2E,6E-farnesol

2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.

Cross Reference

Introduction

To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2E,6E-farnesol?

2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Arteriosclerosis D001161 86 associated lipids
Body Weight D001835 333 associated lipids
Candidiasis, Oral D002180 11 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Dermatomycoses D003881 17 associated lipids
Edema D004487 152 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Fibrosis D005355 23 associated lipids
Per page 10 20 50 | Total 42

PubChem Associated disorders and diseases

What pathways are associated with 2E,6E-farnesol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2E,6E-farnesol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 2E,6E-farnesol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2E,6E-farnesol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 2E,6E-farnesol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2E,6E-farnesol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 2E,6E-farnesol

Download all related citations
Per page 10 20 50 100 | Total 950
Authors Title Published Journal PubMed Link
Berzat AC et al. Using inhibitors of prenylation to block localization and transforming activity. 2006 Meth. Enzymol. pmid:16757354
Jahangir T et al. Farnesol prevents Fe-NTA-mediated renal oxidative stress and early tumour promotion markers in rats. 2006 Hum Exp Toxicol pmid:16758765
Green TR et al. Compartmentation of isopentenyl pyophosphate isomerase and prenyl transferase in developing castor bean endosperm. 1975 Biochem. Biophys. Res. Commun. pmid:167761
Erlich S et al. Ras inhibition results in growth arrest and death of androgen-dependent and androgen-independent prostate cancer cells. 2006 Biochem. Pharmacol. pmid:16780807
Fuchs BB and Mylonakis E Using non-mammalian hosts to study fungal virulence and host defense. 2006 Curr. Opin. Microbiol. pmid:16814595
Saidi S et al. In vitro synergistic effect of farnesol and human gingival cells against Candida albicans. 2006 Yeast pmid:16845684
Rung E et al. Depletion of substrates for protein prenylation increases apoptosis in human periovulatory granulosa cells. 2006 Mol. Reprod. Dev. pmid:16868926
Alem MA et al. Production of tyrosol by Candida albicans biofilms and its role in quorum sensing and biofilm development. 2006 Eukaryotic Cell pmid:16980403
Blum R et al. Suppression of survivin expression in glioblastoma cells by the Ras inhibitor farnesylthiosalicylic acid promotes caspase-dependent apoptosis. 2006 Mol. Cancer Ther. pmid:16985068
Barkan B et al. The Ras inhibitor farnesylthiosalicylic acid as a potential therapy for neurofibromatosis type 1. 2006 Clin. Cancer Res. pmid:17000690
Binda C et al. Structure of the human mitochondrial monoamine oxidase B: new chemical implications for neuroprotectant drug design. 2006 Neurology pmid:17030739
Jabra-Rizk MA et al. Effect of farnesol on Candida dubliniensis biofilm formation and fluconazole resistance. 2006 FEMS Yeast Res. pmid:17042756
Hasmim M et al. Zoledronate inhibits endothelial cell adhesion, migration and survival through the suppression of multiple, prenylation-dependent signaling pathways. 2007 J. Thromb. Haemost. pmid:17059425
Jones G et al. The retinoid-X receptor ortholog, ultraspiracle, binds with nanomolar affinity to an endogenous morphogenetic ligand. 2006 FEBS J. pmid:17064257
Hamada M et al. Inhibitory activity of 1-farnesylpyridinium on the spatial control over the assembly of cell wall polysaccharides in Schizosaccharomyces pombe. 2006 J. Biochem. pmid:17092950
Shapira S et al. The tumor suppressor neurofibromin confers sensitivity to apoptosis by Ras-dependent and Ras-independent pathways. 2007 Cell Death Differ. pmid:17096025
Cetin A et al. Angiotensin II-induced MAPK phosphorylation mediated by Ras and/or phospholipase C-dependent phosphorylations but not by protein kinase C phosphorylation in cultured rat vascular smooth muscle cells. 2007 Pharmacology pmid:17135774
Wiseman DA et al. Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21(Cip1) and p27(Kip1) in human pancreatic adenocarcinoma cells. 2007 J. Pharmacol. Exp. Ther. pmid:17138864
Wendland J et al. Use of the Porcine Intestinal Epithelium (PIE)-Assay to analyze early stages of colonization by the human fungal pathogen Candida albicans. 2006 J. Basic Microbiol. pmid:17139615
Fairn GD et al. A chemogenomic screen in Saccharomyces cerevisiae uncovers a primary role for the mitochondria in farnesol toxicity and its regulation by the Pkc1 pathway. 2007 J. Biol. Chem. pmid:17164236
Nokhodchi A et al. The effect of terpene concentrations on the skin penetration of diclofenac sodium. 2007 Int J Pharm pmid:17174049
L'Helias C [Juvenile hormone in diapausing Pieris brassicae and mutations. Tetrahydrofolic acid and pterins incubated in chrysalids, provoking ontogenic and mutagenic genetic information alterations in Drosophila melanogaster]. 1975 Mar-Apr Ann. Endocrinol. (Paris) pmid:172004
Lombardi L et al. Circadian rhythms in Neurospora crassa: clock mutant effects in the absence of a frq-based oscillator. 2007 Genetics pmid:17237512
Kuroda M et al. Sesquiterpene farnesol inhibits recycling of the C55 lipid carrier of the murein monomer precursor contributing to increased susceptibility to beta-lactams in methicillin-resistant Staphylococcus aureus. 2007 J. Antimicrob. Chemother. pmid:17242033
Henriques M et al. Effect of farnesol on Candida dubliniensis morphogenesis. 2007 Lett. Appl. Microbiol. pmid:17257261
Dumitru R et al. In vivo and in vitro anaerobic mating in Candida albicans. 2007 Eukaryotic Cell pmid:17259544
Shintre MS et al. Evaluation of an alcohol-based surgical hand disinfectant containing a synergistic combination of farnesol and benzethonium chloride for immediate and persistent activity against resident hand flora of volunteers and with a novel in vitro pig skin model. 2007 Infect Control Hosp Epidemiol pmid:17265401
Navarathna DH et al. Effect of farnesol on a mouse model of systemic candidiasis, determined by use of a DPP3 knockout mutant of Candida albicans. 2007 Infect. Immun. pmid:17283095
Journe F et al. Farnesol, a mevalonate pathway intermediate, stimulates MCF-7 breast cancer cell growth through farnesoid-X-receptor-mediated estrogen receptor activation. 2008 Breast Cancer Res. Treat. pmid:17333335
Touhara K and Prestwich GD Binding site mapping of a photoaffinity-labeled juvenile hormone binding protein. 1992 Biochem. Biophys. Res. Commun. pmid:1734862
Blum R et al. Gene expression signature of human cancer cell lines treated with the ras inhibitor salirasib (S-farnesylthiosalicylic acid). 2007 Cancer Res. pmid:17409441
Crowell DN et al. Arabidopsis thaliana plants possess a specific farnesylcysteine lyase that is involved in detoxification and recycling of farnesylcysteine. 2007 Plant J. pmid:17425716
Woodard B et al. 3D-QSAR of fungal quorum-sensing inhibiting analogs of farnesol. 2007 Mar-Apr J Environ Sci Health B pmid:17454380
Bellahcène A et al. Zoledronate inhibits alphavbeta3 and alphavbeta5 integrin cell surface expression in endothelial cells. 2007 Mar-Apr Endothelium pmid:17497369
Navarathna DH et al. Exogenous farnesol interferes with the normal progression of cytokine expression during candidiasis in a mouse model. 2007 Infect. Immun. pmid:17517874
Cheng AX et al. The rice (E)-beta-caryophyllene synthase (OsTPS3) accounts for the major inducible volatile sesquiterpenes. 2007 Phytochemistry pmid:17524436
Zundelevich A et al. Suppression of lung cancer tumor growth in a nude mouse model by the Ras inhibitor salirasib (farnesylthiosalicylic acid). 2007 Mol. Cancer Ther. pmid:17541036
Kuroda M et al. Sesquiterpene farnesol as a competitive inhibitor of lipase activity of Staphylococcus aureus. 2007 FEMS Microbiol. Lett. pmid:17559400
Uppuluri P et al. Farnesol-mediated inhibition of Candida albicans yeast growth and rescue by a diacylglycerol analogue. 2007 Yeast pmid:17583896
Yue W et al. Mechanisms of acquired resistance to endocrine therapy in hormone-dependent breast cancer cells. 2007 Aug-Sep J. Steroid Biochem. Mol. Biol. pmid:17616457
Cugini C et al. Farnesol, a common sesquiterpene, inhibits PQS production in Pseudomonas aeruginosa. 2007 Mol. Microbiol. pmid:17640272
da Silva Morais A et al. Inhibition of the Ras oncoprotein reduces proliferation of hepatocytes in vitro and in vivo in rats. 2008 Clin. Sci. pmid:17678500
Rossignol T et al. Transcriptional response of Candida parapsilosis following exposure to farnesol. 2007 Antimicrob. Agents Chemother. pmid:17684006
Zhang L and Hill RP Hypoxia enhances metastatic efficiency in HT1080 fibrosarcoma cells by increasing cell survival in lungs, not cell adhesion and invasion. 2007 Cancer Res. pmid:17699784
Joo JH et al. Farnesol-induced apoptosis in human lung carcinoma cells is coupled to the endoplasmic reticulum stress response. 2007 Cancer Res. pmid:17699800
Lee H et al. Characterization of (E,E)-farnesol and its fatty acid esters from anal scent glands of nutria (Myocastor coypus) by gas chromatography-mass spectrometry and gas chromatography-infrared spectrometry. 2007 J Chromatogr A pmid:17709112
Marciano D et al. Neuroprotective effects of the Ras inhibitor S-trans-trans-farnesylthiosalicylic acid, measured by diffusion-weighted imaging after traumatic brain injury in rats. 2007 J. Neurotrauma pmid:17711399
Dionigi CP et al. Effects of farnesol and the off-flavor derivative geosmin on Streptomyces tendae. 1991 Appl. Environ. Microbiol. pmid:1785920
Haklai R et al. Orally administered FTS (salirasib) inhibits human pancreatic tumor growth in nude mice. 2008 Cancer Chemother. Pharmacol. pmid:17909812
Vik A et al. Screening of terpenes and derivatives for antimycobacterial activity; identification of geranylgeraniol and geranylgeranyl acetate as potent inhibitors of Mycobacterium tuberculosis in vitro. 2007 Planta Med. pmid:17924309