2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Hornby JM and Nickerson KW | Enhanced production of farnesol by Candida albicans treated with four azoles. | 2004 | Antimicrob. Agents Chemother. | pmid:15155241 |
Pfister C et al. | Detection and quantification of farnesol-induced apoptosis in difficult primary cell cultures by TaqMan protein assay. | 2013 | Apoptosis | pmid:23315006 |
Song L | A soluble form of phosphatase in Saccharomyces cerevisiae capable of converting farnesyl diphosphate into E,E-farnesol. | 2006 | Appl. Biochem. Biotechnol. | pmid:16484724 |
Dionigi CP et al. | Effects of farnesol and the off-flavor derivative geosmin on Streptomyces tendae. | 1991 | Appl. Environ. Microbiol. | pmid:1785920 |
Hornby JM et al. | Quorum sensing in the dimorphic fungus Candida albicans is mediated by farnesol. | 2001 | Appl. Environ. Microbiol. | pmid:11425711 |
de Salas F et al. | Quorum-Sensing Mechanisms Mediated by Farnesol in Ophiostoma piceae: Effect on Secretion of Sterol Esterase. | 2015 | Appl. Environ. Microbiol. | pmid:25888179 |
Ramage G et al. | Inhibition of Candida albicans biofilm formation by farnesol, a quorum-sensing molecule. | 2002 | Appl. Environ. Microbiol. | pmid:12406738 |
Hornby JM et al. | Inoculum size effect in dimorphic fungi: extracellular control of yeast-mycelium dimorphism in Ceratocystis ulmi. | 2004 | Appl. Environ. Microbiol. | pmid:15006753 |
Mosel DD et al. | Farnesol concentrations required to block germ tube formation in Candida albicans in the presence and absence of serum. | 2005 | Appl. Environ. Microbiol. | pmid:16085901 |
Nickerson KW et al. | Quorum sensing in dimorphic fungi: farnesol and beyond. | 2006 | Appl. Environ. Microbiol. | pmid:16751484 |
Muramatsu M et al. | Accumulation of prenyl alcohols by terpenoid biosynthesis inhibitors in various microorganisms. | 2008 | Appl. Microbiol. Biotechnol. | pmid:18636253 |
Brockmann H and Knobloch G | [A new bacteriochlorophyll from Rhodospirillum rubrum]. | 1972 | Arch Mikrobiol | pmid:4627398 |
Havel CM and Watson JA | Isopentenoid synthesis in isolated embryonic Drosophila cells: absolute, basal mevalonate synthesis rate determination. | 1992 | Arch. Biochem. Biophys. | pmid:1567218 |
Bai M and Prestwich GD | Inhibition and activation of porcine squalene epoxidase. | 1992 | Arch. Biochem. Biophys. | pmid:1536566 |
Vaidya S et al. | Massive production of farnesol-derived dicarboxylic acids in mice treated with the squalene synthase inhibitor zaragozic acid A. | 1998 | Arch. Biochem. Biophys. | pmid:9647670 |
Benedict CR et al. | Properties of farnesyl pyrophosphate synthetase of pig liver. | 1965 | Arch. Biochem. Biophys. | pmid:4284635 |
Bentinger M et al. | Phosphorylation of farnesol in rat liver microsomes: properties of farnesol kinase and farnesyl phosphate kinase. | 1998 | Arch. Biochem. Biophys. | pmid:9606952 |
Parmryd I and Dallner G | In vivo prenylation of rat proteins: modification of proteins with penta- and hexaprenyl groups. | 1999 | Arch. Biochem. Biophys. | pmid:10190969 |
Keller RK et al. | Farnesol is not the nonsterol regulator mediating degradation of HMG-CoA reductase in rat liver. | 1996 | Arch. Biochem. Biophys. | pmid:8645011 |
Andres DA et al. | Expression cloning of a novel farnesylated protein, RDJ2, encoding a DnaJ protein homologue. | 1997 | Arch. Biochem. Biophys. | pmid:9328291 |