2E,6E-farnesol

2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.

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Introduction

To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2E,6E-farnesol?

2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol

MeSH term MeSH ID Detail
Leukemia, Myeloid D007951 52 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Dermatomycoses D003881 17 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Meningioma D008579 11 associated lipids
Neuritis, Autoimmune, Experimental D009444 4 associated lipids
Glioblastoma D005909 27 associated lipids
Nephritis D009393 19 associated lipids
Per page 10 20 50 | Total 42

PubChem Associated disorders and diseases

What pathways are associated with 2E,6E-farnesol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2E,6E-farnesol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 2E,6E-farnesol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2E,6E-farnesol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 2E,6E-farnesol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2E,6E-farnesol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 2E,6E-farnesol

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Per page 10 20 50 100 | Total 950
Authors Title Published Journal PubMed Link
Duncan RE and Archer MC Farnesol decreases serum triglycerides in rats: identification of mechanisms including up-regulation of PPARalpha and down-regulation of fatty acid synthase in hepatocytes. 2008 Lipids pmid:18509688
Savoldi M et al. Farnesol induces the transcriptional accumulation of the Aspergillus nidulans Apoptosis-Inducing Factor (AIF)-like mitochondrial oxidoreductase. 2008 Mol. Microbiol. pmid:18681941
Kotti T et al. Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation. 2008 Proc. Natl. Acad. Sci. U.S.A. pmid:18685105
Au-Yeung KK et al. Herbal isoprenols induce apoptosis in human colon cancer cells through transcriptional activation of PPARgamma. 2008 Cancer Invest. pmid:18608213
Geraldo IM et al. Rapid antibacterial activity of 2 novel hand soaps: evaluation of the risk of development of bacterial resistance to the antibacterial agents. 2008 Infect Control Hosp Epidemiol pmid:18616390
Muramatsu M et al. Accumulation of prenyl alcohols by terpenoid biosynthesis inhibitors in various microorganisms. 2008 Appl. Microbiol. Biotechnol. pmid:18636253
Lapczynski A et al. Fragrance material review on farnesol. 2008 Food Chem. Toxicol. pmid:18640198
Jahangir T and Sultana S Benzo(a)pyrene-induced genotoxicity: attenuation by farnesol in a mouse model. 2008 J Enzyme Inhib Med Chem pmid:18618320
Schleimer K et al. Competition between native liver and graft in auxiliary liver transplantation in a rat model. 2008 Transplant. Proc. pmid:18555091
Hisajima T et al. Protective effects of farnesol against oral candidiasis in mice. 2008 Microbiol. Immunol. pmid:18667031
Scheper MA et al. Farnesol, a fungal quorum-sensing molecule triggers apoptosis in human oral squamous carcinoma cells. 2008 Neoplasia pmid:18714396
Muramatsu M et al. Various oils and detergents enhance the microbial production of farnesol and related prenyl alcohols. 2008 J. Biosci. Bioeng. pmid:18930003
Qamar W and Sultana S Farnesol ameliorates massive inflammation, oxidative stress and lung injury induced by intratracheal instillation of cigarette smoke extract in rats: an initial step in lung chemoprevention. 2008 Chem. Biol. Interact. pmid:18793622
Peleg AY et al. Prokaryote-eukaryote interactions identified by using Caenorhabditis elegans. 2008 Proc. Natl. Acad. Sci. U.S.A. pmid:18794525
Cho T and Aoyama T [Quorum sensing in fungal pathogenesis]. 2008 Nippon Rinsho pmid:19069092
Goldberg L et al. Salirasib (farnesyl thiosalicylic acid) for brain tumor treatment: a convection-enhanced drug delivery study in rats. 2008 Mol. Cancer Ther. pmid:19001442
Cho T et al. [Farnesol as a quorum-sensing molecule in Candida albicans]. 2008 Nihon Ishinkin Gakkai Zasshi pmid:19001754
Davis-Hanna A et al. Farnesol and dodecanol effects on the Candida albicans Ras1-cAMP signalling pathway and the regulation of morphogenesis. 2008 Mol. Microbiol. pmid:18078440
Abbasnezhad H et al. Two different mechanisms for adhesion of Gram-negative bacterium, Pseudomonas fluorescens LP6a, to an oil-water interface. 2008 Colloids Surf B Biointerfaces pmid:17997081
Koo H Strategies to enhance the biological effects of fluoride on dental biofilms. 2008 Adv. Dent. Res. pmid:18694872
Haklai R et al. Orally administered FTS (salirasib) inhibits human pancreatic tumor growth in nude mice. 2008 Cancer Chemother. Pharmacol. pmid:17909812
Zvibel I et al. The effect of Ras inhibition on the proliferation, apoptosis and matrix metalloproteases activity in rat hepatic stellate cells. 2008 Dig. Dis. Sci. pmid:17934818
Journe F et al. Farnesol, a mevalonate pathway intermediate, stimulates MCF-7 breast cancer cell growth through farnesoid-X-receptor-mediated estrogen receptor activation. 2008 Breast Cancer Res. Treat. pmid:17333335
da Silva Morais A et al. Inhibition of the Ras oncoprotein reduces proliferation of hepatocytes in vitro and in vivo in rats. 2008 Clin. Sci. pmid:17678500
Togashi N et al. Effects of two terpene alcohols on the antibacterial activity and the mode of action of farnesol against Staphylococcus aureus. 2008 Molecules pmid:19078849
Shchepin R et al. Influence of heterocyclic and oxime-containing farnesol analogs on quorum sensing and pathogenicity in Candida albicans. 2008 Bioorg. Med. Chem. pmid:18037299
Semighini CP et al. Inhibition of Fusarium graminearum growth and development by farnesol. 2008 FEMS Microbiol. Lett. pmid:18201191
Golczak M et al. Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina. 2008 J. Biol. Chem. pmid:18195010
Maher M et al. Activation of TRPA1 by farnesyl thiosalicylic acid. 2008 Mol. Pharmacol. pmid:18171730
Shimomura K et al. Homofarnesals: female sex attractant pheromone components of the southern cowpea weevil, Callosobruchus chinensis. 2008 J. Chem. Ecol. pmid:18351422
Weber K et al. Secretion of E,E-farnesol and biofilm formation in eight different Candida species. 2008 Antimicrob. Agents Chemother. pmid:18332168
Teshima K and Kondo T Analytical method for determination of allylic isoprenols in rat tissues by liquid chromatography/tandem mass spectrometry following chemical derivatization with 3-nitrophtalic anhydride. 2008 J Pharm Biomed Anal pmid:18313250
Blum R et al. Inhibitors of chronically active ras: potential for treatment of human malignancies. 2008 Recent Pat Anticancer Drug Discov pmid:18289122
Tsangarakis C et al. Zeolite NaY-promoted cyclization of farnesal: a short route to nanaimoal. 2008 J. Org. Chem. pmid:18321121
McAlester G et al. Signal-mediated interactions between Pseudomonas aeruginosa and Candida albicans. 2008 J. Med. Microbiol. pmid:18436588
Joo JH and Jetten AM NF-kappaB-dependent transcriptional activation in lung carcinoma cells by farnesol involves p65/RelA(Ser276) phosphorylation via the MEK-MSK1 signaling pathway. 2008 J. Biol. Chem. pmid:18424438
Kebaara BW et al. Candida albicans Tup1 is involved in farnesol-mediated inhibition of filamentous-growth induction. 2008 Eukaryotic Cell pmid:18424510
Rotblat B et al. The Ras inhibitor farnesylthiosalicylic acid (Salirasib) disrupts the spatiotemporal localization of active Ras: a potential treatment for cancer. 2008 Meth. Enzymol. pmid:18374183
Lorek J et al. Influence of farnesol on the morphogenesis of Aspergillus niger. 2008 J. Basic Microbiol. pmid:18383232
Marcuzzi A et al. Natural isoprenoids are able to reduce inflammation in a mouse model of mevalonate kinase deficiency. 2008 Pediatr. Res. pmid:18391837
Chen CK et al. The effect of mutation of F87 on the properties of CYP102A1-CYP4C7 chimeras: altered regiospecificity and substrate selectivity. 2008 J. Biol. Inorg. Chem. pmid:18392864
Woodard B et al. 3D-QSAR of fungal quorum-sensing inhibiting analogs of farnesol. 2007 Mar-Apr J Environ Sci Health B pmid:17454380
Bellahcène A et al. Zoledronate inhibits alphavbeta3 and alphavbeta5 integrin cell surface expression in endothelial cells. 2007 Mar-Apr Endothelium pmid:17497369
Yue W et al. Mechanisms of acquired resistance to endocrine therapy in hormone-dependent breast cancer cells. 2007 Aug-Sep J. Steroid Biochem. Mol. Biol. pmid:17616457
Cugini C et al. Farnesol, a common sesquiterpene, inhibits PQS production in Pseudomonas aeruginosa. 2007 Mol. Microbiol. pmid:17640272
Dumitru R et al. In vivo and in vitro anaerobic mating in Candida albicans. 2007 Eukaryotic Cell pmid:17259544
Shintre MS et al. Evaluation of an alcohol-based surgical hand disinfectant containing a synergistic combination of farnesol and benzethonium chloride for immediate and persistent activity against resident hand flora of volunteers and with a novel in vitro pig skin model. 2007 Infect Control Hosp Epidemiol pmid:17265401
Zhang L and Hill RP Hypoxia enhances metastatic efficiency in HT1080 fibrosarcoma cells by increasing cell survival in lungs, not cell adhesion and invasion. 2007 Cancer Res. pmid:17699784
Joo JH et al. Farnesol-induced apoptosis in human lung carcinoma cells is coupled to the endoplasmic reticulum stress response. 2007 Cancer Res. pmid:17699800
Lee H et al. Characterization of (E,E)-farnesol and its fatty acid esters from anal scent glands of nutria (Myocastor coypus) by gas chromatography-mass spectrometry and gas chromatography-infrared spectrometry. 2007 J Chromatogr A pmid:17709112