2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Van Dessel G et al. | Internalisation of short-chain isoprenyl diphosphates by chromaffin cells from bovine adrenal medulla. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9299441 |
Crick DC et al. | Novel salvage pathway utilizing farnesol and geranylgeraniol for protein isoprenylation. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9299388 |
Takaichi S et al. | The major carotenoid in all known species of heliobacteria is the C30 carotenoid 4,4'-diaponeurosporene, not neurosporene. | 1997 | Arch. Microbiol. | pmid:9297464 |
Zhang L et al. | Isolation and characterization of a prenylcysteine lyase from bovine brain. | 1997 | J. Biol. Chem. | pmid:9287348 |
Meigs TE and Simoni RD | Farnesol as a regulator of HMG-CoA reductase degradation: characterization and role of farnesyl pyrophosphatase. | 1997 | Arch. Biochem. Biophys. | pmid:9281305 |
Blazer-Yost BL et al. | Protein prenylation is required for aldosterone-stimulated Na+ transport. | 1997 | Am. J. Physiol. | pmid:9227422 |
Flint OP et al. | Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro. | 1997 | Toxicol. Appl. Pharmacol. | pmid:9221828 |
Leitner JW et al. | Hyperinsulinemia potentiates activation of p21Ras by growth factors. | 1997 | Endocrinology | pmid:9112423 |
Crick DC et al. | Geranylgeraniol promotes entry of UT-2 cells into the cell cycle in the absence of mevalonate. | 1997 | Exp. Cell Res. | pmid:9087171 |
Bostedor RG et al. | Farnesol-derived dicarboxylic acids in the urine of animals treated with zaragozic acid A or with farnesol. | 1997 | J. Biol. Chem. | pmid:9083051 |
Denda M et al. | Epidermal injury stimulates prenylation in the epidermis of hairless mice. | 1997 | Arch. Dermatol. Res. | pmid:9049045 |
Tamone SL et al. | Identification and characterization of methyl farnesoate binding proteins from the crab, Cancer magister. | 1997 | Gen. Comp. Endocrinol. | pmid:9038249 |
Tisch D et al. | Activation of signaling pathways in HL60 cells and human neutrophils by farnesylthiosalicylate. | 1996 | Eur. J. Biochem. | pmid:9022678 |
King HL and Rilling HC | Avian liver prenyltransferase. The role of metal in substrate binding and the orientation of substrates during catalysis. | 1977 | Biochemistry | pmid:901755 |
Westfall D et al. | Metabolism of farnesol: phosphorylation of farnesol by rat liver microsomal and peroxisomal fractions. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9015362 |
Styczyńska B et al. | [2,3-methylenefarnesenic acid derivatives as juvenile hormone analogs against housefly (Musca domestica L.)]. | 1977 | Wiad Parazytol | pmid:899003 |
Carel K et al. | Insulin stimulates mitogen-activated protein kinase by a Ras-independent pathway in 3T3-L1 adipocytes. | 1996 | J. Biol. Chem. | pmid:8940037 |
Vogt A et al. | Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts. | 1996 | Oncogene | pmid:8934546 |
Willumsen BM et al. | Novel determinants of H-Ras plasma membrane localization and transformation. | 1996 | Oncogene | pmid:8934536 |
Peter MG et al. | [Incorporation experiments with (3H and 14C) doubly labelled farnesols into cantharidin (author's transl)]. | 1977 | Helv. Chim. Acta | pmid:893117 |