2E,6E-farnesol

2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.

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Introduction

To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2E,6E-farnesol?

2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Arteriosclerosis D001161 86 associated lipids
Body Weight D001835 333 associated lipids
Candidiasis, Oral D002180 11 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Dermatomycoses D003881 17 associated lipids
Edema D004487 152 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Fibrosis D005355 23 associated lipids
Glioblastoma D005909 27 associated lipids
Glioma D005910 112 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Insulin Resistance D007333 99 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Per page 10 20 50 | Total 42

PubChem Associated disorders and diseases

What pathways are associated with 2E,6E-farnesol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2E,6E-farnesol?

Related references are published most in these journals:

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What functions are associated with 2E,6E-farnesol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2E,6E-farnesol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 2E,6E-farnesol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2E,6E-farnesol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 2E,6E-farnesol

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Authors Title Published Journal PubMed Link
Lochnit G and Geyer R Evidence for the presence of the Kennedy and Bremer- Greenberg pathways in Caenorhabditis elegans. 2003 Acta Biochim. Pol. pmid:14740010
Granshaw T et al. Circadian rhythms in Neurospora crassa: farnesol or geraniol allow expression of rhythmicity in the otherwise arrhythmic strains frq10, wc-1, and wc-2. 2003 J. Biol. Rhythms pmid:12932081
Koo H et al. Inhibition of Streptococcus mutans biofilm accumulation and polysaccharide production by apigenin and tt-farnesol. 2003 J. Antimicrob. Chemother. pmid:14563892
Tóth M et al. Identification of pheromones and optimization of bait composition for click beetle pests (Coleoptera: Elateridae) in Central and Western Europe. 2003 Pest Manag. Sci. pmid:12701702
Sen SE et al. Juvenile hormone biosynthesis in moths: synthesis and evaluation of farnesol homologs as alternate substrates of farnesol oxidase. 2003 Insect Biochem. Mol. Biol. pmid:12770578
Katzav A et al. Inhibition of ras by farnesylthiosalicylate significantly reduces the levels of autoantibodies in two animal models of the antiphospholipid syndrome. 2003 Immunobiology pmid:12638903
Berstein LM et al. New approaches to the understanding of tamoxifen action and resistance. 2003 Endocr. Relat. Cancer pmid:12790788
Shohami E et al. The Ras inhibitor S-trans, trans-farnesylthiosalicylic acid exerts long-lasting neuroprotection in a mouse closed head injury model. 2003 J. Cereb. Blood Flow Metab. pmid:12796721
Shchepin R et al. Quorum sensing in Candida albicans: probing farnesol's mode of action with 40 natural and synthetic farnesol analogs. 2003 Chem. Biol. pmid:12954333
Giricz Z et al. Role of cholesterol-enriched diet and the mevalonate pathway in cardiac nitric oxide synthesis. 2003 Basic Res. Cardiol. pmid:12955403
Iguchi T et al. Nitrogen-containing bisphosphonates induce S-phase cell cycle arrest and apoptosis of myeloma cells by activating MAPK pathway and inhibiting mevalonate pathway. 2003 Cell. Signal. pmid:12742232
Clarke HC et al. Ras antagonist farnesylthiosalicylic acid (FTS) reduces glomerular cellular proliferation and macrophage number in rat thy-1 nephritis. 2003 J. Am. Soc. Nephrol. pmid:12660318
Jones TH et al. Farnesylamine from the ant Monomorium fieldi Forel. 2003 J. Nat. Prod. pmid:12662086
Smalley KS and Eisen TG Farnesyl transferase inhibitor SCH66336 is cytostatic, pro-apoptotic and enhances chemosensitivity to cisplatin in melanoma cells. 2003 Int. J. Cancer pmid:12673674
Song L Detection of farnesyl diphosphate accumulation in yeast ERG9 mutants. 2003 Anal. Biochem. pmid:12758256
Halaschek-Wiener J et al. Farnesyl thiosalicylic acid chemosensitizes human melanoma in vivo. 2003 J. Invest. Dermatol. pmid:12535206
Zoccarato F et al. The adenosine inhibition of glutamate exocytosis in synaptosomes is removed by the collapse of the vesicle-cytosol deltapH plus the opening of farnesol-sensitive Ca(2+) channels. 2003 Cell Calcium pmid:12618148
Still K et al. Effects of risedronate, alendronate, and etidronate on the viability and activity of rat bone marrow stromal cells in vitro. 2003 Calcif. Tissue Int. pmid:12457261
Hiyoshi H et al. Squalene synthase inhibitors suppress triglyceride biosynthesis through the farnesol pathway in rat hepatocytes. 2003 J. Lipid Res. pmid:12518031
Töyräs A et al. Inhibition of mevalonate pathway is involved in alendronate-induced cell growth inhibition, but not in cytokine secretion from macrophages in vitro. 2003 Eur J Pharm Sci pmid:12885386
Houten SM et al. Isoprenoid biosynthesis in hereditary periodic fever syndromes and inflammation. 2003 Cell. Mol. Life Sci. pmid:12861380
Brehm-Stecher BF and Johnson EA Sensitization of Staphylococcus aureus and Escherichia coli to antibiotics by the sesquiterpenoids nerolidol, farnesol, bisabolol, and apritone. 2003 Antimicrob. Agents Chemother. pmid:14506058
Ownby SE and Hohl RJ Isoprenoid alcohols restore protein isoprenylation in a time-dependent manner independent of protein synthesis. 2003 Lipids pmid:14506838
Mau CJ et al. Protein farnesyltransferase inhibitors interfere with farnesyl diphosphate binding by rubber transferase. 2003 Eur. J. Biochem. pmid:14511375
Li X et al. New polyoxygenated farnesylcyclohexenones, deacetoxyyanuthone A and its hydro derivative from the marine-derived fungus Penicillium sp. 2003 J. Nat. Prod. pmid:14640527
McAnally JA et al. Farnesyl-O-acetylhydroquinone and geranyl-O-acetylhydroquinone suppress the proliferation of murine B16 melanoma cells, human prostate and colon adenocarcinoma cells, human lung carcinoma cells, and human leukemia cells. 2003 Cancer Lett. pmid:14643448
Sever N et al. Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol. 2003 J. Biol. Chem. pmid:14563840
Grossman R et al. Increase in peripheral benzodiazepine receptors and loss of glutamate NMDA receptors in a mouse model of closed head injury: a quantitative autoradiographic study. 2003 Neuroimage pmid:14683703
Wang Z et al. Farnesol for aerosol inhalation: nebulization and activity against human lung cancer cells. 2003 Jan-Apr J Pharm Pharm Sci pmid:12753732
Ruiz-Velasco N et al. Statins upregulate CD36 expression in human monocytes, an effect strengthened when combined with PPAR-gamma ligands Putative contribution of Rho GTPases in statin-induced CD36 expression. 2004 Biochem. Pharmacol. pmid:14698043
Downie MM et al. Peroxisome proliferator-activated receptor and farnesoid X receptor ligands differentially regulate sebaceous differentiation in human sebaceous gland organ cultures in vitro. 2004 Br. J. Dermatol. pmid:15491415
Yang Z et al. Host plant volatiles synergize response to sex pheromone in codling moth, Cydia pomonella. 2004 J. Chem. Ecol. pmid:15139312
Inoue Y et al. The antibacterial effects of terpene alcohols on Staphylococcus aureus and their mode of action. 2004 FEMS Microbiol. Lett. pmid:15321680
Rowat AC and Davis JH Farnesol-DMPC phase behaviour: a (2)H-NMR study. 2004 Biochim. Biophys. Acta pmid:15003880
Hogan DA et al. A Pseudomonas aeruginosa quorum-sensing molecule influences Candida albicans morphology. 2004 Mol. Microbiol. pmid:15554963
Luxová A et al. Absolute configuration of chiral terpenes in marking pheromones of bumblebees and cuckoo bumblebees. 2004 Chirality pmid:15034905
Murataliev MB et al. Chimeragenesis of the fatty acid binding site of cytochrome P450BM3. Replacement of residues 73-84 with the homologous residues from the insect cytochrome P450 CYP4C7. 2004 Biochemistry pmid:14967018
McPherson RA et al. The novel Ras antagonist, farnesylthiosalicylate, suppresses growth of prostate cancer in vitro. 2004 Prostate pmid:14968433
Hornby JM et al. Inoculum size effect in dimorphic fungi: extracellular control of yeast-mycelium dimorphism in Ceratocystis ulmi. 2004 Appl. Environ. Microbiol. pmid:15006753
Wozniak M et al. Alternative farnesoid structures induce different conformational outcomes upon the Drosophila ortholog of the retinoid X receptor, ultraspiracle. 2004 Insect Biochem. Mol. Biol. pmid:15522611
Rudi A et al. Likonides A and B: new ansa farnesyl quinols from the marine sponge Hyatella sp. 2004 Org. Lett. pmid:15496087
Shalom-Feuerstein R et al. Restoration of sensitivity to anoikis in Ras-transformed rat intestinal epithelial cells by a Ras inhibitor. 2004 Cell Death Differ. pmid:14576773
Reif S et al. Treatment of thioacetamide-induced liver cirrhosis by the Ras antagonist, farnesylthiosalicylic acid. 2004 J. Hepatol. pmid:15288472
Staines AG et al. Farnesol is glucuronidated in human liver, kidney and intestine in vitro, and is a novel substrate for UGT2B7 and UGT1A1. 2004 Biochem. J. pmid:15320866
Kruppa M et al. The two-component signal transduction protein Chk1p regulates quorum sensing in Candida albicans. 2004 Eukaryotic Cell pmid:15302838
Fukuda S and Pelus LM Activated H-Ras regulates hematopoietic cell survival by modulating Survivin. 2004 Biochem. Biophys. Res. Commun. pmid:15369798
Chin PC et al. The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism. 2004 J. Neurochem. pmid:15255937
Dumitru R et al. Defined anaerobic growth medium for studying Candida albicans basic biology and resistance to eight antifungal drugs. 2004 Antimicrob. Agents Chemother. pmid:15215080
Rodrigues Goulart H et al. Terpenes arrest parasite development and inhibit biosynthesis of isoprenoids in Plasmodium falciparum. 2004 Antimicrob. Agents Chemother. pmid:15215101
Schnuch A et al. Contact allergy to farnesol in 2021 consecutively patch tested patients. Results of the IVDK. 2004 Contact Derm. pmid:15153123
Hornby JM and Nickerson KW Enhanced production of farnesol by Candida albicans treated with four azoles. 2004 Antimicrob. Agents Chemother. pmid:15155241
DeBarber AE et al. Omega-hydroxylation of farnesol by mammalian cytochromes p450. 2004 Biochim. Biophys. Acta pmid:15158752
Hartman HL et al. Lysine beta311 of protein geranylgeranyltransferase type I partially replaces magnesium. 2004 J. Biol. Chem. pmid:15131129
Sato T et al. Farnesol, a morphogenetic autoregulatory substance in the dimorphic fungus Candida albicans, inhibits hyphae growth through suppression of a mitogen-activated protein kinase cascade. 2004 Biol. Pharm. Bull. pmid:15133261
Thorpe JL et al. Germ cell migration in zebrafish is dependent on HMGCoA reductase activity and prenylation. 2004 Dev. Cell pmid:14960282
George J et al. Inhibition of intimal thickening in the rat carotid artery injury model by a nontoxic Ras inhibitor. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:14670932
Kafri M et al. Inhibition of Ras attenuates the course of experimental autoimmune neuritis. 2005 J. Neuroimmunol. pmid:16154640
Taylor MM et al. Enhanced apoptosis through farnesol inhibition of phospholipase D signal transduction. 2005 FEBS J. pmid:16176276
Lakshman R et al. Use of CYP2E1-transfected human liver cell lines in elucidating the actions of ethanol. 2005 Alcohol. Clin. Exp. Res. pmid:16205373
Lagace TA and Ridgway ND Induction of apoptosis by lipophilic activators of CTP:phosphocholine cytidylyltransferase alpha (CCTalpha). 2005 Biochem. J. pmid:16097951
Chen AP et al. Substrate and product specificities of cis-type undecaprenyl pyrophosphate synthase. 2005 Biochem. J. pmid:15447632
Frosch PJ et al. Patch testing with a new fragrance mix detects additional patients sensitive to perfumes and missed by the current fragrance mix. 2005 Contact Derm. pmid:15859993
Frosch PJ et al. Patch testing with a new fragrance mix - reactivity to the individual constituents and chemical detection in relevant cosmetic products. 2005 Contact Derm. pmid:15859994
Koo H et al. Apigenin and tt-farnesol with fluoride effects on S. mutans biofilms and dental caries. 2005 J. Dent. Res. pmid:16246933
Horn TL et al. Modulation of hepatic and renal drug metabolizing enzyme activities in rats by subchronic administration of farnesol. 2005 Chem. Biol. Interact. pmid:15840382
Laffey SF and Butler G Phenotype switching affects biofilm formation by Candida parapsilosis. 2005 Microbiology (Reading, Engl.) pmid:15817776
Yang SP and Raner GM Cytochrome P450 expression and activities in human tongue cells and their modulation by green tea extract. 2005 Toxicol. Appl. Pharmacol. pmid:15629189
Shearer AG and Hampton RY Lipid-mediated, reversible misfolding of a sterol-sensing domain protein. 2005 EMBO J. pmid:15635451
Williams JM and Savage CO Characterization of the regulation and functional consequences of p21ras activation in neutrophils by antineutrophil cytoplasm antibodies. 2005 J. Am. Soc. Nephrol. pmid:15548565
Aronovich R et al. Antiphospholipid antibodies, thrombin and LPS activate brain endothelial cells and Ras-dependent pathways through distinct mechanisms. 2005 Immunobiology pmid:16325498
Westwater C et al. Candida albicans-conditioned medium protects yeast cells from oxidative stress: a possible link between quorum sensing and oxidative stress resistance. 2005 Eukaryotic Cell pmid:16215173
Braun PC The effect of farnesol on amino acid incorporation by a wild-type and cell-wall variant strain of Candida albicans. 2005 Can. J. Microbiol. pmid:16234870
Yu JS et al. Synthesis of farnesol isomers via a modified Wittig procedure. 2005 Org. Lett. pmid:16235893
Navarathna DH et al. Enhanced pathogenicity of Candida albicans pre-treated with subinhibitory concentrations of fluconazole in a mouse model of disseminated candidiasis. 2005 J. Antimicrob. Chemother. pmid:16239285
Ferri N et al. Isothiazole dioxide derivative 6n inhibits vascular smooth muscle cell proliferation and protein farnesylation. 2005 Biochem. Pharmacol. pmid:16257390
McMahon LP et al. Farnesylthiosalicylic acid inhibits mammalian target of rapamycin (mTOR) activity both in cells and in vitro by promoting dissociation of the mTOR-raptor complex. 2005 Mol. Endocrinol. pmid:15459249
Khwaja A et al. The inhibition of human mesangial cell proliferation by S-trans, trans-farnesylthiosalicylic acid. 2005 Kidney Int. pmid:16014024
Mosel DD et al. Farnesol concentrations required to block germ tube formation in Candida albicans in the presence and absence of serum. 2005 Appl. Environ. Microbiol. pmid:16085901
Martin SW et al. Cell cycle dynamics and quorum sensing in Candida albicans chlamydospores are distinct from budding and hyphal growth. 2005 Eukaryotic Cell pmid:16002645
Enjalbert B and Whiteway M Release from quorum-sensing molecules triggers hyphal formation during Candida albicans resumption of growth. 2005 Eukaryotic Cell pmid:16002646
Cao YY et al. cDNA microarray analysis of differential gene expression in Candida albicans biofilm exposed to farnesol. 2005 Antimicrob. Agents Chemother. pmid:15673737
Blum R et al. Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death. 2005 Cancer Res. pmid:15705901
Hubálek F et al. Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors. 2005 J. Biol. Chem. pmid:15710600
Katsuyama M et al. A novel method to control the balance of skin microflora. Part 1. Attack on biofilm of Staphylococcus aureus without antibiotics. 2005 J. Dermatol. Sci. pmid:15927813
Katsuyama M et al. A novel method to control the balance of skin microflora Part 2. A study to assess the effect of a cream containing farnesol and xylitol on atopic dry skin. 2005 J. Dermatol. Sci. pmid:15927814
Shchepin R et al. Biologically active fluorescent farnesol analogs. 2005 Chem. Biol. pmid:15975508
Kang L et al. SMGA gels for the skin permeation of haloperidol. 2005 J Control Release pmid:15975680
Yue W et al. Farnesylthiosalicylic acid blocks mammalian target of rapamycin signaling in breast cancer cells. 2005 Int. J. Cancer pmid:15957161
Bachireddy P et al. Getting at MYC through RAS. 2005 Clin. Cancer Res. pmid:15958607
Yaari S et al. Disruption of cooperation between Ras and MycN in human neuroblastoma cells promotes growth arrest. 2005 Clin. Cancer Res. pmid:15958613
Rowat AC et al. Effects of farnesol on the physical properties of DMPC membranes. 2005 Biochim. Biophys. Acta pmid:15963943
Jahangir T et al. Alleviation of free radical mediated oxidative and genotoxic effects of cadmium by farnesol in Swiss albino mice. 2005 Redox Rep. pmid:16438802
Funari SS et al. Farnesol and geranylgeraniol modulate the structural properties of phosphatidylethanolamine model membranes. 2005 Jul-Aug Mol. Membr. Biol. pmid:16154902
Goodman CL et al. Partial morphological and functional characterization of the corpus allatum-corpus cardiacum complex from the two-spotted stinkbug, Perillus bioculatus (Hemiptera: Pentatomidae). 2005 Mar-Apr In Vitro Cell. Dev. Biol. Anim. pmid:16029075
Chana RS and Brunskill NJ Thiazolidinediones inhibit albumin uptake by proximal tubular cells through a mechanism independent of peroxisome proliferator activated receptor gamma. 2006 Am. J. Nephrol. pmid:16508249
Erlich S et al. Ras inhibition results in growth arrest and death of androgen-dependent and androgen-independent prostate cancer cells. 2006 Biochem. Pharmacol. pmid:16780807
Fuchs BB and Mylonakis E Using non-mammalian hosts to study fungal virulence and host defense. 2006 Curr. Opin. Microbiol. pmid:16814595
Shintre MS et al. Efficacy of an alcohol-based healthcare hand rub containing synergistic combination of farnesol and benzethonium chloride. 2006 Int J Hyg Environ Health pmid:16750419
Nickerson KW et al. Quorum sensing in dimorphic fungi: farnesol and beyond. 2006 Appl. Environ. Microbiol. pmid:16751484
Jensen EC et al. Farnesol restores wild-type colony morphology to 96% of Candida albicans colony morphology variants recovered following treatment with mutagens. 2006 Genome pmid:16699554