2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Bhandari J et al. | Identification of a novel abscisic acid-regulated farnesol dehydrogenase from Arabidopsis. | 2010 | Plant Physiol. | pmid:20807998 |
Schnee C et al. | The maize gene terpene synthase 1 encodes a sesquiterpene synthase catalyzing the formation of (E)-beta-farnesene, (E)-nerolidol, and (E,E)-farnesol after herbivore damage. | 2002 | Plant Physiol. | pmid:12481088 |
Hemmerlin A and Bach TJ | Farnesol-induced cell death and stimulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in tobacco cv bright yellow-2 cells. | 2000 | Plant Physiol. | pmid:10938345 |
Fitzpatrick AH et al. | Roles for farnesol and ABA in Arabidopsis flower development. | 2011 | Plant Signal Behav | pmid:21758018 |
Cantrell CL et al. | Antimycobacterial plant terpenoids. | 2001 | Planta Med. | pmid:11731906 |
Shin KO et al. | Terpene alcohols inhibit de novo sphingolipid biosynthesis. | 2012 | Planta Med. | pmid:22274813 |
Rajab MS et al. | Antimycobacterial activity of (E)-phytol and derivatives: a preliminary structure-activity study. | 1998 | Planta Med. | pmid:9491760 |
Vik A et al. | Screening of terpenes and derivatives for antimycobacterial activity; identification of geranylgeraniol and geranylgeranyl acetate as potent inhibitors of Mycobacterium tuberculosis in vitro. | 2007 | Planta Med. | pmid:17924309 |
Zhu J et al. | Farnesol-induced apoptosis in Candida albicans is mediated by Cdr1-p extrusion and depletion of intracellular glutathione. | 2011 | PLoS ONE | pmid:22205973 |
Wu L et al. | Farnesylthiosalicylic acid sensitizes hepatocarcinoma cells to artemisinin derivatives. | 2017 | PLoS ONE | pmid:28182780 |