MeSH term | MeSH ID | Detail |
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Candidiasis, Invasive | D058365 | 2 associated lipids |
Anisakiasis | D017129 | 2 associated lipids |
2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Vogt A et al. | Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts. | 1996 | Oncogene | pmid:8934546 |
Tisch D et al. | Activation of signaling pathways in HL60 cells and human neutrophils by farnesylthiosalicylate. | 1996 | Eur. J. Biochem. | pmid:9022678 |
McGuire TF et al. | Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation. | 1996 | J. Biol. Chem. | pmid:8910319 |
Miquel K et al. | Farnesol and geranylgeraniol induce actin cytoskeleton disorganization and apoptosis in A549 lung adenocarcinoma cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8780704 |
Keller RK et al. | Farnesol is not the nonsterol regulator mediating degradation of HMG-CoA reductase in rat liver. | 1996 | Arch. Biochem. Biophys. | pmid:8645011 |
Koyama T et al. | Identification of significant residues in the substrate binding site of Bacillus stearothermophilus farnesyl diphosphate synthase. | 1996 | Biochemistry | pmid:8755734 |
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O'Brien ML et al. | Convergence of three steroid receptor pathways in the mediation of nongenotoxic hepatocarcinogenesis. | 1996 | Carcinogenesis | pmid:8625436 |
Bostedor RG et al. | Farnesol-derived dicarboxylic acids in the urine of animals treated with zaragozic acid A or with farnesol. | 1997 | J. Biol. Chem. | pmid:9083051 |
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Iazlovitskaia EM et al. | Human leukemia CEM C-1 cells possess a high affinity binding site for farnesol. | 1997 Mar-Apr | Ukr. Biokhim. Zh. | pmid:9463231 |
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Miquel K et al. | Competitive inhibition of choline phosphotransferase by geranylgeraniol and farnesol inhibits phosphatidylcholine synthesis and induces apoptosis in human lung adenocarcinoma A549 cells. | 1998 | J. Biol. Chem. | pmid:9748300 |
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Szilvassy Z et al. | Improvement of nitrergic relaxation by farnesol of the sphincter of Oddi from hypercholesterolaemic rabbits. | 1998 | Eur. J. Pharmacol. | pmid:9721042 |
Machida K et al. | Farnesol-induced generation of reactive oxygen species via indirect inhibition of the mitochondrial electron transport chain in the yeast Saccharomyces cerevisiae. | 1998 | J. Bacteriol. | pmid:9721283 |
Strickland CL et al. | Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue. | 1998 | Biochemistry | pmid:9843427 |
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Llorente-Cortés V et al. | Esterified cholesterol accumulation induced by aggregated LDL uptake in human vascular smooth muscle cells is reduced by HMG-CoA reductase inhibitors. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9598832 |
Pérez-Sala D et al. | Analogs of farnesylcysteine induce apoptosis in HL-60 cells. | 1998 | FEBS Lett. | pmid:9600259 |
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