Thujone

Thujone is a lipid of Prenol Lipids (PR) class. Thujone is associated with abnormalities such as Consumption-archaic term for TB, Malnutrition, Diabetes, abnormal fragmented structure and Dehydration. The involved functions are known as sabinene synthase activity, Anabolism, diterpene biosynthesis, Selection, Genetic and Biochemical Pathway. Thujone often locates in Tissue membrane, Clone, Epithelium, Back and Cell surface. The associated genes with Thujone are monoterpene synthase, Candidate Disease Gene, Recombinant Proteins, HM13 gene and DAND5 gene. The related lipids are Pinene, Palmitates and absinthium.

Cross Reference

Introduction

To understand associated biological information of Thujone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Thujone?

Thujone is suspected in Malnutrition, Diabetes, Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Thujone

MeSH term MeSH ID Detail
Seizures D012640 87 associated lipids
Insulin Resistance D007333 99 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Total 3

PubChem Associated disorders and diseases

What pathways are associated with Thujone

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Thujone through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Thujone?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Thujone?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Thujone?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Thujone?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Thujone?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Thujone

Download all related citations
Per page 10 20 50 100 | Total 162
Authors Title Published Journal PubMed Link
pmid:25146764
pmid:25055158
pmid:17192005
pmid:14659733
pmid:25529699
pmid:20542104
pmid:19501966
pmid:29421510
pmid:19401923
pmid:19085007
pmid:17506022
pmid:17230311
pmid:16278011
pmid:15635687
pmid:12624823
pmid:11312652
pmid:28395994
pmid:27451252
pmid:27181395
pmid:27174212
pmid:26900077
pmid:26305878
pmid:26773227
pmid:26655741
pmid:26467601
pmid:25853962
pmid:25818694
pmid:25770648
pmid:23081929
pmid:24076562
pmid:21894557
pmid:15030239
pmid:19535210
pmid:25103502
pmid:20355101
pmid:20020464
pmid:19886685
pmid:16366708
pmid:12391564
pmid:18397765
pmid:18283947
pmid:22492499
pmid:11409986
pmid:16814443
pmid:16190647
pmid:12689680
pmid:12677536
pmid:11697542
pmid:21907890
pmid:28477412
pmid:28378196
pmid:28314999
pmid:18511141
pmid:20156520
pmid:26482939
pmid:
Sapra B et al. Percutaneous permeation enhancement by terpenes: mechanistic view. 2008 AAPS J pmid:18446512
Waller PJ et al. Plants as de-worming agents of livestock in the Nordic countries: historical perspective, popular beliefs and prospects for the future. 2001 Acta Vet. Scand. pmid:11455900
Alkhateeb H and Bonen A Thujone, a component of medicinal herbs, rescues palmitate-induced insulin resistance in skeletal muscle. 2010 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:20573988
D'Ulivo L The absinthe challenge. 2014 Anal Bioanal Chem pmid:24632744
Walch SG et al. Holistic Control of Herbal Teas and Tinctures Based on Sage (Salvia officinalis L.) for Compounds with Beneficial and Adverse Effects using NMR Spectroscopy. 2012 Anal Chem Insights pmid:22493561
Alkhateeb H et al. Skeletal muscle fatty acid oxidation is not directly associated with AMPK or ACC2 phosphorylation. 2011 Appl Physiol Nutr Metab pmid:21574785
Dehal SS and Croteau R Metabolism of monoterpenes: specificity of the dehydrogenases responsible for the biosynthesis of camphor, 3-thujone, and 3-isothujone. 1987 Arch. Biochem. Biophys. pmid:3310901
Brieskorn CH and Schwack W [Condensation of thujone with biogenic amines and amino acids]. 1983 Arch. Pharm. (Weinheim) pmid:6882159
Behrens M et al. The human taste receptor hTAS2R14 responds to a variety of different bitter compounds. 2004 Biochem. Biophys. Res. Commun. pmid:15178431
Bonkovsky HL et al. Porphyrogenic properties of the terpenes camphor, pinene, and thujone (with a note on historic implications for absinthe and the illness of Vincent van Gogh). 1992 Biochem. Pharmacol. pmid:1610401
Jiang Y et al. Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes. 2006 Biochemistry pmid:16401082
Strang J et al. Absinthe: what's your poison? Though absinthe is intriguing, it is alcohol in general we should worry about. 1999 Dec 18-25 BMJ pmid:10600949
Rivera EM et al. Central α- and β-thujone: similar anxiogenic-like effects and differential modulation on GABAA receptors in neonatal chicks. 2014 Brain Res. pmid:24486357
Chapuis Y [Absinthe rehabilitated]. 2013 Bull. Acad. Natl. Med. pmid:24919378
Siveen KS and Kuttan G Thujone inhibits lung metastasis induced by B16F-10 melanoma cells in C57BL/6 mice. 2011 Can. J. Physiol. Pharmacol. pmid:21905822
Walch SG et al. Determination of the biologically active flavour substances thujone and camphor in foods and medicines containing sage (Salvia officinalis L.). 2011 Chem Cent J pmid:21777420
Mighri H et al. Composition and intraspecific chemical variability of the essential oil from Artemisia herba-alba growing wild in a Tunisian arid zone. 2010 Chem. Biodivers. pmid:21072770
Höld KM et al. Detoxification of alpha- and beta-Thujones (the active ingredients of absinthe): site specificity and species differences in cytochrome P450 oxidation in vitro and in vivo. 2001 Chem. Res. Toxicol. pmid:11368559
Jiang Y and Ortiz de Montellano PR Cooperative effects on radical recombination in CYP3A4-catalyzed oxidation of the radical clock beta-thujone. 2009 Chembiochem pmid:19189363
Chiang LC et al. Antiviral activities of extracts and selected pure constituents of Ocimum basilicum. 2005 Clin. Exp. Pharmacol. Physiol. pmid:16173941
Lachenmeier DW et al. Absinthe--a review. 2006 Crit Rev Food Sci Nutr pmid:16891209
Hall AC et al. Modulation of human GABAA and glycine receptor currents by menthol and related monoterpenoids. 2004 Eur. J. Pharmacol. pmid:15588619
Czyzewska MM and Mozrzymas JW Monoterpene α-thujone exerts a differential inhibitory action on GABA(A) receptors implicated in phasic and tonic GABAergic inhibition. 2013 Eur. J. Pharmacol. pmid:23376563
Adams JD and Garcia C Women's health among the Chumash. 2006 Evid Based Complement Alternat Med pmid:16550233
Arora R et al. Potential of Complementary and Alternative Medicine in Preventive Management of Novel H1N1 Flu (Swine Flu) Pandemic: Thwarting Potential Disasters in the Bud. 2011 Evid Based Complement Alternat Med pmid:20976081
Biswas R et al. Thujone-Rich Fraction of Thuja occidentalis Demonstrates Major Anti-Cancer Potentials: Evidences from In Vitro Studies on A375 Cells. 2011 Evid Based Complement Alternat Med pmid:21647317
Bellavite P et al. Immunology and homeopathy. 2. Cells of the immune system and inflammation. 2006 Evid Based Complement Alternat Med pmid:16550219
Nikolić B et al. Modulation of genotoxicity and DNA repair by plant monoterpenes camphor, eucalyptol and thujone in Escherichia coli and mammalian cells. 2011 Food Chem. Toxicol. pmid:21620923
Tenore GC et al. Antimicrobial and antioxidant properties of the essential oil of Salvia lanigera from Cyprus. 2011 Food Chem. Toxicol. pmid:20977923
Gambelunghe C and Melai P Absinthe: enjoying a new popularity among young people? 2002 Forensic Sci. Int. pmid:12477641
Lachenmeier DW et al. Thujone--cause of absinthism? 2006 Forensic Sci. Int. pmid:15896935
Lachenmeier DW [Absinthe - history of dependence to thujone or to alcohol?]. 2007 Fortschr Neurol Psychiatr pmid:17506021
Eckert GP Traditional used Plants against Cognitive Decline and Alzheimer Disease. 2010 Front Pharmacol pmid:21833177
Walch SG et al. Antioxidant Capacity and Polyphenolic Composition as Quality Indicators for Aqueous Infusions of Salvia officinalis L. (sage tea). 2011 Front Pharmacol pmid:22194722
Rad F et al. Randomized comparative clinical trial of Artemisia sieberi 5% lotion and clotrimazole 1% lotion for the treatment of pityriasis versicolor. 2008 Indian J Dermatol pmid:19882007
Vogt DD and Montagne M Absinthe: behind the emerald mask. 1982 Int J Addict pmid:6754635
Phua DH et al. Dietary supplements and herbal medicine toxicities-when to anticipate them and how to manage them. 2009 Int J Emerg Med pmid:20157447
Hudson J et al. The antimicrobial properties of cedar leaf (Thuja plicata) oil; a safe and efficient decontamination agent for buildings. 2011 Int J Environ Res Public Health pmid:22408584
Lachenmeier DW and Nathan-Maister D Absinthe and tobacco--a new look at an old problem? (Comment on: Absinthe--is its history relevant for current public health?). 2008 Int J Epidemiol pmid:17898026
Siveen KS and Kuttan G Augmentation of humoral and cell mediated immune responses by Thujone. 2011 Int. Immunopharmacol. pmid:21884824
Rekand T Absinthe, the nervous system and painting. 2006 Int. Rev. Neurobiol. pmid:16730520
Horváth G et al. TLC-direct bioautography for determination of antibacterial activity of Artemisia adamsii essential oil. 2013 Nov-Dec J AOAC Int pmid:24645495
Galli CL et al. Quantitative analysis of alpha, beta-thujone, pulegone, safrole, coumarin and beta-asarone in alcoholic beverages by selected-ion monitoring. 1984 J Appl Toxicol pmid:6512167
Lans C Ethnomedicines used in Trinidad and Tobago for reproductive problems. 2007 J Ethnobiol Ethnomed pmid:17362507