| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Endophthalmitis | D009877 | 12 associated lipids |
| Uveitis, Posterior | D015866 | 5 associated lipids |
Total
3
(+)-Pulegone
(+)-pulegone is a lipid of Prenol Lipids (PR) class. The involved functions are known as Excretory function, conjugation, Competitive inhibition, radiochemical and Synthesis. (+)-pulegone often locates in Microsomes. The associated genes with (+)-Pulegone are 4S-limonene synthase.
Cross Reference
Introduction
To understand associated biological information of (+)-Pulegone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (+)-Pulegone?
There are no associated biomedical information in the current reference collection.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (+)-Pulegone
PubChem Associated disorders and diseases
What pathways are associated with (+)-Pulegone
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (+)-Pulegone?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with (+)-Pulegone?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (+)-Pulegone?
There are no associated biomedical information in the current reference collection.
What genes are associated with (+)-Pulegone?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (+)-Pulegone?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (+)-Pulegone
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid:27074837 | ||||
| pmid:22782882 | ||||
| pmid:22782877 | ||||
| pmid:22727859 | ||||
| pmid:28893105 | ||||
| pmid:18969310 | ||||
| pmid:22953891 | ||||
| pmid:14987832 | ||||
| pmid:21075197 | ||||
| pmid:11393529 | ||||
| pmid:15900460 | ||||
| pmid:22871061 | ||||
| pmid:21421570 | ||||
| pmid:21142949 | ||||
| pmid:11864761 | ||||
| pmid:20496356 | ||||
| pmid:20049972 | ||||
| pmid:19401912 | ||||
| pmid:19285534 | ||||
| pmid:18533667 | ||||
| pmid:12974293 | ||||
| pmid:17945329 | ||||
| pmid:16602084 | ||||
| pmid:17061837 | ||||
| pmid:16529887 | ||||
| pmid:15714462 | ||||
| pmid:15556450 | ||||
| pmid:14575506 | ||||
| pmid:12919025 | ||||
| pmid:12580592 | ||||
| pmid:12490239 | ||||
| pmid:12375890 | ||||
| pmid:11529771 | ||||
| pmid:11405711 | ||||
| pmid:27815078 | ||||
| pmid:27561660 | ||||
| pmid:26969934 | ||||
| pmid:26067677 | ||||
| pmid:25534256 | ||||
| pmid:25529699 | ||||
| pmid:25499726 | ||||
| pmid:25143303 | ||||
| pmid:24912864 | ||||
| pmid:24506214 | ||||
| pmid:25445298 | ||||
| pmid:20658666 | ||||
| pmid:15231435 | ||||
| pmid:15023449 | ||||
| pmid:12628335 | ||||
| pmid:12769534 | ||||
| pmid:19086001 | ||||
| pmid:17680495 | ||||
| pmid:25496469 | ||||
| pmid:17370029 | ||||
| pmid: | ||||
| Thorup I et al. | Short term toxicity study in rats dosed with pulegone and menthol. | 1983 | Toxicol. Lett. | pmid:6658833 |
| Andersen PH and Jensen NJ | Mutagenic investigation of peppermint oil in the Salmonella/mammalian-microsome test. | 1984 | Mutat. Res. | pmid:6387476 |
| Galli CL et al. | Quantitative analysis of alpha, beta-thujone, pulegone, safrole, coumarin and beta-asarone in alcoholic beverages by selected-ion monitoring. | 1984 | J Appl Toxicol | pmid:6512167 |
| Madyastha P et al. | In vivo and in vitro destruction of rat liver cytochrome P-450 by a monoterpene ketone, pulegone. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3994727 |
| Croteau R and Venkatachalam KV | Metabolism of monoterpenes: demonstration that (+)-cis-isopulegone, not piperitenone, is the key intermediate in the conversion of (-)-isopiperitenone to (+)-pulegone in peppermint (Mentha piperita). | 1986 | Arch. Biochem. Biophys. | pmid:3755881 |
| Gordon WP et al. | The metabolism of the abortifacient terpene, (R)-(+)-pulegone, to a proximate toxin, menthofuran. | 1987 Sep-Oct | Drug Metab. Dispos. | pmid:2891472 |
| Thomassen D et al. | Contribution of menthofuran to the hepatotoxicity of pulegone: assessment based on matched area under the curve and on matched time course. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3252034 |
| Moorthy B et al. | Hepatotoxicity of pulegone in rats: its effects on microsomal enzymes, in vivo. | 1989 | Toxicology | pmid:2541521 |
| Madyastha KM and Moorthy B | Pulegone mediated hepatotoxicity: evidence for covalent binding of R(+)-[14C]pulegone to microsomal proteins in vitro. | 1989 | Chem. Biol. Interact. | pmid:2691105 |
| Moorthy B et al. | Metabolism of a monoterpene ketone, R-(+)-pulegone--a hepatotoxin in rat. | 1989 | Xenobiotica | pmid:2728495 |
| Ortiz de Urbina AV et al. | Antihistaminic activity of pulegone on the guinea-pig ileum. | 1990 | J. Pharm. Pharmacol. | pmid:1974304 |
| Thomassen D et al. | Menthofuran-dependent and independent aspects of pulegone hepatotoxicity: roles of glutathione. | 1990 | J. Pharmacol. Exp. Ther. | pmid:2338648 |
| Madyastha KM and Raj CP | Biotransformations of R-(+)-pulegone and menthofuran in vitro: chemical basis for toxicity. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2268314 |
| Thomassen D et al. | Partial characterization of biliary metabolites of pulegone by tandem mass spectrometry. Detection of glucuronide, glutathione, and glutathionyl glucuronide conjugates. | 1991 Sep-Oct | Drug Metab. Dispos. | pmid:1686249 |
| Yao QS and Chiou GC | Inhibition of crystallins-induced inflammation in rabbit eyes with five phytogenic compounds. | 1993 | Zhongguo Yao Li Xue Bao | pmid:8503279 |
| Madyastha KM and Raj CP | Studies on the metabolism of a monoterpene ketone, R-(+)-pulegone--a hepatotoxin in rat: isolation and characterization of new metabolites. | 1993 | Xenobiotica | pmid:8342298 |
| Nelson SD | Mechanisms of the formation and disposition of reactive metabolites that can cause acute liver injury. | 1995 | Drug Metab. Rev. | pmid:7641574 |
| Anderson IB et al. | Pennyroyal toxicity: measurement of toxic metabolite levels in two cases and review of the literature. | 1996 | Ann. Intern. Med. | pmid:8633832 |
| Bakerink JA et al. | Multiple organ failure after ingestion of pennyroyal oil from herbal tea in two infants. | 1996 | Pediatrics | pmid:8909490 |
| Madyastha KM and Gaikwad NW | Metabolic fate of S-(-)-pulegone in rat. | 1998 | Xenobiotica | pmid:9741951 |
| Vadiraja BB et al. | Hepatoprotective effect of C-phycocyanin: protection for carbon tetrachloride and R-(+)-pulegone-mediated hepatotoxicty in rats. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9712713 |
| Mølck AM et al. | Lack of histological cerebellar changes in Wistar rats given pulegone for 28 days. Comparison of immersion and perfusion tissue fixation. | 1998 | Toxicol. Lett. | pmid:9635415 |
| Khojasteh-Bakht SC et al. | Metabolism of (R)-(+)-pulegone and (R)-(+)-menthofuran by human liver cytochrome P-450s: evidence for formation of a furan epoxide. | 1999 | Drug Metab. Dispos. | pmid:10220485 |
| Flamini G et al. | Antimicrobial activity of the essential oil of Calamintha nepeta and its constituent pulegone against bacteria and fungi. | 1999 | Phytother Res | pmid:10404547 |
| Khojasteh-Bakht SC et al. | Glutathione S-transferase catalyzes the isomerization of (R)-2-hydroxymenthofuran to mintlactones. | 1999 | Arch. Biochem. Biophys. | pmid:10496977 |
| Madyastha KM and Thulasiram HV | Transformation of a monoterpene ketone, (R)-(+)-pulegone, a potent hepatotoxin, in Mucor piriformis. | 1999 | J. Agric. Food Chem. | pmid:10552438 |
| Fuchs S et al. | Biogenetic studies in Mentha x piperita. 2. Stereoselectivity in the bioconversion of pulegone into menthone and isomenthone. | 1999 | J. Agric. Food Chem. | pmid:10552608 |
| Fuchs S et al. | Biosynthesis of menthofuran in Mentha x piperita: stereoselective and mechanistic studies. | 1999 | J. Agric. Food Chem. | pmid:10552773 |
| Thulasiram HV et al. | Role of C-5 chiral center in R-(+)-pulegone-mediated hepatotoxicity: metabolic disposition and toxicity of 5, 5-dimethyl-2-(1-Methylethylidene)-cyclohexanone in rats. | 2000 | Drug Metab. Dispos. | pmid:10859158 |
| Mucciarelli M et al. | Effect of (+)-pulegone and other oil components of Mentha x Piperita on cucumber respiration. | 2001 | Phytochemistry | pmid:11336266 |
| Jia YX et al. | Synthetic studies of the HIV-1 protease inhibitive didemnaketals: stereocontrolled synthetic approach to the key mother spiroketals. | 2001 | Org. Lett. | pmid:11263897 |
| Maffei M et al. | Effect of Mentha x piperita essential oil and monoterpenes on cucumber root membrane potential. | 2001 | Phytochemistry | pmid:11672734 |
| Chen LJ et al. | Metabolism of (R)-(+)-pulegone in F344 rats. | 2001 | Drug Metab. Dispos. | pmid:11717176 |
| Fuchs S et al. | Different stereoselectivity in the reduction of pulegone by Mentha species. | 2001 | Planta Med. | pmid:11345699 |
| Thulasiram HV et al. | Effect of ring size in R-(+)-pulegone-mediated hepatotoxicity: studies on the metabolism of R-(+)-4-methyl-2-(1-methylethylidene)-cyclopentanone and DL-camphorone in rats. | 2001 | Drug Metab. Dispos. | pmid:11353750 |
| Bertea CM et al. | Demonstration that menthofuran synthase of mint (Mentha) is a cytochrome P450 monooxygenase: cloning, functional expression, and characterization of the responsible gene. | 2001 | Arch. Biochem. Biophys. | pmid:11396930 |
| Umezu T et al. | Ambulation-promoting effect of peppermint oil and identification of its active constituents. | 2001 Jul-Aug | Pharmacol. Biochem. Behav. | pmid:11509195 |
| Maruyama T et al. | Molecular cloning, functional expression and characterization of d-limonene synthase from Agastache rugosa. | 2002 | Biol. Pharm. Bull. | pmid:12033511 |
| Madyastha KM and Raj CP | Stereoselective hydroxylation of 4-methyl-2-cyclohexenone in rats: its relevance to R-(+)-pulegone-mediated hepatotoxicity. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12237102 |
| Bartoli G et al. | An efficient procedure for the preparation of (E)-alpha-alkylidenecycloalkanones mediated by a CeCl(3) x 7H(2)O-NaI system. Novel methodology for the synthesis of (S)-(-)-pulegone. | 2002 | J. Org. Chem. | pmid:12467442 |
| Oumzil H et al. | Antibacterial and antifungal activity of essential oils of Mentha suaveolens. | 2002 | Phytother Res | pmid:12458474 |
| Valladares GR et al. | Phytochemical induction by herbivores could affect quality of essential oils from aromatic plants. | 2002 | J. Agric. Food Chem. | pmid:12083883 |
| Daferera DJ et al. | Characterization of essential oils from lamiaceae species by fourier transform Raman spectroscopy. | 2002 | J. Agric. Food Chem. | pmid:12236670 |
| Mahmoud SS and Croteau RB | Menthofuran regulates essential oil biosynthesis in peppermint by controlling a downstream monoterpene reductase. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:14623962 |
| Sztajnkrycer MD et al. | Mitigation of pennyroyal oil hepatotoxicity in the mouse. | 2003 | Acad Emerg Med | pmid:14525732 |