MeSH term | MeSH ID | Detail |
---|---|---|
Arteriosclerosis | D001161 | 86 associated lipids |
Adenocarcinoma | D000230 | 166 associated lipids |
2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Eglin D et al. | Farnesol-modified biodegradable polyurethanes for cartilage tissue engineering. | 2010 | J Biomed Mater Res A | pmid:19191318 |
Fujiyama A et al. | S-farnesylation and methyl esterification of C-terminal domain of yeast RAS2 protein prior to fatty acid acylation. | 1991 | J. Biol. Chem. | pmid:1917931 |
Pando R et al. | The Ras antagonist farnesylthiosalicylic acid ameliorates experimental myocarditis in the rat. | 2010 Mar-Apr | Cardiovasc. Pathol. | pmid:19144546 |
Ohto C et al. | Prenyl alcohol production by expression of exogenous isopentenyl diphosphate isomerase and farnesyl diphosphate synthase genes in Escherichia coli. | 2009 | Biosci. Biotechnol. Biochem. | pmid:19129660 |
Décanis N et al. | Farnesol promotes epithelial cell defense against Candida albicans through Toll-like receptor 2 expression, interleukin-6 and human beta-defensin 2 production. | 2009 | Cytokine | pmid:19121950 |
Togashi N et al. | Effects of two terpene alcohols on the antibacterial activity and the mode of action of farnesol against Staphylococcus aureus. | 2008 | Molecules | pmid:19078849 |
Goldberg L et al. | New derivatives of farnesylthiosalicylic acid (salirasib) for cancer treatment: farnesylthiosalicylamide inhibits tumor growth in nude mice models. | 2009 | J. Med. Chem. | pmid:19072665 |
Cho T and Aoyama T | [Quorum sensing in fungal pathogenesis]. | 2008 | Nippon Rinsho | pmid:19069092 |
Cho T et al. | [Farnesol as a quorum-sensing molecule in Candida albicans]. | 2008 | Nihon Ishinkin Gakkai Zasshi | pmid:19001754 |
Goldberg L et al. | Salirasib (farnesyl thiosalicylic acid) for brain tumor treatment: a convection-enhanced drug delivery study in rats. | 2008 | Mol. Cancer Ther. | pmid:19001442 |
Muramatsu M et al. | Various oils and detergents enhance the microbial production of farnesol and related prenyl alcohols. | 2008 | J. Biosci. Bioeng. | pmid:18930003 |
de Montellano PR et al. | Inhibition of squalene synthetase by farnesyl pyrophosphate analogues. | 1977 | J. Med. Chem. | pmid:189031 |
Cushion MT et al. | Biofilm formation by Pneumocystis spp. | 2009 | Eukaryotic Cell | pmid:18820078 |
Peleg AY et al. | Prokaryote-eukaryote interactions identified by using Caenorhabditis elegans. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18794525 |
Qamar W and Sultana S | Farnesol ameliorates massive inflammation, oxidative stress and lung injury induced by intratracheal instillation of cigarette smoke extract in rats: an initial step in lung chemoprevention. | 2008 | Chem. Biol. Interact. | pmid:18793622 |
Scheper MA et al. | Farnesol, a fungal quorum-sensing molecule triggers apoptosis in human oral squamous carcinoma cells. | 2008 | Neoplasia | pmid:18714396 |
Koo H | Strategies to enhance the biological effects of fluoride on dental biofilms. | 2008 | Adv. Dent. Res. | pmid:18694872 |
Kotti T et al. | Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18685105 |
Savoldi M et al. | Farnesol induces the transcriptional accumulation of the Aspergillus nidulans Apoptosis-Inducing Factor (AIF)-like mitochondrial oxidoreductase. | 2008 | Mol. Microbiol. | pmid:18681941 |
Hisajima T et al. | Protective effects of farnesol against oral candidiasis in mice. | 2008 | Microbiol. Immunol. | pmid:18667031 |
Lapczynski A et al. | Fragrance material review on farnesol. | 2008 | Food Chem. Toxicol. | pmid:18640198 |
Muramatsu M et al. | Accumulation of prenyl alcohols by terpenoid biosynthesis inhibitors in various microorganisms. | 2008 | Appl. Microbiol. Biotechnol. | pmid:18636253 |
Jahangir T and Sultana S | Benzo(a)pyrene-induced genotoxicity: attenuation by farnesol in a mouse model. | 2008 | J Enzyme Inhib Med Chem | pmid:18618320 |
Geraldo IM et al. | Rapid antibacterial activity of 2 novel hand soaps: evaluation of the risk of development of bacterial resistance to the antibacterial agents. | 2008 | Infect Control Hosp Epidemiol | pmid:18616390 |
Au-Yeung KK et al. | Herbal isoprenols induce apoptosis in human colon cancer cells through transcriptional activation of PPARgamma. | 2008 | Cancer Invest. | pmid:18608213 |
Schleimer K et al. | Competition between native liver and graft in auxiliary liver transplantation in a rat model. | 2008 | Transplant. Proc. | pmid:18555091 |
Zhao M et al. | Determination of salirasib (S-trans,trans-farnesylthiosalicylic acid) in human plasma using liquid chromatography-tandem mass spectrometry. | 2008 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:18534927 |
Duncan RE and Archer MC | Farnesol decreases serum triglycerides in rats: identification of mechanisms including up-regulation of PPARalpha and down-regulation of fatty acid synthase in hepatocytes. | 2008 | Lipids | pmid:18509688 |
Mor A et al. | N-Ras or K-Ras inhibition increases the number and enhances the function of Foxp3 regulatory T cells. | 2008 | Eur. J. Immunol. | pmid:18461565 |
McAlester G et al. | Signal-mediated interactions between Pseudomonas aeruginosa and Candida albicans. | 2008 | J. Med. Microbiol. | pmid:18436588 |
Kebaara BW et al. | Candida albicans Tup1 is involved in farnesol-mediated inhibition of filamentous-growth induction. | 2008 | Eukaryotic Cell | pmid:18424510 |
Joo JH and Jetten AM | NF-kappaB-dependent transcriptional activation in lung carcinoma cells by farnesol involves p65/RelA(Ser276) phosphorylation via the MEK-MSK1 signaling pathway. | 2008 | J. Biol. Chem. | pmid:18424438 |
Gallagher BM and Hartig WJ | Hormonal studies of uridine utilization in an insect cell line CP-1268 derived from the codling moth Laspeyresia pomonella. | 1976 | In Vitro | pmid:184032 |
Chen CK et al. | The effect of mutation of F87 on the properties of CYP102A1-CYP4C7 chimeras: altered regiospecificity and substrate selectivity. | 2008 | J. Biol. Inorg. Chem. | pmid:18392864 |
Marcuzzi A et al. | Natural isoprenoids are able to reduce inflammation in a mouse model of mevalonate kinase deficiency. | 2008 | Pediatr. Res. | pmid:18391837 |
Lorek J et al. | Influence of farnesol on the morphogenesis of Aspergillus niger. | 2008 | J. Basic Microbiol. | pmid:18383232 |
Rotblat B et al. | The Ras inhibitor farnesylthiosalicylic acid (Salirasib) disrupts the spatiotemporal localization of active Ras: a potential treatment for cancer. | 2008 | Meth. Enzymol. | pmid:18374183 |
Shimomura K et al. | Homofarnesals: female sex attractant pheromone components of the southern cowpea weevil, Callosobruchus chinensis. | 2008 | J. Chem. Ecol. | pmid:18351422 |
Weber K et al. | Secretion of E,E-farnesol and biofilm formation in eight different Candida species. | 2008 | Antimicrob. Agents Chemother. | pmid:18332168 |
Tsangarakis C et al. | Zeolite NaY-promoted cyclization of farnesal: a short route to nanaimoal. | 2008 | J. Org. Chem. | pmid:18321121 |
Teshima K and Kondo T | Analytical method for determination of allylic isoprenols in rat tissues by liquid chromatography/tandem mass spectrometry following chemical derivatization with 3-nitrophtalic anhydride. | 2008 | J Pharm Biomed Anal | pmid:18313250 |
Blum R et al. | Inhibitors of chronically active ras: potential for treatment of human malignancies. | 2008 | Recent Pat Anticancer Drug Discov | pmid:18289122 |
Semighini CP et al. | Inhibition of Fusarium graminearum growth and development by farnesol. | 2008 | FEMS Microbiol. Lett. | pmid:18201191 |
Golczak M et al. | Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina. | 2008 | J. Biol. Chem. | pmid:18195010 |
Maher M et al. | Activation of TRPA1 by farnesyl thiosalicylic acid. | 2008 | Mol. Pharmacol. | pmid:18171730 |
Davis-Hanna A et al. | Farnesol and dodecanol effects on the Candida albicans Ras1-cAMP signalling pathway and the regulation of morphogenesis. | 2008 | Mol. Microbiol. | pmid:18078440 |
Shchepin R et al. | Influence of heterocyclic and oxime-containing farnesol analogs on quorum sensing and pathogenicity in Candida albicans. | 2008 | Bioorg. Med. Chem. | pmid:18037299 |
Abbasnezhad H et al. | Two different mechanisms for adhesion of Gram-negative bacterium, Pseudomonas fluorescens LP6a, to an oil-water interface. | 2008 | Colloids Surf B Biointerfaces | pmid:17997081 |
Cho T et al. | Transcriptional changes in Candida albicans Genes by both farnesol and high cell density at an early stage of morphogenesis in N-acetyl-D-glucosamine medium. | 2007 | Nihon Ishinkin Gakkai Zasshi | pmid:17975531 |
Zvibel I et al. | The effect of Ras inhibition on the proliferation, apoptosis and matrix metalloproteases activity in rat hepatic stellate cells. | 2008 | Dig. Dis. Sci. | pmid:17934818 |
Vik A et al. | Screening of terpenes and derivatives for antimycobacterial activity; identification of geranylgeraniol and geranylgeranyl acetate as potent inhibitors of Mycobacterium tuberculosis in vitro. | 2007 | Planta Med. | pmid:17924309 |
Haklai R et al. | Orally administered FTS (salirasib) inhibits human pancreatic tumor growth in nude mice. | 2008 | Cancer Chemother. Pharmacol. | pmid:17909812 |
Dionigi CP et al. | Effects of farnesol and the off-flavor derivative geosmin on Streptomyces tendae. | 1991 | Appl. Environ. Microbiol. | pmid:1785920 |
Marciano D et al. | Neuroprotective effects of the Ras inhibitor S-trans-trans-farnesylthiosalicylic acid, measured by diffusion-weighted imaging after traumatic brain injury in rats. | 2007 | J. Neurotrauma | pmid:17711399 |
Lee H et al. | Characterization of (E,E)-farnesol and its fatty acid esters from anal scent glands of nutria (Myocastor coypus) by gas chromatography-mass spectrometry and gas chromatography-infrared spectrometry. | 2007 | J Chromatogr A | pmid:17709112 |
Joo JH et al. | Farnesol-induced apoptosis in human lung carcinoma cells is coupled to the endoplasmic reticulum stress response. | 2007 | Cancer Res. | pmid:17699800 |
Zhang L and Hill RP | Hypoxia enhances metastatic efficiency in HT1080 fibrosarcoma cells by increasing cell survival in lungs, not cell adhesion and invasion. | 2007 | Cancer Res. | pmid:17699784 |
Rossignol T et al. | Transcriptional response of Candida parapsilosis following exposure to farnesol. | 2007 | Antimicrob. Agents Chemother. | pmid:17684006 |
da Silva Morais A et al. | Inhibition of the Ras oncoprotein reduces proliferation of hepatocytes in vitro and in vivo in rats. | 2008 | Clin. Sci. | pmid:17678500 |
Cugini C et al. | Farnesol, a common sesquiterpene, inhibits PQS production in Pseudomonas aeruginosa. | 2007 | Mol. Microbiol. | pmid:17640272 |
Yue W et al. | Mechanisms of acquired resistance to endocrine therapy in hormone-dependent breast cancer cells. | 2007 Aug-Sep | J. Steroid Biochem. Mol. Biol. | pmid:17616457 |
Uppuluri P et al. | Farnesol-mediated inhibition of Candida albicans yeast growth and rescue by a diacylglycerol analogue. | 2007 | Yeast | pmid:17583896 |
Kuroda M et al. | Sesquiterpene farnesol as a competitive inhibitor of lipase activity of Staphylococcus aureus. | 2007 | FEMS Microbiol. Lett. | pmid:17559400 |
Zundelevich A et al. | Suppression of lung cancer tumor growth in a nude mouse model by the Ras inhibitor salirasib (farnesylthiosalicylic acid). | 2007 | Mol. Cancer Ther. | pmid:17541036 |
Cheng AX et al. | The rice (E)-beta-caryophyllene synthase (OsTPS3) accounts for the major inducible volatile sesquiterpenes. | 2007 | Phytochemistry | pmid:17524436 |
Navarathna DH et al. | Exogenous farnesol interferes with the normal progression of cytokine expression during candidiasis in a mouse model. | 2007 | Infect. Immun. | pmid:17517874 |
Bellahcène A et al. | Zoledronate inhibits alphavbeta3 and alphavbeta5 integrin cell surface expression in endothelial cells. | 2007 Mar-Apr | Endothelium | pmid:17497369 |
Woodard B et al. | 3D-QSAR of fungal quorum-sensing inhibiting analogs of farnesol. | 2007 Mar-Apr | J Environ Sci Health B | pmid:17454380 |
Crowell DN et al. | Arabidopsis thaliana plants possess a specific farnesylcysteine lyase that is involved in detoxification and recycling of farnesylcysteine. | 2007 | Plant J. | pmid:17425716 |
Blum R et al. | Gene expression signature of human cancer cell lines treated with the ras inhibitor salirasib (S-farnesylthiosalicylic acid). | 2007 | Cancer Res. | pmid:17409441 |
Touhara K and Prestwich GD | Binding site mapping of a photoaffinity-labeled juvenile hormone binding protein. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1734862 |
Journe F et al. | Farnesol, a mevalonate pathway intermediate, stimulates MCF-7 breast cancer cell growth through farnesoid-X-receptor-mediated estrogen receptor activation. | 2008 | Breast Cancer Res. Treat. | pmid:17333335 |
Navarathna DH et al. | Effect of farnesol on a mouse model of systemic candidiasis, determined by use of a DPP3 knockout mutant of Candida albicans. | 2007 | Infect. Immun. | pmid:17283095 |
Shintre MS et al. | Evaluation of an alcohol-based surgical hand disinfectant containing a synergistic combination of farnesol and benzethonium chloride for immediate and persistent activity against resident hand flora of volunteers and with a novel in vitro pig skin model. | 2007 | Infect Control Hosp Epidemiol | pmid:17265401 |
Dumitru R et al. | In vivo and in vitro anaerobic mating in Candida albicans. | 2007 | Eukaryotic Cell | pmid:17259544 |
Henriques M et al. | Effect of farnesol on Candida dubliniensis morphogenesis. | 2007 | Lett. Appl. Microbiol. | pmid:17257261 |
Kuroda M et al. | Sesquiterpene farnesol inhibits recycling of the C55 lipid carrier of the murein monomer precursor contributing to increased susceptibility to beta-lactams in methicillin-resistant Staphylococcus aureus. | 2007 | J. Antimicrob. Chemother. | pmid:17242033 |
Lombardi L et al. | Circadian rhythms in Neurospora crassa: clock mutant effects in the absence of a frq-based oscillator. | 2007 | Genetics | pmid:17237512 |
L'Helias C | [Juvenile hormone in diapausing Pieris brassicae and mutations. Tetrahydrofolic acid and pterins incubated in chrysalids, provoking ontogenic and mutagenic genetic information alterations in Drosophila melanogaster]. | 1975 Mar-Apr | Ann. Endocrinol. (Paris) | pmid:172004 |
Nokhodchi A et al. | The effect of terpene concentrations on the skin penetration of diclofenac sodium. | 2007 | Int J Pharm | pmid:17174049 |
Fairn GD et al. | A chemogenomic screen in Saccharomyces cerevisiae uncovers a primary role for the mitochondria in farnesol toxicity and its regulation by the Pkc1 pathway. | 2007 | J. Biol. Chem. | pmid:17164236 |
Wendland J et al. | Use of the Porcine Intestinal Epithelium (PIE)-Assay to analyze early stages of colonization by the human fungal pathogen Candida albicans. | 2006 | J. Basic Microbiol. | pmid:17139615 |
Wiseman DA et al. | Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21(Cip1) and p27(Kip1) in human pancreatic adenocarcinoma cells. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17138864 |
Cetin A et al. | Angiotensin II-induced MAPK phosphorylation mediated by Ras and/or phospholipase C-dependent phosphorylations but not by protein kinase C phosphorylation in cultured rat vascular smooth muscle cells. | 2007 | Pharmacology | pmid:17135774 |
Shapira S et al. | The tumor suppressor neurofibromin confers sensitivity to apoptosis by Ras-dependent and Ras-independent pathways. | 2007 | Cell Death Differ. | pmid:17096025 |
Hamada M et al. | Inhibitory activity of 1-farnesylpyridinium on the spatial control over the assembly of cell wall polysaccharides in Schizosaccharomyces pombe. | 2006 | J. Biochem. | pmid:17092950 |
Jones G et al. | The retinoid-X receptor ortholog, ultraspiracle, binds with nanomolar affinity to an endogenous morphogenetic ligand. | 2006 | FEBS J. | pmid:17064257 |
Hasmim M et al. | Zoledronate inhibits endothelial cell adhesion, migration and survival through the suppression of multiple, prenylation-dependent signaling pathways. | 2007 | J. Thromb. Haemost. | pmid:17059425 |
Jabra-Rizk MA et al. | Effect of farnesol on Candida dubliniensis biofilm formation and fluconazole resistance. | 2006 | FEMS Yeast Res. | pmid:17042756 |
Binda C et al. | Structure of the human mitochondrial monoamine oxidase B: new chemical implications for neuroprotectant drug design. | 2006 | Neurology | pmid:17030739 |
Barkan B et al. | The Ras inhibitor farnesylthiosalicylic acid as a potential therapy for neurofibromatosis type 1. | 2006 | Clin. Cancer Res. | pmid:17000690 |
Blum R et al. | Suppression of survivin expression in glioblastoma cells by the Ras inhibitor farnesylthiosalicylic acid promotes caspase-dependent apoptosis. | 2006 | Mol. Cancer Ther. | pmid:16985068 |
Alem MA et al. | Production of tyrosol by Candida albicans biofilms and its role in quorum sensing and biofilm development. | 2006 | Eukaryotic Cell | pmid:16980403 |
Rung E et al. | Depletion of substrates for protein prenylation increases apoptosis in human periovulatory granulosa cells. | 2006 | Mol. Reprod. Dev. | pmid:16868926 |
Saidi S et al. | In vitro synergistic effect of farnesol and human gingival cells against Candida albicans. | 2006 | Yeast | pmid:16845684 |
Fuchs BB and Mylonakis E | Using non-mammalian hosts to study fungal virulence and host defense. | 2006 | Curr. Opin. Microbiol. | pmid:16814595 |
Erlich S et al. | Ras inhibition results in growth arrest and death of androgen-dependent and androgen-independent prostate cancer cells. | 2006 | Biochem. Pharmacol. | pmid:16780807 |
Green TR et al. | Compartmentation of isopentenyl pyophosphate isomerase and prenyl transferase in developing castor bean endosperm. | 1975 | Biochem. Biophys. Res. Commun. | pmid:167761 |
Jahangir T et al. | Farnesol prevents Fe-NTA-mediated renal oxidative stress and early tumour promotion markers in rats. | 2006 | Hum Exp Toxicol | pmid:16758765 |
Berzat AC et al. | Using inhibitors of prenylation to block localization and transforming activity. | 2006 | Meth. Enzymol. | pmid:16757354 |