2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Akopyan TN et al. | Cleavage of farnesylated COOH-terminal heptapeptide of mouse N-ras by brain microsomal membranes: evidence for a carboxypeptidase which specifically removes the COOH-terminal methionine. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1417809 |
Nigg EA et al. | Targeting lamin proteins to the nuclear envelope: the role of CaaX box modifications. | 1992 | Biochem. Soc. Trans. | pmid:1397650 |
Lowe PN et al. | Expression of polyisoprenylated Ras proteins in the insect/baculovirus system. | 1992 | Biochem. Soc. Trans. | pmid:1397645 |
Cox AD et al. | Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein. | 1992 | Mol. Cell. Biol. | pmid:1375323 |
Shindo T et al. | A farnesyl arabinoside as an enhancer of glucose transport in rat adipocytes from a soft coral, Sinularia sp. | 1992 | Experientia | pmid:1353460 |
Giricz Z et al. | Role of cholesterol-enriched diet and the mevalonate pathway in cardiac nitric oxide synthesis. | 2003 | Basic Res. Cardiol. | pmid:12955403 |
Shchepin R et al. | Quorum sensing in Candida albicans: probing farnesol's mode of action with 40 natural and synthetic farnesol analogs. | 2003 | Chem. Biol. | pmid:12954333 |
Dietrich A et al. | Studies on G-protein alpha.betagamma heterotrimer formation reveal a putative S-prenyl-binding site in the alpha subunit. | 2003 | Biochem. J. | pmid:12952523 |
Okazaki S et al. | [A 52-week dermal toxicity study of prednisolone farnesylate (PNF) gel in rats with a recovery period of 8 weeks]. | 1992 | J Toxicol Sci | pmid:1293331 |
Okazaki S et al. | [A 13-week dermal toxicity study of prednisolone farnesylate (PNF) gel in rats with a recovery period of 5 weeks]. | 1992 | J Toxicol Sci | pmid:1293330 |