MeSH term | MeSH ID | Detail |
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Arteriosclerosis | D001161 | 86 associated lipids |
Adenocarcinoma | D000230 | 166 associated lipids |
2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Ferdinandy P et al. | Rapid pacing-induced preconditioning is recaptured by farnesol treatment in hearts of cholesterol-fed rats: role of polyprenyl derivatives and nitric oxide. | 1998 | Mol. Cell. Biochem. | pmid:9774182 |
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Ura H et al. | Selective cytotoxicity of farnesylamine to pancreatic carcinoma cells and Ki-ras-transformed fibroblasts. | 1998 | Mol. Carcinog. | pmid:9496909 |
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Roullet JB et al. | Inhibition of Ca2+ uptake into A7r5 vascular smooth muscle cells by farnesol: lack of effect on membrane fluidity and Ca2+-ATPase activities. | 1997 | J. Hypertens. | pmid:9488229 |
Haklai R et al. | Dislodgment and accelerated degradation of Ras. | 1998 | Biochemistry | pmid:9477957 |
Hohl RJ et al. | Stereochemistry-dependent inhibition of RAS farnesylation by farnesyl phosphonic acids. | 1998 | Lipids | pmid:9470172 |
Iazlovitskaia EM et al. | Human leukemia CEM C-1 cells possess a high affinity binding site for farnesol. | 1997 Mar-Apr | Ukr. Biokhim. Zh. | pmid:9463231 |
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Gana-Weisz M et al. | The Ras antagonist S-farnesylthiosalicylic acid induces inhibition of MAPK activation. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9367867 |
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Andres DA et al. | Expression cloning of a novel farnesylated protein, RDJ2, encoding a DnaJ protein homologue. | 1997 | Arch. Biochem. Biophys. | pmid:9328291 |
Saisho Y et al. | Determination of farnesyl pyrophosphate in dog and human plasma by high-performance liquid chromatography with fluorescence detection. | 1997 | Anal. Biochem. | pmid:9324945 |
Nozawa Y et al. | Stachybotrin C and parvisporin, novel neuritogenic compounds. II. Structure determination. | 1997 | J. Antibiot. | pmid:9315075 |
Van Dessel G et al. | Internalisation of short-chain isoprenyl diphosphates by chromaffin cells from bovine adrenal medulla. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9299441 |
Crick DC et al. | Novel salvage pathway utilizing farnesol and geranylgeraniol for protein isoprenylation. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9299388 |
Takaichi S et al. | The major carotenoid in all known species of heliobacteria is the C30 carotenoid 4,4'-diaponeurosporene, not neurosporene. | 1997 | Arch. Microbiol. | pmid:9297464 |
Zhang L et al. | Isolation and characterization of a prenylcysteine lyase from bovine brain. | 1997 | J. Biol. Chem. | pmid:9287348 |
Meigs TE and Simoni RD | Farnesol as a regulator of HMG-CoA reductase degradation: characterization and role of farnesyl pyrophosphatase. | 1997 | Arch. Biochem. Biophys. | pmid:9281305 |
Blazer-Yost BL et al. | Protein prenylation is required for aldosterone-stimulated Na+ transport. | 1997 | Am. J. Physiol. | pmid:9227422 |
Flint OP et al. | Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro. | 1997 | Toxicol. Appl. Pharmacol. | pmid:9221828 |
Leitner JW et al. | Hyperinsulinemia potentiates activation of p21Ras by growth factors. | 1997 | Endocrinology | pmid:9112423 |
Crick DC et al. | Geranylgeraniol promotes entry of UT-2 cells into the cell cycle in the absence of mevalonate. | 1997 | Exp. Cell Res. | pmid:9087171 |
Bostedor RG et al. | Farnesol-derived dicarboxylic acids in the urine of animals treated with zaragozic acid A or with farnesol. | 1997 | J. Biol. Chem. | pmid:9083051 |