MeSH term | MeSH ID | Detail |
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Candidiasis, Invasive | D058365 | 2 associated lipids |
Anisakiasis | D017129 | 2 associated lipids |
2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Zvibel I et al. | The effect of Ras inhibition on the proliferation, apoptosis and matrix metalloproteases activity in rat hepatic stellate cells. | 2008 | Dig. Dis. Sci. | pmid:17934818 |
Cho T et al. | Transcriptional changes in Candida albicans Genes by both farnesol and high cell density at an early stage of morphogenesis in N-acetyl-D-glucosamine medium. | 2007 | Nihon Ishinkin Gakkai Zasshi | pmid:17975531 |
Abbasnezhad H et al. | Two different mechanisms for adhesion of Gram-negative bacterium, Pseudomonas fluorescens LP6a, to an oil-water interface. | 2008 | Colloids Surf B Biointerfaces | pmid:17997081 |
Shchepin R et al. | Influence of heterocyclic and oxime-containing farnesol analogs on quorum sensing and pathogenicity in Candida albicans. | 2008 | Bioorg. Med. Chem. | pmid:18037299 |
Davis-Hanna A et al. | Farnesol and dodecanol effects on the Candida albicans Ras1-cAMP signalling pathway and the regulation of morphogenesis. | 2008 | Mol. Microbiol. | pmid:18078440 |
Maher M et al. | Activation of TRPA1 by farnesyl thiosalicylic acid. | 2008 | Mol. Pharmacol. | pmid:18171730 |
Golczak M et al. | Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina. | 2008 | J. Biol. Chem. | pmid:18195010 |
Semighini CP et al. | Inhibition of Fusarium graminearum growth and development by farnesol. | 2008 | FEMS Microbiol. Lett. | pmid:18201191 |
Blum R et al. | Inhibitors of chronically active ras: potential for treatment of human malignancies. | 2008 | Recent Pat Anticancer Drug Discov | pmid:18289122 |
Teshima K and Kondo T | Analytical method for determination of allylic isoprenols in rat tissues by liquid chromatography/tandem mass spectrometry following chemical derivatization with 3-nitrophtalic anhydride. | 2008 | J Pharm Biomed Anal | pmid:18313250 |
Tsangarakis C et al. | Zeolite NaY-promoted cyclization of farnesal: a short route to nanaimoal. | 2008 | J. Org. Chem. | pmid:18321121 |
Weber K et al. | Secretion of E,E-farnesol and biofilm formation in eight different Candida species. | 2008 | Antimicrob. Agents Chemother. | pmid:18332168 |
Shimomura K et al. | Homofarnesals: female sex attractant pheromone components of the southern cowpea weevil, Callosobruchus chinensis. | 2008 | J. Chem. Ecol. | pmid:18351422 |
Rotblat B et al. | The Ras inhibitor farnesylthiosalicylic acid (Salirasib) disrupts the spatiotemporal localization of active Ras: a potential treatment for cancer. | 2008 | Meth. Enzymol. | pmid:18374183 |
Lorek J et al. | Influence of farnesol on the morphogenesis of Aspergillus niger. | 2008 | J. Basic Microbiol. | pmid:18383232 |
Marcuzzi A et al. | Natural isoprenoids are able to reduce inflammation in a mouse model of mevalonate kinase deficiency. | 2008 | Pediatr. Res. | pmid:18391837 |
Chen CK et al. | The effect of mutation of F87 on the properties of CYP102A1-CYP4C7 chimeras: altered regiospecificity and substrate selectivity. | 2008 | J. Biol. Inorg. Chem. | pmid:18392864 |
Gallagher BM and Hartig WJ | Hormonal studies of uridine utilization in an insect cell line CP-1268 derived from the codling moth Laspeyresia pomonella. | 1976 | In Vitro | pmid:184032 |
Joo JH and Jetten AM | NF-kappaB-dependent transcriptional activation in lung carcinoma cells by farnesol involves p65/RelA(Ser276) phosphorylation via the MEK-MSK1 signaling pathway. | 2008 | J. Biol. Chem. | pmid:18424438 |
Kebaara BW et al. | Candida albicans Tup1 is involved in farnesol-mediated inhibition of filamentous-growth induction. | 2008 | Eukaryotic Cell | pmid:18424510 |
McAlester G et al. | Signal-mediated interactions between Pseudomonas aeruginosa and Candida albicans. | 2008 | J. Med. Microbiol. | pmid:18436588 |
Mor A et al. | N-Ras or K-Ras inhibition increases the number and enhances the function of Foxp3 regulatory T cells. | 2008 | Eur. J. Immunol. | pmid:18461565 |
Duncan RE and Archer MC | Farnesol decreases serum triglycerides in rats: identification of mechanisms including up-regulation of PPARalpha and down-regulation of fatty acid synthase in hepatocytes. | 2008 | Lipids | pmid:18509688 |
Zhao M et al. | Determination of salirasib (S-trans,trans-farnesylthiosalicylic acid) in human plasma using liquid chromatography-tandem mass spectrometry. | 2008 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:18534927 |
Schleimer K et al. | Competition between native liver and graft in auxiliary liver transplantation in a rat model. | 2008 | Transplant. Proc. | pmid:18555091 |
Au-Yeung KK et al. | Herbal isoprenols induce apoptosis in human colon cancer cells through transcriptional activation of PPARgamma. | 2008 | Cancer Invest. | pmid:18608213 |
Geraldo IM et al. | Rapid antibacterial activity of 2 novel hand soaps: evaluation of the risk of development of bacterial resistance to the antibacterial agents. | 2008 | Infect Control Hosp Epidemiol | pmid:18616390 |
Jahangir T and Sultana S | Benzo(a)pyrene-induced genotoxicity: attenuation by farnesol in a mouse model. | 2008 | J Enzyme Inhib Med Chem | pmid:18618320 |
Muramatsu M et al. | Accumulation of prenyl alcohols by terpenoid biosynthesis inhibitors in various microorganisms. | 2008 | Appl. Microbiol. Biotechnol. | pmid:18636253 |
Lapczynski A et al. | Fragrance material review on farnesol. | 2008 | Food Chem. Toxicol. | pmid:18640198 |
Hisajima T et al. | Protective effects of farnesol against oral candidiasis in mice. | 2008 | Microbiol. Immunol. | pmid:18667031 |
Savoldi M et al. | Farnesol induces the transcriptional accumulation of the Aspergillus nidulans Apoptosis-Inducing Factor (AIF)-like mitochondrial oxidoreductase. | 2008 | Mol. Microbiol. | pmid:18681941 |
Kotti T et al. | Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18685105 |
Koo H | Strategies to enhance the biological effects of fluoride on dental biofilms. | 2008 | Adv. Dent. Res. | pmid:18694872 |
Scheper MA et al. | Farnesol, a fungal quorum-sensing molecule triggers apoptosis in human oral squamous carcinoma cells. | 2008 | Neoplasia | pmid:18714396 |
Qamar W and Sultana S | Farnesol ameliorates massive inflammation, oxidative stress and lung injury induced by intratracheal instillation of cigarette smoke extract in rats: an initial step in lung chemoprevention. | 2008 | Chem. Biol. Interact. | pmid:18793622 |
Peleg AY et al. | Prokaryote-eukaryote interactions identified by using Caenorhabditis elegans. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18794525 |
Cushion MT et al. | Biofilm formation by Pneumocystis spp. | 2009 | Eukaryotic Cell | pmid:18820078 |
de Montellano PR et al. | Inhibition of squalene synthetase by farnesyl pyrophosphate analogues. | 1977 | J. Med. Chem. | pmid:189031 |
Muramatsu M et al. | Various oils and detergents enhance the microbial production of farnesol and related prenyl alcohols. | 2008 | J. Biosci. Bioeng. | pmid:18930003 |
Goldberg L et al. | Salirasib (farnesyl thiosalicylic acid) for brain tumor treatment: a convection-enhanced drug delivery study in rats. | 2008 | Mol. Cancer Ther. | pmid:19001442 |
Cho T et al. | [Farnesol as a quorum-sensing molecule in Candida albicans]. | 2008 | Nihon Ishinkin Gakkai Zasshi | pmid:19001754 |
Cho T and Aoyama T | [Quorum sensing in fungal pathogenesis]. | 2008 | Nippon Rinsho | pmid:19069092 |
Goldberg L et al. | New derivatives of farnesylthiosalicylic acid (salirasib) for cancer treatment: farnesylthiosalicylamide inhibits tumor growth in nude mice models. | 2009 | J. Med. Chem. | pmid:19072665 |
Togashi N et al. | Effects of two terpene alcohols on the antibacterial activity and the mode of action of farnesol against Staphylococcus aureus. | 2008 | Molecules | pmid:19078849 |
Décanis N et al. | Farnesol promotes epithelial cell defense against Candida albicans through Toll-like receptor 2 expression, interleukin-6 and human beta-defensin 2 production. | 2009 | Cytokine | pmid:19121950 |
Ohto C et al. | Prenyl alcohol production by expression of exogenous isopentenyl diphosphate isomerase and farnesyl diphosphate synthase genes in Escherichia coli. | 2009 | Biosci. Biotechnol. Biochem. | pmid:19129660 |
Pando R et al. | The Ras antagonist farnesylthiosalicylic acid ameliorates experimental myocarditis in the rat. | 2010 Mar-Apr | Cardiovasc. Pathol. | pmid:19144546 |
Fujiyama A et al. | S-farnesylation and methyl esterification of C-terminal domain of yeast RAS2 protein prior to fatty acid acylation. | 1991 | J. Biol. Chem. | pmid:1917931 |
Eglin D et al. | Farnesol-modified biodegradable polyurethanes for cartilage tissue engineering. | 2010 | J Biomed Mater Res A | pmid:19191318 |
Banfi C et al. | Proteomic analysis of human low-density lipoprotein reveals the presence of prenylcysteine lyase, a hydrogen peroxide-generating enzyme. | 2009 | Proteomics | pmid:19253276 |
Ohguro H et al. | Carboxyl methylation and farnesylation of transducin gamma-subunit synergistically enhance its coupling with metarhodopsin II. | 1991 | EMBO J. | pmid:1935895 |
Shirtliff ME et al. | Farnesol-induced apoptosis in Candida albicans. | 2009 | Antimicrob. Agents Chemother. | pmid:19364863 |
Gomes FI et al. | Effect of farnesol on planktonic and biofilm cells of Staphylococcus epidermidis. | 2009 | Curr. Microbiol. | pmid:19365686 |
Derengowski LS et al. | Antimicrobial effect of farnesol, a Candida albicans quorum sensing molecule, on Paracoccidioides brasiliensis growth and morphogenesis. | 2009 | Ann. Clin. Microbiol. Antimicrob. | pmid:19402910 |
RodrÃguez C et al. | Statins normalize vascular lysyl oxidase down-regulation induced by proatherogenic risk factors. | 2009 | Cardiovasc. Res. | pmid:19406911 |
Pando R et al. | Ras inhibition attenuates myocardial ischemia-reperfusion injury. | 2009 | Biochem. Pharmacol. | pmid:19426696 |
Schneider-Merck T et al. | The Ras inhibitor farnesylthiosalicyclic acid (FTS) prevents nodule formation and development of preneoplastic foci of altered hepatocytes in rats. | 2009 | Eur. J. Cancer | pmid:19427195 |
Rhome R and Del Poeta M | Lipid signaling in pathogenic fungi. | 2009 | Annu. Rev. Microbiol. | pmid:19450140 |
Chaudhary SC et al. | Chemopreventive effect of farnesol on DMBA/TPA-induced skin tumorigenesis: involvement of inflammation, Ras-ERK pathway and apoptosis. | 2009 | Life Sci. | pmid:19470390 |
Tsimberidou AM et al. | Phase 1 first-in-human clinical study of S-trans,trans-farnesylthiosalicylic acid (salirasib) in patients with solid tumors. | 2010 | Cancer Chemother. Pharmacol. | pmid:19484470 |
Kraitzer A et al. | Novel farnesylthiosalicylate (FTS)-eluting composite structures. | 2009 | Eur J Pharm Sci | pmid:19491026 |
Abe S et al. | Suppression of anti-Candida activity of macrophages by a quorum-sensing molecule, farnesol, through induction of oxidative stress. | 2009 | Microbiol. Immunol. | pmid:19493200 |
Joo JH and Jetten AM | Molecular mechanisms involved in farnesol-induced apoptosis. | 2010 | Cancer Lett. | pmid:19520495 |
Mor A et al. | Ras inhibition increases the frequency and function of regulatory T cells and attenuates type-1 diabetes in non-obese diabetic mice. | 2009 | Eur. J. Pharmacol. | pmid:19527709 |
Song L | Recovery of E,E-farnesol from cultures of yeast erg9 mutants: extraction with polymeric beads and purification by normal-phase chromatography. | 2009 Jul-Aug | Biotechnol. Prog. | pmid:19569196 |
Muramatsu M et al. | Alkaline pH enhances farnesol production by Saccharomyces cerevisiae. | 2009 | J. Biosci. Bioeng. | pmid:19577192 |
Xiao Y et al. | A two-component female-produced pheromone of the spider Pholcus beijingensis. | 2009 | J. Chem. Ecol. | pmid:19579045 |
Nowak M and Kurnatowski P | [Biofilm caused by fungi--structure, quorum sensing, morphogenetic changes, resistance to drugs]. | 2009 | Wiad Parazytol | pmid:19579780 |
Goldstein JL and Brown MS | Regulation of the mevalonate pathway. | 1990 | Nature | pmid:1967820 |
Rennemeier C et al. | Microbial quorum-sensing molecules induce acrosome loss and cell death in human spermatozoa. | 2009 | Infect. Immun. | pmid:19687207 |
Chen F et al. | Tooth-binding micelles for dental caries prevention. | 2009 | Antimicrob. Agents Chemother. | pmid:19704121 |
Koo H and Jeon JG | Naturally occurring molecules as alternative therapeutic agents against cariogenic biofilms. | 2009 | Adv. Dent. Res. | pmid:19717411 |
Chen CK et al. | Scanning chimeragenesis: the approach used to change the substrate selectivity of fatty acid monooxygenase CYP102A1 to that of terpene omega-hydroxylase CYP4C7. | 2010 | J. Biol. Inorg. Chem. | pmid:19727859 |
Doan K et al. | In vivo and in vitro skin absorption of lipophilic compounds, dibutyl phthalate, farnesol and geraniol in the hairless guinea pig. | 2010 | Food Chem. Toxicol. | pmid:19747520 |
Raptis C et al. | Acid-catalyzed cyclization of terpenes under homogeneous and heterogeneous conditions as probed through stereoisotopic studies: a concerted process with competing preorganized chair and boat transition states. | 2009 | Chemistry | pmid:19780112 |
Räikkönen J et al. | Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells. | 2010 | Biochem. Pharmacol. | pmid:19819230 |
Mackie H and Overton KH | Hydrolysis and isomerization of trans,trans-farnesyl diphosphate by Andrographis tissue-culture enzymes. | 1977 | Eur. J. Biochem. | pmid:198206 |
Hanker AB et al. | Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling. | 2010 | Oncogene | pmid:19838215 |
Chagas CE et al. | Farnesol inhibits cell proliferation and induces apoptosis after partial hepatectomy in rats. | 2009 Sep-Oct | Acta Cir Bras | pmid:19851690 |
Jeon JG et al. | Influences of naturally occurring agents in combination with fluoride on gene expression and structural organization of Streptococcus mutans in biofilms. | 2009 | BMC Microbiol. | pmid:19863808 |
Unnanuntana A et al. | The effects of farnesol on Staphylococcus aureus biofilms and osteoblasts. An in vitro study. | 2009 | J Bone Joint Surg Am | pmid:19884443 |
Keung WM | Human liver alcohol dehydrogenases catalyze the oxidation of the intermediary alcohols of the shunt pathway of mevalonate metabolism. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1993065 |
Langford ML et al. | Activity and toxicity of farnesol towards Candida albicans are dependent on growth conditions. | 2010 | Antimicrob. Agents Chemother. | pmid:19933803 |
Mayoral JG et al. | NADP+-dependent farnesol dehydrogenase, a corpora allata enzyme involved in juvenile hormone synthesis. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19940247 |
Langford ML et al. | Cellular interactions of farnesol, a quorum-sensing molecule produced by Candida albicans. | 2009 | Future Microbiol | pmid:19995193 |
Yaari-Stark S et al. | Ras inhibits endoplasmic reticulum stress in human cancer cells with amplified Myc. | 2010 | Int. J. Cancer | pmid:19998334 |
Grienke U et al. | Antiviral potential and molecular insight into neuraminidase inhibiting diarylheptanoids from Alpinia katsumadai. | 2010 | J. Med. Chem. | pmid:20014777 |
Moya M et al. | Enhanced steatosis by nuclear receptor ligands: a study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile. | 2010 | Chem. Biol. Interact. | pmid:20079722 |
Deveau A et al. | Farnesol induces hydrogen peroxide resistance in Candida albicans yeast by inhibiting the Ras-cyclic AMP signaling pathway. | 2010 | Eukaryotic Cell | pmid:20118211 |
Lee SJ and Moon HI | Immunotoxicity activity of the major essential oil of Filipendula glaberrima against Aedes aegypti L. | 2010 | Immunopharmacol Immunotoxicol | pmid:20175741 |
Endo S et al. | Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10. | 2010 | Bioorg. Med. Chem. | pmid:20304656 |
Liu P et al. | Farnesol induces apoptosis and oxidative stress in the fungal pathogen Penicillium expansum. | 2010 Mar-Apr | Mycologia | pmid:20361499 |
Dichtl K et al. | Farnesol misplaces tip-localized Rho proteins and inhibits cell wall integrity signalling in Aspergillus fumigatus. | 2010 | Mol. Microbiol. | pmid:20398212 |
Epplen R et al. | Differential effects of ibandronate, docetaxel and farnesol treatment alone and in combination on the growth of prostate cancer cell lines. | 2011 | Acta Oncol | pmid:20429730 |
Ling Y et al. | Synthesis and evaluation of nitric oxide-releasing derivatives of farnesylthiosalicylic acid as anti-tumor agents. | 2010 | Bioorg. Med. Chem. | pmid:20435479 |
Sarazin A et al. | In vitro pro- and anti-inflammatory responses to viable Candida albicans yeasts by a murine macrophage cell line. | 2010 | Med. Mycol. | pmid:20438293 |
Banke TG et al. | Dynamic changes in the TRPA1 selectivity filter lead to progressive but reversible pore dilation. | 2010 | Am. J. Physiol., Cell Physiol. | pmid:20457836 |
Biran A et al. | Downregulation of survivin and aurora A by histone deacetylase and RAS inhibitors: a new drug combination for cancer therapy. | 2011 | Int. J. Cancer | pmid:20473860 |
Bustinza-Linares E et al. | Salirasib in the treatment of pancreatic cancer. | 2010 | Future Oncol | pmid:20528225 |