2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Morozova NP et al. | [The effect of a controlled gas atmosphere on farnesene dynamics and the development of sunburn in apples]. | 1974 Jul-Aug | Prikl. Biokhim. Mikrobiol. | pmid:4453546 |
Madhani HD | Quorum sensing in fungi: Q&A. | 2011 | PLoS Pathog. | pmid:22046125 |
Lopez-Medina E et al. | Candida albicans Inhibits Pseudomonas aeruginosa Virulence through Suppression of Pyochelin and Pyoverdine Biosynthesis. | 2015 | PLoS Pathog. | pmid:26313907 |
Nevo Y et al. | The Ras antagonist, farnesylthiosalicylic acid (FTS), decreases fibrosis and improves muscle strength in dy/dy mouse model of muscular dystrophy. | 2011 | PLoS ONE | pmid:21445359 |
Chen M et al. | Use of synthetic isoprenoids to target protein prenylation and Rho GTPases in breast cancer invasion. | 2014 | PLoS ONE | pmid:24587105 |
Zhu J et al. | Farnesol-induced apoptosis in Candida albicans is mediated by Cdr1-p extrusion and depletion of intracellular glutathione. | 2011 | PLoS ONE | pmid:22205973 |
Zhang L et al. | Bisbibenzyls, a new type of antifungal agent, inhibit morphogenesis switch and biofilm formation through upregulation of DPP3 in Candida albicans. | 2011 | PLoS ONE | pmid:22174935 |
Chang W et al. | Retigeric acid B attenuates the virulence of Candida albicans via inhibiting adenylyl cyclase activity targeted by enhanced farnesol production. | 2012 | PLoS ONE | pmid:22848547 |
Fu MS et al. | Functional characterization of the small heat shock protein Hsp12p from Candida albicans. | 2012 | PLoS ONE | pmid:22880130 |
Zhu J et al. | Mevalonate-Farnesal Biosynthesis in Ticks: Comparative Synganglion Transcriptomics and a New Perspective. | 2016 | PLoS ONE | pmid:26959814 |
Xu H et al. | Glucanase induces filamentation of the fungal pathogen Candida albicans. | 2013 | PLoS ONE | pmid:23737947 |
Nyati P et al. | Farnesyl phosphatase, a Corpora allata enzyme involved in juvenile hormone biosynthesis in Aedes aegypti. | 2013 | PLoS ONE | pmid:23940797 |
Schokoroy S et al. | Disrupting the oncogenic synergism between nucleolin and Ras results in cell growth inhibition and cell death. | 2013 | PLoS ONE | pmid:24086490 |
Mologni L et al. | Synergistic effects of combined Wnt/KRAS inhibition in colorectal cancer cells. | 2012 | PLoS ONE | pmid:23227266 |
Mor A et al. | Ras inhibition induces insulin sensitivity and glucose uptake. | 2011 | PLoS ONE | pmid:21738773 |
Wu L et al. | Farnesylthiosalicylic acid sensitizes hepatocarcinoma cells to artemisinin derivatives. | 2017 | PLoS ONE | pmid:28182780 |
Schmukler E et al. | Continuous treatment with FTS confers resistance to apoptosis and affects autophagy. | 2017 | PLoS ONE | pmid:28151959 |
Jung SI et al. | Comparison of E,E-Farnesol Secretion and the Clinical Characteristics of Candida albicans Bloodstream Isolates from Different Multilocus Sequence Typing Clades. | 2016 | PLoS ONE | pmid:26848577 |
Seman-Kamarulzaman AF et al. | Novel NAD+-Farnesal Dehydrogenase from Polygonum minus Leaves. Purification and Characterization of Enzyme in Juvenile Hormone III Biosynthetic Pathway in Plant. | 2016 | PLoS ONE | pmid:27560927 |
Strube-Bloss MF et al. | Extracting the Behaviorally Relevant Stimulus: Unique Neural Representation of Farnesol, a Component of the Recruitment Pheromone of Bombus terrestris. | 2015 | PLoS ONE | pmid:26340263 |