| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Injury | D055370 | 14 associated lipids |
| Candidiasis, Invasive | D058365 | 2 associated lipids |
2E,6E-farnesol
2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
Cross Reference
Introduction
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 2E,6E-farnesol?
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
PubChem Associated disorders and diseases
What pathways are associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 2E,6E-farnesol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 2E,6E-farnesol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 2E,6E-farnesol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 2E,6E-farnesol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 2E,6E-farnesol?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 2E,6E-farnesol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bachireddy P et al. | Getting at MYC through RAS. | 2005 | Clin. Cancer Res. | pmid:15958607 |
| Yaari S et al. | Disruption of cooperation between Ras and MycN in human neuroblastoma cells promotes growth arrest. | 2005 | Clin. Cancer Res. | pmid:15958613 |
| Rowat AC et al. | Effects of farnesol on the physical properties of DMPC membranes. | 2005 | Biochim. Biophys. Acta | pmid:15963943 |
| Newman CM et al. | Post-translational processing of Schizosaccharomyces pombe YPT proteins. | 1992 | J. Biol. Chem. | pmid:1597466 |
| Shchepin R et al. | Biologically active fluorescent farnesol analogs. | 2005 | Chem. Biol. | pmid:15975508 |
| Kang L et al. | SMGA gels for the skin permeation of haloperidol. | 2005 | J Control Release | pmid:15975680 |
| Martin SW et al. | Cell cycle dynamics and quorum sensing in Candida albicans chlamydospores are distinct from budding and hyphal growth. | 2005 | Eukaryotic Cell | pmid:16002645 |
| Enjalbert B and Whiteway M | Release from quorum-sensing molecules triggers hyphal formation during Candida albicans resumption of growth. | 2005 | Eukaryotic Cell | pmid:16002646 |
| Khwaja A et al. | The inhibition of human mesangial cell proliferation by S-trans, trans-farnesylthiosalicylic acid. | 2005 | Kidney Int. | pmid:16014024 |
| Sobotka-Briner C and Chelsky D | COOH-terminal methylation of lamin B and inhibition of methylation by farnesylated peptides corresponding to lamin B and other CAAX motif proteins. | 1992 | J. Biol. Chem. | pmid:1601879 |
| Goodman CL et al. | Partial morphological and functional characterization of the corpus allatum-corpus cardiacum complex from the two-spotted stinkbug, Perillus bioculatus (Hemiptera: Pentatomidae). | 2005 Mar-Apr | In Vitro Cell. Dev. Biol. Anim. | pmid:16029075 |
| Mosel DD et al. | Farnesol concentrations required to block germ tube formation in Candida albicans in the presence and absence of serum. | 2005 | Appl. Environ. Microbiol. | pmid:16085901 |
| Lagace TA and Ridgway ND | Induction of apoptosis by lipophilic activators of CTP:phosphocholine cytidylyltransferase alpha (CCTalpha). | 2005 | Biochem. J. | pmid:16097951 |
| Kafri M et al. | Inhibition of Ras attenuates the course of experimental autoimmune neuritis. | 2005 | J. Neuroimmunol. | pmid:16154640 |
| Funari SS et al. | Farnesol and geranylgeraniol modulate the structural properties of phosphatidylethanolamine model membranes. | 2005 Jul-Aug | Mol. Membr. Biol. | pmid:16154902 |
| Taylor MM et al. | Enhanced apoptosis through farnesol inhibition of phospholipase D signal transduction. | 2005 | FEBS J. | pmid:16176276 |
| Lakshman R et al. | Use of CYP2E1-transfected human liver cell lines in elucidating the actions of ethanol. | 2005 | Alcohol. Clin. Exp. Res. | pmid:16205373 |
| Westwater C et al. | Candida albicans-conditioned medium protects yeast cells from oxidative stress: a possible link between quorum sensing and oxidative stress resistance. | 2005 | Eukaryotic Cell | pmid:16215173 |
| Pérez-Sala D et al. | Prenylated protein methyltransferases do not distinguish between farnesylated and geranylgeranylated substrates. | 1992 | Biochem. J. | pmid:1622400 |
| Braun PC | The effect of farnesol on amino acid incorporation by a wild-type and cell-wall variant strain of Candida albicans. | 2005 | Can. J. Microbiol. | pmid:16234870 |
| Yu JS et al. | Synthesis of farnesol isomers via a modified Wittig procedure. | 2005 | Org. Lett. | pmid:16235893 |
| Navarathna DH et al. | Enhanced pathogenicity of Candida albicans pre-treated with subinhibitory concentrations of fluconazole in a mouse model of disseminated candidiasis. | 2005 | J. Antimicrob. Chemother. | pmid:16239285 |
| Amos S et al. | Farnesylthiosalicylic acid induces caspase activation and apoptosis in glioblastoma cells. | 2006 | Cell Death Differ. | pmid:16239932 |
| Koo H et al. | Apigenin and tt-farnesol with fluoride effects on S. mutans biofilms and dental caries. | 2005 | J. Dent. Res. | pmid:16246933 |
| Ferri N et al. | Isothiazole dioxide derivative 6n inhibits vascular smooth muscle cell proliferation and protein farnesylation. | 2005 | Biochem. Pharmacol. | pmid:16257390 |
| Rüegg T et al. | 3-Farnesyl-2-hydroxybenzoic acid is a new anti-Helicobacter pylori compound from Piper multiplinervium. | 2006 | J Ethnopharmacol | pmid:16266794 |
| Hemmerlin A et al. | Monitoring farnesol-induced toxicity in tobacco BY-2 cells with a fluorescent analog. | 2006 | Arch. Biochem. Biophys. | pmid:16307722 |
| Ma YT and Rando RR | A microsomal endoprotease that specifically cleaves isoprenylated peptides. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1631119 |
| Kato K et al. | Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1631135 |
| Santen RJ et al. | Farnesylthiosalicylic acid: inhibition of proliferation and enhancement of apoptosis of hormone-dependent breast cancer cells. | 2006 | Anticancer Drugs | pmid:16317288 |
| Aronovich R et al. | Antiphospholipid antibodies, thrombin and LPS activate brain endothelial cells and Ras-dependent pathways through distinct mechanisms. | 2005 | Immunobiology | pmid:16325498 |
| Melnykovych G et al. | Growth inhibition of leukemia cell line CEM-C1 by farnesol: effects of phosphatidylcholine and diacylglycerol. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1632790 |
| Ong TP et al. | Farnesol and geraniol chemopreventive activities during the initial phases of hepatocarcinogenesis involve similar actions on cell proliferation and DNA damage, but distinct actions on apoptosis, plasma cholesterol and HMGCoA reductase. | 2006 | Carcinogenesis | pmid:16332721 |
| Semighini CP et al. | Farnesol-induced apoptosis in Aspergillus nidulans reveals a possible mechanism for antagonistic interactions between fungi. | 2006 | Mol. Microbiol. | pmid:16420349 |
| Merino SM and Maren S | Hitting Ras where it counts: Ras antagonism in the basolateral amygdala inhibits long-term fear memory. | 2006 | Eur. J. Neurosci. | pmid:16420429 |
| Jahangir T et al. | Alleviation of free radical mediated oxidative and genotoxic effects of cadmium by farnesol in Swiss albino mice. | 2005 | Redox Rep. | pmid:16438802 |
| Khalil AA et al. | Isolation and characterization of a monoamine oxidase B selective inhibitor from tobacco smoke. | 2006 | Bioorg. Med. Chem. | pmid:16458520 |
| Song L | A soluble form of phosphatase in Saccharomyces cerevisiae capable of converting farnesyl diphosphate into E,E-farnesol. | 2006 | Appl. Biochem. Biotechnol. | pmid:16484724 |
| Xie J et al. | Microparticles developed by electrohydrodynamic atomization for the local delivery of anticancer drug to treat C6 glioma in vitro. | 2006 | Biomaterials | pmid:16490248 |
| Blum R et al. | E2F1 identified by promoter and biochemical analysis as a central target of glioblastoma cell-cycle arrest in response to Ras inhibition. | 2006 | Int. J. Cancer | pmid:16496386 |
| Chana RS and Brunskill NJ | Thiazolidinediones inhibit albumin uptake by proximal tubular cells through a mechanism independent of peroxisome proliferator activated receptor gamma. | 2006 | Am. J. Nephrol. | pmid:16508249 |
| Semighini CP et al. | Functional characterization of the putative Aspergillus nidulans poly(ADP-ribose) polymerase homolog PrpA. | 2006 | Genetics | pmid:16510786 |
| Beiner ME et al. | Ras antagonist inhibits growth and chemosensitizes human epithelial ovarian cancer cells. | 2006 Jan-Feb | Int. J. Gynecol. Cancer | pmid:16515591 |
| Duncan RE and Archer MC | Farnesol induces thyroid hormone receptor (THR) beta1 but inhibits THR-mediated signaling in MCF-7 human breast cancer cells. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16540091 |
| Jabra-Rizk MA et al. | Effect of farnesol on Staphylococcus aureus biofilm formation and antimicrobial susceptibility. | 2006 | Antimicrob. Agents Chemother. | pmid:16569866 |
| Kubista B et al. | Anticancer effects of zoledronic acid against human osteosarcoma cells. | 2006 | J. Orthop. Res. | pmid:16602111 |
| Hogan DA | Talking to themselves: autoregulation and quorum sensing in fungi. | 2006 | Eukaryotic Cell | pmid:16607008 |
| Jensen EC et al. | Farnesol restores wild-type colony morphology to 96% of Candida albicans colony morphology variants recovered following treatment with mutagens. | 2006 | Genome | pmid:16699554 |
| Shintre MS et al. | Efficacy of an alcohol-based healthcare hand rub containing synergistic combination of farnesol and benzethonium chloride. | 2006 | Int J Hyg Environ Health | pmid:16750419 |
| Nickerson KW et al. | Quorum sensing in dimorphic fungi: farnesol and beyond. | 2006 | Appl. Environ. Microbiol. | pmid:16751484 |