MeSH term | MeSH ID | Detail |
---|---|---|
Lung Neoplasms | D008175 | 171 associated lipids |
Body Weight | D001835 | 333 associated lipids |
2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Ruiz-Velasco N et al. | Statins upregulate CD36 expression in human monocytes, an effect strengthened when combined with PPAR-gamma ligands Putative contribution of Rho GTPases in statin-induced CD36 expression. | 2004 | Biochem. Pharmacol. | pmid:14698043 |
Downie MM et al. | Peroxisome proliferator-activated receptor and farnesoid X receptor ligands differentially regulate sebaceous differentiation in human sebaceous gland organ cultures in vitro. | 2004 | Br. J. Dermatol. | pmid:15491415 |
Inoue Y et al. | The antibacterial effects of terpene alcohols on Staphylococcus aureus and their mode of action. | 2004 | FEMS Microbiol. Lett. | pmid:15321680 |
Rowat AC and Davis JH | Farnesol-DMPC phase behaviour: a (2)H-NMR study. | 2004 | Biochim. Biophys. Acta | pmid:15003880 |
Hogan DA et al. | A Pseudomonas aeruginosa quorum-sensing molecule influences Candida albicans morphology. | 2004 | Mol. Microbiol. | pmid:15554963 |
Luxová A et al. | Absolute configuration of chiral terpenes in marking pheromones of bumblebees and cuckoo bumblebees. | 2004 | Chirality | pmid:15034905 |
Murataliev MB et al. | Chimeragenesis of the fatty acid binding site of cytochrome P450BM3. Replacement of residues 73-84 with the homologous residues from the insect cytochrome P450 CYP4C7. | 2004 | Biochemistry | pmid:14967018 |
McPherson RA et al. | The novel Ras antagonist, farnesylthiosalicylate, suppresses growth of prostate cancer in vitro. | 2004 | Prostate | pmid:14968433 |
Hornby JM et al. | Inoculum size effect in dimorphic fungi: extracellular control of yeast-mycelium dimorphism in Ceratocystis ulmi. | 2004 | Appl. Environ. Microbiol. | pmid:15006753 |
Wozniak M et al. | Alternative farnesoid structures induce different conformational outcomes upon the Drosophila ortholog of the retinoid X receptor, ultraspiracle. | 2004 | Insect Biochem. Mol. Biol. | pmid:15522611 |
Rudi A et al. | Likonides A and B: new ansa farnesyl quinols from the marine sponge Hyatella sp. | 2004 | Org. Lett. | pmid:15496087 |
Chin PC et al. | The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism. | 2004 | J. Neurochem. | pmid:15255937 |
Dumitru R et al. | Defined anaerobic growth medium for studying Candida albicans basic biology and resistance to eight antifungal drugs. | 2004 | Antimicrob. Agents Chemother. | pmid:15215080 |
Rodrigues Goulart H et al. | Terpenes arrest parasite development and inhibit biosynthesis of isoprenoids in Plasmodium falciparum. | 2004 | Antimicrob. Agents Chemother. | pmid:15215101 |
Schnuch A et al. | Contact allergy to farnesol in 2021 consecutively patch tested patients. Results of the IVDK. | 2004 | Contact Derm. | pmid:15153123 |
Hornby JM and Nickerson KW | Enhanced production of farnesol by Candida albicans treated with four azoles. | 2004 | Antimicrob. Agents Chemother. | pmid:15155241 |
DeBarber AE et al. | Omega-hydroxylation of farnesol by mammalian cytochromes p450. | 2004 | Biochim. Biophys. Acta | pmid:15158752 |
Hartman HL et al. | Lysine beta311 of protein geranylgeranyltransferase type I partially replaces magnesium. | 2004 | J. Biol. Chem. | pmid:15131129 |
Sato T et al. | Farnesol, a morphogenetic autoregulatory substance in the dimorphic fungus Candida albicans, inhibits hyphae growth through suppression of a mitogen-activated protein kinase cascade. | 2004 | Biol. Pharm. Bull. | pmid:15133261 |
Thorpe JL et al. | Germ cell migration in zebrafish is dependent on HMGCoA reductase activity and prenylation. | 2004 | Dev. Cell | pmid:14960282 |
George J et al. | Inhibition of intimal thickening in the rat carotid artery injury model by a nontoxic Ras inhibitor. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:14670932 |
Wang Z et al. | Farnesol for aerosol inhalation: nebulization and activity against human lung cancer cells. | 2003 Jan-Apr | J Pharm Pharm Sci | pmid:12753732 |
Lochnit G and Geyer R | Evidence for the presence of the Kennedy and Bremer- Greenberg pathways in Caenorhabditis elegans. | 2003 | Acta Biochim. Pol. | pmid:14740010 |
Sakata T et al. | Chemical ecology of oribatid mites III. Chemical composition of oil gland exudates from two oribatid mites, Trhypochthoniellus sp. and Trhypochthonius japonicus (Acari: Trhypochthoniidae). | 2003 | Exp. Appl. Acarol. | pmid:14635814 |
Granshaw T et al. | Circadian rhythms in Neurospora crassa: farnesol or geraniol allow expression of rhythmicity in the otherwise arrhythmic strains frq10, wc-1, and wc-2. | 2003 | J. Biol. Rhythms | pmid:12932081 |
Koo H et al. | Inhibition of Streptococcus mutans biofilm accumulation and polysaccharide production by apigenin and tt-farnesol. | 2003 | J. Antimicrob. Chemother. | pmid:14563892 |
Tóth M et al. | Identification of pheromones and optimization of bait composition for click beetle pests (Coleoptera: Elateridae) in Central and Western Europe. | 2003 | Pest Manag. Sci. | pmid:12701702 |
Sen SE et al. | Juvenile hormone biosynthesis in moths: synthesis and evaluation of farnesol homologs as alternate substrates of farnesol oxidase. | 2003 | Insect Biochem. Mol. Biol. | pmid:12770578 |
Katzav A et al. | Inhibition of ras by farnesylthiosalicylate significantly reduces the levels of autoantibodies in two animal models of the antiphospholipid syndrome. | 2003 | Immunobiology | pmid:12638903 |
Berstein LM et al. | New approaches to the understanding of tamoxifen action and resistance. | 2003 | Endocr. Relat. Cancer | pmid:12790788 |
Shohami E et al. | The Ras inhibitor S-trans, trans-farnesylthiosalicylic acid exerts long-lasting neuroprotection in a mouse closed head injury model. | 2003 | J. Cereb. Blood Flow Metab. | pmid:12796721 |
Hornby JM et al. | Farnesol biosynthesis in Candida albicans: cellular response to sterol inhibition by zaragozic acid B. | 2003 | Antimicrob. Agents Chemother. | pmid:12821501 |
Xu L and Simoni RD | The inhibition of degradation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase by sterol regulatory element binding protein cleavage-activating protein requires four phenylalanine residues in span 6 of HMG-CoA reductase transmembrane domain. | 2003 | Arch. Biochem. Biophys. | pmid:12781775 |
Dietrich A et al. | Studies on G-protein alpha.betagamma heterotrimer formation reveal a putative S-prenyl-binding site in the alpha subunit. | 2003 | Biochem. J. | pmid:12952523 |
Shchepin R et al. | Quorum sensing in Candida albicans: probing farnesol's mode of action with 40 natural and synthetic farnesol analogs. | 2003 | Chem. Biol. | pmid:12954333 |
Giricz Z et al. | Role of cholesterol-enriched diet and the mevalonate pathway in cardiac nitric oxide synthesis. | 2003 | Basic Res. Cardiol. | pmid:12955403 |
Iguchi T et al. | Nitrogen-containing bisphosphonates induce S-phase cell cycle arrest and apoptosis of myeloma cells by activating MAPK pathway and inhibiting mevalonate pathway. | 2003 | Cell. Signal. | pmid:12742232 |
Clarke HC et al. | Ras antagonist farnesylthiosalicylic acid (FTS) reduces glomerular cellular proliferation and macrophage number in rat thy-1 nephritis. | 2003 | J. Am. Soc. Nephrol. | pmid:12660318 |
Jones TH et al. | Farnesylamine from the ant Monomorium fieldi Forel. | 2003 | J. Nat. Prod. | pmid:12662086 |
Smalley KS and Eisen TG | Farnesyl transferase inhibitor SCH66336 is cytostatic, pro-apoptotic and enhances chemosensitivity to cisplatin in melanoma cells. | 2003 | Int. J. Cancer | pmid:12673674 |
Song L | Detection of farnesyl diphosphate accumulation in yeast ERG9 mutants. | 2003 | Anal. Biochem. | pmid:12758256 |
Halaschek-Wiener J et al. | Farnesyl thiosalicylic acid chemosensitizes human melanoma in vivo. | 2003 | J. Invest. Dermatol. | pmid:12535206 |
Zoccarato F et al. | The adenosine inhibition of glutamate exocytosis in synaptosomes is removed by the collapse of the vesicle-cytosol deltapH plus the opening of farnesol-sensitive Ca(2+) channels. | 2003 | Cell Calcium | pmid:12618148 |
Still K et al. | Effects of risedronate, alendronate, and etidronate on the viability and activity of rat bone marrow stromal cells in vitro. | 2003 | Calcif. Tissue Int. | pmid:12457261 |
Hiyoshi H et al. | Squalene synthase inhibitors suppress triglyceride biosynthesis through the farnesol pathway in rat hepatocytes. | 2003 | J. Lipid Res. | pmid:12518031 |
Töyräs A et al. | Inhibition of mevalonate pathway is involved in alendronate-induced cell growth inhibition, but not in cytokine secretion from macrophages in vitro. | 2003 | Eur J Pharm Sci | pmid:12885386 |
Houten SM et al. | Isoprenoid biosynthesis in hereditary periodic fever syndromes and inflammation. | 2003 | Cell. Mol. Life Sci. | pmid:12861380 |
Brehm-Stecher BF and Johnson EA | Sensitization of Staphylococcus aureus and Escherichia coli to antibiotics by the sesquiterpenoids nerolidol, farnesol, bisabolol, and apritone. | 2003 | Antimicrob. Agents Chemother. | pmid:14506058 |
Ownby SE and Hohl RJ | Isoprenoid alcohols restore protein isoprenylation in a time-dependent manner independent of protein synthesis. | 2003 | Lipids | pmid:14506838 |
Mau CJ et al. | Protein farnesyltransferase inhibitors interfere with farnesyl diphosphate binding by rubber transferase. | 2003 | Eur. J. Biochem. | pmid:14511375 |
Li X et al. | New polyoxygenated farnesylcyclohexenones, deacetoxyyanuthone A and its hydro derivative from the marine-derived fungus Penicillium sp. | 2003 | J. Nat. Prod. | pmid:14640527 |
McAnally JA et al. | Farnesyl-O-acetylhydroquinone and geranyl-O-acetylhydroquinone suppress the proliferation of murine B16 melanoma cells, human prostate and colon adenocarcinoma cells, human lung carcinoma cells, and human leukemia cells. | 2003 | Cancer Lett. | pmid:14643448 |
Sever N et al. | Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol. | 2003 | J. Biol. Chem. | pmid:14563840 |
Grossman R et al. | Increase in peripheral benzodiazepine receptors and loss of glutamate NMDA receptors in a mouse model of closed head injury: a quantitative autoradiographic study. | 2003 | Neuroimage | pmid:14683703 |
Koo H et al. | Effects of apigenin and tt-farnesol on glucosyltransferase activity, biofilm viability and caries development in rats. | 2002 | Oral Microbiol. Immunol. | pmid:12485324 |
Schnee C et al. | The maize gene terpene synthase 1 encodes a sesquiterpene synthase catalyzing the formation of (E)-beta-farnesene, (E)-nerolidol, and (E,E)-farnesol after herbivore damage. | 2002 | Plant Physiol. | pmid:12481088 |
Hamada M et al. | Farnesylpyridinium, an analog of isoprenoid farnesol, induces apoptosis but suppresses apoptotic body formation in human promyelocytic leukemia cells. | 2002 | FEBS Lett. | pmid:11943160 |
Mizukami Y | [Oleylamine (long-chain fatty amine)-induced cell death through MAP kinase pathways in human pancreatic cancer cells]. | 2002 | Hokkaido Igaku Zasshi | pmid:11868368 |
Ownby SE and Hohl RJ | Farnesol and geranylgeraniol: prevention and reversion of lovastatin-induced effects in NIH3T3 cells. | 2002 | Lipids | pmid:11908910 |
Gana-Weisz M et al. | The Ras inhibitor S-trans,trans-farnesylthiosalicylic acid chemosensitizes human tumor cells without causing resistance. | 2002 | Clin. Cancer Res. | pmid:11839677 |
Smalley KS and Eisen TG | Farnesyl thiosalicylic acid inhibits the growth of melanoma cells through a combination of cytostatic and pro-apoptotic effects. | 2002 | Int. J. Cancer | pmid:11920610 |
Inoue I et al. | Fibrate and statin synergistically increase the transcriptional activities of PPARalpha/RXRalpha and decrease the transactivation of NFkappaB. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11779144 |
Teal PE | Effects of allatotropin and allatostatin on in vitro production of juvenile hormones by the corpora allata of virgin females of the moths of Heliothis virescens and Manduca sexta. | 2002 | Peptides | pmid:11897385 |
Meinhardt G et al. | Effect of novel modulators of protein kinase C activity upon chemotherapy-induced differentiation and apoptosis in myeloid leukemic cells. | 2002 | Anticancer Drugs | pmid:12187329 |
Chakrabarti D et al. | Protein farnesyltransferase and protein prenylation in Plasmodium falciparum. | 2002 | J. Biol. Chem. | pmid:12194969 |
Akiyama H et al. | Actions of farnesol and xylitol against Staphylococcus aureus. | 2002 | Chemotherapy | pmid:12138327 |
Takahashi N et al. | Dual action of isoprenols from herbal medicines on both PPARgamma and PPARalpha in 3T3-L1 adipocytes and HepG2 hepatocytes. | 2002 | FEBS Lett. | pmid:11943173 |
George J et al. | Functional inhibition of Ras by S-trans,trans-farnesyl thiosalicylic acid attenuates atherosclerosis in apolipoprotein E knockout mice. | 2002 | Circulation | pmid:12021230 |
Raner GM et al. | Farnesol as an inhibitor and substrate for rabbit liver microsomal P450 enzymes. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12054554 |
Lagace TA et al. | Caspase processing and nuclear export of CTP:phosphocholine cytidylyltransferase alpha during farnesol-induced apoptosis. | 2002 | Mol. Cell. Biol. | pmid:12052891 |
Frenkel J et al. | Lack of isoprenoid products raises ex vivo interleukin-1beta secretion in hyperimmunoglobulinemia D and periodic fever syndrome. | 2002 | Arthritis Rheum. | pmid:12384940 |
Ludolph B et al. | Solution- and solid-phase synthesis of the polybasic lipid-modified C termini of Rho A and K-Ras 4B. | 2002 | Chembiochem | pmid:12210992 |
Ramage G et al. | Inhibition of Candida albicans biofilm formation by farnesol, a quorum-sensing molecule. | 2002 | Appl. Environ. Microbiol. | pmid:12406738 |
Wright MM and McMaster CR | Phospholipid synthesis, diacylglycerol compartmentation, and apoptosis. | 2002 | Biol. Res. | pmid:12415740 |
Kato N et al. | Treatment of the chronic inflammation in peripheral target tissue improves the crushed nerve recovery in the rat: histopathological assessment of the nerve recovery. | 2002 | J. Neurol. Sci. | pmid:12220695 |
Ward SM et al. | TGFbeta regulates the expression of G alpha(i2) via an effect on the localization of ras. | 2002 | J. Mol. Cell. Cardiol. | pmid:12392895 |
Goodwin TE et al. | African elephant sesquiterpenes. II. Identification and synthesis of new derivatives of 2,3-dihydrofarnesol. | 2002 | J. Nat. Prod. | pmid:12350155 |
Rao CV et al. | Chemopreventive effect of farnesol and lanosterol on colon carcinogenesis. | 2002 | Cancer Detect. Prev. | pmid:12507226 |
Winn LM and Wells PG | Evidence for Ras-dependent signal transduction in phenytoin teratogenicity. | 2002 | Toxicol. Appl. Pharmacol. | pmid:12460742 |
Kim S et al. | Evaluation of morphogenic regulatory activity of farnesoic acid and its derivatives against Candida albicans dimorphism. | 2002 | Bioorg. Med. Chem. Lett. | pmid:11958988 |
Du Y and Wiemer DF | Alpha-phosphono lactone analogues of farnesyl pyrophosphate: an asymmetric synthesis via ring-closing metathesis. | 2002 | J. Org. Chem. | pmid:12153272 |
Radetich B and Corey EJ | A general stereocontrolled, convergent synthesis of oligoprenols that parallels the biosynthetic pathway. | 2002 | J. Am. Chem. Soc. | pmid:11890779 |
Cheng QF et al. | Effect of perillic acid, a putative isoprenylation inhibitor, on the cultured rat lens. | 2001 | Exp. Eye Res. | pmid:11446774 |
Cantrell CL et al. | Antimycobacterial plant terpenoids. | 2001 | Planta Med. | pmid:11731906 |
Hanley K et al. | Cholesterol sulfate stimulates involucrin transcription in keratinocytes by increasing Fra-1, Fra-2, and Jun D. | 2001 | J. Lipid Res. | pmid:11254751 |
Sperry AE and Sen SE | Farnesol oxidation in insects: evidence that the biosynthesis of insect juvenile hormone is mediated by a specific alcohol oxidase. | 2001 | Insect Biochem. Mol. Biol. | pmid:11164339 |
Villegas LF et al. | (+)-epi-Alpha-bisabolol [correction of bisbolol] is the wound-healing principle of Peperomia galioides: investigation of the in vivo wound-healing activity of related terpenoids. | 2001 | J. Nat. Prod. | pmid:11678668 |
Mizukami Y et al. | Requirement of c-jun N-terminal kinase for apoptotic cell death induced by farnesyltransferase inhibitor, farnesylamine, in human pancreatic cancer cells. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11594773 |
Karussis D et al. | The Ras-pathway inhibitor, S-trans-trans-farnesylthiosalicylic acid, suppresses experimental allergic encephalomyelitis. | 2001 | J. Neuroimmunol. | pmid:11694313 |
Kim SY et al. | Inhibition effect of new farnesol derivatives on all-trans-retinoic acid metabolism. | 2001 | Metab. Clin. Exp. | pmid:11699057 |
Sari R et al. | Impairment by lovastatin of neural relaxation of the rabbit sphincter of Oddi. | 2001 | Eur. J. Pharmacol. | pmid:11734192 |
Rakhit RD et al. | Role of G proteins and modulation of p38 MAPK activation in the protection by nitric oxide against ischemia-reoxygenation injury. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11527399 |
Nah J et al. | Partial characterization of farnesyl and geranylgeranyl diphosphatases induced in rice seedlings by UV-C irradiation. | 2001 | Plant Cell Physiol. | pmid:11522913 |
Katzav A et al. | Treatment of MRL/lpr mice, a genetic autoimmune model, with the Ras inhibitor, farnesylthiosalicylate (FTS). | 2001 | Clin. Exp. Immunol. | pmid:11737078 |
Clausen VA et al. | Stereochemical analysis of the reaction catalyzed by human protein geranylgeranyl transferase. | 2001 | Biochemistry | pmid:11300771 |
Rosado JA and Sage SO | Role of the ERK pathway in the activation of store-mediated calcium entry in human platelets. | 2001 | J. Biol. Chem. | pmid:11278479 |
Wright MM et al. | Uncoupling farnesol-induced apoptosis from its inhibition of phosphatidylcholine synthesis. | 2001 | J. Biol. Chem. | pmid:11306571 |
Daily D et al. | Glutaredoxin protects cerebellar granule neurons from dopamine-induced apoptosis by dual activation of the ras-phosphoinositide 3-kinase and jun n-terminal kinase pathways. | 2001 | J. Biol. Chem. | pmid:11290748 |
Fayard E et al. | Xol INXS: role of the liver X and the farnesol X receptors. | 2001 | Curr. Opin. Lipidol. | pmid:11264982 |
Tschantz WR et al. | Lysosomal prenylcysteine lyase is a FAD-dependent thioether oxidase. | 2001 | J. Biol. Chem. | pmid:11078725 |