Thujone

Thujone is a lipid of Prenol Lipids (PR) class. Thujone is associated with abnormalities such as Consumption-archaic term for TB, Malnutrition, Diabetes, abnormal fragmented structure and Dehydration. The involved functions are known as sabinene synthase activity, Anabolism, diterpene biosynthesis, Selection, Genetic and Biochemical Pathway. Thujone often locates in Tissue membrane, Clone, Epithelium, Back and Cell surface. The associated genes with Thujone are monoterpene synthase, Candidate Disease Gene, Recombinant Proteins, HM13 gene and DAND5 gene. The related lipids are Pinene, Palmitates and absinthium.

Cross Reference

Introduction

To understand associated biological information of Thujone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Thujone?

Thujone is suspected in Malnutrition, Diabetes, Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Thujone

MeSH term MeSH ID Detail
Seizures D012640 87 associated lipids
Insulin Resistance D007333 99 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Total 3

PubChem Associated disorders and diseases

What pathways are associated with Thujone

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Thujone through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Thujone?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Thujone?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Thujone?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Thujone?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Thujone?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Thujone

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Authors Title Published Journal PubMed Link
pmid:
Meschler JP and Howlett AC Thujone exhibits low affinity for cannabinoid receptors but fails to evoke cannabimimetic responses. 1999 Pharmacol. Biochem. Behav. pmid:10080239
Strang J et al. Absinthe: what's your poison? Though absinthe is intriguing, it is alcohol in general we should worry about. 1999 Dec 18-25 BMJ pmid:10600949
Höld KM et al. Alpha-thujone (the active component of absinthe): gamma-aminobutyric acid type A receptor modulation and metabolic detoxification. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:10725394
Olsen RW Absinthe and gamma-aminobutyric acid receptors. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:10781032
Salisová M et al. Comparison of conventional and ultrasonically assisted extractions of pharmaceutically active compounds from Salvia officinalis. 1997 Ultrason Sonochem pmid:11237030
Sirisoma NS et al. alpha- and beta-Thujones (herbal medicines and food additives): synthesis and analysis of hydroxy and dehydro metabolites. 2001 J. Agric. Food Chem. pmid:11308346
pmid:11312652
Höld KM et al. Detoxification of alpha- and beta-Thujones (the active ingredients of absinthe): site specificity and species differences in cytochrome P450 oxidation in vitro and in vivo. 2001 Chem. Res. Toxicol. pmid:11368559
pmid:11409986