2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Shareck J and Belhumeur P | Modulation of morphogenesis in Candida albicans by various small molecules. | 2011 | Eukaryotic Cell | pmid:21642508 |
Yang L et al. | ZL11n is a novel nitric oxide-releasing derivative of farnesylthiosalicylic acid that induces apoptosis in human hepatoma HepG2 cells via MAPK/mitochondrial pathways. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21621522 |
Barkan B et al. | Phenotypic reversion of invasive neurofibromin-deficient schwannoma by FTS: Ras inhibition reduces BMP4/Erk/Smad signaling. | 2011 | Mol. Cancer Ther. | pmid:21632464 |
Fitzpatrick AH et al. | Farnesol kinase is involved in farnesol metabolism, ABA signaling and flower development in Arabidopsis. | 2011 | Plant J. | pmid:21395888 |
Nevo Y et al. | The Ras antagonist, farnesylthiosalicylic acid (FTS), decreases fibrosis and improves muscle strength in dy/dy mouse model of muscular dystrophy. | 2011 | PLoS ONE | pmid:21445359 |
Khan R and Sultana S | Farnesol attenuates 1,2-dimethylhydrazine induced oxidative stress, inflammation and apoptotic responses in the colon of Wistar rats. | 2011 | Chem. Biol. Interact. | pmid:21453689 |
Gonçalves O et al. | Evaluation of the mutagenicity of sesquiterpenic compounds and their influence on the susceptibility towards antibiotics of two clinically relevant bacterial strains. | 2011 | Mutat. Res. | pmid:21453784 |
Mor A et al. | Inhibitory effect of farnesylthiosalicylic acid on mediators release by mast cells: preferential inhibition of prostaglandin D(2) and tumor necrosis factor-α release. | 2011 | Inflammation | pmid:20706780 |
Ling Y et al. | Novel nitric oxide-releasing derivatives of farnesylthiosalicylic acid: synthesis and evaluation of antihepatocellular carcinoma activity. | 2011 | J. Med. Chem. | pmid:21504204 |
Jeon JG et al. | Influences of trans-trans farnesol, a membrane-targeting sesquiterpenoid, on Streptococcus mutans physiology and survival within mixed-species oral biofilms. | 2011 | Int J Oral Sci | pmid:21485314 |
Hogan DA and Muhlschlegel FA | Candida albicans developmental regulation: adenylyl cyclase as a coincidence detector of parallel signals. | 2011 | Curr. Opin. Microbiol. | pmid:22014725 |
Bai C et al. | Characterization of a hyperactive Cyr1 mutant reveals new regulatory mechanisms for cellular cAMP levels in Candida albicans. | 2011 | Mol. Microbiol. | pmid:21992526 |
Biran A et al. | Downregulation of survivin and aurora A by histone deacetylase and RAS inhibitors: a new drug combination for cancer therapy. | 2011 | Int. J. Cancer | pmid:20473860 |
Kraitzer A et al. | Composite fiber structures with antiproliferative agents exhibit advantageous drug delivery and cell growth inhibition in vitro. | 2011 | J Pharm Sci | pmid:20623695 |
Sharma M and Prasad R | The quorum-sensing molecule farnesol is a modulator of drug efflux mediated by ABC multidrug transporters and synergizes with drugs in Candida albicans. | 2011 | Antimicrob. Agents Chemother. | pmid:21768514 |
Nishimori R et al. | Biosynthesis of unnatural bacteriochlorophyll c derivatives esterified with α,ω-diols in the green sulfur photosynthetic bacterium Chlorobaculum tepidum. | 2011 | Biochemistry | pmid:21846125 |
Riely GJ et al. | A phase II trial of Salirasib in patients with lung adenocarcinomas with KRAS mutations. | 2011 | J Thorac Oncol | pmid:21847063 |
Ganguly S et al. | Zap1 control of cell-cell signaling in Candida albicans biofilms. | 2011 | Eukaryotic Cell | pmid:21890817 |
Dinamarco TM et al. | Farnesol-induced cell death in the filamentous fungus Aspergillus nidulans. | 2011 | Biochem. Soc. Trans. | pmid:21936849 |
Mor A et al. | Inhibition of contact sensitivity by farnesylthiosalicylic acid-amide, a potential Rap1 inhibitor. | 2011 | J. Invest. Dermatol. | pmid:21716322 |
Tsuji F et al. | The geranyl-modified tryptophan residue is crucial for ComXRO-E-2 pheromone biological activity. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21636272 |
Kaneko M et al. | Effect of farnesol on mevalonate pathway of Staphylococcus aureus. | 2011 | J. Antibiot. | pmid:21772307 |
Piérard GE et al. | Miconazole, a pharmacological barrier to skin fungal infections. | 2012 | Expert Opin Pharmacother | pmid:22568580 |
Laheru D et al. | Integrated preclinical and clinical development of S-trans, trans-Farnesylthiosalicylic Acid (FTS, Salirasib) in pancreatic cancer. | 2012 | Invest New Drugs | pmid:22547163 |
Aizman E et al. | Ras inhibition by FTS attenuates brain tumor growth in mice by direct antitumor activity and enhanced reactivity of cytotoxic lymphocytes. | 2012 | Oncotarget | pmid:22323550 |
Qamar W et al. | Benzo(a)pyrene-induced pulmonary inflammation, edema, surfactant dysfunction, and injuries in rats: alleviation by farnesol. | 2012 | Exp. Lung Res. | pmid:22168545 |
Mans RA et al. | Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation. | 2012 | Neuroscience | pmid:22192838 |
Mashiach-Farkash E et al. | Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton. | 2012 | Oncotarget | pmid:22776759 |
András IE et al. | Lipid rafts and functional caveolae regulate HIV-induced amyloid beta accumulation in brain endothelial cells. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22490665 |
Mor A et al. | Celecoxib enhances the anti-inflammatory effects of farnesylthiosalicylic acid on T cells independent of prostaglandin E(2) production. | 2012 | Inflammation | pmid:22688643 |
Nasr N et al. | HIV-1 infection of human macrophages directly induces viperin which inhibits viral production. | 2012 | Blood | pmid:22677126 |
Cordeiro Rde A et al. | Farnesol inhibits in vitro growth of the Cryptococcus neoformans species complex with no significant changes in virulence-related exoenzymes. | 2012 | Vet. Microbiol. | pmid:22580194 |
Cerca N et al. | Confocal laser scanning microscopy analysis of S. epidermidis biofilms exposed to farnesol, vancomycin and rifampicin. | 2012 | BMC Res Notes | pmid:22591918 |
Costa CB et al. | Farnesyltransferase inhibitors: molecular evidence of therapeutic efficacy in acute lymphoblastic leukemia through cyclin D1 inhibition. | 2012 | Anticancer Res. | pmid:22399601 |
Wang X et al. | Waikialoid A suppresses hyphal morphogenesis and inhibits biofilm development in pathogenic Candida albicans. | 2012 | J. Nat. Prod. | pmid:22400916 |
Goldberg L et al. | FTS and 2-DG induce pancreatic cancer cell death and tumor shrinkage in mice. | 2012 | Cell Death Dis | pmid:22419113 |
Han TL et al. | The metabolic response of Candida albicans to farnesol under hyphae-inducing conditions. | 2012 | FEMS Yeast Res. | pmid:22846172 |
Chang W et al. | Retigeric acid B attenuates the virulence of Candida albicans via inhibiting adenylyl cyclase activity targeted by enhanced farnesol production. | 2012 | PLoS ONE | pmid:22848547 |
Lindsay AK et al. | Farnesol and cyclic AMP signaling effects on the hypha-to-yeast transition in Candida albicans. | 2012 | Eukaryotic Cell | pmid:22886999 |
Fu MS et al. | Functional characterization of the small heat shock protein Hsp12p from Candida albicans. | 2012 | PLoS ONE | pmid:22880130 |
Lichtor PA and Miller SJ | Combinatorial evolution of site- and enantioselective catalysts for polyene epoxidation. | 2012 | Nat Chem | pmid:23174978 |
Jamalian A et al. | Chemical composition and antifungal activity of Matricaria recutita flower essential oil against medically important dermatophytes and soil-borne pathogens. | 2012 | J Mycol Med | pmid:23518164 |
Green SA et al. | Identification, functional characterization, and regulation of the enzyme responsible for floral (E)-nerolidol biosynthesis in kiwifruit (Actinidia chinensis). | 2012 | J. Exp. Bot. | pmid:22162874 |
Shin KO et al. | Terpene alcohols inhibit de novo sphingolipid biosynthesis. | 2012 | Planta Med. | pmid:22274813 |
Jin Y and Qiu FG | A convergent stereocontrolled total synthesis of (-)-terpestacin. | 2012 | Org. Biomol. Chem. | pmid:22710980 |
Mologni L et al. | Synergistic effects of combined Wnt/KRAS inhibition in colorectal cancer cells. | 2012 | PLoS ONE | pmid:23227266 |
Wartenberg D et al. | Proteome analysis of the farnesol-induced stress response in Aspergillus nidulans--The role of a putative dehydrin. | 2012 | J Proteomics | pmid:22634043 |
Yu LH et al. | Possible inhibitory molecular mechanism of farnesol on the development of fluconazole resistance in Candida albicans biofilm. | 2012 | Antimicrob. Agents Chemother. | pmid:22106223 |
Oron T et al. | Prevention of induced colitis in mice by the ras antagonist farnesylthiosalicylic acid. | 2012 | Dig. Dis. Sci. | pmid:21901261 |
Stärkel P et al. | Ras inhibition in hepatocarcinoma by S-trans-trans-farnesylthiosalicyclic acid: association of its tumor preventive effect with cell proliferation, cell cycle events, and angiogenesis. | 2012 | Mol. Carcinog. | pmid:21882255 |