2E,6E-farnesol

2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.

Cross Reference

Introduction

To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2E,6E-farnesol?

2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Arteriosclerosis D001161 86 associated lipids
Body Weight D001835 333 associated lipids
Candidiasis, Oral D002180 11 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Dermatomycoses D003881 17 associated lipids
Edema D004487 152 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Fibrosis D005355 23 associated lipids
Glioblastoma D005909 27 associated lipids
Glioma D005910 112 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Insulin Resistance D007333 99 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Meningioma D008579 11 associated lipids
Neoplasms, Glandular and Epithelial D009375 12 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Nephritis D009393 19 associated lipids
Neuralgia D009437 28 associated lipids
Neurilemmoma D009442 10 associated lipids
Neuritis, Autoimmune, Experimental D009444 4 associated lipids
Neuroblastoma D009447 66 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Precancerous Conditions D011230 48 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Osteosarcoma D012516 50 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
HIV Infections D015658 20 associated lipids
Head Injuries, Closed D016489 5 associated lipids
Anisakiasis D017129 2 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Nerve Sheath Neoplasms D018317 4 associated lipids
Lung Injury D055370 14 associated lipids
Candidiasis, Invasive D058365 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with 2E,6E-farnesol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2E,6E-farnesol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 2E,6E-farnesol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2E,6E-farnesol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 2E,6E-farnesol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2E,6E-farnesol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 2E,6E-farnesol

Download all related citations
Per page 10 20 50 100 | Total 950
Authors Title Published Journal PubMed Link
Fukada Y et al. Farnesylated gamma-subunit of photoreceptor G protein indispensable for GTP-binding. 1990 Nature pmid:2385292
Lowy DR and Willumsen BM Protein modification: new clue to Ras lipid glue. 1989 Nature pmid:2677741
Calam DH Species and sex-specific compounds from the heads of male bumblebees (Bombus spp.). 1969 Nature pmid:5765060
Masner P et al. Sexually spread insect sterility induced by the analogues of juvenile hormone. 1968 Nature pmid:5690848
Farag MA and Al-Mahdy DA Comparative study of the chemical composition and biological activities of Magnolia grandiflora and Magnolia virginiana flower essential oils. 2013 Nat. Prod. Res. pmid:22690913
Cortés M et al. Drimenol: A versatile synthon for compounds with trans-drimane skeleton. 2011 Nat Prod Commun pmid:21560760
Lichtor PA and Miller SJ Combinatorial evolution of site- and enantioselective catalysts for polyene epoxidation. 2012 Nat Chem pmid:23174978
Cotoras M et al. Farnesol induces apoptosis-like phenotype in the phytopathogenic fungus Botrytis cinerea. 2013 Jan-Feb Mycologia pmid:22962358
Liu P et al. Farnesol induces apoptosis and oxidative stress in the fungal pathogen Penicillium expansum. 2010 Mar-Apr Mycologia pmid:20361499
Gonçalves O et al. Evaluation of the mutagenicity of sesquiterpenic compounds and their influence on the susceptibility towards antibiotics of two clinically relevant bacterial strains. 2011 Mutat. Res. pmid:21453784
Jin J et al. Farnesol, a potential efflux pump inhibitor in Mycobacterium smegmatis. 2010 Molecules pmid:21042264
Špičáková A et al. Nerolidol and Farnesol Inhibit Some Cytochrome P450 Activities but Did Not Affect Other Xenobiotic-Metabolizing Enzymes in Rat and Human Hepatic Subcellular Fractions. 2017 Molecules pmid:28338641
Togashi N et al. Effects of two terpene alcohols on the antibacterial activity and the mode of action of farnesol against Staphylococcus aureus. 2008 Molecules pmid:19078849
Rung E et al. Depletion of substrates for protein prenylation increases apoptosis in human periovulatory granulosa cells. 2006 Mol. Reprod. Dev. pmid:16868926
Benford HL et al. Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs. 1999 Mol. Pharmacol. pmid:10385693
Maher M et al. Activation of TRPA1 by farnesyl thiosalicylic acid. 2008 Mol. Pharmacol. pmid:18171730
Bandara HM et al. Incorporation of Farnesol Significantly Increases the Efficacy of Liposomal Ciprofloxacin against Pseudomonas aeruginosa Biofilms in Vitro. 2016 Mol. Pharm. pmid:27383205
Zhang X et al. PEG-farnesyl thiosalicylic acid telodendrimer micelles as an improved formulation for targeted delivery of paclitaxel. 2014 Mol. Pharm. pmid:24987803
Savoldi M et al. Farnesol induces the transcriptional accumulation of the Aspergillus nidulans Apoptosis-Inducing Factor (AIF)-like mitochondrial oxidoreductase. 2008 Mol. Microbiol. pmid:18681941
Cugini C et al. Farnesol, a common sesquiterpene, inhibits PQS production in Pseudomonas aeruginosa. 2007 Mol. Microbiol. pmid:17640272