2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Egozi Y et al. | Growth inhibition of ras-dependent tumors in nude mice by a potent ras-dislodging antagonist. | 1999 | Int. J. Cancer | pmid:10074926 |
Machida K et al. | Farnesol-induced growth inhibition in Saccharomyces cerevisiae by a cell cycle mechanism. | 1999 | Microbiology (Reading, Engl.) | pmid:10075411 |
Parmryd I and Dallner G | In vivo prenylation of rat proteins: modification of proteins with penta- and hexaprenyl groups. | 1999 | Arch. Biochem. Biophys. | pmid:10190969 |
Luft UC et al. | Farnesol blocks the L-type Ca2+ channel by targeting the alpha 1C subunit. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10195923 |
Hanson JR and Nyfeler R | Studies in terpenoid biosynthesis. Part 18. Biosynthesis of culmorin. | 1976 | J. Chem. Soc. Perkin Trans. I | pmid:1034641 |
Weisz B et al. | A new functional Ras antagonist inhibits human pancreatic tumor growth in nude mice. | 1999 | Oncogene | pmid:10353601 |
Benford HL et al. | Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs. | 1999 | Mol. Pharmacol. | pmid:10385693 |
Anthony ML et al. | Inhibition of phosphatidylcholine biosynthesis following induction of apoptosis in HL-60 cells. | 1999 | J. Biol. Chem. | pmid:10391908 |
Andres DA et al. | Rapid identification of cysteine-linked isoprenyl groups by metabolic labeling with [3H]farnesol and [3H]geranylgeraniol. | 1999 | Methods Mol. Biol. | pmid:10399149 |