2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Piérard GE et al. | Miconazole, a pharmacological barrier to skin fungal infections. | 2012 | Expert Opin Pharmacother | pmid:22568580 |
Laheru D et al. | Integrated preclinical and clinical development of S-trans, trans-Farnesylthiosalicylic Acid (FTS, Salirasib) in pancreatic cancer. | 2012 | Invest New Drugs | pmid:22547163 |
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Jaggi AS and Singh N | Analgesic potential of intrathecal farnesyl thiosalicylic acid and GW 5074 in vincristine-induced neuropathic pain in rats. | 2012 | Food Chem. Toxicol. | pmid:22326968 |
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Mans RA et al. | Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation. | 2012 | Neuroscience | pmid:22192838 |
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Cordeiro Rde A et al. | Farnesol inhibits in vitro growth of the Cryptococcus neoformans species complex with no significant changes in virulence-related exoenzymes. | 2012 | Vet. Microbiol. | pmid:22580194 |
Cerca N et al. | Confocal laser scanning microscopy analysis of S. epidermidis biofilms exposed to farnesol, vancomycin and rifampicin. | 2012 | BMC Res Notes | pmid:22591918 |
Costa CB et al. | Farnesyltransferase inhibitors: molecular evidence of therapeutic efficacy in acute lymphoblastic leukemia through cyclin D1 inhibition. | 2012 | Anticancer Res. | pmid:22399601 |
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Chang W et al. | Retigeric acid B attenuates the virulence of Candida albicans via inhibiting adenylyl cyclase activity targeted by enhanced farnesol production. | 2012 | PLoS ONE | pmid:22848547 |
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Fu MS et al. | Functional characterization of the small heat shock protein Hsp12p from Candida albicans. | 2012 | PLoS ONE | pmid:22880130 |
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Mologni L et al. | Synergistic effects of combined Wnt/KRAS inhibition in colorectal cancer cells. | 2012 | PLoS ONE | pmid:23227266 |
Oron T et al. | Prevention of induced colitis in mice by the ras antagonist farnesylthiosalicylic acid. | 2012 | Dig. Dis. Sci. | pmid:21901261 |
Stärkel P et al. | Ras inhibition in hepatocarcinoma by S-trans-trans-farnesylthiosalicyclic acid: association of its tumor preventive effect with cell proliferation, cell cycle events, and angiogenesis. | 2012 | Mol. Carcinog. | pmid:21882255 |
Brilhante RS et al. | Sesquiterpene farnesol contributes to increased susceptibility to β-lactams in strains of Burkholderia pseudomallei. | 2012 | Antimicrob. Agents Chemother. | pmid:22290941 |
Berrocal A et al. | Quorum sensing activity in Ophiostoma ulmi: effects of fusel oils and branched chain amino acids on yeast-mycelial dimorphism. | 2012 | J. Appl. Microbiol. | pmid:22519968 |
Falsetta ML et al. | Novel antibiofilm chemotherapy targets exopolysaccharide synthesis and stress tolerance in Streptococcus mutans to modulate virulence expression in vivo. | 2012 | Antimicrob. Agents Chemother. | pmid:22985885 |
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de Castro Pimentel Figueiredo B et al. | The Aspergillus nidulans nucA(EndoG) homologue is not involved in cell death. | 2011 | Eukaryotic Cell | pmid:21131437 |
Gomes F et al. | Farnesol as antibiotics adjuvant in Staphylococcus epidermidis control in vitro. | 2011 | Am. J. Med. Sci. | pmid:21107231 |
Mor A et al. | Inhibitory effect of farnesylthiosalicylic acid on mediators release by mast cells: preferential inhibition of prostaglandin D(2) and tumor necrosis factor-α release. | 2011 | Inflammation | pmid:20706780 |
Endo S et al. | Roles of rat and human aldo-keto reductases in metabolism of farnesol and geranylgeraniol. | 2011 | Chem. Biol. Interact. | pmid:21187079 |
Cortés M et al. | Drimenol: A versatile synthon for compounds with trans-drimane skeleton. | 2011 | Nat Prod Commun | pmid:21560760 |
Borbath I and Stärkel P | Chemoprevention of hepatocellular carcinoma. Proof of concept in animal models. | 2011 | Acta Gastroenterol. Belg. | pmid:21563652 |
Piispanen AE et al. | Roles of Ras1 membrane localization during Candida albicans hyphal growth and farnesol response. | 2011 | Eukaryotic Cell | pmid:21908593 |
Biran A et al. | Downregulation of survivin and aurora A by histone deacetylase and RAS inhibitors: a new drug combination for cancer therapy. | 2011 | Int. J. Cancer | pmid:20473860 |
Nagai H et al. | Development of a novel PPARγ ligand screening system using pinpoint fluorescence-probed protein. | 2011 | Biosci. Biotechnol. Biochem. | pmid:21307572 |
Rahman NK et al. | Enzymatic synthesis of farnesyl laurate in organic solvent: initial water activity, kinetics mechanism, optimization of continuous operation using packed bed reactor and mass transfer studies. | 2011 | Bioprocess Biosyst Eng | pmid:21327986 |
Gori K et al. | Alcohol-based quorum sensing plays a role in adhesion and sliding motility of the yeast Debaryomyces hansenii. | 2011 | FEMS Yeast Res. | pmid:22093748 |
Madhani HD | Quorum sensing in fungi: Q&A. | 2011 | PLoS Pathog. | pmid:22046125 |
Gomes F et al. | Effect of farnesol on structure and composition of Staphylococcus epidermidis biofilm matrix. | 2011 | Curr. Microbiol. | pmid:21800262 |
Pammi M et al. | Farnesol decreases biofilms of Staphylococcus epidermidis and exhibits synergy with nafcillin and vancomycin. | 2011 | Pediatr. Res. | pmid:21857375 |
Teodoro JS et al. | Hepatic FXR: key regulator of whole-body energy metabolism. | 2011 | Trends Endocrinol. Metab. | pmid:21862343 |
Goto T et al. | Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARα-dependent and -independent pathways. | 2011 | Am. J. Physiol. Endocrinol. Metab. | pmid:21862726 |
Fitzpatrick AH et al. | Roles for farnesol and ABA in Arabidopsis flower development. | 2011 | Plant Signal Behav | pmid:21758018 |
Mor A et al. | Ras inhibition induces insulin sensitivity and glucose uptake. | 2011 | PLoS ONE | pmid:21738773 |
Sharma M and Prasad R | The quorum-sensing molecule farnesol is a modulator of drug efflux mediated by ABC multidrug transporters and synergizes with drugs in Candida albicans. | 2011 | Antimicrob. Agents Chemother. | pmid:21768514 |
Tsuji F et al. | The geranyl-modified tryptophan residue is crucial for ComXRO-E-2 pheromone biological activity. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21636272 |
Kaneko M et al. | Effect of farnesol on mevalonate pathway of Staphylococcus aureus. | 2011 | J. Antibiot. | pmid:21772307 |