2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Kothapalli R et al. | Farnesylamine: an inhibitor of farnesylation and growth of ras-transformed cells. | 1993 | Lipids | pmid:8277827 |
Touhara K and Prestwich GD | Juvenile hormone epoxide hydrolase. Photoaffinity labeling, purification, and characterization from tobacco hornworm eggs. | 1993 | J. Biol. Chem. | pmid:8396141 |
O'Donnell MP et al. | Lovastatin inhibits proliferation of rat mesangial cells. | 1993 | J. Clin. Invest. | pmid:8423236 |
Søgaard M et al. | A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles. | 1994 | Cell | pmid:7923363 |
Biermann BJ et al. | Novel isoprenylated proteins identified by an expression library screen. | 1994 | J. Biol. Chem. | pmid:7929216 |
Munro E et al. | Inhibition of human vascular smooth muscle cell proliferation by lovastatin: the role of isoprenoid intermediates of cholesterol synthesis. | 1994 | Eur. J. Clin. Invest. | pmid:7890015 |
Tojo K et al. | Diffusion and metabolism of prednisolone farnesylate in viable skin of the hairless mouse. | 1994 | Pharm. Res. | pmid:8008705 |
Fukada Y et al. | Effects of carboxyl methylation of photoreceptor G protein gamma-subunit in visual transduction. | 1994 | J. Biol. Chem. | pmid:8106497 |
Caldwell GA et al. | Consequences of altered isoprenylation targets on a-factor export and bioactivity. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8108401 |
Kothapalli R et al. | Effects of long-chain fatty amines on the growth of ras-transformed NIH 3T3 cells. | 1994 | Biochem. Pharmacol. | pmid:8204109 |
Inoue H et al. | Phosphorylation of farnesol by a cell-free system from Botryococcus braunii. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8179579 |
Bondar OP et al. | Effects of farnesol on the thermotropic behavior of dimyristoylphosphatidylcholine. | 1994 | Chem. Phys. Lipids | pmid:7820904 |
Aronheim A et al. | Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway. | 1994 | Cell | pmid:7923364 |
Haug JS et al. | Directed cell killing (apoptosis) in human lymphoblastoid cells incubated in the presence of farnesol: effect of phosphatidylcholine. | 1994 | Biochim. Biophys. Acta | pmid:8061045 |
Kisselev OG et al. | A farnesylated domain in the G protein gamma subunit is a specific determinant of receptor coupling. | 1994 | J. Biol. Chem. | pmid:8063769 |
Lübben M and Morand K | Novel prenylated hemes as cofactors of cytochrome oxidases. Archaea have modified hemes A and O. | 1994 | J. Biol. Chem. | pmid:8063781 |
Neuhüser T et al. | Responsiveness of the adult cricket (Gryllus bimaculatus and Acheta domesticus) retrocerebral complex to allatostatin-1 from a cockroach, Diploptera punctata. | 1994 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:8014257 |
Adany I et al. | Differences in sensitivity to farnesol toxicity between neoplastically- and non-neoplastically-derived cells in culture. | 1994 | Cancer Lett. | pmid:8019976 |
Correll CC et al. | Identification of farnesol as the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | 1994 | J. Biol. Chem. | pmid:8021239 |
Mallat A et al. | Effect of simvastatin, an inhibitor of hydroxy-methylglutaryl coenzyme A reductase, on the growth of human Ito cells. | 1994 | Hepatology | pmid:7982659 |
Cox AD et al. | The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. | 1994 | J. Biol. Chem. | pmid:8034681 |
Akopyan TN et al. | Proteolytic processing of farnesylated peptides: assay and partial purification from pig brain membranes of an endopeptidase which has the characteristics of E.C. 3.4.24.15. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8297391 |
Kisselev O et al. | Efficient interaction with a receptor requires a specific type of prenyl group on the G protein gamma subunit. | 1995 | J. Biol. Chem. | pmid:7592699 |
Corsini A et al. | Pathogenesis of atherosclerosis and the role of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. | 1995 | Am. J. Cardiol. | pmid:7604791 |
Crick DC et al. | Farnesol is utilized for protein isoprenylation and the biosynthesis of cholesterol in mammalian cells. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7794274 |
Meigs TE et al. | Farnesyl acetate, a derivative of an isoprenoid of the mevalonate pathway, inhibits DNA replication in hamster and human cells. | 1995 | Exp. Cell Res. | pmid:7641798 |
Yazlovitskaya EM and Melnykovych G | Selective farnesol toxicity and translocation of protein kinase C in neoplastic HeLa-S3K and non-neoplastic CF-3 cells. | 1995 | Cancer Lett. | pmid:7874691 |
Forman BM et al. | Identification of a nuclear receptor that is activated by farnesol metabolites. | 1995 | Cell | pmid:7774010 |
Voziyan PA et al. | Mechanism of farnesol cytotoxicity: further evidence for the role of PKC-dependent signal transduction in farnesol-induced apoptotic cell death. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7626062 |
Marom M et al. | Selective inhibition of Ras-dependent cell growth by farnesylthiosalisylic acid. | 1995 | J. Biol. Chem. | pmid:7673206 |
Gilbert BA et al. | Farnesyl thiotriazole, a potent neutrophil agonist and structurally novel activator of protein kinase C. | 1995 | Biochemistry | pmid:7696255 |
Fliesler SJ and Keller RK | Metabolism of [3H]farnesol to cholesterol and cholesterogenic intermediates in the living rat eye. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7763243 |
Marciano D et al. | Farnesyl derivatives of rigid carboxylic acids-inhibitors of ras-dependent cell growth. | 1995 | J. Med. Chem. | pmid:7731012 |
Epand RM et al. | Lipid-mediated a-factor interactions with artificial membranes. | 1995 | Meth. Enzymol. | pmid:7651149 |
Parmryd I et al. | Identification of spinach farnesyl protein transferase. Dithiothreitol as an acceptor in vitro. | 1995 | Eur. J. Biochem. | pmid:8575428 |
Meigs TE et al. | Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation by the nonsterol mevalonate metabolite farnesol in vivo. | 1996 | J. Biol. Chem. | pmid:8626470 |
Tachibana A et al. | Evidence for farnesol-mediated isoprenoid synthesis regulation in a halophilic archaeon, Haloferax volcanii. | 1996 | FEBS Lett. | pmid:8566226 |
Satoh T et al. | The effects of pravastatin, an HMG-CoA reductase inhibitor, on cell viability and DNA production of rat hepatocytes. | 1996 | Life Sci. | pmid:8831797 |
Crick DC et al. | Geranylgeraniol restores cell proliferation to lovastatin treated C6 glial cells. | 1996 | SAAS Bull. Biochem. Biotechnol. | pmid:8652130 |
Tanaka H et al. | MEKA/phosducin attenuates hydrophobicity of transducin beta gamma subunits without binding to farnesyl moiety. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8687440 |
Nishio E et al. | 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor impairs cell p4fferentiation in cultured adipogenic cells (3T3-L1). | 1996 | Eur. J. Pharmacol. | pmid:8773465 |
Carel K et al. | Insulin stimulates mitogen-activated protein kinase by a Ras-independent pathway in 3T3-L1 adipocytes. | 1996 | J. Biol. Chem. | pmid:8940037 |
Willumsen BM et al. | Novel determinants of H-Ras plasma membrane localization and transformation. | 1996 | Oncogene | pmid:8934536 |
Vogt A et al. | Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts. | 1996 | Oncogene | pmid:8934546 |
Miquel K et al. | Farnesol and geranylgeraniol induce actin cytoskeleton disorganization and apoptosis in A549 lung adenocarcinoma cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8780704 |
Keller RK et al. | Farnesol is not the nonsterol regulator mediating degradation of HMG-CoA reductase in rat liver. | 1996 | Arch. Biochem. Biophys. | pmid:8645011 |
Koyama T et al. | Identification of significant residues in the substrate binding site of Bacillus stearothermophilus farnesyl diphosphate synthase. | 1996 | Biochemistry | pmid:8755734 |
Umetani N et al. | Lovastatin inhibits gene expression of type-I scavenger receptor in THP-1 human macrophages. | 1996 | Biochim. Biophys. Acta | pmid:8908154 |
Roullet JB et al. | Farnesyl analogues inhibit vasoconstriction in animal and human arteries. | 1996 | J. Clin. Invest. | pmid:8636420 |
O'Brien ML et al. | Convergence of three steroid receptor pathways in the mediation of nongenotoxic hepatocarcinogenesis. | 1996 | Carcinogenesis | pmid:8625436 |