MeSH term | MeSH ID | Detail |
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Candidiasis, Invasive | D058365 | 2 associated lipids |
Anisakiasis | D017129 | 2 associated lipids |
2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Makovski V et al. | Farnesylthiosalicylic acid (salirasib) inhibits Rheb in TSC2-null ELT3 cells: a potential treatment for lymphangioleiomyomatosis. | 2012 | Int. J. Cancer | pmid:21500191 |
Piérard GE et al. | Miconazole, a pharmacological barrier to skin fungal infections. | 2012 | Expert Opin Pharmacother | pmid:22568580 |
Laheru D et al. | Integrated preclinical and clinical development of S-trans, trans-Farnesylthiosalicylic Acid (FTS, Salirasib) in pancreatic cancer. | 2012 | Invest New Drugs | pmid:22547163 |
Agassandian M et al. | Calcium-calmodulin kinase I cooperatively regulates nucleocytoplasmic shuttling of CCTα by accessing a nuclear export signal. | 2012 | Mol. Biol. Cell | pmid:22621903 |
András IE et al. | Lipid rafts and functional caveolae regulate HIV-induced amyloid beta accumulation in brain endothelial cells. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22490665 |
Mor A et al. | Celecoxib enhances the anti-inflammatory effects of farnesylthiosalicylic acid on T cells independent of prostaglandin E(2) production. | 2012 | Inflammation | pmid:22688643 |
Nasr N et al. | HIV-1 infection of human macrophages directly induces viperin which inhibits viral production. | 2012 | Blood | pmid:22677126 |
Cordeiro Rde A et al. | Farnesol inhibits in vitro growth of the Cryptococcus neoformans species complex with no significant changes in virulence-related exoenzymes. | 2012 | Vet. Microbiol. | pmid:22580194 |
Cerca N et al. | Confocal laser scanning microscopy analysis of S. epidermidis biofilms exposed to farnesol, vancomycin and rifampicin. | 2012 | BMC Res Notes | pmid:22591918 |
Costa CB et al. | Farnesyltransferase inhibitors: molecular evidence of therapeutic efficacy in acute lymphoblastic leukemia through cyclin D1 inhibition. | 2012 | Anticancer Res. | pmid:22399601 |
Wang X et al. | Waikialoid A suppresses hyphal morphogenesis and inhibits biofilm development in pathogenic Candida albicans. | 2012 | J. Nat. Prod. | pmid:22400916 |
Goldberg L et al. | FTS and 2-DG induce pancreatic cancer cell death and tumor shrinkage in mice. | 2012 | Cell Death Dis | pmid:22419113 |
Han TL et al. | The metabolic response of Candida albicans to farnesol under hyphae-inducing conditions. | 2012 | FEMS Yeast Res. | pmid:22846172 |
Chang W et al. | Retigeric acid B attenuates the virulence of Candida albicans via inhibiting adenylyl cyclase activity targeted by enhanced farnesol production. | 2012 | PLoS ONE | pmid:22848547 |
Lindsay AK et al. | Farnesol and cyclic AMP signaling effects on the hypha-to-yeast transition in Candida albicans. | 2012 | Eukaryotic Cell | pmid:22886999 |
Fu MS et al. | Functional characterization of the small heat shock protein Hsp12p from Candida albicans. | 2012 | PLoS ONE | pmid:22880130 |
Jamalian A et al. | Chemical composition and antifungal activity of Matricaria recutita flower essential oil against medically important dermatophytes and soil-borne pathogens. | 2012 | J Mycol Med | pmid:23518164 |
Green SA et al. | Identification, functional characterization, and regulation of the enzyme responsible for floral (E)-nerolidol biosynthesis in kiwifruit (Actinidia chinensis). | 2012 | J. Exp. Bot. | pmid:22162874 |
Shin KO et al. | Terpene alcohols inhibit de novo sphingolipid biosynthesis. | 2012 | Planta Med. | pmid:22274813 |
Jin Y and Qiu FG | A convergent stereocontrolled total synthesis of (-)-terpestacin. | 2012 | Org. Biomol. Chem. | pmid:22710980 |
Mologni L et al. | Synergistic effects of combined Wnt/KRAS inhibition in colorectal cancer cells. | 2012 | PLoS ONE | pmid:23227266 |
Wartenberg D et al. | Proteome analysis of the farnesol-induced stress response in Aspergillus nidulans--The role of a putative dehydrin. | 2012 | J Proteomics | pmid:22634043 |
Yu LH et al. | Possible inhibitory molecular mechanism of farnesol on the development of fluconazole resistance in Candida albicans biofilm. | 2012 | Antimicrob. Agents Chemother. | pmid:22106223 |
Oron T et al. | Prevention of induced colitis in mice by the ras antagonist farnesylthiosalicylic acid. | 2012 | Dig. Dis. Sci. | pmid:21901261 |
Stärkel P et al. | Ras inhibition in hepatocarcinoma by S-trans-trans-farnesylthiosalicyclic acid: association of its tumor preventive effect with cell proliferation, cell cycle events, and angiogenesis. | 2012 | Mol. Carcinog. | pmid:21882255 |
Brilhante RS et al. | Sesquiterpene farnesol contributes to increased susceptibility to β-lactams in strains of Burkholderia pseudomallei. | 2012 | Antimicrob. Agents Chemother. | pmid:22290941 |
Berrocal A et al. | Quorum sensing activity in Ophiostoma ulmi: effects of fusel oils and branched chain amino acids on yeast-mycelial dimorphism. | 2012 | J. Appl. Microbiol. | pmid:22519968 |
Falsetta ML et al. | Novel antibiofilm chemotherapy targets exopolysaccharide synthesis and stress tolerance in Streptococcus mutans to modulate virulence expression in vivo. | 2012 | Antimicrob. Agents Chemother. | pmid:22985885 |
Deveau A and Hogan DA | Linking quorum sensing regulation and biofilm formation by Candida albicans. | 2011 | Methods Mol. Biol. | pmid:21031315 |
Mann FM et al. | Rv0989c encodes a novel (E)-geranyl diphosphate synthase facilitating decaprenyl diphosphate biosynthesis in Mycobacterium tuberculosis. | 2011 | FEBS Lett. | pmid:21237161 |
de Castro Pimentel Figueiredo B et al. | The Aspergillus nidulans nucA(EndoG) homologue is not involved in cell death. | 2011 | Eukaryotic Cell | pmid:21131437 |
Gomes F et al. | Farnesol as antibiotics adjuvant in Staphylococcus epidermidis control in vitro. | 2011 | Am. J. Med. Sci. | pmid:21107231 |
Busch S and Unruh T | The influence of additives on the nanoscopic dynamics of the phospholipid dimyristoylphosphatidylcholine. | 2011 | Biochim. Biophys. Acta | pmid:21036141 |
Shareck J and Belhumeur P | Modulation of morphogenesis in Candida albicans by various small molecules. | 2011 | Eukaryotic Cell | pmid:21642508 |
Yang L et al. | ZL11n is a novel nitric oxide-releasing derivative of farnesylthiosalicylic acid that induces apoptosis in human hepatoma HepG2 cells via MAPK/mitochondrial pathways. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21621522 |
Barkan B et al. | Phenotypic reversion of invasive neurofibromin-deficient schwannoma by FTS: Ras inhibition reduces BMP4/Erk/Smad signaling. | 2011 | Mol. Cancer Ther. | pmid:21632464 |
Yoo S et al. | Antimicrobial traits of tea- and cranberry-derived polyphenols against Streptococcus mutans. | 2011 | Caries Res. | pmid:21720161 |
Fitzpatrick AH et al. | Farnesol kinase is involved in farnesol metabolism, ABA signaling and flower development in Arabidopsis. | 2011 | Plant J. | pmid:21395888 |
Nevo Y et al. | The Ras antagonist, farnesylthiosalicylic acid (FTS), decreases fibrosis and improves muscle strength in dy/dy mouse model of muscular dystrophy. | 2011 | PLoS ONE | pmid:21445359 |
Khan R and Sultana S | Farnesol attenuates 1,2-dimethylhydrazine induced oxidative stress, inflammation and apoptotic responses in the colon of Wistar rats. | 2011 | Chem. Biol. Interact. | pmid:21453689 |
Gonçalves O et al. | Evaluation of the mutagenicity of sesquiterpenic compounds and their influence on the susceptibility towards antibiotics of two clinically relevant bacterial strains. | 2011 | Mutat. Res. | pmid:21453784 |
Mor A et al. | Inhibitory effect of farnesylthiosalicylic acid on mediators release by mast cells: preferential inhibition of prostaglandin D(2) and tumor necrosis factor-α release. | 2011 | Inflammation | pmid:20706780 |
Ling Y et al. | Novel nitric oxide-releasing derivatives of farnesylthiosalicylic acid: synthesis and evaluation of antihepatocellular carcinoma activity. | 2011 | J. Med. Chem. | pmid:21504204 |
Jeon JG et al. | Influences of trans-trans farnesol, a membrane-targeting sesquiterpenoid, on Streptococcus mutans physiology and survival within mixed-species oral biofilms. | 2011 | Int J Oral Sci | pmid:21485314 |
Navarro-Moll MC et al. | In vitro and in vivo activity of three sesquiterpenes against L(3) larvae of Anisakis type I. | 2011 | Exp. Parasitol. | pmid:20932829 |
Huang J et al. | Electrohydrodynamic deposition of nanotitanium doped hydroxyapatite coating for medical and dental applications. | 2011 | J Mater Sci Mater Med | pmid:21243517 |
Hogan DA and Muhlschlegel FA | Candida albicans developmental regulation: adenylyl cyclase as a coincidence detector of parallel signals. | 2011 | Curr. Opin. Microbiol. | pmid:22014725 |
Krasowski MD et al. | The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species. | 2011 | BMC Biochem. | pmid:21291553 |
Bai C et al. | Characterization of a hyperactive Cyr1 mutant reveals new regulatory mechanisms for cellular cAMP levels in Candida albicans. | 2011 | Mol. Microbiol. | pmid:21992526 |
Endo S et al. | Roles of rat and human aldo-keto reductases in metabolism of farnesol and geranylgeraniol. | 2011 | Chem. Biol. Interact. | pmid:21187079 |
Cortés M et al. | Drimenol: A versatile synthon for compounds with trans-drimane skeleton. | 2011 | Nat Prod Commun | pmid:21560760 |
Borbath I and Stärkel P | Chemoprevention of hepatocellular carcinoma. Proof of concept in animal models. | 2011 | Acta Gastroenterol. Belg. | pmid:21563652 |
Zhu J et al. | Farnesol-induced apoptosis in Candida albicans is mediated by Cdr1-p extrusion and depletion of intracellular glutathione. | 2011 | PLoS ONE | pmid:22205973 |
Piispanen AE et al. | Roles of Ras1 membrane localization during Candida albicans hyphal growth and farnesol response. | 2011 | Eukaryotic Cell | pmid:21908593 |
Zhang L et al. | Bisbibenzyls, a new type of antifungal agent, inhibit morphogenesis switch and biofilm formation through upregulation of DPP3 in Candida albicans. | 2011 | PLoS ONE | pmid:22174935 |
Hall RA et al. | The quorum-sensing molecules farnesol/homoserine lactone and dodecanol operate via distinct modes of action in Candida albicans. | 2011 | Eukaryotic Cell | pmid:21666074 |
Biran A et al. | Downregulation of survivin and aurora A by histone deacetylase and RAS inhibitors: a new drug combination for cancer therapy. | 2011 | Int. J. Cancer | pmid:20473860 |
Fong C et al. | Monodisperse nonionic isoprenoid-type hexahydrofarnesyl ethylene oxide surfactants: high throughput lyotropic liquid crystalline phase determination. | 2011 | Langmuir | pmid:21294552 |
Kraitzer A et al. | Composite fiber structures with antiproliferative agents exhibit advantageous drug delivery and cell growth inhibition in vitro. | 2011 | J Pharm Sci | pmid:20623695 |
Charron G et al. | Alkynyl-farnesol reporters for detection of protein S-prenylation in cells. | 2011 | Mol Biosyst | pmid:21107478 |
Epplen R et al. | Differential effects of ibandronate, docetaxel and farnesol treatment alone and in combination on the growth of prostate cancer cell lines. | 2011 | Acta Oncol | pmid:20429730 |
Bendena WG et al. | Evidence for differential biosynthesis of juvenile hormone (and related) sesquiterpenoids in Drosophila melanogaster. | 2011 | Gen. Comp. Endocrinol. | pmid:21354154 |
Nagai H et al. | Development of a novel PPARγ ligand screening system using pinpoint fluorescence-probed protein. | 2011 | Biosci. Biotechnol. Biochem. | pmid:21307572 |
Rahman NK et al. | Enzymatic synthesis of farnesyl laurate in organic solvent: initial water activity, kinetics mechanism, optimization of continuous operation using packed bed reactor and mass transfer studies. | 2011 | Bioprocess Biosyst Eng | pmid:21327986 |
Gori K et al. | Alcohol-based quorum sensing plays a role in adhesion and sliding motility of the yeast Debaryomyces hansenii. | 2011 | FEMS Yeast Res. | pmid:22093748 |
Madhani HD | Quorum sensing in fungi: Q&A. | 2011 | PLoS Pathog. | pmid:22046125 |
Gomes F et al. | Effect of farnesol on structure and composition of Staphylococcus epidermidis biofilm matrix. | 2011 | Curr. Microbiol. | pmid:21800262 |
Pammi M et al. | Farnesol decreases biofilms of Staphylococcus epidermidis and exhibits synergy with nafcillin and vancomycin. | 2011 | Pediatr. Res. | pmid:21857375 |
Teodoro JS et al. | Hepatic FXR: key regulator of whole-body energy metabolism. | 2011 | Trends Endocrinol. Metab. | pmid:21862343 |
Goto T et al. | Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARα-dependent and -independent pathways. | 2011 | Am. J. Physiol. Endocrinol. Metab. | pmid:21862726 |
Fitzpatrick AH et al. | Roles for farnesol and ABA in Arabidopsis flower development. | 2011 | Plant Signal Behav | pmid:21758018 |
Mor A et al. | Ras inhibition induces insulin sensitivity and glucose uptake. | 2011 | PLoS ONE | pmid:21738773 |
Sharma M and Prasad R | The quorum-sensing molecule farnesol is a modulator of drug efflux mediated by ABC multidrug transporters and synergizes with drugs in Candida albicans. | 2011 | Antimicrob. Agents Chemother. | pmid:21768514 |
Nishimori R et al. | Biosynthesis of unnatural bacteriochlorophyll c derivatives esterified with α,ω-diols in the green sulfur photosynthetic bacterium Chlorobaculum tepidum. | 2011 | Biochemistry | pmid:21846125 |
Riely GJ et al. | A phase II trial of Salirasib in patients with lung adenocarcinomas with KRAS mutations. | 2011 | J Thorac Oncol | pmid:21847063 |
Ganguly S et al. | Zap1 control of cell-cell signaling in Candida albicans biofilms. | 2011 | Eukaryotic Cell | pmid:21890817 |
Dinamarco TM et al. | Farnesol-induced cell death in the filamentous fungus Aspergillus nidulans. | 2011 | Biochem. Soc. Trans. | pmid:21936849 |
Mor A et al. | Inhibition of contact sensitivity by farnesylthiosalicylic acid-amide, a potential Rap1 inhibitor. | 2011 | J. Invest. Dermatol. | pmid:21716322 |
Tsuji F et al. | The geranyl-modified tryptophan residue is crucial for ComXRO-E-2 pheromone biological activity. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21636272 |
Kaneko M et al. | Effect of farnesol on mevalonate pathway of Staphylococcus aureus. | 2011 | J. Antibiot. | pmid:21772307 |
Pando R et al. | The Ras antagonist farnesylthiosalicylic acid ameliorates experimental myocarditis in the rat. | 2010 Mar-Apr | Cardiovasc. Pathol. | pmid:19144546 |
Liu P et al. | Farnesol induces apoptosis and oxidative stress in the fungal pathogen Penicillium expansum. | 2010 Mar-Apr | Mycologia | pmid:20361499 |
Gilpin S and Maibach H | Allergic contact dermatitis caused by farnesol: clinical relevance. | 2010 | Cutan Ocul Toxicol | pmid:20858058 |
Charette N et al. | Salirasib inhibits the growth of hepatocarcinoma cell lines in vitro and tumor growth in vivo through ras and mTOR inhibition. | 2010 | Mol. Cancer | pmid:20860815 |
Wang C et al. | Farnesol production from Escherichia coli by harnessing the exogenous mevalonate pathway. | 2010 | Biotechnol. Bioeng. | pmid:20552672 |
Aizman E et al. | The combined treatment of Copaxone and Salirasib attenuates experimental autoimmune encephalomyelitis (EAE) in mice. | 2010 | J. Neuroimmunol. | pmid:20869125 |
Kubesová A et al. | Separation of attogram terpenes by the capillary zone electrophoresis with fluorometric detection. | 2010 | J Chromatogr A | pmid:20933239 |
Bhagatji P et al. | Multiple cellular proteins modulate the dynamics of K-ras association with the plasma membrane. | 2010 | Biophys. J. | pmid:21081081 |
Bhandari J et al. | Identification of a novel abscisic acid-regulated farnesol dehydrogenase from Arabidopsis. | 2010 | Plant Physiol. | pmid:20807998 |
Jin J et al. | Farnesol, a potential efflux pump inhibitor in Mycobacterium smegmatis. | 2010 | Molecules | pmid:21042264 |
Eglin D et al. | Farnesol-modified biodegradable polyurethanes for cartilage tissue engineering. | 2010 | J Biomed Mater Res A | pmid:19191318 |
Tsimberidou AM et al. | Phase 1 first-in-human clinical study of S-trans,trans-farnesylthiosalicylic acid (salirasib) in patients with solid tumors. | 2010 | Cancer Chemother. Pharmacol. | pmid:19484470 |
Joo JH and Jetten AM | Molecular mechanisms involved in farnesol-induced apoptosis. | 2010 | Cancer Lett. | pmid:19520495 |
Hanker AB et al. | Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling. | 2010 | Oncogene | pmid:19838215 |
Dinamarco TM et al. | The roles played by Aspergillus nidulans apoptosis-inducing factor (AIF)-like mitochondrial oxidoreductase (AifA) and NADH-ubiquinone oxidoreductases (NdeA-B and NdiA) in farnesol resistance. | 2010 | Fungal Genet. Biol. | pmid:20654725 |
Cugini C et al. | Candida albicans-produced farnesol stimulates Pseudomonas quinolone signal production in LasR-defective Pseudomonas aeruginosa strains. | 2010 | Microbiology (Reading, Engl.) | pmid:20656785 |
Weber K et al. | The quorum-sensing molecule E,E-farnesol--its variable secretion and its impact on the growth and metabolism of Candida species. | 2010 | Yeast | pmid:20641010 |
Bustinza-Linares E et al. | Salirasib in the treatment of pancreatic cancer. | 2010 | Future Oncol | pmid:20528225 |
Deveau A et al. | Farnesol induces hydrogen peroxide resistance in Candida albicans yeast by inhibiting the Ras-cyclic AMP signaling pathway. | 2010 | Eukaryotic Cell | pmid:20118211 |
Moya M et al. | Enhanced steatosis by nuclear receptor ligands: a study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile. | 2010 | Chem. Biol. Interact. | pmid:20079722 |