| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Myeloid | D007951 | 52 associated lipids |
| Leukemia, Myeloid, Acute | D015470 | 19 associated lipids |
| Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
| Dermatomycoses | D003881 | 17 associated lipids |
| Hypergammaglobulinemia | D006942 | 9 associated lipids |
| Encephalomyelitis, Autoimmune, Experimental | D004681 | 26 associated lipids |
| Meningioma | D008579 | 11 associated lipids |
| Neuritis, Autoimmune, Experimental | D009444 | 4 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Nephritis | D009393 | 19 associated lipids |
2E,6E-farnesol
2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
Cross Reference
Introduction
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 2E,6E-farnesol?
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
PubChem Associated disorders and diseases
What pathways are associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 2E,6E-farnesol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 2E,6E-farnesol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 2E,6E-farnesol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 2E,6E-farnesol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 2E,6E-farnesol?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 2E,6E-farnesol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Abbasnezhad H et al. | Two different mechanisms for adhesion of Gram-negative bacterium, Pseudomonas fluorescens LP6a, to an oil-water interface. | 2008 | Colloids Surf B Biointerfaces | pmid:17997081 |
| Weber K et al. | Secretion of E,E-farnesol and biofilm formation in eight different Candida species. | 2008 | Antimicrob. Agents Chemother. | pmid:18332168 |
| Cushion MT et al. | Biofilm formation by Pneumocystis spp. | 2009 | Eukaryotic Cell | pmid:18820078 |
| Rennemeier C et al. | Microbial quorum-sensing molecules induce acrosome loss and cell death in human spermatozoa. | 2009 | Infect. Immun. | pmid:19687207 |
| Banfi C et al. | Proteomic analysis of human low-density lipoprotein reveals the presence of prenylcysteine lyase, a hydrogen peroxide-generating enzyme. | 2009 | Proteomics | pmid:19253276 |
| Koo H and Jeon JG | Naturally occurring molecules as alternative therapeutic agents against cariogenic biofilms. | 2009 | Adv. Dent. Res. | pmid:19717411 |
| Gomes FI et al. | Effect of farnesol on planktonic and biofilm cells of Staphylococcus epidermidis. | 2009 | Curr. Microbiol. | pmid:19365686 |
| Shirtliff ME et al. | Farnesol-induced apoptosis in Candida albicans. | 2009 | Antimicrob. Agents Chemother. | pmid:19364863 |
| Chen F et al. | Tooth-binding micelles for dental caries prevention. | 2009 | Antimicrob. Agents Chemother. | pmid:19704121 |
| Goldberg L et al. | New derivatives of farnesylthiosalicylic acid (salirasib) for cancer treatment: farnesylthiosalicylamide inhibits tumor growth in nude mice models. | 2009 | J. Med. Chem. | pmid:19072665 |
| Ohto C et al. | Prenyl alcohol production by expression of exogenous isopentenyl diphosphate isomerase and farnesyl diphosphate synthase genes in Escherichia coli. | 2009 | Biosci. Biotechnol. Biochem. | pmid:19129660 |
| Décanis N et al. | Farnesol promotes epithelial cell defense against Candida albicans through Toll-like receptor 2 expression, interleukin-6 and human beta-defensin 2 production. | 2009 | Cytokine | pmid:19121950 |
| Rhome R and Del Poeta M | Lipid signaling in pathogenic fungi. | 2009 | Annu. Rev. Microbiol. | pmid:19450140 |
| Chaudhary SC et al. | Chemopreventive effect of farnesol on DMBA/TPA-induced skin tumorigenesis: involvement of inflammation, Ras-ERK pathway and apoptosis. | 2009 | Life Sci. | pmid:19470390 |
| Kraitzer A et al. | Novel farnesylthiosalicylate (FTS)-eluting composite structures. | 2009 | Eur J Pharm Sci | pmid:19491026 |
| Mor A et al. | Ras inhibition increases the frequency and function of regulatory T cells and attenuates type-1 diabetes in non-obese diabetic mice. | 2009 | Eur. J. Pharmacol. | pmid:19527709 |
| Muramatsu M et al. | Alkaline pH enhances farnesol production by Saccharomyces cerevisiae. | 2009 | J. Biosci. Bioeng. | pmid:19577192 |
| Nowak M and Kurnatowski P | [Biofilm caused by fungi--structure, quorum sensing, morphogenetic changes, resistance to drugs]. | 2009 | Wiad Parazytol | pmid:19579780 |
| Abe S et al. | Suppression of anti-Candida activity of macrophages by a quorum-sensing molecule, farnesol, through induction of oxidative stress. | 2009 | Microbiol. Immunol. | pmid:19493200 |
| Derengowski LS et al. | Antimicrobial effect of farnesol, a Candida albicans quorum sensing molecule, on Paracoccidioides brasiliensis growth and morphogenesis. | 2009 | Ann. Clin. Microbiol. Antimicrob. | pmid:19402910 |
| RodrÃguez C et al. | Statins normalize vascular lysyl oxidase down-regulation induced by proatherogenic risk factors. | 2009 | Cardiovasc. Res. | pmid:19406911 |
| Pando R et al. | Ras inhibition attenuates myocardial ischemia-reperfusion injury. | 2009 | Biochem. Pharmacol. | pmid:19426696 |
| Schneider-Merck T et al. | The Ras inhibitor farnesylthiosalicyclic acid (FTS) prevents nodule formation and development of preneoplastic foci of altered hepatocytes in rats. | 2009 | Eur. J. Cancer | pmid:19427195 |
| Unnanuntana A et al. | The effects of farnesol on Staphylococcus aureus biofilms and osteoblasts. An in vitro study. | 2009 | J Bone Joint Surg Am | pmid:19884443 |
| Mayoral JG et al. | NADP+-dependent farnesol dehydrogenase, a corpora allata enzyme involved in juvenile hormone synthesis. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19940247 |
| Langford ML et al. | Cellular interactions of farnesol, a quorum-sensing molecule produced by Candida albicans. | 2009 | Future Microbiol | pmid:19995193 |
| Jeon JG et al. | Influences of naturally occurring agents in combination with fluoride on gene expression and structural organization of Streptococcus mutans in biofilms. | 2009 | BMC Microbiol. | pmid:19863808 |
| Raptis C et al. | Acid-catalyzed cyclization of terpenes under homogeneous and heterogeneous conditions as probed through stereoisotopic studies: a concerted process with competing preorganized chair and boat transition states. | 2009 | Chemistry | pmid:19780112 |
| Xiao Y et al. | A two-component female-produced pheromone of the spider Pholcus beijingensis. | 2009 | J. Chem. Ecol. | pmid:19579045 |
| Song L | Recovery of E,E-farnesol from cultures of yeast erg9 mutants: extraction with polymeric beads and purification by normal-phase chromatography. | 2009 Jul-Aug | Biotechnol. Prog. | pmid:19569196 |
| Chagas CE et al. | Farnesol inhibits cell proliferation and induces apoptosis after partial hepatectomy in rats. | 2009 Sep-Oct | Acta Cir Bras | pmid:19851690 |
| Ivanov SS et al. | Lipidation by the host prenyltransferase machinery facilitates membrane localization of Legionella pneumophila effector proteins. | 2010 | J. Biol. Chem. | pmid:20813839 |
| Levy R et al. | Galectin-3 promotes chronic activation of K-Ras and differentiation block in malignant thyroid carcinomas. | 2010 | Mol. Cancer Ther. | pmid:20682656 |
| Colabardini AC et al. | Involvement of the Aspergillus nidulans protein kinase C with farnesol tolerance is related to the unfolded protein response. | 2010 | Mol. Microbiol. | pmid:21091509 |
| Gilpin S and Maibach H | Allergic contact dermatitis caused by farnesol: clinical relevance. | 2010 | Cutan Ocul Toxicol | pmid:20858058 |
| Charette N et al. | Salirasib inhibits the growth of hepatocarcinoma cell lines in vitro and tumor growth in vivo through ras and mTOR inhibition. | 2010 | Mol. Cancer | pmid:20860815 |
| Wang C et al. | Farnesol production from Escherichia coli by harnessing the exogenous mevalonate pathway. | 2010 | Biotechnol. Bioeng. | pmid:20552672 |
| Aizman E et al. | The combined treatment of Copaxone and Salirasib attenuates experimental autoimmune encephalomyelitis (EAE) in mice. | 2010 | J. Neuroimmunol. | pmid:20869125 |
| Kubesová A et al. | Separation of attogram terpenes by the capillary zone electrophoresis with fluorometric detection. | 2010 | J Chromatogr A | pmid:20933239 |
| Bhagatji P et al. | Multiple cellular proteins modulate the dynamics of K-ras association with the plasma membrane. | 2010 | Biophys. J. | pmid:21081081 |
| Bhandari J et al. | Identification of a novel abscisic acid-regulated farnesol dehydrogenase from Arabidopsis. | 2010 | Plant Physiol. | pmid:20807998 |
| Jin J et al. | Farnesol, a potential efflux pump inhibitor in Mycobacterium smegmatis. | 2010 | Molecules | pmid:21042264 |
| Eglin D et al. | Farnesol-modified biodegradable polyurethanes for cartilage tissue engineering. | 2010 | J Biomed Mater Res A | pmid:19191318 |
| Chen CK et al. | Scanning chimeragenesis: the approach used to change the substrate selectivity of fatty acid monooxygenase CYP102A1 to that of terpene omega-hydroxylase CYP4C7. | 2010 | J. Biol. Inorg. Chem. | pmid:19727859 |
| Tsimberidou AM et al. | Phase 1 first-in-human clinical study of S-trans,trans-farnesylthiosalicylic acid (salirasib) in patients with solid tumors. | 2010 | Cancer Chemother. Pharmacol. | pmid:19484470 |
| Joo JH and Jetten AM | Molecular mechanisms involved in farnesol-induced apoptosis. | 2010 | Cancer Lett. | pmid:19520495 |
| Lee SJ and Moon HI | Immunotoxicity activity of the major essential oil of Filipendula glaberrima against Aedes aegypti L. | 2010 | Immunopharmacol Immunotoxicol | pmid:20175741 |
| Hanker AB et al. | Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling. | 2010 | Oncogene | pmid:19838215 |
| Langford ML et al. | Activity and toxicity of farnesol towards Candida albicans are dependent on growth conditions. | 2010 | Antimicrob. Agents Chemother. | pmid:19933803 |
| Grienke U et al. | Antiviral potential and molecular insight into neuraminidase inhibiting diarylheptanoids from Alpinia katsumadai. | 2010 | J. Med. Chem. | pmid:20014777 |
| Yaari-Stark S et al. | Ras inhibits endoplasmic reticulum stress in human cancer cells with amplified Myc. | 2010 | Int. J. Cancer | pmid:19998334 |
| Banke TG et al. | Dynamic changes in the TRPA1 selectivity filter lead to progressive but reversible pore dilation. | 2010 | Am. J. Physiol., Cell Physiol. | pmid:20457836 |
| Ling Y et al. | Synthesis and evaluation of nitric oxide-releasing derivatives of farnesylthiosalicylic acid as anti-tumor agents. | 2010 | Bioorg. Med. Chem. | pmid:20435479 |
| Sarazin A et al. | In vitro pro- and anti-inflammatory responses to viable Candida albicans yeasts by a murine macrophage cell line. | 2010 | Med. Mycol. | pmid:20438293 |
| Lee J et al. | Proto-oncogenic H-Ras, K-Ras, and N-Ras are involved in muscle differentiation via phosphatidylinositol 3-kinase. | 2010 | Cell Res. | pmid:20603646 |
| Shimomura K et al. | 2,3-Dihydrohomofarnesal: female sex attractant pheromone component of Callosobruchus rhodesianus (Pic). | 2010 | J. Chem. Ecol. | pmid:20607368 |
| Gregus P et al. | Ultra high performance liquid chromatography tandem mass spectrometry analysis of quorum-sensing molecules of Candida albicans. | 2010 | J Pharm Biomed Anal | pmid:20580513 |
| Ghosh S et al. | Candida albicans cell wall components and farnesol stimulate the expression of both inflammatory and regulatory cytokines in the murine RAW264.7 macrophage cell line. | 2010 | FEMS Immunol. Med. Microbiol. | pmid:20618847 |
| Dinamarco TM et al. | The roles played by Aspergillus nidulans apoptosis-inducing factor (AIF)-like mitochondrial oxidoreductase (AifA) and NADH-ubiquinone oxidoreductases (NdeA-B and NdiA) in farnesol resistance. | 2010 | Fungal Genet. Biol. | pmid:20654725 |
| Cugini C et al. | Candida albicans-produced farnesol stimulates Pseudomonas quinolone signal production in LasR-defective Pseudomonas aeruginosa strains. | 2010 | Microbiology (Reading, Engl.) | pmid:20656785 |
| Weber K et al. | The quorum-sensing molecule E,E-farnesol--its variable secretion and its impact on the growth and metabolism of Candida species. | 2010 | Yeast | pmid:20641010 |
| Bustinza-Linares E et al. | Salirasib in the treatment of pancreatic cancer. | 2010 | Future Oncol | pmid:20528225 |
| Deveau A et al. | Farnesol induces hydrogen peroxide resistance in Candida albicans yeast by inhibiting the Ras-cyclic AMP signaling pathway. | 2010 | Eukaryotic Cell | pmid:20118211 |
| Moya M et al. | Enhanced steatosis by nuclear receptor ligands: a study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile. | 2010 | Chem. Biol. Interact. | pmid:20079722 |
| Räikkönen J et al. | Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells. | 2010 | Biochem. Pharmacol. | pmid:19819230 |
| Doan K et al. | In vivo and in vitro skin absorption of lipophilic compounds, dibutyl phthalate, farnesol and geraniol in the hairless guinea pig. | 2010 | Food Chem. Toxicol. | pmid:19747520 |
| Endo S et al. | Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10. | 2010 | Bioorg. Med. Chem. | pmid:20304656 |
| Dichtl K et al. | Farnesol misplaces tip-localized Rho proteins and inhibits cell wall integrity signalling in Aspergillus fumigatus. | 2010 | Mol. Microbiol. | pmid:20398212 |
| Pando R et al. | The Ras antagonist farnesylthiosalicylic acid ameliorates experimental myocarditis in the rat. | 2010 Mar-Apr | Cardiovasc. Pathol. | pmid:19144546 |
| Liu P et al. | Farnesol induces apoptosis and oxidative stress in the fungal pathogen Penicillium expansum. | 2010 Mar-Apr | Mycologia | pmid:20361499 |
| Deveau A and Hogan DA | Linking quorum sensing regulation and biofilm formation by Candida albicans. | 2011 | Methods Mol. Biol. | pmid:21031315 |
| Gonçalves O et al. | Evaluation of the mutagenicity of sesquiterpenic compounds and their influence on the susceptibility towards antibiotics of two clinically relevant bacterial strains. | 2011 | Mutat. Res. | pmid:21453784 |
| Mor A et al. | Inhibitory effect of farnesylthiosalicylic acid on mediators release by mast cells: preferential inhibition of prostaglandin D(2) and tumor necrosis factor-α release. | 2011 | Inflammation | pmid:20706780 |
| Ling Y et al. | Novel nitric oxide-releasing derivatives of farnesylthiosalicylic acid: synthesis and evaluation of antihepatocellular carcinoma activity. | 2011 | J. Med. Chem. | pmid:21504204 |
| Jeon JG et al. | Influences of trans-trans farnesol, a membrane-targeting sesquiterpenoid, on Streptococcus mutans physiology and survival within mixed-species oral biofilms. | 2011 | Int J Oral Sci | pmid:21485314 |
| Navarro-Moll MC et al. | In vitro and in vivo activity of three sesquiterpenes against L(3) larvae of Anisakis type I. | 2011 | Exp. Parasitol. | pmid:20932829 |
| Huang J et al. | Electrohydrodynamic deposition of nanotitanium doped hydroxyapatite coating for medical and dental applications. | 2011 | J Mater Sci Mater Med | pmid:21243517 |
| Hogan DA and Muhlschlegel FA | Candida albicans developmental regulation: adenylyl cyclase as a coincidence detector of parallel signals. | 2011 | Curr. Opin. Microbiol. | pmid:22014725 |
| Krasowski MD et al. | The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species. | 2011 | BMC Biochem. | pmid:21291553 |
| Bai C et al. | Characterization of a hyperactive Cyr1 mutant reveals new regulatory mechanisms for cellular cAMP levels in Candida albicans. | 2011 | Mol. Microbiol. | pmid:21992526 |
| Endo S et al. | Roles of rat and human aldo-keto reductases in metabolism of farnesol and geranylgeraniol. | 2011 | Chem. Biol. Interact. | pmid:21187079 |
| Cortés M et al. | Drimenol: A versatile synthon for compounds with trans-drimane skeleton. | 2011 | Nat Prod Commun | pmid:21560760 |
| Borbath I and Stärkel P | Chemoprevention of hepatocellular carcinoma. Proof of concept in animal models. | 2011 | Acta Gastroenterol. Belg. | pmid:21563652 |
| Zhu J et al. | Farnesol-induced apoptosis in Candida albicans is mediated by Cdr1-p extrusion and depletion of intracellular glutathione. | 2011 | PLoS ONE | pmid:22205973 |
| Piispanen AE et al. | Roles of Ras1 membrane localization during Candida albicans hyphal growth and farnesol response. | 2011 | Eukaryotic Cell | pmid:21908593 |
| Charron G et al. | Alkynyl-farnesol reporters for detection of protein S-prenylation in cells. | 2011 | Mol Biosyst | pmid:21107478 |
| Epplen R et al. | Differential effects of ibandronate, docetaxel and farnesol treatment alone and in combination on the growth of prostate cancer cell lines. | 2011 | Acta Oncol | pmid:20429730 |
| Bendena WG et al. | Evidence for differential biosynthesis of juvenile hormone (and related) sesquiterpenoids in Drosophila melanogaster. | 2011 | Gen. Comp. Endocrinol. | pmid:21354154 |
| Nagai H et al. | Development of a novel PPARγ ligand screening system using pinpoint fluorescence-probed protein. | 2011 | Biosci. Biotechnol. Biochem. | pmid:21307572 |
| Rahman NK et al. | Enzymatic synthesis of farnesyl laurate in organic solvent: initial water activity, kinetics mechanism, optimization of continuous operation using packed bed reactor and mass transfer studies. | 2011 | Bioprocess Biosyst Eng | pmid:21327986 |
| Gori K et al. | Alcohol-based quorum sensing plays a role in adhesion and sliding motility of the yeast Debaryomyces hansenii. | 2011 | FEMS Yeast Res. | pmid:22093748 |
| Madhani HD | Quorum sensing in fungi: Q&A. | 2011 | PLoS Pathog. | pmid:22046125 |
| Gomes F et al. | Effect of farnesol on structure and composition of Staphylococcus epidermidis biofilm matrix. | 2011 | Curr. Microbiol. | pmid:21800262 |
| Pammi M et al. | Farnesol decreases biofilms of Staphylococcus epidermidis and exhibits synergy with nafcillin and vancomycin. | 2011 | Pediatr. Res. | pmid:21857375 |
| Teodoro JS et al. | Hepatic FXR: key regulator of whole-body energy metabolism. | 2011 | Trends Endocrinol. Metab. | pmid:21862343 |
| Goto T et al. | Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARα-dependent and -independent pathways. | 2011 | Am. J. Physiol. Endocrinol. Metab. | pmid:21862726 |
| Fitzpatrick AH et al. | Roles for farnesol and ABA in Arabidopsis flower development. | 2011 | Plant Signal Behav | pmid:21758018 |
| Mor A et al. | Inhibition of contact sensitivity by farnesylthiosalicylic acid-amide, a potential Rap1 inhibitor. | 2011 | J. Invest. Dermatol. | pmid:21716322 |
| Tsuji F et al. | The geranyl-modified tryptophan residue is crucial for ComXRO-E-2 pheromone biological activity. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21636272 |
| Kaneko M et al. | Effect of farnesol on mevalonate pathway of Staphylococcus aureus. | 2011 | J. Antibiot. | pmid:21772307 |