MeSH term | MeSH ID | Detail |
---|---|---|
Body Weight | D001835 | 333 associated lipids |
Endophthalmitis | D009877 | 12 associated lipids |
Uveitis, Posterior | D015866 | 5 associated lipids |
(+)-pulegone is a lipid of Prenol Lipids (PR) class. The involved functions are known as Excretory function, conjugation, Competitive inhibition, radiochemical and Synthesis. (+)-pulegone often locates in Microsomes. The associated genes with (+)-Pulegone are 4S-limonene synthase.
To understand associated biological information of (+)-Pulegone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (+)-Pulegone
MeSH term | MeSH ID | Detail |
---|---|---|
Body Weight | D001835 | 333 associated lipids |
Endophthalmitis | D009877 | 12 associated lipids |
Uveitis, Posterior | D015866 | 5 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Segev D et al. | Chemical and morphological diversity in wild populations of Mentha longifolia in Israel. | 2012 | Chem. Biodivers. | pmid:22422525 |
Chen XW et al. | Herbal bioactivation, molecular targets and the toxicity relevance. | 2011 | Chem. Biol. Interact. | pmid:21459083 |
Madyastha KM and Moorthy B | Pulegone mediated hepatotoxicity: evidence for covalent binding of R(+)-[14C]pulegone to microsomal proteins in vitro. | 1989 | Chem. Biol. Interact. | pmid:2691105 |
Li F et al. | Profiling the reactive metabolites of xenobiotics using metabolomic technologies. | 2011 | Chem. Res. Toxicol. | pmid:21469730 |
Gan J et al. | Dansyl glutathione as a trapping agent for the quantitative estimation and identification of reactive metabolites. | 2005 | Chem. Res. Toxicol. | pmid:15892584 |
Zhou SF et al. | Metabolic activation of herbal and dietary constituents and its clinical and toxicological implications: an update. | 2007 | Curr. Drug Metab. | pmid:17691916 |
Souza R et al. | Gastroprotective activity of α-terpineol in two experimental models of gastric ulcer in rats. | 2011 | Daru | pmid:22615669 |
Khojasteh-Bakht SC et al. | Metabolism of (R)-(+)-pulegone and (R)-(+)-menthofuran by human liver cytochrome P-450s: evidence for formation of a furan epoxide. | 1999 | Drug Metab. Dispos. | pmid:10220485 |
Chen LJ et al. | Metabolism of (R)-(+)-pulegone in F344 rats. | 2001 | Drug Metab. Dispos. | pmid:11717176 |
Thulasiram HV et al. | Effect of ring size in R-(+)-pulegone-mediated hepatotoxicity: studies on the metabolism of R-(+)-4-methyl-2-(1-methylethylidene)-cyclopentanone and DL-camphorone in rats. | 2001 | Drug Metab. Dispos. | pmid:11353750 |
Chen LJ et al. | Comparative disposition of (R)-(+)-pulegone in B6C3F1 mice and F344 rats. | 2003 | Drug Metab. Dispos. | pmid:12814966 |
Thomassen D et al. | Partial characterization of biliary metabolites of pulegone by tandem mass spectrometry. Detection of glucuronide, glutathione, and glutathionyl glucuronide conjugates. | 1991 Sep-Oct | Drug Metab. Dispos. | pmid:1686249 |
Chen LJ et al. | Metabolism of (R)-(+)-menthofuran in Fischer-344 rats: identification of sulfonic acid metabolites. | 2003 | Drug Metab. Dispos. | pmid:12975329 |
Gordon WP et al. | The metabolism of the abortifacient terpene, (R)-(+)-pulegone, to a proximate toxin, menthofuran. | 1987 Sep-Oct | Drug Metab. Dispos. | pmid:2891472 |
Thulasiram HV et al. | Role of C-5 chiral center in R-(+)-pulegone-mediated hepatotoxicity: metabolic disposition and toxicity of 5, 5-dimethyl-2-(1-Methylethylidene)-cyclohexanone in rats. | 2000 | Drug Metab. Dispos. | pmid:10859158 |
Inoue K et al. | A trapping method for semi-quantitative assessment of reactive metabolite formation using [35S]cysteine and [14C]cyanide. | 2009 | Drug Metab. Pharmacokinet. | pmid:19571436 |
Nelson SD | Mechanisms of the formation and disposition of reactive metabolites that can cause acute liver injury. | 1995 | Drug Metab. Rev. | pmid:7641574 |
de Cerqueira SV et al. | R(+)-pulegone impairs Ca²+ homeostasis and causes negative inotropism in mammalian myocardium. | 2011 | Eur. J. Pharmacol. | pmid:22004607 |
Amiri H | Essential oils composition and antioxidant properties of three thymus species. | 2012 | Evid Based Complement Alternat Med | pmid:21876714 |
Rossi YE et al. | Molecular response of Musca domestica L. to Mintostachys verticillata essential oil, (4R)+-pulegone and menthone. | 2012 | Fitoterapia | pmid:22155595 |