| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
2E,6E-farnesol
2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
Cross Reference
Introduction
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 2E,6E-farnesol?
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
PubChem Associated disorders and diseases
What pathways are associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 2E,6E-farnesol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with 2E,6E-farnesol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 2E,6E-farnesol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 2E,6E-farnesol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 2E,6E-farnesol?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 2E,6E-farnesol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Rotblat B et al. | The Ras inhibitor farnesylthiosalicylic acid (Salirasib) disrupts the spatiotemporal localization of active Ras: a potential treatment for cancer. | 2008 | Meth. Enzymol. | pmid:18374183 |
| Berzat AC et al. | Using inhibitors of prenylation to block localization and transforming activity. | 2006 | Meth. Enzymol. | pmid:16757354 |
| Epand RM et al. | Lipid-mediated a-factor interactions with artificial membranes. | 1995 | Meth. Enzymol. | pmid:7651149 |
| Wang C et al. | Engineered heterologous FPP synthases-mediated Z,E-FPP synthesis in E. coli. | 2013 | Metab. Eng. | pmid:23608473 |
| Kim SY et al. | Inhibition effect of new farnesol derivatives on all-trans-retinoic acid metabolism. | 2001 | Metab. Clin. Exp. | pmid:11699057 |
| Tashiro M et al. | Pravastatin inhibits farnesol production in Candida albicans and improves survival in a mouse model of systemic candidiasis. | 2012 | Med. Mycol. | pmid:21954955 |
| Cordeiro RA et al. | Minimum inhibitory concentrations of amphotericin B, azoles and caspofungin against Candida species are reduced by farnesol. | 2013 | Med. Mycol. | pmid:22712455 |
| Sarazin A et al. | In vitro pro- and anti-inflammatory responses to viable Candida albicans yeasts by a murine macrophage cell line. | 2010 | Med. Mycol. | pmid:20438293 |
| Ershova LS et al. | [Action of an analog of insect juvenile hormone farnesol ester on the flea Xenopsylla conformis Wagn]. | 1988 May-Jun | Med Parazitol (Mosk) | pmid:3173246 |
| Leonhardt I et al. | The fungal quorum-sensing molecule farnesol activates innate immune cells but suppresses cellular adaptive immunity. | 2015 | MBio | pmid:25784697 |
| Duncan RE and Archer MC | Farnesol decreases serum triglycerides in rats: identification of mechanisms including up-regulation of PPARalpha and down-regulation of fatty acid synthase in hepatocytes. | 2008 | Lipids | pmid:18509688 |
| Hohl RJ et al. | Stereochemistry-dependent inhibition of RAS farnesylation by farnesyl phosphonic acids. | 1998 | Lipids | pmid:9470172 |
| Ownby SE and Hohl RJ | Farnesol and geranylgeraniol: prevention and reversion of lovastatin-induced effects in NIH3T3 cells. | 2002 | Lipids | pmid:11908910 |
| Ownby SE and Hohl RJ | Isoprenoid alcohols restore protein isoprenylation in a time-dependent manner independent of protein synthesis. | 2003 | Lipids | pmid:14506838 |
| Kothapalli R et al. | Farnesylamine: an inhibitor of farnesylation and growth of ras-transformed cells. | 1993 | Lipids | pmid:8277827 |
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| Satoh T et al. | The effects of pravastatin, an HMG-CoA reductase inhibitor, on cell viability and DNA production of rat hepatocytes. | 1996 | Life Sci. | pmid:8831797 |
| Chaudhary SC et al. | Chemopreventive effect of farnesol on DMBA/TPA-induced skin tumorigenesis: involvement of inflammation, Ras-ERK pathway and apoptosis. | 2009 | Life Sci. | pmid:19470390 |
| Pratt GE and Tobe SS | Juvenile hormones radiobiosynthesised by corpora allata of adult female locusts in vitro. | 1974 | Life Sci. | pmid:4823991 |
| JarolÃm V et al. | Natural and synthetic materials with insect hormones activity. 8. Juvenile activity of the farnesane-type compounds on Galleria mellonella. | 1969 | Life Sci. | pmid:5803377 |