| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Endophthalmitis | D009877 | 12 associated lipids |
| Uveitis, Posterior | D015866 | 5 associated lipids |
Total
3
(+)-Pulegone
(+)-pulegone is a lipid of Prenol Lipids (PR) class. The involved functions are known as Excretory function, conjugation, Competitive inhibition, radiochemical and Synthesis. (+)-pulegone often locates in Microsomes. The associated genes with (+)-Pulegone are 4S-limonene synthase.
Cross Reference
Introduction
To understand associated biological information of (+)-Pulegone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (+)-Pulegone?
There are no associated biomedical information in the current reference collection.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (+)-Pulegone
PubChem Associated disorders and diseases
What pathways are associated with (+)-Pulegone
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (+)-Pulegone?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with (+)-Pulegone?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (+)-Pulegone?
There are no associated biomedical information in the current reference collection.
What genes are associated with (+)-Pulegone?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (+)-Pulegone?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (+)-Pulegone
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Khojasteh-Bakht SC et al. | Metabolism of (R)-(+)-pulegone and (R)-(+)-menthofuran by human liver cytochrome P-450s: evidence for formation of a furan epoxide. | 1999 | Drug Metab. Dispos. | pmid:10220485 |
| Flamini G et al. | Antimicrobial activity of the essential oil of Calamintha nepeta and its constituent pulegone against bacteria and fungi. | 1999 | Phytother Res | pmid:10404547 |
| Khojasteh-Bakht SC et al. | Glutathione S-transferase catalyzes the isomerization of (R)-2-hydroxymenthofuran to mintlactones. | 1999 | Arch. Biochem. Biophys. | pmid:10496977 |
| Madyastha KM and Thulasiram HV | Transformation of a monoterpene ketone, (R)-(+)-pulegone, a potent hepatotoxin, in Mucor piriformis. | 1999 | J. Agric. Food Chem. | pmid:10552438 |
| Fuchs S et al. | Biogenetic studies in Mentha x piperita. 2. Stereoselectivity in the bioconversion of pulegone into menthone and isomenthone. | 1999 | J. Agric. Food Chem. | pmid:10552608 |
| Fuchs S et al. | Biosynthesis of menthofuran in Mentha x piperita: stereoselective and mechanistic studies. | 1999 | J. Agric. Food Chem. | pmid:10552773 |
| Thulasiram HV et al. | Role of C-5 chiral center in R-(+)-pulegone-mediated hepatotoxicity: metabolic disposition and toxicity of 5, 5-dimethyl-2-(1-Methylethylidene)-cyclohexanone in rats. | 2000 | Drug Metab. Dispos. | pmid:10859158 |
| Jia YX et al. | Synthetic studies of the HIV-1 protease inhibitive didemnaketals: stereocontrolled synthetic approach to the key mother spiroketals. | 2001 | Org. Lett. | pmid:11263897 |
| Mucciarelli M et al. | Effect of (+)-pulegone and other oil components of Mentha x Piperita on cucumber respiration. | 2001 | Phytochemistry | pmid:11336266 |
| Fuchs S et al. | Different stereoselectivity in the reduction of pulegone by Mentha species. | 2001 | Planta Med. | pmid:11345699 |
| Thulasiram HV et al. | Effect of ring size in R-(+)-pulegone-mediated hepatotoxicity: studies on the metabolism of R-(+)-4-methyl-2-(1-methylethylidene)-cyclopentanone and DL-camphorone in rats. | 2001 | Drug Metab. Dispos. | pmid:11353750 |
| pmid:11393529 | ||||
| Bertea CM et al. | Demonstration that menthofuran synthase of mint (Mentha) is a cytochrome P450 monooxygenase: cloning, functional expression, and characterization of the responsible gene. | 2001 | Arch. Biochem. Biophys. | pmid:11396930 |
| pmid:11405711 | ||||
| Umezu T et al. | Ambulation-promoting effect of peppermint oil and identification of its active constituents. | 2001 Jul-Aug | Pharmacol. Biochem. Behav. | pmid:11509195 |
| pmid:11529771 | ||||
| Maffei M et al. | Effect of Mentha x piperita essential oil and monoterpenes on cucumber root membrane potential. | 2001 | Phytochemistry | pmid:11672734 |
| Chen LJ et al. | Metabolism of (R)-(+)-pulegone in F344 rats. | 2001 | Drug Metab. Dispos. | pmid:11717176 |
| pmid:11864761 | ||||
| Maruyama T et al. | Molecular cloning, functional expression and characterization of d-limonene synthase from Agastache rugosa. | 2002 | Biol. Pharm. Bull. | pmid:12033511 |
| Valladares GR et al. | Phytochemical induction by herbivores could affect quality of essential oils from aromatic plants. | 2002 | J. Agric. Food Chem. | pmid:12083883 |
| Daferera DJ et al. | Characterization of essential oils from lamiaceae species by fourier transform Raman spectroscopy. | 2002 | J. Agric. Food Chem. | pmid:12236670 |
| Madyastha KM and Raj CP | Stereoselective hydroxylation of 4-methyl-2-cyclohexenone in rats: its relevance to R-(+)-pulegone-mediated hepatotoxicity. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12237102 |
| pmid:12375890 | ||||
| Oumzil H et al. | Antibacterial and antifungal activity of essential oils of Mentha suaveolens. | 2002 | Phytother Res | pmid:12458474 |
| Bartoli G et al. | An efficient procedure for the preparation of (E)-alpha-alkylidenecycloalkanones mediated by a CeCl(3) x 7H(2)O-NaI system. Novel methodology for the synthesis of (S)-(-)-pulegone. | 2002 | J. Org. Chem. | pmid:12467442 |
| Stanfill SB et al. | Concentrations of nine alkenylbenzenes, coumarin, piperonal and pulegone in Indian bidi cigarette tobacco. | 2003 | Food Chem. Toxicol. | pmid:12480305 |
| pmid:12490239 | ||||
| pmid:12580592 | ||||
| pmid:12628335 | ||||
| Gata-Gonçalves L et al. | Photoactive extracts from Thevetia peruviana with antifungal properties against Cladosporium cucumerinum. | 2003 | J. Photochem. Photobiol. B, Biol. | pmid:12745247 |
| pmid:12769534 | ||||
| Chen LJ et al. | Comparative disposition of (R)-(+)-pulegone in B6C3F1 mice and F344 rats. | 2003 | Drug Metab. Dispos. | pmid:12814966 |
| pmid:12919025 | ||||
| pmid:12974293 | ||||
| Chen LJ et al. | Metabolism of (R)-(+)-menthofuran in Fischer-344 rats: identification of sulfonic acid metabolites. | 2003 | Drug Metab. Dispos. | pmid:12975329 |
| Ringer KL et al. | Monoterpene double-bond reductases of the (-)-menthol biosynthetic pathway: isolation and characterization of cDNAs encoding (-)-isopiperitenone reductase and (+)-pulegone reductase of peppermint. | 2003 | Arch. Biochem. Biophys. | pmid:13679086 |
| Sztajnkrycer MD et al. | Mitigation of pennyroyal oil hepatotoxicity in the mouse. | 2003 | Acad Emerg Med | pmid:14525732 |
| Engel W | In vivo studies on the metabolism of the monoterpene pulegone in humans using the metabolism of ingestion-correlated amounts (MICA) approach: explanation for the toxicity differences between (S)-(-)- and (R)-(+)-pulegone. | 2003 | J. Agric. Food Chem. | pmid:14558782 |
| pmid:14575506 | ||||
| Mahmoud SS and Croteau RB | Menthofuran regulates essential oil biosynthesis in peppermint by controlling a downstream monoterpene reductase. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:14623962 |
| Zhou S et al. | Herbal bioactivation: the good, the bad and the ugly. | 2004 | Life Sci. | pmid:14672753 |
| pmid:14987832 | ||||
| pmid:15023449 | ||||
| Dams I et al. | Lactones. 21. Synthesis and odoriferous properties of lactones with the p-menthane system. | 2004 | J. Agric. Food Chem. | pmid:15030222 |
| Thomsen M et al. | Acute liver failure associated with the use of herbal preparations containing black cohosh. | 2004 | Med. J. Aust. | pmid:15175000 |
| pmid:15231435 | ||||
| Duru ME et al. | The constituents of essential oil and in vitro antimicrobial activity of Micromeria cilicica from Turkey. | 2004 | J Ethnopharmacol | pmid:15261961 |
| Turner GW and Croteau R | Organization of monoterpene biosynthesis in Mentha. Immunocytochemical localizations of geranyl diphosphate synthase, limonene-6-hydroxylase, isopiperitenol dehydrogenase, and pulegone reductase. | 2004 | Plant Physiol. | pmid:15542490 |