Thujone

Thujone is a lipid of Prenol Lipids (PR) class. Thujone is associated with abnormalities such as Consumption-archaic term for TB, Malnutrition, Diabetes, abnormal fragmented structure and Dehydration. The involved functions are known as sabinene synthase activity, Anabolism, diterpene biosynthesis, Selection, Genetic and Biochemical Pathway. Thujone often locates in Tissue membrane, Clone, Epithelium, Back and Cell surface. The associated genes with Thujone are monoterpene synthase, Candidate Disease Gene, Recombinant Proteins, HM13 gene and DAND5 gene. The related lipids are Pinene, Palmitates and absinthium.

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Introduction

To understand associated biological information of Thujone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Thujone?

Thujone is suspected in Malnutrition, Diabetes, Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Thujone

MeSH term MeSH ID Detail
Neurotoxicity Syndromes D020258 34 associated lipids
Seizures D012640 87 associated lipids
Insulin Resistance D007333 99 associated lipids
Total 3

PubChem Associated disorders and diseases

What pathways are associated with Thujone

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Thujone through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Thujone?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Thujone?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Thujone?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Thujone?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Thujone?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Thujone

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Authors Title Published Journal PubMed Link
Siveen KS and Kuttan G Thujone inhibits lung metastasis induced by B16F-10 melanoma cells in C57BL/6 mice. 2011 Can. J. Physiol. Pharmacol. pmid:21905822
Walch SG et al. Determination of the biologically active flavour substances thujone and camphor in foods and medicines containing sage (Salvia officinalis L.). 2011 Chem Cent J pmid:21777420
Mighri H et al. Composition and intraspecific chemical variability of the essential oil from Artemisia herba-alba growing wild in a Tunisian arid zone. 2010 Chem. Biodivers. pmid:21072770
Höld KM et al. Detoxification of alpha- and beta-Thujones (the active ingredients of absinthe): site specificity and species differences in cytochrome P450 oxidation in vitro and in vivo. 2001 Chem. Res. Toxicol. pmid:11368559
Jiang Y and Ortiz de Montellano PR Cooperative effects on radical recombination in CYP3A4-catalyzed oxidation of the radical clock beta-thujone. 2009 Chembiochem pmid:19189363
Chiang LC et al. Antiviral activities of extracts and selected pure constituents of Ocimum basilicum. 2005 Clin. Exp. Pharmacol. Physiol. pmid:16173941
Lachenmeier DW et al. Absinthe--a review. 2006 Crit Rev Food Sci Nutr pmid:16891209
Hall AC et al. Modulation of human GABAA and glycine receptor currents by menthol and related monoterpenoids. 2004 Eur. J. Pharmacol. pmid:15588619
Czyzewska MM and Mozrzymas JW Monoterpene α-thujone exerts a differential inhibitory action on GABA(A) receptors implicated in phasic and tonic GABAergic inhibition. 2013 Eur. J. Pharmacol. pmid:23376563
Adams JD and Garcia C Women's health among the Chumash. 2006 Evid Based Complement Alternat Med pmid:16550233