2E,6E-farnesol

2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.

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Introduction

To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2E,6E-farnesol?

2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol

MeSH term MeSH ID Detail
HIV Infections D015658 20 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Neurilemmoma D009442 10 associated lipids
Head Injuries, Closed D016489 5 associated lipids
Insulin Resistance D007333 99 associated lipids
Candidiasis, Oral D002180 11 associated lipids
Neuralgia D009437 28 associated lipids
Lung Injury D055370 14 associated lipids
Neoplasms, Glandular and Epithelial D009375 12 associated lipids
Nerve Sheath Neoplasms D018317 4 associated lipids
Per page 10 20 50 | Total 42

PubChem Associated disorders and diseases

What pathways are associated with 2E,6E-farnesol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2E,6E-farnesol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 2E,6E-farnesol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2E,6E-farnesol?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 2E,6E-farnesol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2E,6E-farnesol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 2E,6E-farnesol

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Authors Title Published Journal PubMed Link
Deveau A and Hogan DA Linking quorum sensing regulation and biofilm formation by Candida albicans. 2011 Methods Mol. Biol. pmid:21031315
Mann FM et al. Rv0989c encodes a novel (E)-geranyl diphosphate synthase facilitating decaprenyl diphosphate biosynthesis in Mycobacterium tuberculosis. 2011 FEBS Lett. pmid:21237161
de Castro Pimentel Figueiredo B et al. The Aspergillus nidulans nucA(EndoG) homologue is not involved in cell death. 2011 Eukaryotic Cell pmid:21131437
Gomes F et al. Farnesol as antibiotics adjuvant in Staphylococcus epidermidis control in vitro. 2011 Am. J. Med. Sci. pmid:21107231
Shareck J and Belhumeur P Modulation of morphogenesis in Candida albicans by various small molecules. 2011 Eukaryotic Cell pmid:21642508
Yang L et al. ZL11n is a novel nitric oxide-releasing derivative of farnesylthiosalicylic acid that induces apoptosis in human hepatoma HepG2 cells via MAPK/mitochondrial pathways. 2011 Biochem. Biophys. Res. Commun. pmid:21621522
Yoo S et al. Antimicrobial traits of tea- and cranberry-derived polyphenols against Streptococcus mutans. 2011 Caries Res. pmid:21720161
Mor A et al. Inhibitory effect of farnesylthiosalicylic acid on mediators release by mast cells: preferential inhibition of prostaglandin D(2) and tumor necrosis factor-α release. 2011 Inflammation pmid:20706780
Zhang L et al. Bisbibenzyls, a new type of antifungal agent, inhibit morphogenesis switch and biofilm formation through upregulation of DPP3 in Candida albicans. 2011 PLoS ONE pmid:22174935
Hall RA et al. The quorum-sensing molecules farnesol/homoserine lactone and dodecanol operate via distinct modes of action in Candida albicans. 2011 Eukaryotic Cell pmid:21666074
Biran A et al. Downregulation of survivin and aurora A by histone deacetylase and RAS inhibitors: a new drug combination for cancer therapy. 2011 Int. J. Cancer pmid:20473860
Madhani HD Quorum sensing in fungi: Q&A. 2011 PLoS Pathog. pmid:22046125
Gomes F et al. Effect of farnesol on structure and composition of Staphylococcus epidermidis biofilm matrix. 2011 Curr. Microbiol. pmid:21800262
Pammi M et al. Farnesol decreases biofilms of Staphylococcus epidermidis and exhibits synergy with nafcillin and vancomycin. 2011 Pediatr. Res. pmid:21857375
Teodoro JS et al. Hepatic FXR: key regulator of whole-body energy metabolism. 2011 Trends Endocrinol. Metab. pmid:21862343
Goto T et al. Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARα-dependent and -independent pathways. 2011 Am. J. Physiol. Endocrinol. Metab. pmid:21862726
Fitzpatrick AH et al. Roles for farnesol and ABA in Arabidopsis flower development. 2011 Plant Signal Behav pmid:21758018
Mor A et al. Ras inhibition induces insulin sensitivity and glucose uptake. 2011 PLoS ONE pmid:21738773
Sharma M and Prasad R The quorum-sensing molecule farnesol is a modulator of drug efflux mediated by ABC multidrug transporters and synergizes with drugs in Candida albicans. 2011 Antimicrob. Agents Chemother. pmid:21768514
Nishimori R et al. Biosynthesis of unnatural bacteriochlorophyll c derivatives esterified with α,ω-diols in the green sulfur photosynthetic bacterium Chlorobaculum tepidum. 2011 Biochemistry pmid:21846125
Riely GJ et al. A phase II trial of Salirasib in patients with lung adenocarcinomas with KRAS mutations. 2011 J Thorac Oncol pmid:21847063
Tsuji F et al. The geranyl-modified tryptophan residue is crucial for ComXRO-E-2 pheromone biological activity. 2011 Bioorg. Med. Chem. Lett. pmid:21636272
Makovski V et al. Farnesylthiosalicylic acid (salirasib) inhibits Rheb in TSC2-null ELT3 cells: a potential treatment for lymphangioleiomyomatosis. 2012 Int. J. Cancer pmid:21500191
Lim CS et al. Candida and invasive candidiasis: back to basics. 2012 Eur. J. Clin. Microbiol. Infect. Dis. pmid:21544694
Piérard GE et al. Miconazole, a pharmacological barrier to skin fungal infections. 2012 Expert Opin Pharmacother pmid:22568580
Laheru D et al. Integrated preclinical and clinical development of S-trans, trans-Farnesylthiosalicylic Acid (FTS, Salirasib) in pancreatic cancer. 2012 Invest New Drugs pmid:22547163
Agassandian M et al. Calcium-calmodulin kinase I cooperatively regulates nucleocytoplasmic shuttling of CCTα by accessing a nuclear export signal. 2012 Mol. Biol. Cell pmid:22621903
Tashiro M et al. Pravastatin inhibits farnesol production in Candida albicans and improves survival in a mouse model of systemic candidiasis. 2012 Med. Mycol. pmid:21954955
Jaggi AS and Singh N Analgesic potential of intrathecal farnesyl thiosalicylic acid and GW 5074 in vincristine-induced neuropathic pain in rats. 2012 Food Chem. Toxicol. pmid:22326968
Aizman E et al. Ras inhibition by FTS attenuates brain tumor growth in mice by direct antitumor activity and enhanced reactivity of cytotoxic lymphocytes. 2012 Oncotarget pmid:22323550
Qamar W et al. Benzo(a)pyrene-induced pulmonary inflammation, edema, surfactant dysfunction, and injuries in rats: alleviation by farnesol. 2012 Exp. Lung Res. pmid:22168545
Mans RA et al. Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation. 2012 Neuroscience pmid:22192838
Mashiach-Farkash E et al. Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton. 2012 Oncotarget pmid:22776759
András IE et al. Lipid rafts and functional caveolae regulate HIV-induced amyloid beta accumulation in brain endothelial cells. 2012 Biochem. Biophys. Res. Commun. pmid:22490665
Mor A et al. Celecoxib enhances the anti-inflammatory effects of farnesylthiosalicylic acid on T cells independent of prostaglandin E(2) production. 2012 Inflammation pmid:22688643
Nasr N et al. HIV-1 infection of human macrophages directly induces viperin which inhibits viral production. 2012 Blood pmid:22677126
Cordeiro Rde A et al. Farnesol inhibits in vitro growth of the Cryptococcus neoformans species complex with no significant changes in virulence-related exoenzymes. 2012 Vet. Microbiol. pmid:22580194
Cerca N et al. Confocal laser scanning microscopy analysis of S. epidermidis biofilms exposed to farnesol, vancomycin and rifampicin. 2012 BMC Res Notes pmid:22591918
Costa CB et al. Farnesyltransferase inhibitors: molecular evidence of therapeutic efficacy in acute lymphoblastic leukemia through cyclin D1 inhibition. 2012 Anticancer Res. pmid:22399601
Wang X et al. Waikialoid A suppresses hyphal morphogenesis and inhibits biofilm development in pathogenic Candida albicans. 2012 J. Nat. Prod. pmid:22400916
Goldberg L et al. FTS and 2-DG induce pancreatic cancer cell death and tumor shrinkage in mice. 2012 Cell Death Dis pmid:22419113
Han TL et al. The metabolic response of Candida albicans to farnesol under hyphae-inducing conditions. 2012 FEMS Yeast Res. pmid:22846172
Chang W et al. Retigeric acid B attenuates the virulence of Candida albicans via inhibiting adenylyl cyclase activity targeted by enhanced farnesol production. 2012 PLoS ONE pmid:22848547
Lindsay AK et al. Farnesol and cyclic AMP signaling effects on the hypha-to-yeast transition in Candida albicans. 2012 Eukaryotic Cell pmid:22886999
Fu MS et al. Functional characterization of the small heat shock protein Hsp12p from Candida albicans. 2012 PLoS ONE pmid:22880130
Lichtor PA and Miller SJ Combinatorial evolution of site- and enantioselective catalysts for polyene epoxidation. 2012 Nat Chem pmid:23174978
Jamalian A et al. Chemical composition and antifungal activity of Matricaria recutita flower essential oil against medically important dermatophytes and soil-borne pathogens. 2012 J Mycol Med pmid:23518164
Green SA et al. Identification, functional characterization, and regulation of the enzyme responsible for floral (E)-nerolidol biosynthesis in kiwifruit (Actinidia chinensis). 2012 J. Exp. Bot. pmid:22162874
Shin KO et al. Terpene alcohols inhibit de novo sphingolipid biosynthesis. 2012 Planta Med. pmid:22274813
Jin Y and Qiu FG A convergent stereocontrolled total synthesis of (-)-terpestacin. 2012 Org. Biomol. Chem. pmid:22710980
Mologni L et al. Synergistic effects of combined Wnt/KRAS inhibition in colorectal cancer cells. 2012 PLoS ONE pmid:23227266
Wartenberg D et al. Proteome analysis of the farnesol-induced stress response in Aspergillus nidulans--The role of a putative dehydrin. 2012 J Proteomics pmid:22634043
Yu LH et al. Possible inhibitory molecular mechanism of farnesol on the development of fluconazole resistance in Candida albicans biofilm. 2012 Antimicrob. Agents Chemother. pmid:22106223
Oron T et al. Prevention of induced colitis in mice by the ras antagonist farnesylthiosalicylic acid. 2012 Dig. Dis. Sci. pmid:21901261
Stärkel P et al. Ras inhibition in hepatocarcinoma by S-trans-trans-farnesylthiosalicyclic acid: association of its tumor preventive effect with cell proliferation, cell cycle events, and angiogenesis. 2012 Mol. Carcinog. pmid:21882255
Brilhante RS et al. Sesquiterpene farnesol contributes to increased susceptibility to β-lactams in strains of Burkholderia pseudomallei. 2012 Antimicrob. Agents Chemother. pmid:22290941
Berrocal A et al. Quorum sensing activity in Ophiostoma ulmi: effects of fusel oils and branched chain amino acids on yeast-mycelial dimorphism. 2012 J. Appl. Microbiol. pmid:22519968
Falsetta ML et al. Novel antibiofilm chemotherapy targets exopolysaccharide synthesis and stress tolerance in Streptococcus mutans to modulate virulence expression in vivo. 2012 Antimicrob. Agents Chemother. pmid:22985885
de Oliveira Júnior WM et al. Farnesol: antinociceptive effect and histopathological analysis of the striatum and hippocampus of mice. 2013 Fundam Clin Pharmacol pmid:22340189
Cordeiro RA et al. Minimum inhibitory concentrations of amphotericin B, azoles and caspofungin against Candida species are reduced by farnesol. 2013 Med. Mycol. pmid:22712455
Farag MA and Al-Mahdy DA Comparative study of the chemical composition and biological activities of Magnolia grandiflora and Magnolia virginiana flower essential oils. 2013 Nat. Prod. Res. pmid:22690913
Zhang X et al. PEG-farnesylthiosalicylate conjugate as a nanomicellar carrier for delivery of paclitaxel. 2013 Bioconjug. Chem. pmid:23425093
Brilhante RS et al. Effect of farnesol on growth, ergosterol biosynthesis, and cell permeability in Coccidioides posadasii. 2013 Antimicrob. Agents Chemother. pmid:23459491
Mor A et al. Immunomodulatory properties of farnesoids: the new steroids? 2013 Curr. Med. Chem. pmid:23432580
Langford ML et al. Candida albicans Czf1 and Efg1 coordinate the response to farnesol during quorum sensing, white-opaque thermal dimorphism, and cell death. 2013 Eukaryotic Cell pmid:23873867
Schmukler E et al. Ras inhibition enhances autophagy, which partially protects cells from death. 2013 Oncotarget pmid:23847721
Wang C et al. Engineered heterologous FPP synthases-mediated Z,E-FPP synthesis in E. coli. 2013 Metab. Eng. pmid:23608473
Cho SW et al. Positive regulation of osteogenesis by bile acid through FXR. 2013 J. Bone Miner. Res. pmid:23609136
Gouveia V et al. Di- and sesquiterpenoids from Cystoseira genus: structure, intra-molecular transformations and biological activity. 2013 Mini Rev Med Chem pmid:23621654
Rivera-Perez C et al. Aldehyde dehydrogenase 3 converts farnesal into farnesoic acid in the corpora allata of mosquitoes. 2013 Insect Biochem. Mol. Biol. pmid:23639754
Jones S et al. β-ionone induces cell cycle arrest and apoptosis in human prostate tumor cells. 2013 Nutr Cancer pmid:23659452
Szűcs G et al. Cardioprotection by farnesol: role of the mevalonate pathway. 2013 Cardiovasc Drugs Ther pmid:23673412
Charette N et al. Salirasib sensitizes hepatocarcinoma cells to TRAIL-induced apoptosis through DR5 and survivin-dependent mechanisms. 2013 Cell Death Dis pmid:23348585
Schmukler E et al. Ras inhibition enhances autophagy, which partially protects cells from death. 2013 Oncotarget pmid:23370967
Kraitzer A et al. Mechanisms of antiproliferative drug release from bioresorbable porous structures. 2013 J Biomed Mater Res A pmid:23065767
Barkan B et al. Ras inhibition boosts galectin-7 at the expense of galectin-1 to sensitize cells to apoptosis. 2013 Oncotarget pmid:23530091
Faigenbaum R et al. Growth of poorly differentiated endometrial carcinoma is inhibited by combined action of medroxyprogesterone acetate and the Ras inhibitor Salirasib. 2013 Oncotarget pmid:23530112
Xu H et al. Glucanase induces filamentation of the fungal pathogen Candida albicans. 2013 PLoS ONE pmid:23737947
Nunes PM et al. Study of trans-trans farnesol effect on hyphae formation by Yarrowia lipolytica. 2013 Bioprocess Biosyst Eng pmid:23715764
Nyati P et al. Farnesyl phosphatase, a Corpora allata enzyme involved in juvenile hormone biosynthesis in Aedes aegypti. 2013 PLoS ONE pmid:23940797
Onono F et al. Efficient use of exogenous isoprenols for protein isoprenylation by MDA-MB-231 cells is regulated independently of the mevalonate pathway. 2013 J. Biol. Chem. pmid:23908355
Schokoroy S et al. Disrupting the oncogenic synergism between nucleolin and Ras results in cell growth inhibition and cell death. 2013 PLoS ONE pmid:24086490
Kloog Y et al. Ras chaperones: new targets for cancer and immunotherapy. 2013 Enzymes pmid:25033809
Pfister C et al. Detection and quantification of farnesol-induced apoptosis in difficult primary cell cultures by TaqMan protein assay. 2013 Apoptosis pmid:23315006
Cerca N et al. Farnesol induces cell detachment from established S. epidermidis biofilms. 2013 J. Antibiot. pmid:23549353
Kuete V and Efferth T Molecular determinants of cancer cell sensitivity and resistance towards the sesquiterpene farnesol. 2013 Pharmazie pmid:23923645
Alves FR et al. Antibiofilm and antibacterial activities of farnesol and xylitol as potential endodontic irrigants. 2013 Braz Dent J pmid:23969910
Lazzerini PE et al. Rosuvastatin inhibits spontaneous and IL-1β-induced interleukin-6 production from human cultured osteoblastic cells. 2013 Joint Bone Spine pmid:22999910
Cotoras M et al. Farnesol induces apoptosis-like phenotype in the phytopathogenic fungus Botrytis cinerea. 2013 Jan-Feb Mycologia pmid:22962358
Alves FR et al. Biofilm biomass disruption by natural substances with potential for endodontic use. 2013 Jan-Feb Braz Oral Res pmid:23306623
Matsuzawa T et al. EFdA, a reverse transcriptase inhibitor, potently blocks HIV-1 ex vivo infection of Langerhans cells within epithelium. 2014 J. Invest. Dermatol. pmid:24384694
Ronderos DS et al. Farnesol-detecting olfactory neurons in Drosophila. 2014 J. Neurosci. pmid:24623773
Lu Y et al. Quorum sensing controls hyphal initiation in Candida albicans through Ubr1-mediated protein degradation. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:24449897
Sakane C et al. Inhibition of lysine-specific demethylase 1 by the acyclic diterpenoid geranylgeranoic acid and its derivatives. 2014 Biochem. Biophys. Res. Commun. pmid:24406160
Sabra A et al. Host-pathogen interaction and signaling molecule secretion are modified in the dpp3 knockout mutant of Candida lusitaniae. 2014 Infect. Immun. pmid:24191303
Aizman E et al. Therapeutic effect of farnesylthiosalicylic acid on adjuvant-induced arthritis through suppressed release of inflammatory cytokines. 2014 Clin. Exp. Immunol. pmid:24215151
Neeman R et al. Vitamin D and S-farnesylthiosalicylic acid have a synergistic effect on hepatic stellate cells proliferation. 2014 Dig. Dis. Sci. pmid:24942325
Zhang X et al. Nanomicellar carriers for targeted delivery of anticancer agents. 2014 Ther Deliv pmid:24341817
Ling Y et al. Synthesis and biological evaluation of farnesylthiosalicylamides as potential anti-tumor agents. 2014 Bioorg. Med. Chem. pmid:24300920
Makovski V et al. Analysis of gene expression array in TSC2-deficient AML cells reveals IRF7 as a pivotal factor in the Rheb/mTOR pathway. 2014 Cell Death Dis pmid:25476905