MeSH term | MeSH ID | Detail |
---|---|---|
Seizures | D012640 | 87 associated lipids |
Insulin Resistance | D007333 | 99 associated lipids |
Neurotoxicity Syndromes | D020258 | 34 associated lipids |
Thujone is a lipid of Prenol Lipids (PR) class. Thujone is associated with abnormalities such as Consumption-archaic term for TB, Malnutrition, Diabetes, abnormal fragmented structure and Dehydration. The involved functions are known as sabinene synthase activity, Anabolism, diterpene biosynthesis, Selection, Genetic and Biochemical Pathway. Thujone often locates in Tissue membrane, Clone, Epithelium, Back and Cell surface. The associated genes with Thujone are monoterpene synthase, Candidate Disease Gene, Recombinant Proteins, HM13 gene and DAND5 gene. The related lipids are Pinene, Palmitates and absinthium.
To understand associated biological information of Thujone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thujone is suspected in Malnutrition, Diabetes, Dehydration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Thujone
MeSH term | MeSH ID | Detail |
---|---|---|
Seizures | D012640 | 87 associated lipids |
Insulin Resistance | D007333 | 99 associated lipids |
Neurotoxicity Syndromes | D020258 | 34 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Thujone through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Waidyanatha S et al. | Toxicokinetics of α-thujone following intravenous and gavage administration of α-thujone or α- and β-thujone mixture in male and female F344/N rats and B6C3F1 mice. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23669748 |
Pelkonen O et al. | Thujone and thujone-containing herbal medicinal and botanical products: toxicological assessment. | 2013 | Regul. Toxicol. Pharmacol. | pmid:23201408 |
Foster AJ et al. | Identification of genes in Thuja plicata foliar terpenoid defenses. | 2013 | Plant Physiol. | pmid:23388118 |
Czyzewska MM and Mozrzymas JW | Monoterpene α-thujone exerts a differential inhibitory action on GABA(A) receptors implicated in phasic and tonic GABAergic inhibition. | 2013 | Eur. J. Pharmacol. | pmid:23376563 |
Kleine S and Müller C | Differences in shoot and root terpenoid profiles and plant responses to fertilisation in Tanacetum vulgare. | 2013 | Phytochemistry | pmid:24128753 |
Chapuis Y | [Absinthe rehabilitated]. | 2013 | Bull. Acad. Natl. Med. | pmid:24919378 |
Grausgruber-Gröger S et al. | Seasonal influence on gene expression of monoterpene synthases in Salvia officinalis (Lamiaceae). | 2012 | J. Plant Physiol. | pmid:22196947 |
Walch SG et al. | Holistic Control of Herbal Teas and Tinctures Based on Sage (Salvia officinalis L.) for Compounds with Beneficial and Adverse Effects using NMR Spectroscopy. | 2012 | Anal Chem Insights | pmid:22493561 |
Szczot M et al. | Modulation of GABAergic synaptic currents and current responses by α-thujone and dihydroumbellulone. | 2012 | J. Nat. Prod. | pmid:22364543 |
Abass K et al. | Metabolism of α-thujone in human hepatic preparations in vitro. | 2011 | Xenobiotica | pmid:21087116 |