MeSH term | MeSH ID | Detail |
---|---|---|
Neurotoxicity Syndromes | D020258 | 34 associated lipids |
Seizures | D012640 | 87 associated lipids |
Insulin Resistance | D007333 | 99 associated lipids |
Thujone is a lipid of Prenol Lipids (PR) class. Thujone is associated with abnormalities such as Consumption-archaic term for TB, Malnutrition, Diabetes, abnormal fragmented structure and Dehydration. The involved functions are known as sabinene synthase activity, Anabolism, diterpene biosynthesis, Selection, Genetic and Biochemical Pathway. Thujone often locates in Tissue membrane, Clone, Epithelium, Back and Cell surface. The associated genes with Thujone are monoterpene synthase, Candidate Disease Gene, Recombinant Proteins, HM13 gene and DAND5 gene. The related lipids are Pinene, Palmitates and absinthium.
To understand associated biological information of Thujone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thujone is suspected in Malnutrition, Diabetes, Dehydration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Thujone
MeSH term | MeSH ID | Detail |
---|---|---|
Neurotoxicity Syndromes | D020258 | 34 associated lipids |
Seizures | D012640 | 87 associated lipids |
Insulin Resistance | D007333 | 99 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Thujone through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Siveen KS and Kuttan G | Thujone inhibits lung metastasis induced by B16F-10 melanoma cells in C57BL/6 mice. | 2011 | Can. J. Physiol. Pharmacol. | pmid:21905822 |
Walch SG et al. | Determination of the biologically active flavour substances thujone and camphor in foods and medicines containing sage (Salvia officinalis L.). | 2011 | Chem Cent J | pmid:21777420 |
Mighri H et al. | Composition and intraspecific chemical variability of the essential oil from Artemisia herba-alba growing wild in a Tunisian arid zone. | 2010 | Chem. Biodivers. | pmid:21072770 |
Höld KM et al. | Detoxification of alpha- and beta-Thujones (the active ingredients of absinthe): site specificity and species differences in cytochrome P450 oxidation in vitro and in vivo. | 2001 | Chem. Res. Toxicol. | pmid:11368559 |
Jiang Y and Ortiz de Montellano PR | Cooperative effects on radical recombination in CYP3A4-catalyzed oxidation of the radical clock beta-thujone. | 2009 | Chembiochem | pmid:19189363 |
Chiang LC et al. | Antiviral activities of extracts and selected pure constituents of Ocimum basilicum. | 2005 | Clin. Exp. Pharmacol. Physiol. | pmid:16173941 |
Lachenmeier DW et al. | Absinthe--a review. | 2006 | Crit Rev Food Sci Nutr | pmid:16891209 |
Hall AC et al. | Modulation of human GABAA and glycine receptor currents by menthol and related monoterpenoids. | 2004 | Eur. J. Pharmacol. | pmid:15588619 |
Czyzewska MM and Mozrzymas JW | Monoterpene α-thujone exerts a differential inhibitory action on GABA(A) receptors implicated in phasic and tonic GABAergic inhibition. | 2013 | Eur. J. Pharmacol. | pmid:23376563 |
Adams JD and Garcia C | Women's health among the Chumash. | 2006 | Evid Based Complement Alternat Med | pmid:16550233 |