| MeSH term | MeSH ID | Detail |
|---|---|---|
| Precancerous Conditions | D011230 | 48 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Leukemia, Myeloid, Acute | D015470 | 19 associated lipids |
| HIV Infections | D015658 | 20 associated lipids |
| Head Injuries, Closed | D016489 | 5 associated lipids |
| Anisakiasis | D017129 | 2 associated lipids |
| Dermatitis, Allergic Contact | D017449 | 20 associated lipids |
| Nerve Sheath Neoplasms | D018317 | 4 associated lipids |
2E,6E-farnesol
2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
Cross Reference
Introduction
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 2E,6E-farnesol?
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
PubChem Associated disorders and diseases
What pathways are associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 2E,6E-farnesol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 2E,6E-farnesol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 2E,6E-farnesol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 2E,6E-farnesol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 2E,6E-farnesol?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 2E,6E-farnesol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Colabardini AC et al. | Involvement of the Aspergillus nidulans protein kinase C with farnesol tolerance is related to the unfolded protein response. | 2010 | Mol. Microbiol. | pmid:21091509 |
| Savoldi M et al. | Farnesol induces the transcriptional accumulation of the Aspergillus nidulans Apoptosis-Inducing Factor (AIF)-like mitochondrial oxidoreductase. | 2008 | Mol. Microbiol. | pmid:18681941 |
| Bai C et al. | Characterization of a hyperactive Cyr1 mutant reveals new regulatory mechanisms for cellular cAMP levels in Candida albicans. | 2011 | Mol. Microbiol. | pmid:21992526 |
| Davis-Hanna A et al. | Farnesol and dodecanol effects on the Candida albicans Ras1-cAMP signalling pathway and the regulation of morphogenesis. | 2008 | Mol. Microbiol. | pmid:18078440 |
| Dichtl K et al. | Farnesol misplaces tip-localized Rho proteins and inhibits cell wall integrity signalling in Aspergillus fumigatus. | 2010 | Mol. Microbiol. | pmid:20398212 |
| Semighini CP et al. | Farnesol-induced apoptosis in Aspergillus nidulans reveals a possible mechanism for antagonistic interactions between fungi. | 2006 | Mol. Microbiol. | pmid:16420349 |
| Funari SS et al. | Farnesol and geranylgeraniol modulate the structural properties of phosphatidylethanolamine model membranes. | 2005 Jul-Aug | Mol. Membr. Biol. | pmid:16154902 |
| Halaschek-Wiener J et al. | A novel Ras antagonist regulates both oncogenic Ras and the tumor suppressor p53 in colon cancer cells. | 2000 | Mol. Med. | pmid:11055588 |
| McMahon LP et al. | Farnesylthiosalicylic acid inhibits mammalian target of rapamycin (mTOR) activity both in cells and in vitro by promoting dissociation of the mTOR-raptor complex. | 2005 | Mol. Endocrinol. | pmid:15459249 |
| Cox AD et al. | Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein. | 1992 | Mol. Cell. Biol. | pmid:1375323 |
| Lagace TA et al. | Caspase processing and nuclear export of CTP:phosphocholine cytidylyltransferase alpha during farnesol-induced apoptosis. | 2002 | Mol. Cell. Biol. | pmid:12052891 |
| Ferdinandy P et al. | Rapid pacing-induced preconditioning is recaptured by farnesol treatment in hearts of cholesterol-fed rats: role of polyprenyl derivatives and nitric oxide. | 1998 | Mol. Cell. Biochem. | pmid:9774182 |
| Léger T et al. | The Metacaspase (Mca1p) Restricts O-glycosylation During Farnesol-induced Apoptosis in Candida albicans. | 2016 | Mol. Cell Proteomics | pmid:27125826 |
| Léger T et al. | The metacaspase (Mca1p) has a dual role in farnesol-induced apoptosis in Candida albicans. | 2015 | Mol. Cell Proteomics | pmid:25348831 |
| Ura H et al. | Selective cytotoxicity of farnesylamine to pancreatic carcinoma cells and Ki-ras-transformed fibroblasts. | 1998 | Mol. Carcinog. | pmid:9496909 |
| Stärkel P et al. | Ras inhibition in hepatocarcinoma by S-trans-trans-farnesylthiosalicyclic acid: association of its tumor preventive effect with cell proliferation, cell cycle events, and angiogenesis. | 2012 | Mol. Carcinog. | pmid:21882255 |
| Levy R et al. | Galectin-3 promotes chronic activation of K-Ras and differentiation block in malignant thyroid carcinomas. | 2010 | Mol. Cancer Ther. | pmid:20682656 |
| Barkan B et al. | Phenotypic reversion of invasive neurofibromin-deficient schwannoma by FTS: Ras inhibition reduces BMP4/Erk/Smad signaling. | 2011 | Mol. Cancer Ther. | pmid:21632464 |
| Zundelevich A et al. | Suppression of lung cancer tumor growth in a nude mouse model by the Ras inhibitor salirasib (farnesylthiosalicylic acid). | 2007 | Mol. Cancer Ther. | pmid:17541036 |
| Blum R et al. | Suppression of survivin expression in glioblastoma cells by the Ras inhibitor farnesylthiosalicylic acid promotes caspase-dependent apoptosis. | 2006 | Mol. Cancer Ther. | pmid:16985068 |