MeSH term | MeSH ID | Detail |
---|---|---|
Lung Injury | D055370 | 14 associated lipids |
Candidiasis, Invasive | D058365 | 2 associated lipids |
2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
McAnally JA et al. | Farnesyl-O-acetylhydroquinone and geranyl-O-acetylhydroquinone suppress the proliferation of murine B16 melanoma cells, human prostate and colon adenocarcinoma cells, human lung carcinoma cells, and human leukemia cells. | 2003 | Cancer Lett. | pmid:14643448 |
George J et al. | Inhibition of intimal thickening in the rat carotid artery injury model by a nontoxic Ras inhibitor. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:14670932 |
Grossman R et al. | Increase in peripheral benzodiazepine receptors and loss of glutamate NMDA receptors in a mouse model of closed head injury: a quantitative autoradiographic study. | 2003 | Neuroimage | pmid:14683703 |
Ruiz-Velasco N et al. | Statins upregulate CD36 expression in human monocytes, an effect strengthened when combined with PPAR-gamma ligands Putative contribution of Rho GTPases in statin-induced CD36 expression. | 2004 | Biochem. Pharmacol. | pmid:14698043 |
Lochnit G and Geyer R | Evidence for the presence of the Kennedy and Bremer- Greenberg pathways in Caenorhabditis elegans. | 2003 | Acta Biochim. Pol. | pmid:14740010 |
Thorpe JL et al. | Germ cell migration in zebrafish is dependent on HMGCoA reductase activity and prenylation. | 2004 | Dev. Cell | pmid:14960282 |
Murataliev MB et al. | Chimeragenesis of the fatty acid binding site of cytochrome P450BM3. Replacement of residues 73-84 with the homologous residues from the insect cytochrome P450 CYP4C7. | 2004 | Biochemistry | pmid:14967018 |
McPherson RA et al. | The novel Ras antagonist, farnesylthiosalicylate, suppresses growth of prostate cancer in vitro. | 2004 | Prostate | pmid:14968433 |
Rowat AC and Davis JH | Farnesol-DMPC phase behaviour: a (2)H-NMR study. | 2004 | Biochim. Biophys. Acta | pmid:15003880 |
Hornby JM et al. | Inoculum size effect in dimorphic fungi: extracellular control of yeast-mycelium dimorphism in Ceratocystis ulmi. | 2004 | Appl. Environ. Microbiol. | pmid:15006753 |
Luxová A et al. | Absolute configuration of chiral terpenes in marking pheromones of bumblebees and cuckoo bumblebees. | 2004 | Chirality | pmid:15034905 |
Hartman HL et al. | Lysine beta311 of protein geranylgeranyltransferase type I partially replaces magnesium. | 2004 | J. Biol. Chem. | pmid:15131129 |
Sato T et al. | Farnesol, a morphogenetic autoregulatory substance in the dimorphic fungus Candida albicans, inhibits hyphae growth through suppression of a mitogen-activated protein kinase cascade. | 2004 | Biol. Pharm. Bull. | pmid:15133261 |
Yang Z et al. | Host plant volatiles synergize response to sex pheromone in codling moth, Cydia pomonella. | 2004 | J. Chem. Ecol. | pmid:15139312 |
Schnuch A et al. | Contact allergy to farnesol in 2021 consecutively patch tested patients. Results of the IVDK. | 2004 | Contact Derm. | pmid:15153123 |
Hornby JM and Nickerson KW | Enhanced production of farnesol by Candida albicans treated with four azoles. | 2004 | Antimicrob. Agents Chemother. | pmid:15155241 |
DeBarber AE et al. | Omega-hydroxylation of farnesol by mammalian cytochromes p450. | 2004 | Biochim. Biophys. Acta | pmid:15158752 |
Dumitru R et al. | Defined anaerobic growth medium for studying Candida albicans basic biology and resistance to eight antifungal drugs. | 2004 | Antimicrob. Agents Chemother. | pmid:15215080 |
Rodrigues Goulart H et al. | Terpenes arrest parasite development and inhibit biosynthesis of isoprenoids in Plasmodium falciparum. | 2004 | Antimicrob. Agents Chemother. | pmid:15215101 |
Chin PC et al. | The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism. | 2004 | J. Neurochem. | pmid:15255937 |
Bradfute DL et al. | Squalene synthase-deficient mutant of Chinese hamster ovary cells. | 1992 | J. Biol. Chem. | pmid:1526971 |
Reif S et al. | Treatment of thioacetamide-induced liver cirrhosis by the Ras antagonist, farnesylthiosalicylic acid. | 2004 | J. Hepatol. | pmid:15288472 |
Kruppa M et al. | The two-component signal transduction protein Chk1p regulates quorum sensing in Candida albicans. | 2004 | Eukaryotic Cell | pmid:15302838 |
Staines AG et al. | Farnesol is glucuronidated in human liver, kidney and intestine in vitro, and is a novel substrate for UGT2B7 and UGT1A1. | 2004 | Biochem. J. | pmid:15320866 |
Inoue Y et al. | The antibacterial effects of terpene alcohols on Staphylococcus aureus and their mode of action. | 2004 | FEMS Microbiol. Lett. | pmid:15321680 |
Bai M and Prestwich GD | Inhibition and activation of porcine squalene epoxidase. | 1992 | Arch. Biochem. Biophys. | pmid:1536566 |
Fukuda S and Pelus LM | Activated H-Ras regulates hematopoietic cell survival by modulating Survivin. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15369798 |
Chen AP et al. | Substrate and product specificities of cis-type undecaprenyl pyrophosphate synthase. | 2005 | Biochem. J. | pmid:15447632 |
McMahon LP et al. | Farnesylthiosalicylic acid inhibits mammalian target of rapamycin (mTOR) activity both in cells and in vitro by promoting dissociation of the mTOR-raptor complex. | 2005 | Mol. Endocrinol. | pmid:15459249 |
Downie MM et al. | Peroxisome proliferator-activated receptor and farnesoid X receptor ligands differentially regulate sebaceous differentiation in human sebaceous gland organ cultures in vitro. | 2004 | Br. J. Dermatol. | pmid:15491415 |
Rudi A et al. | Likonides A and B: new ansa farnesyl quinols from the marine sponge Hyatella sp. | 2004 | Org. Lett. | pmid:15496087 |
Bhavnani BR and Woolever CA | Formation of steroids by the pregnant mare. VI. Metabolism of [14C]farnesyl pyrophosphate and [3H]dehydroepiandrosterone injected into the fetus. | 1978 | Endocrinology | pmid:155006 |
Anant JS and Fung BK | In vivo farnesylation of rat rhodopsin kinase. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1550556 |
Wozniak M et al. | Alternative farnesoid structures induce different conformational outcomes upon the Drosophila ortholog of the retinoid X receptor, ultraspiracle. | 2004 | Insect Biochem. Mol. Biol. | pmid:15522611 |
Williams JM and Savage CO | Characterization of the regulation and functional consequences of p21ras activation in neutrophils by antineutrophil cytoplasm antibodies. | 2005 | J. Am. Soc. Nephrol. | pmid:15548565 |
Hogan DA et al. | A Pseudomonas aeruginosa quorum-sensing molecule influences Candida albicans morphology. | 2004 | Mol. Microbiol. | pmid:15554963 |
Lutz RJ et al. | Nucleoplasmic localization of prelamin A: implications for prenylation-dependent lamin A assembly into the nuclear lamina. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1557405 |
Yang SP and Raner GM | Cytochrome P450 expression and activities in human tongue cells and their modulation by green tea extract. | 2005 | Toxicol. Appl. Pharmacol. | pmid:15629189 |
Shearer AG and Hampton RY | Lipid-mediated, reversible misfolding of a sterol-sensing domain protein. | 2005 | EMBO J. | pmid:15635451 |
Havel CM and Watson JA | Isopentenoid synthesis in isolated embryonic Drosophila cells: absolute, basal mevalonate synthesis rate determination. | 1992 | Arch. Biochem. Biophys. | pmid:1567218 |
Cao YY et al. | cDNA microarray analysis of differential gene expression in Candida albicans biofilm exposed to farnesol. | 2005 | Antimicrob. Agents Chemother. | pmid:15673737 |
Blum R et al. | Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death. | 2005 | Cancer Res. | pmid:15705901 |
Hubálek F et al. | Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors. | 2005 | J. Biol. Chem. | pmid:15710600 |
Laffey SF and Butler G | Phenotype switching affects biofilm formation by Candida parapsilosis. | 2005 | Microbiology (Reading, Engl.) | pmid:15817776 |
Horn TL et al. | Modulation of hepatic and renal drug metabolizing enzyme activities in rats by subchronic administration of farnesol. | 2005 | Chem. Biol. Interact. | pmid:15840382 |
Frosch PJ et al. | Patch testing with a new fragrance mix detects additional patients sensitive to perfumes and missed by the current fragrance mix. | 2005 | Contact Derm. | pmid:15859993 |
Frosch PJ et al. | Patch testing with a new fragrance mix - reactivity to the individual constituents and chemical detection in relevant cosmetic products. | 2005 | Contact Derm. | pmid:15859994 |
Katsuyama M et al. | A novel method to control the balance of skin microflora. Part 1. Attack on biofilm of Staphylococcus aureus without antibiotics. | 2005 | J. Dermatol. Sci. | pmid:15927813 |
Katsuyama M et al. | A novel method to control the balance of skin microflora Part 2. A study to assess the effect of a cream containing farnesol and xylitol on atopic dry skin. | 2005 | J. Dermatol. Sci. | pmid:15927814 |
Yue W et al. | Farnesylthiosalicylic acid blocks mammalian target of rapamycin signaling in breast cancer cells. | 2005 | Int. J. Cancer | pmid:15957161 |