2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Pando R et al. | The Ras antagonist farnesylthiosalicylic acid ameliorates experimental myocarditis in the rat. | 2010 Mar-Apr | Cardiovasc. Pathol. | pmid:19144546 |
Liu P et al. | Farnesol induces apoptosis and oxidative stress in the fungal pathogen Penicillium expansum. | 2010 Mar-Apr | Mycologia | pmid:20361499 |
Ivanov SS et al. | Lipidation by the host prenyltransferase machinery facilitates membrane localization of Legionella pneumophila effector proteins. | 2010 | J. Biol. Chem. | pmid:20813839 |
Levy R et al. | Galectin-3 promotes chronic activation of K-Ras and differentiation block in malignant thyroid carcinomas. | 2010 | Mol. Cancer Ther. | pmid:20682656 |
Colabardini AC et al. | Involvement of the Aspergillus nidulans protein kinase C with farnesol tolerance is related to the unfolded protein response. | 2010 | Mol. Microbiol. | pmid:21091509 |
Wang C et al. | Farnesol production from Escherichia coli by harnessing the exogenous mevalonate pathway. | 2010 | Biotechnol. Bioeng. | pmid:20552672 |
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Bhandari J et al. | Identification of a novel abscisic acid-regulated farnesol dehydrogenase from Arabidopsis. | 2010 | Plant Physiol. | pmid:20807998 |
Jin J et al. | Farnesol, a potential efflux pump inhibitor in Mycobacterium smegmatis. | 2010 | Molecules | pmid:21042264 |
Eglin D et al. | Farnesol-modified biodegradable polyurethanes for cartilage tissue engineering. | 2010 | J Biomed Mater Res A | pmid:19191318 |
Chen CK et al. | Scanning chimeragenesis: the approach used to change the substrate selectivity of fatty acid monooxygenase CYP102A1 to that of terpene omega-hydroxylase CYP4C7. | 2010 | J. Biol. Inorg. Chem. | pmid:19727859 |
Lee SJ and Moon HI | Immunotoxicity activity of the major essential oil of Filipendula glaberrima against Aedes aegypti L. | 2010 | Immunopharmacol Immunotoxicol | pmid:20175741 |
Hanker AB et al. | Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling. | 2010 | Oncogene | pmid:19838215 |
Langford ML et al. | Activity and toxicity of farnesol towards Candida albicans are dependent on growth conditions. | 2010 | Antimicrob. Agents Chemother. | pmid:19933803 |
Grienke U et al. | Antiviral potential and molecular insight into neuraminidase inhibiting diarylheptanoids from Alpinia katsumadai. | 2010 | J. Med. Chem. | pmid:20014777 |
Yaari-Stark S et al. | Ras inhibits endoplasmic reticulum stress in human cancer cells with amplified Myc. | 2010 | Int. J. Cancer | pmid:19998334 |
Räikkönen J et al. | Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells. | 2010 | Biochem. Pharmacol. | pmid:19819230 |
Doan K et al. | In vivo and in vitro skin absorption of lipophilic compounds, dibutyl phthalate, farnesol and geraniol in the hairless guinea pig. | 2010 | Food Chem. Toxicol. | pmid:19747520 |
Endo S et al. | Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10. | 2010 | Bioorg. Med. Chem. | pmid:20304656 |