2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Gilbert BA et al. | Farnesyl thiotriazole, a potent neutrophil agonist and structurally novel activator of protein kinase C. | 1995 | Biochemistry | pmid:7696255 |
Marciano D et al. | Farnesyl derivatives of rigid carboxylic acids-inhibitors of ras-dependent cell growth. | 1995 | J. Med. Chem. | pmid:7731012 |
Fliesler SJ and Keller RK | Metabolism of [3H]farnesol to cholesterol and cholesterogenic intermediates in the living rat eye. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7763243 |
Forman BM et al. | Identification of a nuclear receptor that is activated by farnesol metabolites. | 1995 | Cell | pmid:7774010 |
Crick DC et al. | Farnesol is utilized for protein isoprenylation and the biosynthesis of cholesterol in mammalian cells. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7794274 |
Bondar OP et al. | Effects of farnesol on the thermotropic behavior of dimyristoylphosphatidylcholine. | 1994 | Chem. Phys. Lipids | pmid:7820904 |
Yazlovitskaya EM and Melnykovych G | Selective farnesol toxicity and translocation of protein kinase C in neoplastic HeLa-S3K and non-neoplastic CF-3 cells. | 1995 | Cancer Lett. | pmid:7874691 |
Munro E et al. | Inhibition of human vascular smooth muscle cell proliferation by lovastatin: the role of isoprenoid intermediates of cholesterol synthesis. | 1994 | Eur. J. Clin. Invest. | pmid:7890015 |
Søgaard M et al. | A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles. | 1994 | Cell | pmid:7923363 |
Aronheim A et al. | Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway. | 1994 | Cell | pmid:7923364 |
Biermann BJ et al. | Novel isoprenylated proteins identified by an expression library screen. | 1994 | J. Biol. Chem. | pmid:7929216 |
Mallat A et al. | Effect of simvastatin, an inhibitor of hydroxy-methylglutaryl coenzyme A reductase, on the growth of human Ito cells. | 1994 | Hepatology | pmid:7982659 |
Tojo K et al. | Diffusion and metabolism of prednisolone farnesylate in viable skin of the hairless mouse. | 1994 | Pharm. Res. | pmid:8008705 |
Neuhüser T et al. | Responsiveness of the adult cricket (Gryllus bimaculatus and Acheta domesticus) retrocerebral complex to allatostatin-1 from a cockroach, Diploptera punctata. | 1994 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:8014257 |
Adany I et al. | Differences in sensitivity to farnesol toxicity between neoplastically- and non-neoplastically-derived cells in culture. | 1994 | Cancer Lett. | pmid:8019976 |
Correll CC et al. | Identification of farnesol as the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | 1994 | J. Biol. Chem. | pmid:8021239 |
Cox AD et al. | The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. | 1994 | J. Biol. Chem. | pmid:8034681 |
Haug JS et al. | Directed cell killing (apoptosis) in human lymphoblastoid cells incubated in the presence of farnesol: effect of phosphatidylcholine. | 1994 | Biochim. Biophys. Acta | pmid:8061045 |
Kisselev OG et al. | A farnesylated domain in the G protein gamma subunit is a specific determinant of receptor coupling. | 1994 | J. Biol. Chem. | pmid:8063769 |
Lübben M and Morand K | Novel prenylated hemes as cofactors of cytochrome oxidases. Archaea have modified hemes A and O. | 1994 | J. Biol. Chem. | pmid:8063781 |