MeSH term | MeSH ID | Detail |
---|---|---|
Insulin Resistance | D007333 | 99 associated lipids |
Seizures | D012640 | 87 associated lipids |
Neurotoxicity Syndromes | D020258 | 34 associated lipids |
Thujone is a lipid of Prenol Lipids (PR) class. Thujone is associated with abnormalities such as Consumption-archaic term for TB, Malnutrition, Diabetes, abnormal fragmented structure and Dehydration. The involved functions are known as sabinene synthase activity, Anabolism, diterpene biosynthesis, Selection, Genetic and Biochemical Pathway. Thujone often locates in Tissue membrane, Clone, Epithelium, Back and Cell surface. The associated genes with Thujone are monoterpene synthase, Candidate Disease Gene, Recombinant Proteins, HM13 gene and DAND5 gene. The related lipids are Pinene, Palmitates and absinthium.
To understand associated biological information of Thujone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thujone is suspected in Malnutrition, Diabetes, Dehydration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Thujone
MeSH term | MeSH ID | Detail |
---|---|---|
Insulin Resistance | D007333 | 99 associated lipids |
Seizures | D012640 | 87 associated lipids |
Neurotoxicity Syndromes | D020258 | 34 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Thujone through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Laciar A et al. | Antibacterial and antioxidant activities of the essential oil of Artemisia echegarayi Hieron. (Asteraceae). | 2009 Oct-Dec | Rev. Argent. Microbiol. | pmid:20085186 |
Lachenmeier DW and Uebelacker M | Risk assessment of thujone in foods and medicines containing sage and wormwood--evidence for a need of regulatory changes? | 2010 | Regul. Toxicol. Pharmacol. | pmid:20727933 |
Pelkonen O et al. | Thujone and thujone-containing herbal medicinal and botanical products: toxicological assessment. | 2013 | Regul. Toxicol. Pharmacol. | pmid:23201408 |
Olsen RW | Absinthe and gamma-aminobutyric acid receptors. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10781032 |
Höld KM et al. | Alpha-thujone (the active component of absinthe): gamma-aminobutyric acid type A receptor modulation and metabolic detoxification. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10725394 |
Leitz J et al. | Chemical analysis and risk assessment of diethyl phthalate in alcoholic beverages with special regard to unrecorded alcohol. | 2009 | PLoS ONE | pmid:19956573 |
Gesell A et al. | The gymnosperm cytochrome P450 CYP750B1 catalyzes stereospecific monoterpene hydroxylation of (+)-sabinene in thujone biosynthesis in western redcedar. | 2015 | Plant Physiol. | pmid:25829465 |
Foster AJ et al. | Identification of genes in Thuja plicata foliar terpenoid defenses. | 2013 | Plant Physiol. | pmid:23388118 |
Remberg P et al. | Characteristics, clinical effect profile and tolerability of a nasal spray preparation of Artemisia abrotanum L. for allergic rhinitis. | 2004 | Phytomedicine | pmid:14971719 |
Kleine S and Müller C | Differences in shoot and root terpenoid profiles and plant responses to fertilisation in Tanacetum vulgare. | 2013 | Phytochemistry | pmid:24128753 |