| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Myeloid | D007951 | 52 associated lipids |
| Leukemia, Myeloid, Acute | D015470 | 19 associated lipids |
| Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
| Dermatomycoses | D003881 | 17 associated lipids |
| Hypergammaglobulinemia | D006942 | 9 associated lipids |
| Encephalomyelitis, Autoimmune, Experimental | D004681 | 26 associated lipids |
| Meningioma | D008579 | 11 associated lipids |
| Neuritis, Autoimmune, Experimental | D009444 | 4 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Nephritis | D009393 | 19 associated lipids |
2E,6E-farnesol
2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
Cross Reference
Introduction
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 2E,6E-farnesol?
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
PubChem Associated disorders and diseases
What pathways are associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 2E,6E-farnesol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 2E,6E-farnesol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 2E,6E-farnesol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 2E,6E-farnesol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 2E,6E-farnesol?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 2E,6E-farnesol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ruiz-Velasco N et al. | Statins upregulate CD36 expression in human monocytes, an effect strengthened when combined with PPAR-gamma ligands Putative contribution of Rho GTPases in statin-induced CD36 expression. | 2004 | Biochem. Pharmacol. | pmid:14698043 |
| Downie MM et al. | Peroxisome proliferator-activated receptor and farnesoid X receptor ligands differentially regulate sebaceous differentiation in human sebaceous gland organ cultures in vitro. | 2004 | Br. J. Dermatol. | pmid:15491415 |
| Yang Z et al. | Host plant volatiles synergize response to sex pheromone in codling moth, Cydia pomonella. | 2004 | J. Chem. Ecol. | pmid:15139312 |
| Inoue Y et al. | The antibacterial effects of terpene alcohols on Staphylococcus aureus and their mode of action. | 2004 | FEMS Microbiol. Lett. | pmid:15321680 |
| Rowat AC and Davis JH | Farnesol-DMPC phase behaviour: a (2)H-NMR study. | 2004 | Biochim. Biophys. Acta | pmid:15003880 |
| Hogan DA et al. | A Pseudomonas aeruginosa quorum-sensing molecule influences Candida albicans morphology. | 2004 | Mol. Microbiol. | pmid:15554963 |
| Luxová A et al. | Absolute configuration of chiral terpenes in marking pheromones of bumblebees and cuckoo bumblebees. | 2004 | Chirality | pmid:15034905 |
| Murataliev MB et al. | Chimeragenesis of the fatty acid binding site of cytochrome P450BM3. Replacement of residues 73-84 with the homologous residues from the insect cytochrome P450 CYP4C7. | 2004 | Biochemistry | pmid:14967018 |
| McPherson RA et al. | The novel Ras antagonist, farnesylthiosalicylate, suppresses growth of prostate cancer in vitro. | 2004 | Prostate | pmid:14968433 |
| Hornby JM et al. | Inoculum size effect in dimorphic fungi: extracellular control of yeast-mycelium dimorphism in Ceratocystis ulmi. | 2004 | Appl. Environ. Microbiol. | pmid:15006753 |
| Fukuda S and Pelus LM | Activated H-Ras regulates hematopoietic cell survival by modulating Survivin. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15369798 |
| Chin PC et al. | The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism. | 2004 | J. Neurochem. | pmid:15255937 |
| Dumitru R et al. | Defined anaerobic growth medium for studying Candida albicans basic biology and resistance to eight antifungal drugs. | 2004 | Antimicrob. Agents Chemother. | pmid:15215080 |
| Rodrigues Goulart H et al. | Terpenes arrest parasite development and inhibit biosynthesis of isoprenoids in Plasmodium falciparum. | 2004 | Antimicrob. Agents Chemother. | pmid:15215101 |
| Schnuch A et al. | Contact allergy to farnesol in 2021 consecutively patch tested patients. Results of the IVDK. | 2004 | Contact Derm. | pmid:15153123 |
| Hornby JM and Nickerson KW | Enhanced production of farnesol by Candida albicans treated with four azoles. | 2004 | Antimicrob. Agents Chemother. | pmid:15155241 |
| DeBarber AE et al. | Omega-hydroxylation of farnesol by mammalian cytochromes p450. | 2004 | Biochim. Biophys. Acta | pmid:15158752 |
| Hartman HL et al. | Lysine beta311 of protein geranylgeranyltransferase type I partially replaces magnesium. | 2004 | J. Biol. Chem. | pmid:15131129 |
| Sato T et al. | Farnesol, a morphogenetic autoregulatory substance in the dimorphic fungus Candida albicans, inhibits hyphae growth through suppression of a mitogen-activated protein kinase cascade. | 2004 | Biol. Pharm. Bull. | pmid:15133261 |
| Thorpe JL et al. | Germ cell migration in zebrafish is dependent on HMGCoA reductase activity and prenylation. | 2004 | Dev. Cell | pmid:14960282 |
| George J et al. | Inhibition of intimal thickening in the rat carotid artery injury model by a nontoxic Ras inhibitor. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:14670932 |
| Wang Z et al. | Farnesol for aerosol inhalation: nebulization and activity against human lung cancer cells. | 2003 Jan-Apr | J Pharm Pharm Sci | pmid:12753732 |
| Sakata T et al. | Chemical ecology of oribatid mites III. Chemical composition of oil gland exudates from two oribatid mites, Trhypochthoniellus sp. and Trhypochthonius japonicus (Acari: Trhypochthoniidae). | 2003 | Exp. Appl. Acarol. | pmid:14635814 |
| Granshaw T et al. | Circadian rhythms in Neurospora crassa: farnesol or geraniol allow expression of rhythmicity in the otherwise arrhythmic strains frq10, wc-1, and wc-2. | 2003 | J. Biol. Rhythms | pmid:12932081 |
| Koo H et al. | Inhibition of Streptococcus mutans biofilm accumulation and polysaccharide production by apigenin and tt-farnesol. | 2003 | J. Antimicrob. Chemother. | pmid:14563892 |
| Tóth M et al. | Identification of pheromones and optimization of bait composition for click beetle pests (Coleoptera: Elateridae) in Central and Western Europe. | 2003 | Pest Manag. Sci. | pmid:12701702 |
| Sen SE et al. | Juvenile hormone biosynthesis in moths: synthesis and evaluation of farnesol homologs as alternate substrates of farnesol oxidase. | 2003 | Insect Biochem. Mol. Biol. | pmid:12770578 |
| Berstein LM et al. | New approaches to the understanding of tamoxifen action and resistance. | 2003 | Endocr. Relat. Cancer | pmid:12790788 |
| Shohami E et al. | The Ras inhibitor S-trans, trans-farnesylthiosalicylic acid exerts long-lasting neuroprotection in a mouse closed head injury model. | 2003 | J. Cereb. Blood Flow Metab. | pmid:12796721 |
| Hornby JM et al. | Farnesol biosynthesis in Candida albicans: cellular response to sterol inhibition by zaragozic acid B. | 2003 | Antimicrob. Agents Chemother. | pmid:12821501 |
| Xu L and Simoni RD | The inhibition of degradation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase by sterol regulatory element binding protein cleavage-activating protein requires four phenylalanine residues in span 6 of HMG-CoA reductase transmembrane domain. | 2003 | Arch. Biochem. Biophys. | pmid:12781775 |
| Dietrich A et al. | Studies on G-protein alpha.betagamma heterotrimer formation reveal a putative S-prenyl-binding site in the alpha subunit. | 2003 | Biochem. J. | pmid:12952523 |
| Shchepin R et al. | Quorum sensing in Candida albicans: probing farnesol's mode of action with 40 natural and synthetic farnesol analogs. | 2003 | Chem. Biol. | pmid:12954333 |
| Giricz Z et al. | Role of cholesterol-enriched diet and the mevalonate pathway in cardiac nitric oxide synthesis. | 2003 | Basic Res. Cardiol. | pmid:12955403 |
| Iguchi T et al. | Nitrogen-containing bisphosphonates induce S-phase cell cycle arrest and apoptosis of myeloma cells by activating MAPK pathway and inhibiting mevalonate pathway. | 2003 | Cell. Signal. | pmid:12742232 |
| Clarke HC et al. | Ras antagonist farnesylthiosalicylic acid (FTS) reduces glomerular cellular proliferation and macrophage number in rat thy-1 nephritis. | 2003 | J. Am. Soc. Nephrol. | pmid:12660318 |
| Jones TH et al. | Farnesylamine from the ant Monomorium fieldi Forel. | 2003 | J. Nat. Prod. | pmid:12662086 |
| Smalley KS and Eisen TG | Farnesyl transferase inhibitor SCH66336 is cytostatic, pro-apoptotic and enhances chemosensitivity to cisplatin in melanoma cells. | 2003 | Int. J. Cancer | pmid:12673674 |
| Zoccarato F et al. | The adenosine inhibition of glutamate exocytosis in synaptosomes is removed by the collapse of the vesicle-cytosol deltapH plus the opening of farnesol-sensitive Ca(2+) channels. | 2003 | Cell Calcium | pmid:12618148 |
| Still K et al. | Effects of risedronate, alendronate, and etidronate on the viability and activity of rat bone marrow stromal cells in vitro. | 2003 | Calcif. Tissue Int. | pmid:12457261 |
| Hiyoshi H et al. | Squalene synthase inhibitors suppress triglyceride biosynthesis through the farnesol pathway in rat hepatocytes. | 2003 | J. Lipid Res. | pmid:12518031 |
| Töyräs A et al. | Inhibition of mevalonate pathway is involved in alendronate-induced cell growth inhibition, but not in cytokine secretion from macrophages in vitro. | 2003 | Eur J Pharm Sci | pmid:12885386 |
| Houten SM et al. | Isoprenoid biosynthesis in hereditary periodic fever syndromes and inflammation. | 2003 | Cell. Mol. Life Sci. | pmid:12861380 |
| Brehm-Stecher BF and Johnson EA | Sensitization of Staphylococcus aureus and Escherichia coli to antibiotics by the sesquiterpenoids nerolidol, farnesol, bisabolol, and apritone. | 2003 | Antimicrob. Agents Chemother. | pmid:14506058 |
| Ownby SE and Hohl RJ | Isoprenoid alcohols restore protein isoprenylation in a time-dependent manner independent of protein synthesis. | 2003 | Lipids | pmid:14506838 |
| Mau CJ et al. | Protein farnesyltransferase inhibitors interfere with farnesyl diphosphate binding by rubber transferase. | 2003 | Eur. J. Biochem. | pmid:14511375 |
| Li X et al. | New polyoxygenated farnesylcyclohexenones, deacetoxyyanuthone A and its hydro derivative from the marine-derived fungus Penicillium sp. | 2003 | J. Nat. Prod. | pmid:14640527 |
| McAnally JA et al. | Farnesyl-O-acetylhydroquinone and geranyl-O-acetylhydroquinone suppress the proliferation of murine B16 melanoma cells, human prostate and colon adenocarcinoma cells, human lung carcinoma cells, and human leukemia cells. | 2003 | Cancer Lett. | pmid:14643448 |
| Sever N et al. | Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol. | 2003 | J. Biol. Chem. | pmid:14563840 |
| Grossman R et al. | Increase in peripheral benzodiazepine receptors and loss of glutamate NMDA receptors in a mouse model of closed head injury: a quantitative autoradiographic study. | 2003 | Neuroimage | pmid:14683703 |