MeSH term | MeSH ID | Detail |
---|---|---|
Prostatic Neoplasms | D011471 | 126 associated lipids |
Perillic acid is a lipid of Prenol Lipids (PR) class. The involved functions are known as Membrane Potential, Mitochondrial, Neuroprotection, inhibitors, Protein Geranylgeranylation and mitochondrial depolarization. Perillic acid often locates in Membrane and Extracellular. The associated genes with Perillic acid are RAB3A gene and neutrophil cytosol factor 67K.
To understand associated biological information of Perillic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with Perillic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Prostatic Neoplasms | D011471 | 126 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Perillic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Azzoli CG et al. | A phase I trial of perillyl alcohol in patients with advanced solid tumors. | 2003 | Cancer Chemother. Pharmacol. | pmid:12695855 |
Chow HH et al. | Pharmacokinetics of perillic acid in humans after a single dose administration of a citrus preparation rich in d-limonene content. | 2002 | Cancer Epidemiol. Biomarkers Prev. | pmid:12433729 |
Yeruva L et al. | Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells. | 2007 | Cancer Lett. | pmid:17888568 |
Bardon S et al. | Monoterpenes inhibit proliferation of human colon cancer cells by modulating cell cycle-related protein expression. | 2002 | Cancer Lett. | pmid:12175534 |
Miller JA et al. | Human breast tissue disposition and bioactivity of limonene in women with early-stage breast cancer. | 2013 | Cancer Prev Res (Phila) | pmid:23554130 |
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Montiel M et al. | P2Y receptors activate MAPK/ERK through a pathway involving PI3K/PDK1/PKC-zeta in human vein endothelial cells. | 2006 | Cell. Physiol. Biochem. | pmid:16914897 |
Esmaeili A and Hashemi E | Biotransformation of myrcene by Pseudomonas aeruginosa. | 2011 | Chem Cent J | pmid:21609445 |
Hudes GR et al. | Phase I pharmacokinetic trial of perillyl alcohol (NSC 641066) in patients with refractory solid malignancies. | 2000 | Clin. Cancer Res. | pmid:10955786 |
Schulz S et al. | Prenylated proteins and lymphocyte proliferation: inhibition by d-limonene related monoterpenes. | 1994 | Eur. J. Immunol. | pmid:8299679 |
Choy WY et al. | Role of mitogen-activated protein kinase pathway in acetylcholine-mediated in vitro relaxation of rat pulmonary artery. | 2002 | Eur. J. Pharmacol. | pmid:11755166 |
Seto SW et al. | Modulatory effect of interleukin-1beta on rat isolated basilar artery contraction. | 2006 | Eur. J. Pharmacol. | pmid:16438962 |
Wu CS et al. | Terpinen-4-ol Induces Apoptosis in Human Nonsmall Cell Lung Cancer In Vitro and In Vivo. | 2012 | Evid Based Complement Alternat Med | pmid:21760828 |
Cheng QF et al. | Effect of perillic acid, a putative isoprenylation inhibitor, on the cultured rat lens. | 2001 | Exp. Eye Res. | pmid:11446774 |
Omoigui S | The Interleukin-6 inflammation pathway from cholesterol to aging--role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases. | 2007 | Immun Ageing | pmid:17374166 |
Del Toro-Arreola S et al. | Effect of D-limonene on immune response in BALB/c mice with lymphoma. | 2005 | Int. Immunopharmacol. | pmid:15778119 |
Saldanha SN and Tollefsbol TO | The role of nutraceuticals in chemoprevention and chemotherapy and their clinical outcomes. | 2012 | J Oncol | pmid:22187555 |
Ikechukwu Ezennia E et al. | Analysis of perillic acid in plasma by reversed-phase high-performance liquid chromatography with ultraviolet detection. | 1997 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:9061476 |
Pratheeshkumar P et al. | Protective role of perillic acid against radiation-induced oxidative stress, cytokine profile, DNA damage, and intestinal toxicity in mice. | 2010 | J. Environ. Pathol. Toxicol. Oncol. | pmid:21303327 |
Mukherjee A et al. | 6-Nitro-2-(3-hydroxypropyl)-1H-benz[de]isoquinoline-1,3-dione, a potent antitumor agent, induces cell cycle arrest and apoptosis. | 2010 | J. Exp. Clin. Cancer Res. | pmid:21194464 |