2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Toró A et al. | Transannular Diels-Alder studies on the asymmetric total synthesis of chatancin: the pyranophane approach. | 2000 | Org. Lett. | pmid:10964353 |
Eskens FA et al. | Farnesyl transferase inhibitors: current developments and future perspectives. | 2000 | Cancer Treat. Rev. | pmid:11006134 |
Kloog Y and Cox AD | RAS inhibitors: potential for cancer therapeutics. | 2000 | Mol Med Today | pmid:11006529 |
Bringmann A et al. | Farnesol modulates membrane currents in human retinal glial cells. | 2000 | J. Neurosci. Res. | pmid:11054809 |
Halaschek-Wiener J et al. | A novel Ras antagonist regulates both oncogenic Ras and the tumor suppressor p53 in colon cancer cells. | 2000 | Mol. Med. | pmid:11055588 |
Tschantz WR et al. | Lysosomal prenylcysteine lyase is a FAD-dependent thioether oxidase. | 2001 | J. Biol. Chem. | pmid:11078725 |
Xie H et al. | Synthesis and biological evaluation of the geometric farnesylated analogues of the a-factor mating peptide of Saccharomyces cerevisiae. | 2000 | J. Org. Chem. | pmid:11112575 |
Sperry AE and Sen SE | Farnesol oxidation in insects: evidence that the biosynthesis of insect juvenile hormone is mediated by a specific alcohol oxidase. | 2001 | Insect Biochem. Mol. Biol. | pmid:11164339 |
Fogelman AM et al. | Abnormal induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase in leukocytes from subjects with heterozygous familial hypercholesterolemia. | 1975 | J. Biol. Chem. | pmid:1116997 |