MeSH term | MeSH ID | Detail |
---|---|---|
Body Weight | D001835 | 333 associated lipids |
Endophthalmitis | D009877 | 12 associated lipids |
Uveitis, Posterior | D015866 | 5 associated lipids |
(+)-pulegone is a lipid of Prenol Lipids (PR) class. The involved functions are known as Excretory function, conjugation, Competitive inhibition, radiochemical and Synthesis. (+)-pulegone often locates in Microsomes. The associated genes with (+)-Pulegone are 4S-limonene synthase.
To understand associated biological information of (+)-Pulegone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (+)-Pulegone
MeSH term | MeSH ID | Detail |
---|---|---|
Body Weight | D001835 | 333 associated lipids |
Endophthalmitis | D009877 | 12 associated lipids |
Uveitis, Posterior | D015866 | 5 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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pmid: | ||||
Khojasteh-Bakht SC et al. | Metabolism of (R)-(+)-pulegone and (R)-(+)-menthofuran by human liver cytochrome P-450s: evidence for formation of a furan epoxide. | 1999 | Drug Metab. Dispos. | pmid:10220485 |
Flamini G et al. | Antimicrobial activity of the essential oil of Calamintha nepeta and its constituent pulegone against bacteria and fungi. | 1999 | Phytother Res | pmid:10404547 |
Khojasteh-Bakht SC et al. | Glutathione S-transferase catalyzes the isomerization of (R)-2-hydroxymenthofuran to mintlactones. | 1999 | Arch. Biochem. Biophys. | pmid:10496977 |
Madyastha KM and Thulasiram HV | Transformation of a monoterpene ketone, (R)-(+)-pulegone, a potent hepatotoxin, in Mucor piriformis. | 1999 | J. Agric. Food Chem. | pmid:10552438 |
Fuchs S et al. | Biogenetic studies in Mentha x piperita. 2. Stereoselectivity in the bioconversion of pulegone into menthone and isomenthone. | 1999 | J. Agric. Food Chem. | pmid:10552608 |
Fuchs S et al. | Biosynthesis of menthofuran in Mentha x piperita: stereoselective and mechanistic studies. | 1999 | J. Agric. Food Chem. | pmid:10552773 |
Thulasiram HV et al. | Role of C-5 chiral center in R-(+)-pulegone-mediated hepatotoxicity: metabolic disposition and toxicity of 5, 5-dimethyl-2-(1-Methylethylidene)-cyclohexanone in rats. | 2000 | Drug Metab. Dispos. | pmid:10859158 |
Jia YX et al. | Synthetic studies of the HIV-1 protease inhibitive didemnaketals: stereocontrolled synthetic approach to the key mother spiroketals. | 2001 | Org. Lett. | pmid:11263897 |
Mucciarelli M et al. | Effect of (+)-pulegone and other oil components of Mentha x Piperita on cucumber respiration. | 2001 | Phytochemistry | pmid:11336266 |
Fuchs S et al. | Different stereoselectivity in the reduction of pulegone by Mentha species. | 2001 | Planta Med. | pmid:11345699 |
Thulasiram HV et al. | Effect of ring size in R-(+)-pulegone-mediated hepatotoxicity: studies on the metabolism of R-(+)-4-methyl-2-(1-methylethylidene)-cyclopentanone and DL-camphorone in rats. | 2001 | Drug Metab. Dispos. | pmid:11353750 |
pmid:11393529 | ||||
Bertea CM et al. | Demonstration that menthofuran synthase of mint (Mentha) is a cytochrome P450 monooxygenase: cloning, functional expression, and characterization of the responsible gene. | 2001 | Arch. Biochem. Biophys. | pmid:11396930 |
pmid:11405711 | ||||
Umezu T et al. | Ambulation-promoting effect of peppermint oil and identification of its active constituents. | 2001 Jul-Aug | Pharmacol. Biochem. Behav. | pmid:11509195 |
pmid:11529771 | ||||
Maffei M et al. | Effect of Mentha x piperita essential oil and monoterpenes on cucumber root membrane potential. | 2001 | Phytochemistry | pmid:11672734 |
Chen LJ et al. | Metabolism of (R)-(+)-pulegone in F344 rats. | 2001 | Drug Metab. Dispos. | pmid:11717176 |
pmid:11864761 | ||||
Maruyama T et al. | Molecular cloning, functional expression and characterization of d-limonene synthase from Agastache rugosa. | 2002 | Biol. Pharm. Bull. | pmid:12033511 |
Valladares GR et al. | Phytochemical induction by herbivores could affect quality of essential oils from aromatic plants. | 2002 | J. Agric. Food Chem. | pmid:12083883 |
Daferera DJ et al. | Characterization of essential oils from lamiaceae species by fourier transform Raman spectroscopy. | 2002 | J. Agric. Food Chem. | pmid:12236670 |
Madyastha KM and Raj CP | Stereoselective hydroxylation of 4-methyl-2-cyclohexenone in rats: its relevance to R-(+)-pulegone-mediated hepatotoxicity. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12237102 |
pmid:12375890 | ||||
Oumzil H et al. | Antibacterial and antifungal activity of essential oils of Mentha suaveolens. | 2002 | Phytother Res | pmid:12458474 |
Bartoli G et al. | An efficient procedure for the preparation of (E)-alpha-alkylidenecycloalkanones mediated by a CeCl(3) x 7H(2)O-NaI system. Novel methodology for the synthesis of (S)-(-)-pulegone. | 2002 | J. Org. Chem. | pmid:12467442 |
Stanfill SB et al. | Concentrations of nine alkenylbenzenes, coumarin, piperonal and pulegone in Indian bidi cigarette tobacco. | 2003 | Food Chem. Toxicol. | pmid:12480305 |
pmid:12490239 | ||||
pmid:12580592 | ||||
pmid:12628335 | ||||
Gata-Gonçalves L et al. | Photoactive extracts from Thevetia peruviana with antifungal properties against Cladosporium cucumerinum. | 2003 | J. Photochem. Photobiol. B, Biol. | pmid:12745247 |
pmid:12769534 | ||||
Chen LJ et al. | Comparative disposition of (R)-(+)-pulegone in B6C3F1 mice and F344 rats. | 2003 | Drug Metab. Dispos. | pmid:12814966 |
pmid:12919025 | ||||
pmid:12974293 | ||||
Chen LJ et al. | Metabolism of (R)-(+)-menthofuran in Fischer-344 rats: identification of sulfonic acid metabolites. | 2003 | Drug Metab. Dispos. | pmid:12975329 |
Ringer KL et al. | Monoterpene double-bond reductases of the (-)-menthol biosynthetic pathway: isolation and characterization of cDNAs encoding (-)-isopiperitenone reductase and (+)-pulegone reductase of peppermint. | 2003 | Arch. Biochem. Biophys. | pmid:13679086 |
Sztajnkrycer MD et al. | Mitigation of pennyroyal oil hepatotoxicity in the mouse. | 2003 | Acad Emerg Med | pmid:14525732 |
Engel W | In vivo studies on the metabolism of the monoterpene pulegone in humans using the metabolism of ingestion-correlated amounts (MICA) approach: explanation for the toxicity differences between (S)-(-)- and (R)-(+)-pulegone. | 2003 | J. Agric. Food Chem. | pmid:14558782 |
pmid:14575506 | ||||
Mahmoud SS and Croteau RB | Menthofuran regulates essential oil biosynthesis in peppermint by controlling a downstream monoterpene reductase. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:14623962 |
Zhou S et al. | Herbal bioactivation: the good, the bad and the ugly. | 2004 | Life Sci. | pmid:14672753 |
pmid:14987832 | ||||
pmid:15023449 | ||||
Dams I et al. | Lactones. 21. Synthesis and odoriferous properties of lactones with the p-menthane system. | 2004 | J. Agric. Food Chem. | pmid:15030222 |
Thomsen M et al. | Acute liver failure associated with the use of herbal preparations containing black cohosh. | 2004 | Med. J. Aust. | pmid:15175000 |
pmid:15231435 | ||||
Duru ME et al. | The constituents of essential oil and in vitro antimicrobial activity of Micromeria cilicica from Turkey. | 2004 | J Ethnopharmacol | pmid:15261961 |
Turner GW and Croteau R | Organization of monoterpene biosynthesis in Mentha. Immunocytochemical localizations of geranyl diphosphate synthase, limonene-6-hydroxylase, isopiperitenol dehydrogenase, and pulegone reductase. | 2004 | Plant Physiol. | pmid:15542490 |
pmid:15556450 | ||||
pmid:15714462 | ||||
Soares PM et al. | Inhibitory effects of the essential oil of Mentha pulegium on the isolated rat myometrium. | 2005 | Planta Med. | pmid:15770540 |
Gan J et al. | Dansyl glutathione as a trapping agent for the quantitative estimation and identification of reactive metabolites. | 2005 | Chem. Res. Toxicol. | pmid:15892584 |
pmid:15900460 | ||||
Siano F et al. | Analysis of pulegone and its enanthiomeric distribution in mint-flavoured food products. | 2005 | Food Addit Contam | pmid:16019787 |
Yang JP et al. | [Quantitative analysis of pulegone in Herba Schizonepetae]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16075729 |
Banchio E et al. | Quantitative variations in the essential oil of Minthostachys mollis (Kunth.) Griseb. in response to insects with different feeding habits. | 2005 | J. Agric. Food Chem. | pmid:16104818 |
Banchio E et al. | Effects of mechanical wounding on essential oil composition and emission of volatiles from Minthostachys mollis. | 2005 | J. Chem. Ecol. | pmid:16124247 |
Salehi P et al. | Essential oil composition, antibacterial and antioxidant activity of the oil and various extracts of Ziziphora clinopodioides subsp. rigida (BOISS.) RECH. f. from Iran. | 2005 | Biol. Pharm. Bull. | pmid:16204941 |
Munro IC and Danielewska-Nikiel B | Comparison of estimated daily intakes of flavouring substances with no-observed-effect levels. | 2006 | Food Chem. Toxicol. | pmid:16325977 |
Denmark SE and Venkatraman S | On the mechanism of the Skraup-Doebner-Von Miller quinoline synthesis. | 2006 | J. Org. Chem. | pmid:16468822 |
Senatore F et al. | Chemical composition of the essential oil of Salvia microstegia Boiss. et Balansa growing wild in Lebanon. | 2006 | J Chromatogr A | pmid:16472535 |
pmid:16529887 | ||||
pmid:16602084 | ||||
Rim IS and Jee CH | Acaricidal effects of herb essential oils against Dermatophagoides farinae and D. pteronyssinus (Acari: Pyroglyphidae) and qualitative analysis of a herb Mentha pulegium(pennyroyal). | 2006 | Korean J. Parasitol. | pmid:16809961 |
Thomassen D et al. | Partial characterization of biliary metabolites of pulegone by tandem mass spectrometry. Detection of glucuronide, glutathione, and glutathionyl glucuronide conjugates. | 1991 Sep-Oct | Drug Metab. Dispos. | pmid:1686249 |
pmid:17061837 | ||||
pmid:17370029 | ||||
van Schie CC et al. | Tomato linalool synthase is induced in trichomes by jasmonic acid. | 2007 | Plant Mol. Biol. | pmid:17440821 |
pmid:17680495 | ||||
Ferguson LJ et al. | 14C-labeled pulegone and metabolites binding to alpha2u-globulin in kidneys of male F-344 rats. | 2007 | J. Toxicol. Environ. Health Part A | pmid:17687727 |
Zhou SF et al. | Metabolic activation of herbal and dietary constituents and its clinical and toxicological implications: an update. | 2007 | Curr. Drug Metab. | pmid:17691916 |
pmid:17945329 | ||||
Samarasekera R et al. | Insecticidal activity of menthol derivatives against mosquitoes. | 2008 | Pest Manag. Sci. | pmid:18095385 |
Rios-Estepa R et al. | A systems biology approach identifies the biochemical mechanisms regulating monoterpenoid essential oil composition in peppermint. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18287058 |
Dancewicz K et al. | Enantiospecific effect of pulegone and pulegone-derived lactones on Myzus persicae (Sulz.) settling and feeding. | 2008 | J. Chem. Ecol. | pmid:18340487 |
Kozak JA and Dake GR | Total synthesis of (+)-fawcettidine. | 2008 | Angew. Chem. Int. Ed. Engl. | pmid:18431724 |
Sapra B et al. | Percutaneous permeation enhancement by terpenes: mechanistic view. | 2008 | AAPS J | pmid:18446512 |
pmid:18533667 | ||||
Debie E et al. | Solvent effects on IR and VCD spectra of natural products: an experimental and theoretical VCD study of pulegone. | 2008 | Phys Chem Chem Phys | pmid:18548155 |
Kang H et al. | Immunomodulatory effect of Schizonepeta tenuifolia water extract on mouse Th1/Th2 cytokine production in-vivo and in-vitro. | 2008 | J. Pharm. Pharmacol. | pmid:18549677 |
Kweka EJ et al. | Ethnobotanical study of some of mosquito repellent plants in north-eastern Tanzania. | 2008 | Malar. J. | pmid:18687119 |
Mahboubi M and Haghi G | Antimicrobial activity and chemical composition of Mentha pulegium L. essential oil. | 2008 | J Ethnopharmacol | pmid:18703127 |
Müller-Schwarze D and Thoss V | Defense on the rocks: low monoterpenoid levels in plants on pillars without mammalian herbivores. | 2008 | J. Chem. Ecol. | pmid:18925383 |
pmid:18969310 | ||||
pmid:19086001 | ||||
pmid:19285534 | ||||
pmid:19401912 | ||||
Inoue K et al. | A trapping method for semi-quantitative assessment of reactive metabolite formation using [35S]cysteine and [14C]cyanide. | 2009 | Drug Metab. Pharmacokinet. | pmid:19571436 |
Avila M et al. | Determination of alkenylbenzenes and related flavour compounds in food samples by on-column preconcentration-capillary liquid chromatography. | 2009 | J Chromatogr A | pmid:19735919 |
Ortiz de Urbina AV et al. | Antihistaminic activity of pulegone on the guinea-pig ileum. | 1990 | J. Pharm. Pharmacol. | pmid:1974304 |
Petrakis EA et al. | Quantitative determination of pulegone in pennyroyal oil by FT-IR spectroscopy. | 2009 | J. Agric. Food Chem. | pmid:19817373 |
Brown JR et al. | Enhanced biotransformation of TCE using plant terpenoids in contaminated groundwater. | 2009 | Lett. Appl. Microbiol. | pmid:19843209 |
Brankovic SV et al. | Calcium blocking activity as a mechanism of the spasmolytic effect of the essential oil of Calamintha glandulosa Silic on the isolated rat ileum. | 2009 | Gen. Physiol. Biophys. | pmid:19893097 |
Mkaddem M et al. | Chemical composition and antimicrobial and antioxidant activities of Mentha (longifolia L. and viridis) essential oils. | 2009 | J. Food Sci. | pmid:19895481 |
Umezu T | Evidence for dopamine involvement in ambulation promoted by pulegone in mice. | 2010 | Pharmacol. Biochem. Behav. | pmid:19917306 |
Ribeiro VL et al. | Acaricidal properties of the essential oil from Hesperozygis ringens (Lamiaceae) on the cattle tick Riphicephalus (Boophilus) microplus. | 2010 | Bioresour. Technol. | pmid:19954969 |
Arvidson KB et al. | In silico toxicological screening of natural products. | 2008 | Toxicol. Mech. Methods | pmid:20020917 |
pmid:20049972 |