2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Ward SM et al. | TGFbeta regulates the expression of G alpha(i2) via an effect on the localization of ras. | 2002 | J. Mol. Cell. Cardiol. | pmid:12392895 |
Brilhante RS et al. | Histoplasma capsulatum in planktonic and biofilm forms: in vitro susceptibility to amphotericin B, itraconazole and farnesol. | 2015 | J. Med. Microbiol. | pmid:25657300 |
McAlester G et al. | Signal-mediated interactions between Pseudomonas aeruginosa and Candida albicans. | 2008 | J. Med. Microbiol. | pmid:18436588 |
Sharma RN and Saxena KN | Orientation and developmental inhibition in the housefly by certain terpenoids. | 1974 | J. Med. Entomol. | pmid:4281838 |
Prashad M et al. | N-(arylalkyl)farnesylamines: new potent squalene synthetase inhibitors. | 1993 | J. Med. Chem. | pmid:8496919 |
Ling Y et al. | Novel nitric oxide-releasing derivatives of farnesylthiosalicylic acid: synthesis and evaluation of antihepatocellular carcinoma activity. | 2011 | J. Med. Chem. | pmid:21504204 |
Goldberg L et al. | New derivatives of farnesylthiosalicylic acid (salirasib) for cancer treatment: farnesylthiosalicylamide inhibits tumor growth in nude mice models. | 2009 | J. Med. Chem. | pmid:19072665 |
Grienke U et al. | Antiviral potential and molecular insight into neuraminidase inhibiting diarylheptanoids from Alpinia katsumadai. | 2010 | J. Med. Chem. | pmid:20014777 |
de Montellano PR et al. | Inhibition of squalene synthetase by farnesyl pyrophosphate analogues. | 1977 | J. Med. Chem. | pmid:189031 |
Gibbs BS et al. | Novel farnesol and geranylgeraniol analogues: A potential new class of anticancer agents directed against protein prenylation. | 1999 | J. Med. Chem. | pmid:10508429 |
Marciano D et al. | Farnesyl derivatives of rigid carboxylic acids-inhibitors of ras-dependent cell growth. | 1995 | J. Med. Chem. | pmid:7731012 |
Baker FC et al. | Farnesol and farnesal dehydrogenase(s) in corpora allata of the tobacco hornworm moth, Manduca sexta. | 1983 | J. Lipid Res. | pmid:6366103 |
Sofer SS and Rilling HC | Mechanism of squalene biosynthesis: evidence against the involvement of free nerolidyl pyrophosphate. | 1969 | J. Lipid Res. | pmid:4305712 |
Slakey LL et al. | Occurrence of the enzymes effecting the conversion of acetyl CoA to squalene in homogenates of hog aorta. | 1973 | J. Lipid Res. | pmid:4351784 |
Aboushadi N and Krisans SK | Analysis of isoprenoid biosynthesis in peroxisomal-deficient Pex2 CHO cell lines. | 1998 | J. Lipid Res. | pmid:9741690 |
Hanley K et al. | Cholesterol sulfate stimulates involucrin transcription in keratinocytes by increasing Fra-1, Fra-2, and Jun D. | 2001 | J. Lipid Res. | pmid:11254751 |
Hiyoshi H et al. | Squalene synthase inhibitors suppress triglyceride biosynthesis through the farnesol pathway in rat hepatocytes. | 2003 | J. Lipid Res. | pmid:12518031 |
Matsuzawa T et al. | EFdA, a reverse transcriptase inhibitor, potently blocks HIV-1 ex vivo infection of Langerhans cells within epithelium. | 2014 | J. Invest. Dermatol. | pmid:24384694 |
Mor A et al. | Inhibition of contact sensitivity by farnesylthiosalicylic acid-amide, a potential Rap1 inhibitor. | 2011 | J. Invest. Dermatol. | pmid:21716322 |
Hanley K et al. | Fetal epidermal differentiation and barrier development In vivo is accelerated by nuclear hormone receptor activators. | 1999 | J. Invest. Dermatol. | pmid:10571735 |
Halaschek-Wiener J et al. | Farnesyl thiosalicylic acid chemosensitizes human melanoma in vivo. | 2003 | J. Invest. Dermatol. | pmid:12535206 |
Madhavan K et al. | Farnesol metabolism in Drosophila melanogaster: ontogeny and tissue distribution of octanol dehydrogenase and aldehyde oxidase. | 1973 | J. Insect Physiol. | pmid:4631837 |
Spielman A and Skaff V | Inhibition of metamorphosis and of ecdysis in mosquitoes. | 1967 | J. Insect Physiol. | pmid:6043875 |
Krishnakumaran A and Schneiderman HA | Prothoracotrophic activity of compounds that mimic juvenile hormone. | 1965 | J. Insect Physiol. | pmid:5848789 |
Schneiderman HA et al. | Juvenile hormone activity of structurally unrelated compounds. | 1965 | J. Insect Physiol. | pmid:5848792 |
Lanzrein B | Influence of a juvenile hormone analogue on vitellogenin synthesis and oögenesis in larvae of Nauphoeta cinerea. | 1974 | J. Insect Physiol. | pmid:4413859 |
Roullet JB et al. | Inhibition of Ca2+ uptake into A7r5 vascular smooth muscle cells by farnesol: lack of effect on membrane fluidity and Ca2+-ATPase activities. | 1997 | J. Hypertens. | pmid:9488229 |
Reif S et al. | The Ras antagonist, farnesylthiosalicylic acid (FTS), inhibits experimentally-induced liver cirrhosis in rats. | 1999 | J. Hepatol. | pmid:10604579 |
Reif S et al. | Treatment of thioacetamide-induced liver cirrhosis by the Ras antagonist, farnesylthiosalicylic acid. | 2004 | J. Hepatol. | pmid:15288472 |
Lin HP et al. | Localization of isoprenylated antigen of hepatitis delta virus by anti-farnesyl antibodies. | 1999 | J. Gen. Virol. | pmid:9934689 |
Green SA et al. | Identification, functional characterization, and regulation of the enzyme responsible for floral (E)-nerolidol biosynthesis in kiwifruit (Actinidia chinensis). | 2012 | J. Exp. Bot. | pmid:22162874 |
Katsuyama M et al. | A novel method to control the balance of skin microflora. Part 1. Attack on biofilm of Staphylococcus aureus without antibiotics. | 2005 | J. Dermatol. Sci. | pmid:15927813 |
Katsuyama M et al. | A novel method to control the balance of skin microflora Part 2. A study to assess the effect of a cream containing farnesol and xylitol on atopic dry skin. | 2005 | J. Dermatol. Sci. | pmid:15927814 |
Koo H et al. | Apigenin and tt-farnesol with fluoride effects on S. mutans biofilms and dental caries. | 2005 | J. Dent. Res. | pmid:16246933 |
Neuhüser T et al. | Responsiveness of the adult cricket (Gryllus bimaculatus and Acheta domesticus) retrocerebral complex to allatostatin-1 from a cockroach, Diploptera punctata. | 1994 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:8014257 |
O'Donnell MP et al. | Lovastatin inhibits proliferation of rat mesangial cells. | 1993 | J. Clin. Invest. | pmid:8423236 |
Roullet JB et al. | Farnesyl analogues inhibit vasoconstriction in animal and human arteries. | 1996 | J. Clin. Invest. | pmid:8636420 |
Zhao M et al. | Determination of salirasib (S-trans,trans-farnesylthiosalicylic acid) in human plasma using liquid chromatography-tandem mass spectrometry. | 2008 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:18534927 |
Hanson JR and Nyfeler R | Studies in terpenoid biosynthesis. Part 18. Biosynthesis of culmorin. | 1976 | J. Chem. Soc. Perkin Trans. I | pmid:1034641 |
Canonica L et al. | Biosynthesis of mycophenolic acid. | 1972 | J. Chem. Soc. Perkin Trans. I | pmid:4674609 |
Yang Z et al. | Host plant volatiles synergize response to sex pheromone in codling moth, Cydia pomonella. | 2004 | J. Chem. Ecol. | pmid:15139312 |
Shimomura K et al. | 2,3-Dihydrohomofarnesal: female sex attractant pheromone component of Callosobruchus rhodesianus (Pic). | 2010 | J. Chem. Ecol. | pmid:20607368 |
Shimomura K et al. | Homofarnesals: female sex attractant pheromone components of the southern cowpea weevil, Callosobruchus chinensis. | 2008 | J. Chem. Ecol. | pmid:18351422 |
Xiao Y et al. | A two-component female-produced pheromone of the spider Pholcus beijingensis. | 2009 | J. Chem. Ecol. | pmid:19579045 |
Shohami E et al. | The Ras inhibitor S-trans, trans-farnesylthiosalicylic acid exerts long-lasting neuroprotection in a mouse closed head injury model. | 2003 | J. Cereb. Blood Flow Metab. | pmid:12796721 |
Cho SW et al. | Positive regulation of osteogenesis by bile acid through FXR. | 2013 | J. Bone Miner. Res. | pmid:23609136 |
Muramatsu M et al. | Various oils and detergents enhance the microbial production of farnesol and related prenyl alcohols. | 2008 | J. Biosci. Bioeng. | pmid:18930003 |
Muramatsu M et al. | Alkaline pH enhances farnesol production by Saccharomyces cerevisiae. | 2009 | J. Biosci. Bioeng. | pmid:19577192 |
Granshaw T et al. | Circadian rhythms in Neurospora crassa: farnesol or geraniol allow expression of rhythmicity in the otherwise arrhythmic strains frq10, wc-1, and wc-2. | 2003 | J. Biol. Rhythms | pmid:12932081 |
Chen CK et al. | Scanning chimeragenesis: the approach used to change the substrate selectivity of fatty acid monooxygenase CYP102A1 to that of terpene omega-hydroxylase CYP4C7. | 2010 | J. Biol. Inorg. Chem. | pmid:19727859 |