2E,6E-farnesol

2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.

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Introduction

To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2E,6E-farnesol?

2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol

MeSH term MeSH ID Detail
Candidiasis, Invasive D058365 2 associated lipids
Anisakiasis D017129 2 associated lipids
Nerve Sheath Neoplasms D018317 4 associated lipids
Neuritis, Autoimmune, Experimental D009444 4 associated lipids
Head Injuries, Closed D016489 5 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Neurilemmoma D009442 10 associated lipids
Meningioma D008579 11 associated lipids
Candidiasis, Oral D002180 11 associated lipids
Neoplasms, Glandular and Epithelial D009375 12 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with 2E,6E-farnesol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2E,6E-farnesol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 2E,6E-farnesol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2E,6E-farnesol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 2E,6E-farnesol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2E,6E-farnesol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 2E,6E-farnesol

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Authors Title Published Journal PubMed Link
Jin J et al. Farnesol, a potential efflux pump inhibitor in Mycobacterium smegmatis. 2010 Molecules pmid:21042264
Špičáková A et al. Nerolidol and Farnesol Inhibit Some Cytochrome P450 Activities but Did Not Affect Other Xenobiotic-Metabolizing Enzymes in Rat and Human Hepatic Subcellular Fractions. 2017 Molecules pmid:28338641
Togashi N et al. Effects of two terpene alcohols on the antibacterial activity and the mode of action of farnesol against Staphylococcus aureus. 2008 Molecules pmid:19078849
Rung E et al. Depletion of substrates for protein prenylation increases apoptosis in human periovulatory granulosa cells. 2006 Mol. Reprod. Dev. pmid:16868926
Benford HL et al. Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs. 1999 Mol. Pharmacol. pmid:10385693
Maher M et al. Activation of TRPA1 by farnesyl thiosalicylic acid. 2008 Mol. Pharmacol. pmid:18171730
Bandara HM et al. Incorporation of Farnesol Significantly Increases the Efficacy of Liposomal Ciprofloxacin against Pseudomonas aeruginosa Biofilms in Vitro. 2016 Mol. Pharm. pmid:27383205
Zhang X et al. PEG-farnesyl thiosalicylic acid telodendrimer micelles as an improved formulation for targeted delivery of paclitaxel. 2014 Mol. Pharm. pmid:24987803
Savoldi M et al. Farnesol induces the transcriptional accumulation of the Aspergillus nidulans Apoptosis-Inducing Factor (AIF)-like mitochondrial oxidoreductase. 2008 Mol. Microbiol. pmid:18681941
Cugini C et al. Farnesol, a common sesquiterpene, inhibits PQS production in Pseudomonas aeruginosa. 2007 Mol. Microbiol. pmid:17640272