid:15023449 | ||||
pmid:12628335 | ||||
pmid:12769534 | ||||
pmid:19086001 | ||||
pmid:17680495 | ||||
pmid:25496469 | ||||
pmid:17370029 | ||||
pmid: | ||||
Sapra B et al. | Percutaneous permeation enhancement by terpenes: mechanistic view. | 2008 | AAPS J | pmid:18446512 |
Sztajnkrycer MD et al. | Mitigation of pennyroyal oil hepatotoxicity in the mouse. | 2003 | Acad Emerg Med | pmid:14525732 |
Bertoli A et al. | In vitro production of M. × piperita not containing pulegone and menthofuran. | 2012 | Acta Biochim. Pol. | pmid:22946028 |
Bertoli A et al. | Mentha longifolia in vitro cultures as safe source of flavouring ingredients. | 2011 | Acta Biochim. Pol. | pmid:22175048 |
Kozak JA and Dake GR | Total synthesis of (+)-fawcettidine. | 2008 | Angew. Chem. Int. Ed. Engl. | pmid:18431724 |
Anderson IB et al. | Pennyroyal toxicity: measurement of toxic metabolite levels in two cases and review of the literature. | 1996 | Ann. Intern. Med. | pmid:8633832 |
Khojasteh-Bakht SC et al. | Glutathione S-transferase catalyzes the isomerization of (R)-2-hydroxymenthofuran to mintlactones. | 1999 | Arch. Biochem. Biophys. | pmid:10496977 |
Bertea CM et al. | Demonstration that menthofuran synthase of mint (Mentha) is a cytochrome P450 monooxygenase: cloning, functional expression, and characterization of the responsible gene. | 2001 | Arch. Biochem. Biophys. | pmid:11396930 |
Ringer KL et al. | Monoterpene double-bond reductases of the (-)-menthol biosynthetic pathway: isolation and characterization of cDNAs encoding (-)-isopiperitenone reductase and (+)-pulegone reductase of peppermint. | 2003 | Arch. Biochem. Biophys. | pmid:13679086 |
Croteau R and Venkatachalam KV | Metabolism of monoterpenes: demonstration that (+)-cis-isopulegone, not piperitenone, is the key intermediate in the conversion of (-)-isopiperitenone to (+)-pulegone in peppermint (Mentha piperita). | 1986 | Arch. Biochem. Biophys. | pmid:3755881 |
Gonzalez-Audino P et al. | Comparative toxicity of oxygenated monoterpenoids in experimental hydroalcoholic lotions to permethrin-resistant adult head lice. | 2011 | Arch. Dermatol. Res. | pmid:21174108 |
Vadiraja BB et al. | Hepatoprotective effect of C-phycocyanin: protection for carbon tetrachloride and R-(+)-pulegone-mediated hepatotoxicty in rats. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9712713 |
Madyastha KM and Raj CP | Stereoselective hydroxylation of 4-methyl-2-cyclohexenone in rats: its relevance to R-(+)-pulegone-mediated hepatotoxicity. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12237102 |
Madyastha KM and Raj CP | Biotransformations of R-(+)-pulegone and menthofuran in vitro: chemical basis for toxicity. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2268314 |
Madyastha P et al. | In vivo and in vitro destruction of rat liver cytochrome P-450 by a monoterpene ketone, pulegone. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3994727 |
da Silveira NS et al. | The aversive, anxiolytic-like, and verapamil-sensitive psychostimulant effects of pulegone. | 2014 | Biol. Pharm. Bull. | pmid:24790000 |
Maruyama T et al. | Molecular cloning, functional expression and characterization of d-limonene synthase from Agastache rugosa. | 2002 | Biol. Pharm. Bull. | pmid:12033511 |
Salehi P et al. | Essential oil composition, antibacterial and antioxidant activity of the oil and various extracts of Ziziphora clinopodioides subsp. rigida (BOISS.) RECH. f. from Iran. | 2005 | Biol. Pharm. Bull. | pmid:16204941 |
Ribeiro VL et al. | Acaricidal properties of the essential oil from Hesperozygis ringens (Lamiaceae) on the cattle tick Riphicephalus (Boophilus) microplus. | 2010 | Bioresour. Technol. | pmid:19954969 |
Pietrella D et al. | Beneficial effect of Mentha suaveolens essential oil in the treatment of vaginal candidiasis assessed by real-time monitoring of infection. | 2011 | BMC Complement Altern Med | pmid:21356078 |
Guzman G et al. | Liver Injury with Features Mimicking Autoimmune Hepatitis following the Use of Black Cohosh. | 2009 | Case Rep Med | pmid:20130783 |
Sohn SH et al. | Microarray analysis of the gene expression profile of HMC-1 mast cells following Schizonepeta tenuifolia Briquet treatment. | 2012 May-Jun | Cell. Immunol. | pmid:22726350 |
Sutour S et al. | Composition and chemical variability of Mentha suaveolens ssp. suaveolens and M. suaveolens ssp. insularis from Corsica. | 2010 | Chem. Biodivers. | pmid:20397217 |
Segev D et al. | Chemical and morphological diversity in wild populations of Mentha longifolia in Israel. | 2012 | Chem. Biodivers. | pmid:22422525 |
Radulović NS and Blagojević PD | Plant volatiles providing additional evidences to the occurence of a wild-growing population of Calamintha vardarensis (Greuter et Burdet) Šilić outside of its natural habitat. | 2010 | Chem. Biodivers. | pmid:21161998 |
Aghaei Y et al. | Chemical diversity among the essential oils of wild populations of Stachys lavandulifolia VAHL (Lamiaceae) from Iran. | 2013 | Chem. Biodivers. | pmid:23418173 |
Chen XW et al. | Herbal bioactivation, molecular targets and the toxicity relevance. | 2011 | Chem. Biol. Interact. | pmid:21459083 |
Madyastha KM and Moorthy B | Pulegone mediated hepatotoxicity: evidence for covalent binding of R(+)-[14C]pulegone to microsomal proteins in vitro. | 1989 | Chem. Biol. Interact. | pmid:2691105 |
Li F et al. | Profiling the reactive metabolites of xenobiotics using metabolomic technologies. | 2011 | Chem. Res. Toxicol. | pmid:21469730 |
Gan J et al. | Dansyl glutathione as a trapping agent for the quantitative estimation and identification of reactive metabolites. | 2005 | Chem. Res. Toxicol. | pmid:15892584 |
Zhou SF et al. | Metabolic activation of herbal and dietary constituents and its clinical and toxicological implications: an update. | 2007 | Curr. Drug Metab. | pmid:17691916 |
Souza R et al. | Gastroprotective activity of α-terpineol in two experimental models of gastric ulcer in rats. | 2011 | Daru | pmid:22615669 |
Khojasteh-Bakht SC et al. | Metabolism of (R)-(+)-pulegone and (R)-(+)-menthofuran by human liver cytochrome P-450s: evidence for formation of a furan epoxide. | 1999 | Drug Metab. Dispos. | pmid:10220485 |
Chen LJ et al. | Metabolism of (R)-(+)-pulegone in F344 rats. | 2001 | Drug Metab. Dispos. | pmid:11717176 |
Thulasiram HV et al. | Effect of ring size in R-(+)-pulegone-mediated hepatotoxicity: studies on the metabolism of R-(+)-4-methyl-2-(1-methylethylidene)-cyclopentanone and DL-camphorone in rats. | 2001 | Drug Metab. Dispos. | pmid:11353750 |
Chen LJ et al. | Comparative disposition of (R)-(+)-pulegone in B6C3F1 mice and F344 rats. | 2003 | Drug Metab. Dispos. | pmid:12814966 |
Thomassen D et al. | Partial characterization of biliary metabolites of pulegone by tandem mass spectrometry. Detection of glucuronide, glutathione, and glutathionyl glucuronide conjugates. | 1991 Sep-Oct | Drug Metab. Dispos. | pmid:1686249 |
Chen LJ et al. | Metabolism of (R)-(+)-menthofuran in Fischer-344 rats: identification of sulfonic acid metabolites. | 2003 | Drug Metab. Dispos. | pmid:12975329 |
Gordon WP et al. | The metabolism of the abortifacient terpene, (R)-(+)-pulegone, to a proximate toxin, menthofuran. | 1987 Sep-Oct | Drug Metab. Dispos. | pmid:2891472 |
Thulasiram HV et al. | Role of C-5 chiral center in R-(+)-pulegone-mediated hepatotoxicity: metabolic disposition and toxicity of 5, 5-dimethyl-2-(1-Methylethylidene)-cyclohexanone in rats. | 2000 | Drug Metab. Dispos. | pmid:10859158 |
Inoue K et al. | A trapping method for semi-quantitative assessment of reactive metabolite formation using [35S]cysteine and [14C]cyanide. | 2009 | Drug Metab. Pharmacokinet. | pmid:19571436 |
Nelson SD | Mechanisms of the formation and disposition of reactive metabolites that can cause acute liver injury. | 1995 | Drug Metab. Rev. | pmid:7641574 |
de Cerqueira SV et al. | R(+)-pulegone impairs Ca²+ homeostasis and causes negative inotropism in mammalian myocardium. | 2011 | Eur. J. Pharmacol. | pmid:22004607 |
Amiri H | Essential oils composition and antioxidant properties of three thymus species. | 2012 | Evid Based Complement Alternat Med | pmid:21876714 |
Rossi YE et al. | Molecular response of Musca domestica L. to Mintostachys verticillata essential oil, (4R)+-pulegone and menthone. | 2012 | Fitoterapia | pmid:22155595 |