| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Dental Caries | D003731 | 6 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Nerve Compression Syndromes | D009408 | 4 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Occupational Diseases | D009784 | 42 associated lipids |
Thymol
Thymol is a lipid of Prenol Lipids (PR) class. Thymol is associated with abnormalities such as Anemia, end organ damage, Dental caries, CLEFT LIP, CONGENITAL HEALED and Wiskott-Aldrich Syndrome. The involved functions are known as synergism, antagonists, Metabolic Inhibition, Pressure- physical agent and Drug Interactions. Thymol often locates in Mucous Membrane, apical membrane, Protoplasm, Extracellular and Serosal. The associated genes with Thymol are HIST1H1C gene, TRPA1 gene, MERTK wt Allele, SLC12A2 gene and TRPV3 gene. The related lipids are Propionate, Pinene, palmitoleic acid, pentadecanoic acid and stearic acid.
Cross Reference
Introduction
To understand associated biological information of Thymol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Thymol?
Thymol is suspected in Anemia, Infestation, end organ damage, CLEFT LIP, CONGENITAL HEALED, Echinococcosis, Malaria and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Thymol
PubChem Associated disorders and diseases
What pathways are associated with Thymol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Thymol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
- J. Biol. Chem. (1)
- Am. J. Physiol. Gastrointest. Liver Physiol. (1)
- Antimicrob. Agents Chemother. (1)
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Thymol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Thymol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Thymol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Thymol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Thymol?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Thymol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Reginato CF et al. | Antifungal activity of synthetic antiseptics and natural compounds against Candida dubliniensis before and after in vitro fluconazole exposure. | 2017 Jan-Feb | Rev. Soc. Bras. Med. Trop. | pmid:28327805 |
| Figueiredo MB et al. | Lethal and sublethal effects of essential oil of Lippia sidoides (Verbenaceae) and monoterpenes on Chagas' disease vector Rhodnius prolixus. | 2017 | Mem. Inst. Oswaldo Cruz | pmid:27878214 |
| Riasat M et al. | The constituents of essential oil in leaves of Karaj accession of Trigonella foenum graecum. | 2017 | Nat. Prod. Res. | pmid:28278666 |
| Dong LM et al. | Two New Thymol Derivatives from the Roots of Ageratina adenophora. | 2017 | Molecules | pmid:28397757 |
| Wu H et al. | Thymol mitigates lipopolysaccharide-induced endometritis by regulating the TLR4- and ROS-mediated NF-κB signaling pathways. | 2017 | Oncotarget | pmid:28223539 |
| Gracia MJ et al. | Field efficacy of acaricides against Varroa destructor. | 2017 | PLoS ONE | pmid:28158303 |
| Kissels W et al. | Short communication: Interaction of the isomers carvacrol and thymol with the antibiotics doxycycline and tilmicosin: In vitro effects against pathogenic bacteria commonly found in the respiratory tract of calves. | 2017 | J. Dairy Sci. | pmid:28012625 |
| Zhang W et al. | Inhibitory Effects of Emodin, Thymol, and Astragalin on Leptospira interrogans-Induced Inflammatory Response in the Uterine and Endometrium Epithelial Cells of Mice. | 2017 | Inflammation | pmid:28210912 |
| Marcial GE et al. | Influence of oregano essential oil on traditional Argentinean cheese elaboration: Effect on lactic starter cultures. | 2016 Jul - Sep | Rev. Argent. Microbiol. | pmid:27577090 |
| Xavier FJ et al. | Synthesis and In Vitro Anti Leishmania amazonensis Biological Screening of Morita-Baylis-Hillman Adducts Prepared from Eugenol, Thymol and Carvacrol. | 2016 | Molecules | pmid:27834831 |
| Costa-Júnior LM et al. | Acaricidal efficacies of Lippia gracilis essential oil and its phytochemicals against organophosphate-resistant and susceptible strains of Rhipicephalus (Boophilus) microplus. | 2016 | Vet. Parasitol. | pmid:27692332 |
| Khosravi AR and Erle DJ | Chitin-Induced Airway Epithelial Cell Innate Immune Responses Are Inhibited by Carvacrol/Thymol. | 2016 | PLoS ONE | pmid:27463381 |
| Ran C et al. | Thymol and Carvacrol Affect Hybrid Tilapia through the Combination of Direct Stimulation and an Intestinal Microbiota-Mediated Effect: Insights from a Germ-Free Zebrafish Model. | 2016 | J. Nutr. | pmid:27075912 |
| Samii SS et al. | Effects of limonene on ruminal concentrations, fermentation, and lysine degradation in cattle. | 2016 | J. Anim. Sci. | pmid:27695807 |
| El-Sayed el-SM et al. | Thymol and Carvacrol Prevent Doxorubicin-Induced Cardiotoxicity by Abrogation of Oxidative Stress, Inflammation, and Apoptosis in Rats. | 2016 | J. Biochem. Mol. Toxicol. | pmid:26387986 |
| Ye X et al. | Thymol Mitigates Cadmium Stress by Regulating Glutathione Levels and Reactive Oxygen Species Homeostasis in Tobacco Seedlings. | 2016 | Molecules | pmid:27754435 |
| Bustos-Brito C et al. | Antidiarrheal Thymol Derivatives from Ageratina glabrata. Structure and Absolute Configuration of 10-Benzoyloxy-8,9-epoxy-6-hydroxythymol Isobutyrate. | 2016 | Molecules | pmid:27626392 |
| Gao T et al. | The Fungicidal Activity of Thymol against Fusarium graminearum via Inducing Lipid Peroxidation and Disrupting Ergosterol Biosynthesis. | 2016 | Molecules | pmid:27322238 |
| Sharif-Abdullah SS et al. | The effect of chlorhexidine in reducing oral colonisation in geriatric patients: a randomised controlled trial. | 2016 | Singapore Med J | pmid:27211885 |
| Shen Q et al. | ROS Involves the Fungicidal Actions of Thymol against Spores of Aspergillus flavus via the Induction of Nitric Oxide. | 2016 | PLoS ONE | pmid:27196096 |
| Kang SH et al. | Anticancer Effect of Thymol on AGS Human Gastric Carcinoma Cells. | 2016 | J. Microbiol. Biotechnol. | pmid:26437948 |
| Ribeiro AR et al. | Gastroprotective effects of thymol on acute and chronic ulcers in rats: The role of prostaglandins, ATP-sensitive K(+) channels, and gastric mucus secretion. | 2016 | Chem. Biol. Interact. | pmid:26689173 |
| Games E et al. | Structurally Related Monoterpenes p-Cymene, Carvacrol and Thymol Isolated from Essential Oil from Leaves of Lippia sidoides Cham. (Verbenaceae) Protect Mice against Elastase-Induced Emphysema. | 2016 | Molecules | pmid:27775634 |
| Dzhavakhiya VG et al. | Effect of Various Compounds Blocking the Colony Pigmentation on the Aflatoxin B1 Production by Aspergillus flavus. | 2016 | Toxins (Basel) | pmid:27801823 |
| Bizhang M et al. | Effect of 10% fluoride on the remineralization of dentin in situ. | 2015 Nov-Dec | J Appl Oral Sci | pmid:26814458 |
| Witkowska-Banaszczak E et al. | IN-VITRO ANTIMICROBIAL ACTIVITY OF BRONCHOSOL. | 2015 Mar-Apr | Acta Pol Pharm | pmid:26642688 |
| Kim JH et al. | Augmenting the Activity of Monoterpenoid Phenols against Fungal Pathogens Using 2-Hydroxy-4-methoxybenzaldehyde that Target Cell Wall Integrity. | 2015 | Int J Mol Sci | pmid:26569223 |
| Guevara L et al. | Impact of Moderate Heat, Carvacrol, and Thymol Treatments on the Viability, Injury, and Stress Response of Listeria monocytogenes. | 2015 | Biomed Res Int | pmid:26539510 |
| Novato TP et al. | Evaluation of the combined effect of thymol, carvacrol and (E)-cinnamaldehyde on Amblyomma sculptum (Acari: Ixodidae) and Dermacentor nitens (Acari: Ixodidae) larvae. | 2015 | Vet. Parasitol. | pmid:26346899 |
| Field D et al. | Efficacies of nisin A and nisin V semipurified preparations alone and in combination with plant essential oils for controlling Listeria monocytogenes. | 2015 | Appl. Environ. Microbiol. | pmid:25662980 |
| Lansdell SJ et al. | Activation of human 5-hydroxytryptamine type 3 receptors via an allosteric transmembrane site. | 2015 | Mol. Pharmacol. | pmid:25338672 |
| Biller OM et al. | Possible Synergistic Effects of Thymol and Nicotine Against Crithidia bombi Parasitism in Bumble Bees. | 2015 | PLoS ONE | pmid:26657643 |
| Labib GS and Aldawsari H | Innovation of natural essential oil-loaded Orabase for local treatment of oral candidiasis. | 2015 | Drug Des Devel Ther | pmid:26170621 |
| Faraone N et al. | Plant Essential Oils Synergize and Antagonize Toxicity of Different Conventional Insecticides against Myzus persicae (Hemiptera: Aphididae). | 2015 | PLoS ONE | pmid:26010088 |
| de Castro RD et al. | Antifungal activity and mode of action of thymol and its synergism with nystatin against Candida species involved with infections in the oral cavity: an in vitro study. | 2015 | BMC Complement Altern Med | pmid:26601661 |
| Thibodeau A et al. | Chicken Caecal Microbiome Modifications Induced by Campylobacter jejuni Colonization and by a Non-Antibiotic Feed Additive. | 2015 | PLoS ONE | pmid:26161743 |
| Grilli E et al. | Impact of dietary organic acids and botanicals on intestinal integrity and inflammation in weaned pigs. | 2015 | BMC Vet. Res. | pmid:25889654 |
| Zhang LW et al. | Safety assessment of potential food ingredients in canine hepatocytes. | 2015 | Food Chem. Toxicol. | pmid:25660481 |
| Cossu A et al. | Antifungal activity against Candida albicans of starch Pickering emulsion with thymol or amphotericin B in suspension and calcium alginate films. | 2015 | Int J Pharm | pmid:26231107 |
| Chang HT et al. | Effects of Thymol on Ca²⺠Homeostasis and Apoptosis in MDCK Renal Tubular Cells. | 2014 | Chin J Physiol | pmid:24694198 |
| Chauhan AK et al. | Potentiation of macrophage activity by thymol through augmenting phagocytosis. | 2014 | Int. Immunopharmacol. | pmid:24316253 |
| Gomes GA et al. | Acaricidal activity of essential oil from Lippia sidoides on unengorged larvae and nymphs of Rhipicephalus sanguineus (Acari: Ixodidae) and Amblyomma cajennense (Acari: Ixodidae). | 2014 | Exp. Parasitol. | pmid:24333789 |
| Tananaki C et al. | Evaluation of the impact of Exomite Pro on Varroa mite (Varroa destructor) populations and honeybee (Apis mellifera) colonies: efficacy, side effects and residues. | 2014 | Parasitol. Res. | pmid:24549753 |
| Aman S et al. | Antimicrobial polyphenols from small tropical fruits, tea and spice oilseeds. | 2014 | Food Sci Technol Int | pmid:23703103 |
| Cruz EM et al. | Water deficit and seasonality study on essential oil constituents of Lippia gracilis Schauer germplasm. | 2014 | ScientificWorldJournal | pmid:25302321 |
| Hernández-Hernández E et al. | Microencapsulation, chemical characterization, and antimicrobial activity of Mexican (Lippia graveolens H.B.K.) and European (Origanum vulgare L.) oregano essential oils. | 2014 | ScientificWorldJournal | pmid:25177730 |
| Boskabady MH et al. | Carum copticum L.: a herbal medicine with various pharmacological effects. | 2014 | Biomed Res Int | pmid:25089273 |
| Moazeni M et al. | In vivo study of the efficacy of the aromatic water of Zataria multiflora on hydatid cysts. | 2014 | Antimicrob. Agents Chemother. | pmid:25070113 |
| Price KL and Lummis SC | An atypical residue in the pore of Varroa destructor GABA-activated RDL receptors affects picrotoxin block and thymol modulation. | 2014 | Insect Biochem. Mol. Biol. | pmid:25460510 |
| de Morais SM et al. | Thymol and eugenol derivatives as potential antileishmanial agents. | 2014 | Bioorg. Med. Chem. | pmid:25281268 |
| de Vasconcelos LC et al. | Cell viability of Candida albicans against the antifungal activity of thymol. | 2014 | Braz Dent J | pmid:25250489 |
| Khan MS et al. | Carum copticum and Thymus vulgaris oils inhibit virulence in Trichophyton rubrum and Aspergillus spp. | 2014 | Braz. J. Microbiol. | pmid:25242937 |
| Li H et al. | Antibacterial activity and mechanism of action of Monarda punctata essential oil and its main components against common bacterial pathogens in respiratory tract. | 2014 | Int J Clin Exp Pathol | pmid:25550774 |
| Veras HN et al. | Antimicrobial effect of Lippia sidoides and thymol on Enterococcus faecalis biofilm of the bacterium isolated from root canals. | 2014 | ScientificWorldJournal | pmid:24683344 |
| Khadivi-Khub A et al. | Population genetic structure and trait associations in forest savory using molecular, morphological and phytochemical markers. | 2014 | Gene | pmid:24878369 |
| Gallucci MN et al. | In vitro activity of natural phenolic compounds against fluconazole-resistant Candida species: a quantitative structure-activity relationship analysis. | 2014 | J. Appl. Microbiol. | pmid:24387763 |
| Fadli M et al. | Natural extracts stimulate membrane-associated mechanisms of resistance in Gram-negative bacteria. | 2014 | Lett. Appl. Microbiol. | pmid:24447247 |
| Llana-Ruiz-Cabello M et al. | Cytotoxicity and morphological effects induced by carvacrol and thymol on the human cell line Caco-2. | 2014 | Food Chem. Toxicol. | pmid:24326232 |
| Neyret C et al. | Plant-derived compounds as natural antimicrobials to control paper mill biofilms. | 2014 | J. Ind. Microbiol. Biotechnol. | pmid:24170384 |
| Bitu Vde C et al. | Chemical composition of the essential oil of Lippia gracilis Schauer leaves and its potential as modulator of bacterial resistance. | 2014 | Nat. Prod. Res. | pmid:24479735 |
| Borugă O et al. | Thymus vulgaris essential oil: chemical composition and antimicrobial activity. | 2014 | J Med Life | pmid:25870697 |
| Kim YS et al. | Thymol from Thymus quinquecostatus Celak. protects against tert-butyl hydroperoxide-induced oxidative stress in Chang cells. | 2014 | J Nat Med | pmid:23771524 |
| Zhang Y et al. | Fabrication, characterization and antimicrobial activities of thymol-loaded zein nanoparticles stabilized by sodium caseinate-chitosan hydrochloride double layers. | 2014 | Food Chem | pmid:24001841 |
| Matos RS et al. | Determination of the susceptibility of unengorged larvae and engorged females of Rhipicephalus microplus (Acari: Ixodidae) to different methods of dissolving thymol. | 2014 | Parasitol. Res. | pmid:24292541 |
| Haque MR et al. | Monoterpene phenolic compound thymol prevents high fat diet induced obesity in murine model. | 2014 | Toxicol. Mech. Methods | pmid:24175857 |
| Cerisuelo A et al. | The impact of a specific blend of essential oil components and sodium butyrate in feed on growth performance and Salmonella counts in experimentally challenged broilers. | 2014 | Poult. Sci. | pmid:24604853 |
| Sancheti J et al. | Characterization of anticonvulsant and antiepileptogenic potential of thymol in various experimental models. | 2014 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:24065087 |
| Carayon JL et al. | Thymol as an alternative to pesticides: persistence and effects of Apilife Var on the phototactic behavior of the honeybee Apis mellifera. | 2014 | Environ Sci Pollut Res Int | pmid:24043507 |
| Nieddu M et al. | Improvement of thymol properties by complexation with cyclodextrins: in vitro and in vivo studies. | 2014 | Carbohydr Polym | pmid:24507296 |
| Xue J and Zhong Q | Blending lecithin and gelatin improves the formation of thymol nanodispersions. | 2014 | J. Agric. Food Chem. | pmid:24627984 |
| Charpentier G et al. | Lethal and sub-lethal effects of thymol on honeybee (Apis mellifera) larvae reared in vitro. | 2014 | Pest Manag. Sci. | pmid:23512688 |
| Low SB et al. | Evaluation of a topical gel containing a novel combination of essential oils and antioxidants for reducing oral malodor in dogs. | 2014 | Am. J. Vet. Res. | pmid:24959732 |
| Bustos-Brito C et al. | Structure, absolute configuration, and antidiarrheal activity of a thymol derivative from Ageratina cylindrica. | 2014 | J. Nat. Prod. | pmid:24502360 |
| Liang D et al. | Thymol inhibits LPS-stimulated inflammatory response via down-regulation of NF-κB and MAPK signaling pathways in mouse mammary epithelial cells. | 2014 | Inflammation | pmid:24057926 |
| Medeiros Barreto H et al. | Phytochemical prospection and modulation of antibiotic activity in vitro by Lippia origanoides H.B.K. in methicillin resistant Staphylococcus aureus. | 2014 | Biomed Res Int | pmid:24683545 |
| Pan K et al. | Thymol nanoencapsulated by sodium caseinate: physical and antilisterial properties. | 2014 | J. Agric. Food Chem. | pmid:24484459 |
| Wechsler JB et al. | IgE-mediated mast cell responses are inhibited by thymol-mediated, activation-induced cell death in skin inflammation. | 2014 | J. Allergy Clin. Immunol. | pmid:24486068 |
| Sakagami H et al. | Biological interaction between Sasa senanensis Rehder leaf extract and toothpaste ingredients. | 2013 Mar-Apr | In Vivo | pmid:23422490 |
| Silva EJ et al. | Long-term cytotoxic effects of contemporary root canal sealers. | 2013 Jan-Feb | J Appl Oral Sci | pmid:23559111 |
| Wu S et al. | [Chemical composition of essential oil from Thymus citriodorus and its toxic effect on liver cancer cells]. | 2013 | Zhong Yao Cai | pmid:24218968 |
| Hanlidou E and Lazari D | Essential oils of Thymus leucospermus Hartvig, a Greek endemic rich in phenolic monoterpenes. | 2013 | Nat. Prod. Res. | pmid:23297716 |
| Beena D et al. | Synthesis and antioxidant activity of thymol and carvacrol based Schiff bases. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23273412 |
| Hallier A et al. | Development of a method to determine essential oil residues in cow milk. | 2013 | J. Dairy Sci. | pmid:23313003 |
| Ahmad A et al. | Reversal of efflux mediated antifungal resistance underlies synergistic activity of two monoterpenes with fluconazole. | 2013 | Eur J Pharm Sci | pmid:23111348 |
| Upadhyaya I et al. | Effect of plant derived antimicrobials on Salmonella enteritidis adhesion to and invasion of primary chicken oviduct epithelial cells in vitro and virulence gene expression. | 2013 | Int J Mol Sci | pmid:23698782 |
| Cruz EM et al. | Acaricidal activity of Lippia gracilis essential oil and its major constituents on the tick Rhipicephalus (Boophilus) microplus. | 2013 | Vet. Parasitol. | pmid:23337330 |
| Ferraz RP et al. | Cytotoxic effect of leaf essential oil of Lippia gracilis Schauer (Verbenaceae). | 2013 | Phytomedicine | pmid:23453306 |
| Lage TC et al. | Activity of essential oil of Lippia triplinervis Gardner (Verbenaceae) on Rhipicephalus microplus (Acari: Ixodidae). | 2013 | Parasitol. Res. | pmid:23224609 |
| Miguel MG et al. | Propolis volatiles characterisation from acaricide-treated and -untreated beehives maintained at Algarve (Portugal). | 2013 | Nat. Prod. Res. | pmid:22724515 |
| Kavoosi G et al. | Evaluation of antioxidant and antimicrobial activities of essential oils from Carum copticum seed and Ferula assafoetida latex. | 2013 | J. Food Sci. | pmid:23320824 |
| Veras HN et al. | Topical antiinflammatory activity of essential oil of Lippia sidoides cham: possible mechanism of action. | 2013 | Phytother Res | pmid:22511564 |
| Mahmud H et al. | Suicidal erythrocyte death, eryptosis, as a novel mechanism in heart failure-associated anaemia. | 2013 | Cardiovasc. Res. | pmid:23341574 |
| Baygin O et al. | Comparison of combined application treatment with one-visit varnish treatments in an orthodontic population. | 2013 | Med Oral Patol Oral Cir Bucal | pmid:23385499 |
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| Ohwada H et al. | Predictors, including blood, urine, anthropometry, and nutritional indices, of all-cause mortality among institutionalized individuals with intellectual disability. | 2013 | Res Dev Disabil | pmid:23123878 |
| Chandiran S et al. | Synthesis and evaluation of antioxidant-s-(+)-Ibuprofen hybrids as gastro sparing NSAIDs. | 2013 | Med Chem | pmid:23061566 |
| Grilli E et al. | Development of a feed additive to reduce caecal Campylobacter jejuni in broilers at slaughter age: from in vitro to in vivo, a proof of concept. | 2013 | J. Appl. Microbiol. | pmid:23110383 |
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