MeSH term | MeSH ID | Detail |
---|---|---|
Candidiasis, Invasive | D058365 | 2 associated lipids |
Anisakiasis | D017129 | 2 associated lipids |
2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Kuroda M et al. | Sesquiterpene farnesol inhibits recycling of the C55 lipid carrier of the murein monomer precursor contributing to increased susceptibility to beta-lactams in methicillin-resistant Staphylococcus aureus. | 2007 | J. Antimicrob. Chemother. | pmid:17242033 |
Nokhodchi A et al. | The effect of terpene concentrations on the skin penetration of diclofenac sodium. | 2007 | Int J Pharm | pmid:17174049 |
Shapira S et al. | The tumor suppressor neurofibromin confers sensitivity to apoptosis by Ras-dependent and Ras-independent pathways. | 2007 | Cell Death Differ. | pmid:17096025 |
Cho T et al. | Transcriptional changes in Candida albicans Genes by both farnesol and high cell density at an early stage of morphogenesis in N-acetyl-D-glucosamine medium. | 2007 | Nihon Ishinkin Gakkai Zasshi | pmid:17975531 |
Henriques M et al. | Effect of farnesol on Candida dubliniensis morphogenesis. | 2007 | Lett. Appl. Microbiol. | pmid:17257261 |
Navarathna DH et al. | Effect of farnesol on a mouse model of systemic candidiasis, determined by use of a DPP3 knockout mutant of Candida albicans. | 2007 | Infect. Immun. | pmid:17283095 |
Kuroda M et al. | Sesquiterpene farnesol as a competitive inhibitor of lipase activity of Staphylococcus aureus. | 2007 | FEMS Microbiol. Lett. | pmid:17559400 |
Zundelevich A et al. | Suppression of lung cancer tumor growth in a nude mouse model by the Ras inhibitor salirasib (farnesylthiosalicylic acid). | 2007 | Mol. Cancer Ther. | pmid:17541036 |
Navarathna DH et al. | Exogenous farnesol interferes with the normal progression of cytokine expression during candidiasis in a mouse model. | 2007 | Infect. Immun. | pmid:17517874 |
Uppuluri P et al. | Farnesol-mediated inhibition of Candida albicans yeast growth and rescue by a diacylglycerol analogue. | 2007 | Yeast | pmid:17583896 |
Crowell DN et al. | Arabidopsis thaliana plants possess a specific farnesylcysteine lyase that is involved in detoxification and recycling of farnesylcysteine. | 2007 | Plant J. | pmid:17425716 |
Blum R et al. | Gene expression signature of human cancer cell lines treated with the ras inhibitor salirasib (S-farnesylthiosalicylic acid). | 2007 | Cancer Res. | pmid:17409441 |
Rossignol T et al. | Transcriptional response of Candida parapsilosis following exposure to farnesol. | 2007 | Antimicrob. Agents Chemother. | pmid:17684006 |
Cugini C et al. | Farnesol, a common sesquiterpene, inhibits PQS production in Pseudomonas aeruginosa. | 2007 | Mol. Microbiol. | pmid:17640272 |
Vik A et al. | Screening of terpenes and derivatives for antimycobacterial activity; identification of geranylgeraniol and geranylgeranyl acetate as potent inhibitors of Mycobacterium tuberculosis in vitro. | 2007 | Planta Med. | pmid:17924309 |
Lombardi L et al. | Circadian rhythms in Neurospora crassa: clock mutant effects in the absence of a frq-based oscillator. | 2007 | Genetics | pmid:17237512 |
Cheng AX et al. | The rice (E)-beta-caryophyllene synthase (OsTPS3) accounts for the major inducible volatile sesquiterpenes. | 2007 | Phytochemistry | pmid:17524436 |
Wiseman DA et al. | Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21(Cip1) and p27(Kip1) in human pancreatic adenocarcinoma cells. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17138864 |
Fairn GD et al. | A chemogenomic screen in Saccharomyces cerevisiae uncovers a primary role for the mitochondria in farnesol toxicity and its regulation by the Pkc1 pathway. | 2007 | J. Biol. Chem. | pmid:17164236 |
Cetin A et al. | Angiotensin II-induced MAPK phosphorylation mediated by Ras and/or phospholipase C-dependent phosphorylations but not by protein kinase C phosphorylation in cultured rat vascular smooth muscle cells. | 2007 | Pharmacology | pmid:17135774 |
Hasmim M et al. | Zoledronate inhibits endothelial cell adhesion, migration and survival through the suppression of multiple, prenylation-dependent signaling pathways. | 2007 | J. Thromb. Haemost. | pmid:17059425 |
Beiner ME et al. | Ras antagonist inhibits growth and chemosensitizes human epithelial ovarian cancer cells. | 2006 Jan-Feb | Int. J. Gynecol. Cancer | pmid:16515591 |
Kubista B et al. | Anticancer effects of zoledronic acid against human osteosarcoma cells. | 2006 | J. Orthop. Res. | pmid:16602111 |
Chana RS and Brunskill NJ | Thiazolidinediones inhibit albumin uptake by proximal tubular cells through a mechanism independent of peroxisome proliferator activated receptor gamma. | 2006 | Am. J. Nephrol. | pmid:16508249 |
Hemmerlin A et al. | Monitoring farnesol-induced toxicity in tobacco BY-2 cells with a fluorescent analog. | 2006 | Arch. Biochem. Biophys. | pmid:16307722 |
Santen RJ et al. | Farnesylthiosalicylic acid: inhibition of proliferation and enhancement of apoptosis of hormone-dependent breast cancer cells. | 2006 | Anticancer Drugs | pmid:16317288 |
Amos S et al. | Farnesylthiosalicylic acid induces caspase activation and apoptosis in glioblastoma cells. | 2006 | Cell Death Differ. | pmid:16239932 |
Ong TP et al. | Farnesol and geraniol chemopreventive activities during the initial phases of hepatocarcinogenesis involve similar actions on cell proliferation and DNA damage, but distinct actions on apoptosis, plasma cholesterol and HMGCoA reductase. | 2006 | Carcinogenesis | pmid:16332721 |
Rung E et al. | Depletion of substrates for protein prenylation increases apoptosis in human periovulatory granulosa cells. | 2006 | Mol. Reprod. Dev. | pmid:16868926 |
Barkan B et al. | The Ras inhibitor farnesylthiosalicylic acid as a potential therapy for neurofibromatosis type 1. | 2006 | Clin. Cancer Res. | pmid:17000690 |
Saidi S et al. | In vitro synergistic effect of farnesol and human gingival cells against Candida albicans. | 2006 | Yeast | pmid:16845684 |
Blum R et al. | E2F1 identified by promoter and biochemical analysis as a central target of glioblastoma cell-cycle arrest in response to Ras inhibition. | 2006 | Int. J. Cancer | pmid:16496386 |
Semighini CP et al. | Functional characterization of the putative Aspergillus nidulans poly(ADP-ribose) polymerase homolog PrpA. | 2006 | Genetics | pmid:16510786 |
Jabra-Rizk MA et al. | Effect of farnesol on Candida dubliniensis biofilm formation and fluconazole resistance. | 2006 | FEMS Yeast Res. | pmid:17042756 |
Binda C et al. | Structure of the human mitochondrial monoamine oxidase B: new chemical implications for neuroprotectant drug design. | 2006 | Neurology | pmid:17030739 |
Alem MA et al. | Production of tyrosol by Candida albicans biofilms and its role in quorum sensing and biofilm development. | 2006 | Eukaryotic Cell | pmid:16980403 |
Blum R et al. | Suppression of survivin expression in glioblastoma cells by the Ras inhibitor farnesylthiosalicylic acid promotes caspase-dependent apoptosis. | 2006 | Mol. Cancer Ther. | pmid:16985068 |
Jones G et al. | The retinoid-X receptor ortholog, ultraspiracle, binds with nanomolar affinity to an endogenous morphogenetic ligand. | 2006 | FEBS J. | pmid:17064257 |
Wendland J et al. | Use of the Porcine Intestinal Epithelium (PIE)-Assay to analyze early stages of colonization by the human fungal pathogen Candida albicans. | 2006 | J. Basic Microbiol. | pmid:17139615 |
Hamada M et al. | Inhibitory activity of 1-farnesylpyridinium on the spatial control over the assembly of cell wall polysaccharides in Schizosaccharomyces pombe. | 2006 | J. Biochem. | pmid:17092950 |
Duncan RE and Archer MC | Farnesol induces thyroid hormone receptor (THR) beta1 but inhibits THR-mediated signaling in MCF-7 human breast cancer cells. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16540091 |
Semighini CP et al. | Farnesol-induced apoptosis in Aspergillus nidulans reveals a possible mechanism for antagonistic interactions between fungi. | 2006 | Mol. Microbiol. | pmid:16420349 |
Merino SM and Maren S | Hitting Ras where it counts: Ras antagonism in the basolateral amygdala inhibits long-term fear memory. | 2006 | Eur. J. Neurosci. | pmid:16420429 |
Berzat AC et al. | Using inhibitors of prenylation to block localization and transforming activity. | 2006 | Meth. Enzymol. | pmid:16757354 |
Jahangir T et al. | Farnesol prevents Fe-NTA-mediated renal oxidative stress and early tumour promotion markers in rats. | 2006 | Hum Exp Toxicol | pmid:16758765 |
Erlich S et al. | Ras inhibition results in growth arrest and death of androgen-dependent and androgen-independent prostate cancer cells. | 2006 | Biochem. Pharmacol. | pmid:16780807 |
Fuchs BB and Mylonakis E | Using non-mammalian hosts to study fungal virulence and host defense. | 2006 | Curr. Opin. Microbiol. | pmid:16814595 |
Shintre MS et al. | Efficacy of an alcohol-based healthcare hand rub containing synergistic combination of farnesol and benzethonium chloride. | 2006 | Int J Hyg Environ Health | pmid:16750419 |
Nickerson KW et al. | Quorum sensing in dimorphic fungi: farnesol and beyond. | 2006 | Appl. Environ. Microbiol. | pmid:16751484 |
Jensen EC et al. | Farnesol restores wild-type colony morphology to 96% of Candida albicans colony morphology variants recovered following treatment with mutagens. | 2006 | Genome | pmid:16699554 |