2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Duncan RE and Archer MC | Farnesol induces thyroid hormone receptor (THR) beta1 but inhibits THR-mediated signaling in MCF-7 human breast cancer cells. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16540091 |
Semighini CP et al. | Farnesol-induced apoptosis in Aspergillus nidulans reveals a possible mechanism for antagonistic interactions between fungi. | 2006 | Mol. Microbiol. | pmid:16420349 |
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Jahangir T et al. | Farnesol prevents Fe-NTA-mediated renal oxidative stress and early tumour promotion markers in rats. | 2006 | Hum Exp Toxicol | pmid:16758765 |
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Kafri M et al. | Inhibition of Ras attenuates the course of experimental autoimmune neuritis. | 2005 | J. Neuroimmunol. | pmid:16154640 |
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Lakshman R et al. | Use of CYP2E1-transfected human liver cell lines in elucidating the actions of ethanol. | 2005 | Alcohol. Clin. Exp. Res. | pmid:16205373 |
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Chen AP et al. | Substrate and product specificities of cis-type undecaprenyl pyrophosphate synthase. | 2005 | Biochem. J. | pmid:15447632 |
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Koo H et al. | Apigenin and tt-farnesol with fluoride effects on S. mutans biofilms and dental caries. | 2005 | J. Dent. Res. | pmid:16246933 |
Horn TL et al. | Modulation of hepatic and renal drug metabolizing enzyme activities in rats by subchronic administration of farnesol. | 2005 | Chem. Biol. Interact. | pmid:15840382 |
Laffey SF and Butler G | Phenotype switching affects biofilm formation by Candida parapsilosis. | 2005 | Microbiology (Reading, Engl.) | pmid:15817776 |
Yang SP and Raner GM | Cytochrome P450 expression and activities in human tongue cells and their modulation by green tea extract. | 2005 | Toxicol. Appl. Pharmacol. | pmid:15629189 |
Shearer AG and Hampton RY | Lipid-mediated, reversible misfolding of a sterol-sensing domain protein. | 2005 | EMBO J. | pmid:15635451 |
Williams JM and Savage CO | Characterization of the regulation and functional consequences of p21ras activation in neutrophils by antineutrophil cytoplasm antibodies. | 2005 | J. Am. Soc. Nephrol. | pmid:15548565 |
Aronovich R et al. | Antiphospholipid antibodies, thrombin and LPS activate brain endothelial cells and Ras-dependent pathways through distinct mechanisms. | 2005 | Immunobiology | pmid:16325498 |
Westwater C et al. | Candida albicans-conditioned medium protects yeast cells from oxidative stress: a possible link between quorum sensing and oxidative stress resistance. | 2005 | Eukaryotic Cell | pmid:16215173 |
Braun PC | The effect of farnesol on amino acid incorporation by a wild-type and cell-wall variant strain of Candida albicans. | 2005 | Can. J. Microbiol. | pmid:16234870 |
Yu JS et al. | Synthesis of farnesol isomers via a modified Wittig procedure. | 2005 | Org. Lett. | pmid:16235893 |
Navarathna DH et al. | Enhanced pathogenicity of Candida albicans pre-treated with subinhibitory concentrations of fluconazole in a mouse model of disseminated candidiasis. | 2005 | J. Antimicrob. Chemother. | pmid:16239285 |
Ferri N et al. | Isothiazole dioxide derivative 6n inhibits vascular smooth muscle cell proliferation and protein farnesylation. | 2005 | Biochem. Pharmacol. | pmid:16257390 |
McMahon LP et al. | Farnesylthiosalicylic acid inhibits mammalian target of rapamycin (mTOR) activity both in cells and in vitro by promoting dissociation of the mTOR-raptor complex. | 2005 | Mol. Endocrinol. | pmid:15459249 |
Khwaja A et al. | The inhibition of human mesangial cell proliferation by S-trans, trans-farnesylthiosalicylic acid. | 2005 | Kidney Int. | pmid:16014024 |
Mosel DD et al. | Farnesol concentrations required to block germ tube formation in Candida albicans in the presence and absence of serum. | 2005 | Appl. Environ. Microbiol. | pmid:16085901 |
Martin SW et al. | Cell cycle dynamics and quorum sensing in Candida albicans chlamydospores are distinct from budding and hyphal growth. | 2005 | Eukaryotic Cell | pmid:16002645 |
Enjalbert B and Whiteway M | Release from quorum-sensing molecules triggers hyphal formation during Candida albicans resumption of growth. | 2005 | Eukaryotic Cell | pmid:16002646 |
Cao YY et al. | cDNA microarray analysis of differential gene expression in Candida albicans biofilm exposed to farnesol. | 2005 | Antimicrob. Agents Chemother. | pmid:15673737 |
Blum R et al. | Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death. | 2005 | Cancer Res. | pmid:15705901 |
Hubálek F et al. | Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors. | 2005 | J. Biol. Chem. | pmid:15710600 |
Katsuyama M et al. | A novel method to control the balance of skin microflora. Part 1. Attack on biofilm of Staphylococcus aureus without antibiotics. | 2005 | J. Dermatol. Sci. | pmid:15927813 |
Katsuyama M et al. | A novel method to control the balance of skin microflora Part 2. A study to assess the effect of a cream containing farnesol and xylitol on atopic dry skin. | 2005 | J. Dermatol. Sci. | pmid:15927814 |
Shchepin R et al. | Biologically active fluorescent farnesol analogs. | 2005 | Chem. Biol. | pmid:15975508 |
Kang L et al. | SMGA gels for the skin permeation of haloperidol. | 2005 | J Control Release | pmid:15975680 |
Yue W et al. | Farnesylthiosalicylic acid blocks mammalian target of rapamycin signaling in breast cancer cells. | 2005 | Int. J. Cancer | pmid:15957161 |
Bachireddy P et al. | Getting at MYC through RAS. | 2005 | Clin. Cancer Res. | pmid:15958607 |
Yaari S et al. | Disruption of cooperation between Ras and MycN in human neuroblastoma cells promotes growth arrest. | 2005 | Clin. Cancer Res. | pmid:15958613 |
Rowat AC et al. | Effects of farnesol on the physical properties of DMPC membranes. | 2005 | Biochim. Biophys. Acta | pmid:15963943 |
Jahangir T et al. | Alleviation of free radical mediated oxidative and genotoxic effects of cadmium by farnesol in Swiss albino mice. | 2005 | Redox Rep. | pmid:16438802 |
Rowat AC and Davis JH | Farnesol-DMPC phase behaviour: a (2)H-NMR study. | 2004 | Biochim. Biophys. Acta | pmid:15003880 |
Hogan DA et al. | A Pseudomonas aeruginosa quorum-sensing molecule influences Candida albicans morphology. | 2004 | Mol. Microbiol. | pmid:15554963 |
Luxová A et al. | Absolute configuration of chiral terpenes in marking pheromones of bumblebees and cuckoo bumblebees. | 2004 | Chirality | pmid:15034905 |
Fukuda S and Pelus LM | Activated H-Ras regulates hematopoietic cell survival by modulating Survivin. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15369798 |
Chin PC et al. | The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism. | 2004 | J. Neurochem. | pmid:15255937 |
Dumitru R et al. | Defined anaerobic growth medium for studying Candida albicans basic biology and resistance to eight antifungal drugs. | 2004 | Antimicrob. Agents Chemother. | pmid:15215080 |