MeSH term | MeSH ID | Detail |
---|---|---|
Prostatic Neoplasms | D011471 | 126 associated lipids |
Perillic acid is a lipid of Prenol Lipids (PR) class. The involved functions are known as Membrane Potential, Mitochondrial, Neuroprotection, inhibitors, Protein Geranylgeranylation and mitochondrial depolarization. Perillic acid often locates in Membrane and Extracellular. The associated genes with Perillic acid are RAB3A gene and neutrophil cytosol factor 67K.
To understand associated biological information of Perillic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with Perillic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Prostatic Neoplasms | D011471 | 126 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Perillic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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pmid: | ||||
Hardcastle IR et al. | Inhibition of protein prenylation by metabolites of limonene. | 1999 | Biochem. Pharmacol. | pmid:10075086 |
Boon PJ et al. | Cytotoxicity and biotransformation of the anticancer drug perillyl alcohol in PC12 cells and in the rat. | 2000 | Toxicol. Appl. Pharmacol. | pmid:10936079 |
Hudes GR et al. | Phase I pharmacokinetic trial of perillyl alcohol (NSC 641066) in patients with refractory solid malignancies. | 2000 | Clin. Cancer Res. | pmid:10955786 |
Cheng QF et al. | Effect of perillic acid, a putative isoprenylation inhibitor, on the cultured rat lens. | 2001 | Exp. Eye Res. | pmid:11446774 |
Ferri N et al. | Effect of S(-) perillic acid on protein prenylation and arterial smooth muscle cell proliferation. | 2001 | Biochem. Pharmacol. | pmid:11755117 |
Choy WY et al. | Role of mitogen-activated protein kinase pathway in acetylcholine-mediated in vitro relaxation of rat pulmonary artery. | 2002 | Eur. J. Pharmacol. | pmid:11755166 |
Bardon S et al. | Monoterpenes inhibit proliferation of human colon cancer cells by modulating cell cycle-related protein expression. | 2002 | Cancer Lett. | pmid:12175534 |
Chow HH et al. | Pharmacokinetics of perillic acid in humans after a single dose administration of a citrus preparation rich in d-limonene content. | 2002 | Cancer Epidemiol. Biomarkers Prev. | pmid:12433729 |
pmid:12451324 | ||||
Holstein SA and Hohl RJ | Monoterpene regulation of Ras and Ras-related protein expression. | 2003 | J. Lipid Res. | pmid:12671036 |
Azzoli CG et al. | A phase I trial of perillyl alcohol in patients with advanced solid tumors. | 2003 | Cancer Chemother. Pharmacol. | pmid:12695855 |
Duetz WA et al. | Biotransformation of limonene by bacteria, fungi, yeasts, and plants. | 2003 | Appl. Microbiol. Biotechnol. | pmid:12743755 |
Beaupre DM et al. | Farnesyl transferase inhibitors enhance death receptor signals and induce apoptosis in multiple myeloma cells. | 2003 | Leuk. Lymphoma | pmid:14959858 |
Bailey HH et al. | A phase I trial of perillyl alcohol administered four times daily for 14 days out of 28 days. | 2004 | Cancer Chemother. Pharmacol. | pmid:15205914 |
Samaila D et al. | Monoterpenes enhanced the sensitivity of head and neck cancer cells to radiation treatment in vitro. | 2004 Sep-Oct | Anticancer Res. | pmid:15517920 |
Trytek M and Fiedurek J | A novel psychrotrophic fungus, Mortierella minutissima, for D-limonene biotransformation. | 2005 | Biotechnol. Lett. | pmid:15717122 |
Del Toro-Arreola S et al. | Effect of D-limonene on immune response in BALB/c mice with lymphoma. | 2005 | Int. Immunopharmacol. | pmid:15778119 |
Seto SW et al. | Modulatory effect of interleukin-1beta on rat isolated basilar artery contraction. | 2006 | Eur. J. Pharmacol. | pmid:16438962 |
Montiel M et al. | P2Y receptors activate MAPK/ERK through a pathway involving PI3K/PDK1/PKC-zeta in human vein endothelial cells. | 2006 | Cell. Physiol. Biochem. | pmid:16914897 |