2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Donninger C and Popják G | Studies on the biosynthesis of cholesterol. 18. The stereospecificity of mevaldate reductase and the biosynthesis of asymmetrically labelled farnesyl pyrophosphate. | 1966 | Proc. R. Soc. Lond., B, Biol. Sci. | pmid:4379290 |
Jackson JH et al. | Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2183224 |
Laezza C et al. | v-K-ras leads to preferential farnesylation of p21(ras) in FRTL-5 cells: multiple interference with the isoprenoid pathway. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9811854 |
Fisher JE et al. | Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9874784 |
Lai RK et al. | The gamma subunit of transducin is farnesylated. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2217200 |
Stone KJ and Strominger JL | Inhibition of sterol biosynthesis by bacitracin. | 1972 | Proc. Natl. Acad. Sci. U.S.A. | pmid:4338587 |
Jautelat M et al. | Natural-abundance 13C nuclear magnetic resonance spectra of terpenes and carotenes. | 1970 | Proc. Natl. Acad. Sci. U.S.A. | pmid:5263764 |
Thai L et al. | Farnesol is utilized for isoprenoid biosynthesis in plant cells via farnesyl pyrophosphate formed by successive monophosphorylation reactions. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10557276 |
Jansen B et al. | Novel Ras antagonist blocks human melanoma growth. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10570191 |
Law JH et al. | Synthesis of a material with high juvenile hormone activity. | 1966 | Proc. Natl. Acad. Sci. U.S.A. | pmid:5221241 |